0 Bedömningar

ID

44964

Beskrivning

Principal Investigator: S. Faraone, SUNY Upstate Medical University, Syracuse, NY, USA MeSH: Attention Deficit Disorder with Hyperactivity https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000016 The goal of the project is to complete a 600,000 tag SNP genome-wide association scan of 958 parent-child trios from the International Multisite ADHD Genetics (IMAGE) project, in order to assess the association of SNP markers with ADHD, analyze quantitative ADHD phenotypes, complete copy number analyses, assess parent of origin effects and season of birth effects, and test for epistasis among apparently uncorrelated genes. *Acquiring DNA Samples* All consent forms stipulate that the samples can only be used by researchers who have been approved by the National Institute of Mental Health (NIMH), National Institutes of Health. All consent forms, except those used at the Zürich site (N=141 subjects), explicitly indicate that the samples may be used by researchers from commercial enterprises seeking to benefit financially from the analysis of the samples. The Zürich consent does not prohibit such use. The Zürich consent form also included an "opt out" that allowed the subjects to indicate that they did not want their samples stored at the NIMH repository or used by researchers external to the project. No subjects enrolled in the project opted out. *Consent groups and participant set* - ADHD (ADHD): 2758 (924 trios)

Länk

https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000016

Nyckelord

  1. 2022-05-11 2022-05-11 - Martin Dugas
  2. 2022-05-11 2022-05-11 - Martin Dugas
  3. 2022-05-12 2022-05-12 - Martin Dugas
  4. 2022-05-20 2022-05-20 - Dr. Christian Niklas
Rättsinnehavare

S. Faraone, SUNY Upstate Medical University, Syracuse, NY, USA

Uppladdad den

20 maj 2022

DOI

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Licens

Creative Commons BY-NC 4.0

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    dbGaP phs000016 International Multi-Center ADHD Genetics Project

    Eligibility Criteria

    1. StudyEvent: SEV1
      1. Eligibility Criteria
      2. The data table contains the main diagnosis (DSM-IV), information on comorbidity, prorated hyperactivity scores (quantitative trait 1, 2, 3, 4), I.Q. score, medication status (n=10 variables) and sociodemographic information (n=12 variables).
      3. The data table contains information obtained through the Conners' behavioral rating scale (n=80 questions), describing the child's behavior as observed by the parent.
      4. The data table contains information obtained through the Conners' behavioral rating scale (n=59 questions), describing the child's behavior as observed by a teacher.
      5. The data table contains information obtained through the PACS (Parental Account of Childhood Symptoms) interview administered by a trained interviewer (n=200 questions). Questions represent four behavioral sub-categories: emotional pattern; activity level and inattentive behavior; disruptive behavior; comorbidity and other problems (including autism spectrum disorders).
      6. The data table contains information obtained through the SDQ (Strength and Difficulties, n=25 questions) questionnaire describing the child's behavior as observed by the parent. The questions address five subcategories: emotional symptoms scale; conduct problem scale; hyperactivity scale; peer problems scale; prosocial scale.
      7. The data table contains information obtained through the SDQ (Strength and Difficulties, n=25 questions) questionnaire describing the child's behavior as observed by a teacher. The questions address five subcategories: emotional symptoms scale; conduct problem scale; hyperactivity scale; peer problems scale; prosocial scale.
      8. ADHD Pedigree Information
      9. Subject - Consent Information
      10. Subject - Sample Mapping
    Inclusion and exclusion criteria
    Beskrivning

    Inclusion and exclusion criteria

    Proband diagnosis: combined subtype ADHD
    Beskrivning

    Elig.phs000016.v2.p2.1

    Datatyp

    boolean

    Children aged 6-17 years (inclusive)
    Beskrivning

    Elig.phs000016.v2.p2.2

    Datatyp

    boolean

    One or more sibling(s) in the same age range
    Beskrivning

    Elig.phs000016.v2.p2.3

    Datatyp

    boolean

    Both parents available to provide DNA sample or one parent available plus two or more siblings
    Beskrivning

    Elig.phs000016.v2.p2.4

    Datatyp

    boolean

    IQ above 70
    Beskrivning

    Elig.phs000016.v2.p2.5

    Datatyp

    boolean

    Free of single-gene disorders known to be associated with ADHD (e.g. fragile-X, phenylketonuria, hypercalcaemia, thyroid hormone resistance)
    Beskrivning

    Elig.phs000016.v2.p2.6

    Datatyp

    boolean

    Free of neurological disease and damage (e.g. hemiplegia and other cerebral palsies, epilepsy, hydrocephalus, post- encephalitic syndromes, psychosis, sensorimotor handicaps)
    Beskrivning

    Elig.phs000016.v2.p2.7

    Datatyp

    boolean

    Living at home with at least one biological parent and one full sibling
    Beskrivning

    Elig.phs000016.v2.p2.8

    Datatyp

    boolean

    Not meeting criteria for autism or Asperger's syndrome
    Beskrivning

    Elig.phs000016.v2.p2.9

    Datatyp

    boolean

    Similar models

    Eligibility Criteria

    1. StudyEvent: SEV1
      1. Eligibility Criteria
      2. The data table contains the main diagnosis (DSM-IV), information on comorbidity, prorated hyperactivity scores (quantitative trait 1, 2, 3, 4), I.Q. score, medication status (n=10 variables) and sociodemographic information (n=12 variables).
      3. The data table contains information obtained through the Conners' behavioral rating scale (n=80 questions), describing the child's behavior as observed by the parent.
      4. The data table contains information obtained through the Conners' behavioral rating scale (n=59 questions), describing the child's behavior as observed by a teacher.
      5. The data table contains information obtained through the PACS (Parental Account of Childhood Symptoms) interview administered by a trained interviewer (n=200 questions). Questions represent four behavioral sub-categories: emotional pattern; activity level and inattentive behavior; disruptive behavior; comorbidity and other problems (including autism spectrum disorders).
      6. The data table contains information obtained through the SDQ (Strength and Difficulties, n=25 questions) questionnaire describing the child's behavior as observed by the parent. The questions address five subcategories: emotional symptoms scale; conduct problem scale; hyperactivity scale; peer problems scale; prosocial scale.
      7. The data table contains information obtained through the SDQ (Strength and Difficulties, n=25 questions) questionnaire describing the child's behavior as observed by a teacher. The questions address five subcategories: emotional symptoms scale; conduct problem scale; hyperactivity scale; peer problems scale; prosocial scale.
      8. ADHD Pedigree Information
      9. Subject - Consent Information
      10. Subject - Sample Mapping
    Name
    Typ
    Description | Question | Decode (Coded Value)
    Datatyp
    Alias
    Item Group
    Inclusion and exclusion criteria
    Elig.phs000016.v2.p2.1
    Item
    Proband diagnosis: combined subtype ADHD
    boolean
    Elig.phs000016.v2.p2.2
    Item
    Children aged 6-17 years (inclusive)
    boolean
    Elig.phs000016.v2.p2.3
    Item
    One or more sibling(s) in the same age range
    boolean
    Elig.phs000016.v2.p2.4
    Item
    Both parents available to provide DNA sample or one parent available plus two or more siblings
    boolean
    Elig.phs000016.v2.p2.5
    Item
    IQ above 70
    boolean
    Elig.phs000016.v2.p2.6
    Item
    Free of single-gene disorders known to be associated with ADHD (e.g. fragile-X, phenylketonuria, hypercalcaemia, thyroid hormone resistance)
    boolean
    Elig.phs000016.v2.p2.7
    Item
    Free of neurological disease and damage (e.g. hemiplegia and other cerebral palsies, epilepsy, hydrocephalus, post- encephalitic syndromes, psychosis, sensorimotor handicaps)
    boolean
    Elig.phs000016.v2.p2.8
    Item
    Living at home with at least one biological parent and one full sibling
    boolean
    Elig.phs000016.v2.p2.9
    Item
    Not meeting criteria for autism or Asperger's syndrome
    boolean

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