ID

44964

Beskrivning

Principal Investigator: S. Faraone, SUNY Upstate Medical University, Syracuse, NY, USA MeSH: Attention Deficit Disorder with Hyperactivity https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000016 The goal of the project is to complete a 600,000 tag SNP genome-wide association scan of 958 parent-child trios from the International Multisite ADHD Genetics (IMAGE) project, in order to assess the association of SNP markers with ADHD, analyze quantitative ADHD phenotypes, complete copy number analyses, assess parent of origin effects and season of birth effects, and test for epistasis among apparently uncorrelated genes. *Acquiring DNA Samples* All consent forms stipulate that the samples can only be used by researchers who have been approved by the National Institute of Mental Health (NIMH), National Institutes of Health. All consent forms, except those used at the Zürich site (N=141 subjects), explicitly indicate that the samples may be used by researchers from commercial enterprises seeking to benefit financially from the analysis of the samples. The Zürich consent does not prohibit such use. The Zürich consent form also included an "opt out" that allowed the subjects to indicate that they did not want their samples stored at the NIMH repository or used by researchers external to the project. No subjects enrolled in the project opted out. *Consent groups and participant set* - ADHD (ADHD): 2758 (924 trios)

Länk

https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000016

Nyckelord

  1. 2022-05-11 2022-05-11 - Martin Dugas
  2. 2022-05-11 2022-05-11 - Martin Dugas
  3. 2022-05-12 2022-05-12 - Martin Dugas
  4. 2022-05-20 2022-05-20 - Dr. Christian Niklas
Rättsinnehavare

S. Faraone, SUNY Upstate Medical University, Syracuse, NY, USA

Uppladdad den

20 maj 2022

DOI

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Licens

Creative Commons BY-NC 4.0

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dbGaP phs000016 International Multi-Center ADHD Genetics Project

Eligibility Criteria

  1. StudyEvent: SEV1
    1. Eligibility Criteria
    2. The data table contains the main diagnosis (DSM-IV), information on comorbidity, prorated hyperactivity scores (quantitative trait 1, 2, 3, 4), I.Q. score, medication status (n=10 variables) and sociodemographic information (n=12 variables).
    3. The data table contains information obtained through the Conners' behavioral rating scale (n=80 questions), describing the child's behavior as observed by the parent.
    4. The data table contains information obtained through the Conners' behavioral rating scale (n=59 questions), describing the child's behavior as observed by a teacher.
    5. The data table contains information obtained through the PACS (Parental Account of Childhood Symptoms) interview administered by a trained interviewer (n=200 questions). Questions represent four behavioral sub-categories: emotional pattern; activity level and inattentive behavior; disruptive behavior; comorbidity and other problems (including autism spectrum disorders).
    6. The data table contains information obtained through the SDQ (Strength and Difficulties, n=25 questions) questionnaire describing the child's behavior as observed by the parent. The questions address five subcategories: emotional symptoms scale; conduct problem scale; hyperactivity scale; peer problems scale; prosocial scale.
    7. The data table contains information obtained through the SDQ (Strength and Difficulties, n=25 questions) questionnaire describing the child's behavior as observed by a teacher. The questions address five subcategories: emotional symptoms scale; conduct problem scale; hyperactivity scale; peer problems scale; prosocial scale.
    8. ADHD Pedigree Information
    9. Subject - Consent Information
    10. Subject - Sample Mapping
Inclusion and exclusion criteria
Beskrivning

Inclusion and exclusion criteria

Proband diagnosis: combined subtype ADHD
Beskrivning

Elig.phs000016.v2.p2.1

Datatyp

boolean

Children aged 6-17 years (inclusive)
Beskrivning

Elig.phs000016.v2.p2.2

Datatyp

boolean

One or more sibling(s) in the same age range
Beskrivning

Elig.phs000016.v2.p2.3

Datatyp

boolean

Both parents available to provide DNA sample or one parent available plus two or more siblings
Beskrivning

Elig.phs000016.v2.p2.4

Datatyp

boolean

IQ above 70
Beskrivning

Elig.phs000016.v2.p2.5

Datatyp

boolean

Free of single-gene disorders known to be associated with ADHD (e.g. fragile-X, phenylketonuria, hypercalcaemia, thyroid hormone resistance)
Beskrivning

Elig.phs000016.v2.p2.6

Datatyp

boolean

Free of neurological disease and damage (e.g. hemiplegia and other cerebral palsies, epilepsy, hydrocephalus, post- encephalitic syndromes, psychosis, sensorimotor handicaps)
Beskrivning

Elig.phs000016.v2.p2.7

Datatyp

boolean

Living at home with at least one biological parent and one full sibling
Beskrivning

Elig.phs000016.v2.p2.8

Datatyp

boolean

Not meeting criteria for autism or Asperger's syndrome
Beskrivning

Elig.phs000016.v2.p2.9

Datatyp

boolean

Similar models

Eligibility Criteria

  1. StudyEvent: SEV1
    1. Eligibility Criteria
    2. The data table contains the main diagnosis (DSM-IV), information on comorbidity, prorated hyperactivity scores (quantitative trait 1, 2, 3, 4), I.Q. score, medication status (n=10 variables) and sociodemographic information (n=12 variables).
    3. The data table contains information obtained through the Conners' behavioral rating scale (n=80 questions), describing the child's behavior as observed by the parent.
    4. The data table contains information obtained through the Conners' behavioral rating scale (n=59 questions), describing the child's behavior as observed by a teacher.
    5. The data table contains information obtained through the PACS (Parental Account of Childhood Symptoms) interview administered by a trained interviewer (n=200 questions). Questions represent four behavioral sub-categories: emotional pattern; activity level and inattentive behavior; disruptive behavior; comorbidity and other problems (including autism spectrum disorders).
    6. The data table contains information obtained through the SDQ (Strength and Difficulties, n=25 questions) questionnaire describing the child's behavior as observed by the parent. The questions address five subcategories: emotional symptoms scale; conduct problem scale; hyperactivity scale; peer problems scale; prosocial scale.
    7. The data table contains information obtained through the SDQ (Strength and Difficulties, n=25 questions) questionnaire describing the child's behavior as observed by a teacher. The questions address five subcategories: emotional symptoms scale; conduct problem scale; hyperactivity scale; peer problems scale; prosocial scale.
    8. ADHD Pedigree Information
    9. Subject - Consent Information
    10. Subject - Sample Mapping
Name
Typ
Description | Question | Decode (Coded Value)
Datatyp
Alias
Item Group
Inclusion and exclusion criteria
Elig.phs000016.v2.p2.1
Item
Proband diagnosis: combined subtype ADHD
boolean
Elig.phs000016.v2.p2.2
Item
Children aged 6-17 years (inclusive)
boolean
Elig.phs000016.v2.p2.3
Item
One or more sibling(s) in the same age range
boolean
Elig.phs000016.v2.p2.4
Item
Both parents available to provide DNA sample or one parent available plus two or more siblings
boolean
Elig.phs000016.v2.p2.5
Item
IQ above 70
boolean
Elig.phs000016.v2.p2.6
Item
Free of single-gene disorders known to be associated with ADHD (e.g. fragile-X, phenylketonuria, hypercalcaemia, thyroid hormone resistance)
boolean
Elig.phs000016.v2.p2.7
Item
Free of neurological disease and damage (e.g. hemiplegia and other cerebral palsies, epilepsy, hydrocephalus, post- encephalitic syndromes, psychosis, sensorimotor handicaps)
boolean
Elig.phs000016.v2.p2.8
Item
Living at home with at least one biological parent and one full sibling
boolean
Elig.phs000016.v2.p2.9
Item
Not meeting criteria for autism or Asperger's syndrome
boolean

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