ID

44937

Description

https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000016.v2.p2 The goal of the project is to complete a 600,000 tag SNP genome-wide association scan of 958 parent-child trios from the International Multisite ADHD Genetics (IMAGE) project, in order to assess the association of SNP markers with ADHD, analyze quantitative ADHD phenotypes, complete copy number analyses, assess parent of origin effects and season of birth effects, and test for epistasis among apparently uncorrelated genes. *Acquiring DNA Samples* All consent forms stipulate that the samples can only be used by researchers who have been approved by the National Institute of Mental Health (NIMH), National Institutes of Health. All consent forms, except those used at the Zürich site (N=141 subjects), explicitly indicate that the samples may be used by researchers from commercial enterprises seeking to benefit financially from the analysis of the samples. The Zürich consent does not prohibit such use. The Zürich consent form also included an "opt out" that allowed the subjects to indicate that they did not want their samples stored at the NIMH repository or used by researchers external to the project. No subjects enrolled in the project opted out. *Consent groups and participant set* - ADHD (ADHD): 2758 (924 trios)

Lien

https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000016.v2.p2

Mots-clés

  1. 11/05/2022 11/05/2022 - Martin Dugas
  2. 11/05/2022 11/05/2022 - Martin Dugas
  3. 12/05/2022 12/05/2022 - Martin Dugas
  4. 20/05/2022 20/05/2022 - Dr. Christian Niklas
Détendeur de droits

S. Faraone, SUNY Upstate Medical University, Syracuse, NY, USA

Téléchargé le

11 mai 2022

DOI

Pour une demande vous connecter.

Licence

Creative Commons BY-NC 4.0

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dbGaP phs000016.v2.p2 International Multi-Center ADHD Genetics Project

The data table contains the main diagnosis (DSM-IV), information on comorbidity, prorated hyperactivity scores (quantitative trait 1, 2, 3, 4), I.Q. score, medication status (n=10 variables) and sociodemographic information (n=12 variables).

  1. StudyEvent: SEV1
    1. The data table contains the main diagnosis (DSM-IV), information on comorbidity, prorated hyperactivity scores (quantitative trait 1, 2, 3, 4), I.Q. score, medication status (n=10 variables) and sociodemographic information (n=12 variables).
    2. The data table contains information obtained through the Conners' behavioral rating scale (n=80 questions), describing the child's behavior as observed by the parent.
    3. The data table contains information obtained through the Conners' behavioral rating scale (n=59 questions), describing the child's behavior as observed by a teacher.
    4. The data table contains information obtained through the PACS (Parental Account of Childhood Symptoms) interview administered by a trained interviewer (n=200 questions). Questions represent four behavioral sub-categories: emotional pattern; activity level and inattentive behavior; disruptive behavior; comorbidity and other problems (including autism spectrum disorders).
    5. The data table contains information obtained through the SDQ (Strength and Difficulties, n=25 questions) questionnaire describing the child's behavior as observed by the parent. The questions address five subcategories: emotional symptoms scale; conduct problem scale; hyperactivity scale; peer problems scale; prosocial scale.
    6. The data table contains information obtained through the SDQ (Strength and Difficulties, n=25 questions) questionnaire describing the child's behavior as observed by a teacher. The questions address five subcategories: emotional symptoms scale; conduct problem scale; hyperactivity scale; peer problems scale; prosocial scale.
    7. ADHD Pedigree Information
    8. Subject - Consent Information
    9. Subject - Sample Mapping
pht000049.v2.p2
Description

pht000049.v2.p2

Child's Project ID
Description

subid

Type de données

text

Father's Project ID
Description

father

Type de données

text

Mother's Project ID
Description

mother

Type de données

text

Gender of child
Description

sex

Type de données

text

Age at assessment
Description

age

Type de données

text

Main Diagnosis: DSM-IV (Diagnostic and Statistical Manual [of mental disease], IVth edition) ADHD Diagnosis
Description

diag

Type de données

text

DNA barcode at local database/ also sent to Perlegen
Description

dna

Type de données

text

Quantitative trait 1; prorated SDQ Hyperactivity T score, parent's version
Description

sdqp

Type de données

text

Quantitative trait 2; prorated SDQ Hyperactivity T score, teacher's version
Description

sdqt

Type de données

text

Quantitative trait 3; prorated Conners' Hyperactivity T score, parents' version
Description

conp

Type de données

text

Quantitative trait 4; prorated Conners' Hyperactivity T score, teachers' version
Description

cont

Type de données

text

Comorbidity: Conduct Disorder
Description

cd

Type de données

text

Comorbidity: Oppositional Defiant Disorder
Description

odd

Type de données

text

Medication status and rating period
Description

med

Type de données

text

Subject's gestational age at birth in weeks
Description

dges

Type de données

text

Full scale I.Q. (prorated)
Description

iq

Type de données

text

Ethnicity of natural mother
Description

denm

Type de données

text

Ethnicity of grandmother (mother's mother)
Description

degmm

Type de données

text

Ethnicity of grandfather (mother's father)
Description

degfm

Type de données

text

Ethnicity of natural father
Description

denf

Type de données

text

Ethnicity of grandmother (father's mother)
Description

degmf

Type de données

text

Ethnicity of grandfather (father's father)
Description

degff

Type de données

text

Ethnicity of child
Description

dech

Type de données

text

Mother's occupational status
Description

motherocc

Type de données

text

Father's occupational status
Description

fatherocc

Type de données

text

Similar models

The data table contains the main diagnosis (DSM-IV), information on comorbidity, prorated hyperactivity scores (quantitative trait 1, 2, 3, 4), I.Q. score, medication status (n=10 variables) and sociodemographic information (n=12 variables).

  1. StudyEvent: SEV1
    1. The data table contains the main diagnosis (DSM-IV), information on comorbidity, prorated hyperactivity scores (quantitative trait 1, 2, 3, 4), I.Q. score, medication status (n=10 variables) and sociodemographic information (n=12 variables).
    2. The data table contains information obtained through the Conners' behavioral rating scale (n=80 questions), describing the child's behavior as observed by the parent.
    3. The data table contains information obtained through the Conners' behavioral rating scale (n=59 questions), describing the child's behavior as observed by a teacher.
    4. The data table contains information obtained through the PACS (Parental Account of Childhood Symptoms) interview administered by a trained interviewer (n=200 questions). Questions represent four behavioral sub-categories: emotional pattern; activity level and inattentive behavior; disruptive behavior; comorbidity and other problems (including autism spectrum disorders).
    5. The data table contains information obtained through the SDQ (Strength and Difficulties, n=25 questions) questionnaire describing the child's behavior as observed by the parent. The questions address five subcategories: emotional symptoms scale; conduct problem scale; hyperactivity scale; peer problems scale; prosocial scale.
    6. The data table contains information obtained through the SDQ (Strength and Difficulties, n=25 questions) questionnaire describing the child's behavior as observed by a teacher. The questions address five subcategories: emotional symptoms scale; conduct problem scale; hyperactivity scale; peer problems scale; prosocial scale.
    7. ADHD Pedigree Information
    8. Subject - Consent Information
    9. Subject - Sample Mapping
Name
Type
Description | Question | Decode (Coded Value)
Type de données
Alias
Item Group
pht000049.v2.p2
subid
Item
Child's Project ID
text
father
Item
Father's Project ID
text
mother
Item
Mother's Project ID
text
Item
Gender of child
text
Code List
Gender of child
CL Item
Male (1)
CL Item
Female (2)
age
Item
Age at assessment
text
Item
Main Diagnosis: DSM-IV (Diagnostic and Statistical Manual [of mental disease], IVth edition) ADHD Diagnosis
text
Code List
Main Diagnosis: DSM-IV (Diagnostic and Statistical Manual [of mental disease], IVth edition) ADHD Diagnosis
CL Item
Non-ADHD (0)
CL Item
Inattentive subtype (1)
CL Item
Hyperactive subtype (2)
CL Item
Combined subtype (3)
CL Item
ADHD-NOS (Attention Deficit Hyperactivity Disorder-Not Otherwise Specified) (4)
CL Item
Not available (NA)
dna
Item
DNA barcode at local database/ also sent to Perlegen
text
sdqp
Item
Quantitative trait 1; prorated SDQ Hyperactivity T score, parent's version
text
sdqt
Item
Quantitative trait 2; prorated SDQ Hyperactivity T score, teacher's version
text
conp
Item
Quantitative trait 3; prorated Conners' Hyperactivity T score, parents' version
text
cont
Item
Quantitative trait 4; prorated Conners' Hyperactivity T score, teachers' version
text
Item
Comorbidity: Conduct Disorder
text
Code List
Comorbidity: Conduct Disorder
CL Item
No (0)
CL Item
Yes/probable (1)
CL Item
Not enough information to make the diagnosis (9)
CL Item
Not Applicable (NA)
Item
Comorbidity: Oppositional Defiant Disorder
text
Code List
Comorbidity: Oppositional Defiant Disorder
CL Item
No (0)
CL Item
Yes/probable (1)
CL Item
Not enough information to make the diagnosis (9)
CL Item
Not Applicable (NA)
Item
Medication status and rating period
text
Code List
Medication status and rating period
CL Item
Currently not taking medication: rate behaviour over last 6 months with special reference to a representative period (1)
CL Item
Off medication for 1-week: rate behaviour during time off medication (2)
CL Item
Intermittent use of medication: rate behaviour for days off medication (3)
CL Item
Constant use of medication: rate behaviour for last period off medication (retrospective assessment) (4)
CL Item
Constant use of medication, no period off in last 2-years: rating is for behaviour while medicated (5)
CL Item
Not Applicable (NA)
dges
Item
Subject's gestational age at birth in weeks
text
iq
Item
Full scale I.Q. (prorated)
text
Item
Ethnicity of natural mother
text
Code List
Ethnicity of natural mother
CL Item
Not answered (0)
CL Item
European origin (predominantly white Caucasian) (1)
CL Item
Asian origin (2)
CL Item
African origin (3)
CL Item
Mixed ethnicity (4)
CL Item
Other (5)
CL Item
Don't know (6)
CL Item
Not Applicable (NA)
Item
Ethnicity of grandmother (mother's mother)
text
Code List
Ethnicity of grandmother (mother's mother)
CL Item
Not answered (0)
CL Item
European origin (predominantly white Caucasian) (1)
CL Item
Asian origin (2)
CL Item
African origin (3)
CL Item
Mixed ethnicity (4)
CL Item
Other (5)
CL Item
Don't know (6)
CL Item
Not Applicable (NA)
Item
Ethnicity of grandfather (mother's father)
text
Code List
Ethnicity of grandfather (mother's father)
CL Item
Not answered (0)
CL Item
European origin (predominantly white Caucasian) (1)
CL Item
Asian origin (2)
CL Item
African origin (3)
CL Item
Mixed ethnicity (4)
CL Item
Other (5)
CL Item
Don't know (6)
CL Item
Not Applicable (NA)
Item
Ethnicity of natural father
text
Code List
Ethnicity of natural father
CL Item
Not answered (0)
CL Item
European origin (predominantly white Caucasian) (1)
CL Item
Asian origin (2)
CL Item
African origin (3)
CL Item
Mixed ethnicity (4)
CL Item
Other (5)
CL Item
Don't know (6)
CL Item
Not Applicable (NA)
Item
Ethnicity of grandmother (father's mother)
text
Code List
Ethnicity of grandmother (father's mother)
CL Item
Not answered (0)
CL Item
European origin (predominantly white Caucasian) (1)
CL Item
Asian origin (2)
CL Item
African origin (3)
CL Item
Mixed ethnicity (4)
CL Item
Other (5)
CL Item
Don't know (6)
CL Item
Not Applicable (NA)
Item
Ethnicity of grandfather (father's father)
text
Code List
Ethnicity of grandfather (father's father)
CL Item
Not answered (0)
CL Item
European origin (predominantly white Caucasian) (1)
CL Item
Asian origin (2)
CL Item
African origin (3)
CL Item
Mixed ethnicity (4)
CL Item
Other (5)
CL Item
Don't know (6)
CL Item
Not Applicable (NA)
Item
Ethnicity of child
text
Code List
Ethnicity of child
CL Item
Not answered (0)
CL Item
European origin (predominantly white Caucasian) (1)
CL Item
Asian origin (2)
CL Item
African origin (3)
CL Item
Mixed ethnicity (4)
CL Item
Other (5)
CL Item
Don't know (6)
CL Item
Not Applicable (NA)
Item
Mother's occupational status
text
Code List
Mother's occupational status
CL Item
Not completed (0)
CL Item
Professional (1)
CL Item
Clerk (2)
CL Item
Services/Sales (3)
CL Item
Labourer (4)
CL Item
Other (5)
CL Item
Not Applicable (NA)
Item
Father's occupational status
text
Code List
Father's occupational status
CL Item
Not completed (0)
CL Item
Professional (1)
CL Item
Clerk (2)
CL Item
Services/Sales (3)
CL Item
Labourer (4)
CL Item
Other (5)
CL Item
Not Applicable (NA)

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