ID
38904
Description
Study ID: 111364 Clinical Study ID: 111364 Study Title: A 28-Day, Polysomnographic and subjective assessment of Vestipitant (15mg/day) for the treatment of Primary Insomnia in adult Outpatients Patient Level Data: Study Listed on ClinicalStudyDataRequest.com Clinicaltrials.gov Identifier: NCT00992160 Clinicaltrials.gov Links: https://clinicaltrials.gov/ct2/show/NCT00992160 Sponsor: GlaxoSmithKline Collaborators: N/A Phase: Phase 2 Study Recruitment Status: Completed Generic Name: Vestipitant, Placebo Trade Name: N/A Study Indication: Primary Insomnia, Sleep Disorders This phase II, placebo-controlled, double-blind trial studies the polysomnographic and subjective effect of the neurokinin (NK1) antagonist vestipitant (15mg/day at bedtime) for the treatment of primary insomnia in adult outpatients over a period of four weeks. The study consists of a clinical Screening Visit (Visit 1), up to 21 days before investigational product/placebo initiation, two screening polysomnographies (Visits 2 and 3), followed by a placebo run-in until Visit 4, at which the subject is randomized to vestipitant or placebo, taken every night for 28 days. On Day 1 and 2 (Visits 4 and 5), polysomnographies are performed. Visit 6 is a safety visit on Day 15. On Day 27 and 28, Visits 7 and 8 are performed, which again include polysomnography studies. Subjects then undergo a 7 to 10 day placebo run-out period and have Day 7 and Day 14 Follow-Up Visit (Visits 9 and 10). The purpose of this form is to check the subject's eligibility and should be filled in at Visit 1 (Screening).
Link
https://clinicaltrials.gov/ct2/show/NCT00992160
Keywords
Versions (3)
- 3/1/19 3/1/19 -
- 11/12/19 11/12/19 -
- 11/12/19 11/12/19 -
Copyright Holder
GlaxoSmithKline
Uploaded on
November 12, 2019
DOI
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License
Creative Commons BY-NC 3.0
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Polysomnographic Assessment of Vestipitant for the Treatment of Primary Insomnia NCT00992160
Eligibility Criteria
- StudyEvent: ODM
Description
Eligibility Criteria
Alias
- UMLS CUI-1
- C1516637
Description
Inclusion Criteria
Alias
- UMLS CUI-1
- C1512693
Description
Able to Read/Understand/Provide Informed Consent and Protocol Compliance
Data type
boolean
Alias
- UMLS CUI [1,1]
- C0586740
- UMLS CUI [1,2]
- C0021430
- UMLS CUI [2,1]
- C0021430
- UMLS CUI [2,2]
- C0162340
- UMLS CUI [3]
- C0021430
- UMLS CUI [4]
- C0525058
Description
Gender and Age
Data type
boolean
Alias
- UMLS CUI [1]
- C0079399
- UMLS CUI [2]
- C0001779
Description
• A complaint of difficulty initiating and maintaining sleep or of nonrestorative sleep three or more times per week, for at least the 3 months preceding screening . • The sleep disturbance causes clinically significant distress or impairment in social, occupational, or other impo1tant areas of functioning. • The disturbance in sleep does not occur exclusively during the course of another sleep disorder or occur exclusively during the course of another mental disorder. • Lastly, the disturbance is not due to the direct physiological effects of a substance or general medical condition, such as lung disease, cerebrovascular disease, systemic infectious disease, cancer, chronic pain conditions (e.g. arthritis), endocrine conditions, and degenerative neurological disorders.
Data type
boolean
Alias
- UMLS CUI [1]
- C0033139
- UMLS CUI [2]
- C0220952
Description
Self-reported history of sleep problems, by total sleep time, sleep onset latency, and wake after sleep onset
Data type
boolean
Alias
- UMLS CUI [1,1]
- C2700446
- UMLS CUI [1,2]
- C3539544
- UMLS CUI [2]
- C4722414
- UMLS CUI [3]
- C4505222
- UMLS CUI [4]
- C4744894
Description
Time spent in bed
Data type
boolean
Alias
- UMLS CUI [1]
- C2135946
Description
Constant Bedtime, confirmed by diary
Data type
boolean
Alias
- UMLS CUI [1,1]
- C4053890
- UMLS CUI [1,2]
- C1948059
- UMLS CUI [2]
- C3890583
Description
Polysomnography results: Total sleep time, sleep latency, wake after sleep onset
Data type
boolean
Alias
- UMLS CUI [1,1]
- C0162701
- UMLS CUI [1,2]
- C0456984
- UMLS CUI [2]
- C4722414
- UMLS CUI [3]
- C0430629
- UMLS CUI [4]
- C4744894
Description
Non-childbearing potential defined as pre-menopausal females with a documented tubal ligation or hysterectomy; or postmenopausal defined as 12 months of spontaneous amenorrhea [in questionable cases a blood sample with simultaneous follicle stimulating hormone (FSH) > 40 MIU/ml and estradiol < 40 pg/ml (<140 pmol/L) is confirmatory].
Data type
boolean
Alias
- UMLS CUI [1]
- C3831118
- UMLS CUI [2]
- C0700589
Description
Health Status by medical and psychiatric history, physical examination, ECG, and serum chemistry, hematology, serology, and urinalysis
Data type
boolean
Alias
- UMLS CUI [1]
- C0018759
- UMLS CUI [2]
- C0262926
- UMLS CUI [3]
- C0748059
- UMLS CUI [4]
- C0031809
- UMLS CUI [5]
- C1623258
- UMLS CUI [6]
- C1883010
- UMLS CUI [7]
- C0474523
- UMLS CUI [8]
- C0036743
- UMLS CUI [9]
- C0042014
Description
Exclusion Criteria
Alias
- UMLS CUI-1
- C0680251
Description
Symptoms of sleep disorder other than primary insomnia, e.g. sleep apnea, restless leg syndrome, circadian rhythm disorder
Data type
boolean
Alias
- UMLS CUI [1,1]
- C0037088
- UMLS CUI [1,2]
- C0851578
- UMLS CUI [1,3]
- C0033139
- UMLS CUI [1,4]
- C0332300
- UMLS CUI [2]
- C0037315
- UMLS CUI [3]
- C0035258
- UMLS CUI [4]
- C0813142
Description
Significant Psychiatric Axis I except primary insomnia (by DSM-IV)
Data type
boolean
Alias
- UMLS CUI [1,1]
- C0270287
- UMLS CUI [1,2]
- C0004936
- UMLS CUI [1,3]
- C0750502
- UMLS CUI [1,4]
- C0033139
- UMLS CUI [1,5]
- C0332300
- UMLS CUI [2]
- C0220952
Description
Recent mood or mental disorder causing insomnia by investigator judgement
Data type
boolean
Alias
- UMLS CUI [1,1]
- C0525045
- UMLS CUI [1,2]
- C0332185
- UMLS CUI [1,3]
- C0566251
- UMLS CUI [1,4]
- C0917801
- UMLS CUI [1,5]
- C0022423
- UMLS CUI [1,6]
- C0008961
- UMLS CUI [2,1]
- C0205394
- UMLS CUI [2,2]
- C0004936
- UMLS CUI [2,3]
- C0332185
- UMLS CUI [2,4]
- C0566251
- UMLS CUI [2,5]
- C0917801
- UMLS CUI [2,6]
- C0022423
- UMLS CUI [2,7]
- C0008961
Description
Patients scoring 17 to 28 must be confirmed to not have major depressive illness to be eligible.
Data type
boolean
Alias
- UMLS CUI [1]
- C2960571
Description
Recent Alcohol, Narcotic, Benzodiazepine or other Substance Abuse except tobacco use (by DSM-IV criteria)
Data type
boolean
Alias
- UMLS CUI [1,1]
- C0332185
- UMLS CUI [1,2]
- C0085762
- UMLS CUI [2,1]
- C0332185
- UMLS CUI [2,2]
- C0524661
- UMLS CUI [3,1]
- C0332185
- UMLS CUI [3,2]
- C0338768
- UMLS CUI [4,1]
- C0332185
- UMLS CUI [4,2]
- C0205394
- UMLS CUI [4,3]
- C0038580
- UMLS CUI [4,4]
- C1705847
- UMLS CUI [4,5]
- C0543414
- UMLS CUI [5]
- C0220952
Description
Positive Urine Drug Screen (amphetamines, barbiturates, benzodiazepines, cannabinoids, cocaine, opiates)
Data type
boolean
Alias
- UMLS CUI [1]
- C0743300
- UMLS CUI [2]
- C0002667
- UMLS CUI [3]
- C0004745
- UMLS CUI [4]
- C0005064
- UMLS CUI [5]
- C0006864
- UMLS CUI [6]
- C0009170
- UMLS CUI [7]
- C0376196
Description
Positive Alcohol Breath Test
Data type
boolean
Alias
- UMLS CUI [1]
- C1112499
Description
History of neurological disorder (incl. dementia, cognitive disorder, significant head injury) or seizures (except febrile seizures)
Data type
boolean
Alias
- UMLS CUI [1,1]
- C0262926
- UMLS CUI [1,2]
- C0027765
- UMLS CUI [2,1]
- C0262926
- UMLS CUI [2,2]
- C0497327
- UMLS CUI [3,1]
- C0262926
- UMLS CUI [3,2]
- C0009241
- UMLS CUI [4,1]
- C0262926
- UMLS CUI [4,2]
- C0018674
- UMLS CUI [4,3]
- C1546944
- UMLS CUI [5,1]
- C0262926
- UMLS CUI [5,2]
- C0036572
- UMLS CUI [5,3]
- C1705847
- UMLS CUI [5,4]
- C0009952
Description
Unstable Medical Disorder or disorder interfering pharmacodynamics/pharmacokinetics of vestipitant, safety or evaluation
Data type
boolean
Alias
- UMLS CUI [1,1]
- C0012634
- UMLS CUI [1,2]
- C0443343
- UMLS CUI [2,1]
- C0012634
- UMLS CUI [2,2]
- C0521102
- UMLS CUI [2,3]
- C2607417
- UMLS CUI [2,4]
- C0243145
- UMLS CUI [3,1]
- C0012634
- UMLS CUI [3,2]
- C0521102
- UMLS CUI [3,3]
- C2607417
- UMLS CUI [3,4]
- C0031328
- UMLS CUI [4,1]
- C0012634
- UMLS CUI [4,2]
- C0521102
- UMLS CUI [4,3]
- C0036043
- UMLS CUI [5,1]
- C0012634
- UMLS CUI [5,2]
- C0521102
- UMLS CUI [5,3]
- C0220825
Description
ECG Abnormalities by Sponsor criteria
Data type
boolean
Alias
- UMLS CUI [1,1]
- C0522055
- UMLS CUI [1,2]
- C0243161
- UMLS CUI [1,3]
- C2347796
Description
ECG Abnormalities by Investigator Judgement
Data type
boolean
Alias
- UMLS CUI [1,1]
- C0522055
- UMLS CUI [1,2]
- C0022423
- UMLS CUI [1,3]
- C0008961
Description
HIV, Hepatitis B or Hepatitis C
Data type
boolean
Alias
- UMLS CUI [1]
- C0019699
- UMLS CUI [2]
- C0856706
- UMLS CUI [3]
- C1112419
Description
Positive serum/urine pregnancy test, lactating or planning to become pregnant
Data type
boolean
Alias
- UMLS CUI [1]
- C0430059
- UMLS CUI [2]
- C0430063
- UMLS CUI [3]
- C0032992
- UMLS CUI [4]
- C0006147
Description
Laboratory Tests Abnormal by Sponsor criteria
Data type
boolean
Alias
- UMLS CUI [1,1]
- C0438215
- UMLS CUI [1,2]
- C0243161
- UMLS CUI [1,3]
- C2347796
Description
Laboratory Results Abnormal by Investigator Judgement
Data type
boolean
Alias
- UMLS CUI [1,1]
- C0438215
- UMLS CUI [1,2]
- C0022423
- UMLS CUI [1,3]
- C0008961
Description
Abnormal thyroid function
Data type
boolean
Alias
- UMLS CUI [1]
- C0476414
Description
BMI
Data type
boolean
Alias
- UMLS CUI [1]
- C1305855
Description
Apnea-hypopnea Index
Data type
boolean
Alias
- UMLS CUI [1]
- C2111846
Description
Periodic Limb Movements with Arousal
Data type
boolean
Alias
- UMLS CUI [1,1]
- C1561887
- UMLS CUI [1,2]
- C0003808
Description
Recent or current nightshift or rotating shifts
Data type
boolean
Alias
- UMLS CUI [1,1]
- C0332185
- UMLS CUI [1,2]
- C4505094
- UMLS CUI [2,1]
- C0332185
- UMLS CUI [2,2]
- C4505093
- UMLS CUI [3,1]
- C0521116
- UMLS CUI [3,2]
- C4505094
- UMLS CUI [4,1]
- C0521116
- UMLS CUI [4,2]
- C4505093
Description
Recent or planned travel across time zones
Data type
boolean
Alias
- UMLS CUI [1,1]
- C1301732
- UMLS CUI [1,2]
- C2825194
- UMLS CUI [1,3]
- C0040802
- UMLS CUI [2,1]
- C0040802
- UMLS CUI [2,2]
- C2825194
- UMLS CUI [2,3]
- C0332185
Description
Regular Napping
Data type
boolean
Alias
- UMLS CUI [1,1]
- C0870935
- UMLS CUI [1,2]
- C0205272
Description
Note: 360 mL soda = ~50mg, 210 mL coffee or 60 mL espresso = ~100 mg, 210mL tea = ~75mg caffeine.
Data type
boolean
Alias
- UMLS CUI [1]
- C0948365
- UMLS CUI [2,1]
- C0043314
- UMLS CUI [2,2]
- C1512806
Description
Smoking Status or Nighttime smoking
Data type
boolean
Alias
- UMLS CUI [1]
- C1519386
- UMLS CUI [2,1]
- C0037369
- UMLS CUI [2,2]
- C0240526
Description
Note: 1 unit= 240mL beer, 90mL wine, or 30mL hard liquor.
Data type
boolean
Alias
- UMLS CUI [1]
- C0001948
Description
Use of Psychotropic Medications, e.g. benzodiazepines, anxiolytics, barbiturates, narcotics, or others incl. OTC drugs affecting sleep/wake function
Data type
boolean
Alias
- UMLS CUI [1]
- C0033978
- UMLS CUI [2]
- C0005064
- UMLS CUI [3]
- C0040616
- UMLS CUI [4]
- C0004745
- UMLS CUI [5]
- C0027415
- UMLS CUI [6,1]
- C0013227
- UMLS CUI [6,2]
- C0205394
- UMLS CUI [6,3]
- C0521102
- UMLS CUI [6,4]
- C4062291
- UMLS CUI [7,1]
- C2709201
- UMLS CUI [7,2]
- C0013227
- UMLS CUI [7,3]
- C0521102
- UMLS CUI [7,4]
- C4062291
Description
Recently started Cognitive Behavioral Therapy
Data type
boolean
Alias
- UMLS CUI [1,1]
- C0332185
- UMLS CUI [1,2]
- C0439659
- UMLS CUI [1,3]
- C0009244
Description
Chronic Systemic Corticosteroids, except inhaled corticosteroids in controlled asthma
Data type
boolean
Alias
- UMLS CUI [1,1]
- C0205191
- UMLS CUI [1,2]
- C4053960
- UMLS CUI [2,1]
- C1705847
- UMLS CUI [2,2]
- C2911690
- UMLS CUI [2,3]
- C0004096
- UMLS CUI [2,4]
- C2065041
Description
Depot Neuroleptic Use
Data type
boolean
Alias
- UMLS CUI [1]
- C2585377
Description
Drugs (incl. OTC drugs and herbal products) metabolized by CYP3A4 or CYP3A4 inducers/inhibitors
Data type
boolean
Alias
- UMLS CUI [1,1]
- C0013227
- UMLS CUI [1,2]
- C1142644
- UMLS CUI [1,3]
- C1524026
- UMLS CUI [2,1]
- C1142644
- UMLS CUI [2,2]
- C1524026
- UMLS CUI [3,1]
- C0025125
- UMLS CUI [3,2]
- C1142644
- UMLS CUI [3,3]
- C1524026
- UMLS CUI [4]
- C3830624
- UMLS CUI [5]
- C3830625
Description
Allergic Reaction or significant Adverse Effects to Vestipant or similar compounds
Data type
boolean
Alias
- UMLS CUI [1,1]
- C1527304
- UMLS CUI [1,2]
- C2607417
- UMLS CUI [2,1]
- C0750502
- UMLS CUI [2,2]
- C0559546
- UMLS CUI [2,3]
- C2607417
- UMLS CUI [3,1]
- C1527304
- UMLS CUI [3,2]
- C2607417
- UMLS CUI [3,3]
- C2348205
- UMLS CUI [4,1]
- C0750502
- UMLS CUI [4,2]
- C0559546
- UMLS CUI [4,3]
- C2607417
- UMLS CUI [4,4]
- C2348205
Description
Hypersensitivity to NK1 Antagonists
Data type
boolean
Alias
- UMLS CUI [1,1]
- C0020517
- UMLS CUI [1,2]
- C3543440
Description
Drug or Device Trial Participation Status
Data type
boolean
Alias
- UMLS CUI [1,1]
- C2348568
- UMLS CUI [1,2]
- C0304229
- UMLS CUI [2,1]
- C2348568
- UMLS CUI [2,2]
- C0025080
Description
Noncompliance expected in investigator's opinion
Data type
boolean
Alias
- UMLS CUI [1,1]
- C0376405
- UMLS CUI [1,2]
- C0525058
- UMLS CUI [1,3]
- C0022423
- UMLS CUI [1,4]
- C0008961
Similar models
Eligibility Criteria
- StudyEvent: ODM
C2985720 (UMLS CUI [2])
C0021430 (UMLS CUI [1,2])
C0021430 (UMLS CUI [2,1])
C0162340 (UMLS CUI [2,2])
C0021430 (UMLS CUI [3])
C0525058 (UMLS CUI [4])
C0001779 (UMLS CUI [2])
C0220952 (UMLS CUI [2])
C3539544 (UMLS CUI [1,2])
C4722414 (UMLS CUI [2])
C4505222 (UMLS CUI [3])
C4744894 (UMLS CUI [4])
C1948059 (UMLS CUI [1,2])
C3890583 (UMLS CUI [2])
C0456984 (UMLS CUI [1,2])
C4722414 (UMLS CUI [2])
C0430629 (UMLS CUI [3])
C4744894 (UMLS CUI [4])
C0700589 (UMLS CUI [2])
C0262926 (UMLS CUI [2])
C0748059 (UMLS CUI [3])
C0031809 (UMLS CUI [4])
C1623258 (UMLS CUI [5])
C1883010 (UMLS CUI [6])
C0474523 (UMLS CUI [7])
C0036743 (UMLS CUI [8])
C0042014 (UMLS CUI [9])
C0851578 (UMLS CUI [1,2])
C0033139 (UMLS CUI [1,3])
C0332300 (UMLS CUI [1,4])
C0037315 (UMLS CUI [2])
C0035258 (UMLS CUI [3])
C0813142 (UMLS CUI [4])
C0004936 (UMLS CUI [1,2])
C0750502 (UMLS CUI [1,3])
C0033139 (UMLS CUI [1,4])
C0332300 (UMLS CUI [1,5])
C0220952 (UMLS CUI [2])
C0332185 (UMLS CUI [1,2])
C0566251 (UMLS CUI [1,3])
C0917801 (UMLS CUI [1,4])
C0022423 (UMLS CUI [1,5])
C0008961 (UMLS CUI [1,6])
C0205394 (UMLS CUI [2,1])
C0004936 (UMLS CUI [2,2])
C0332185 (UMLS CUI [2,3])
C0566251 (UMLS CUI [2,4])
C0917801 (UMLS CUI [2,5])
C0022423 (UMLS CUI [2,6])
C0008961 (UMLS CUI [2,7])
C0085762 (UMLS CUI [1,2])
C0332185 (UMLS CUI [2,1])
C0524661 (UMLS CUI [2,2])
C0332185 (UMLS CUI [3,1])
C0338768 (UMLS CUI [3,2])
C0332185 (UMLS CUI [4,1])
C0205394 (UMLS CUI [4,2])
C0038580 (UMLS CUI [4,3])
C1705847 (UMLS CUI [4,4])
C0543414 (UMLS CUI [4,5])
C0220952 (UMLS CUI [5])
C0002667 (UMLS CUI [2])
C0004745 (UMLS CUI [3])
C0005064 (UMLS CUI [4])
C0006864 (UMLS CUI [5])
C0009170 (UMLS CUI [6])
C0376196 (UMLS CUI [7])
C0027765 (UMLS CUI [1,2])
C0262926 (UMLS CUI [2,1])
C0497327 (UMLS CUI [2,2])
C0262926 (UMLS CUI [3,1])
C0009241 (UMLS CUI [3,2])
C0262926 (UMLS CUI [4,1])
C0018674 (UMLS CUI [4,2])
C1546944 (UMLS CUI [4,3])
C0262926 (UMLS CUI [5,1])
C0036572 (UMLS CUI [5,2])
C1705847 (UMLS CUI [5,3])
C0009952 (UMLS CUI [5,4])
C0443343 (UMLS CUI [1,2])
C0012634 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C2607417 (UMLS CUI [2,3])
C0243145 (UMLS CUI [2,4])
C0012634 (UMLS CUI [3,1])
C0521102 (UMLS CUI [3,2])
C2607417 (UMLS CUI [3,3])
C0031328 (UMLS CUI [3,4])
C0012634 (UMLS CUI [4,1])
C0521102 (UMLS CUI [4,2])
C0036043 (UMLS CUI [4,3])
C0012634 (UMLS CUI [5,1])
C0521102 (UMLS CUI [5,2])
C0220825 (UMLS CUI [5,3])
C0243161 (UMLS CUI [1,2])
C2347796 (UMLS CUI [1,3])
C0022423 (UMLS CUI [1,2])
C0008961 (UMLS CUI [1,3])
C0856706 (UMLS CUI [2])
C1112419 (UMLS CUI [3])
C0430063 (UMLS CUI [2])
C0032992 (UMLS CUI [3])
C0006147 (UMLS CUI [4])
C0243161 (UMLS CUI [1,2])
C2347796 (UMLS CUI [1,3])
C0022423 (UMLS CUI [1,2])
C0008961 (UMLS CUI [1,3])
C0003808 (UMLS CUI [1,2])
C4505094 (UMLS CUI [1,2])
C0332185 (UMLS CUI [2,1])
C4505093 (UMLS CUI [2,2])
C0521116 (UMLS CUI [3,1])
C4505094 (UMLS CUI [3,2])
C0521116 (UMLS CUI [4,1])
C4505093 (UMLS CUI [4,2])
C2825194 (UMLS CUI [1,2])
C0040802 (UMLS CUI [1,3])
C0040802 (UMLS CUI [2,1])
C2825194 (UMLS CUI [2,2])
C0332185 (UMLS CUI [2,3])
C0205272 (UMLS CUI [1,2])
C0043314 (UMLS CUI [2,1])
C1512806 (UMLS CUI [2,2])
C0037369 (UMLS CUI [2,1])
C0240526 (UMLS CUI [2,2])
C0005064 (UMLS CUI [2])
C0040616 (UMLS CUI [3])
C0004745 (UMLS CUI [4])
C0027415 (UMLS CUI [5])
C0013227 (UMLS CUI [6,1])
C0205394 (UMLS CUI [6,2])
C0521102 (UMLS CUI [6,3])
C4062291 (UMLS CUI [6,4])
C2709201 (UMLS CUI [7,1])
C0013227 (UMLS CUI [7,2])
C0521102 (UMLS CUI [7,3])
C4062291 (UMLS CUI [7,4])
C0439659 (UMLS CUI [1,2])
C0009244 (UMLS CUI [1,3])
C4053960 (UMLS CUI [1,2])
C1705847 (UMLS CUI [2,1])
C2911690 (UMLS CUI [2,2])
C0004096 (UMLS CUI [2,3])
C2065041 (UMLS CUI [2,4])
C1142644 (UMLS CUI [1,2])
C1524026 (UMLS CUI [1,3])
C1142644 (UMLS CUI [2,1])
C1524026 (UMLS CUI [2,2])
C0025125 (UMLS CUI [3,1])
C1142644 (UMLS CUI [3,2])
C1524026 (UMLS CUI [3,3])
C3830624 (UMLS CUI [4])
C3830625 (UMLS CUI [5])
C2607417 (UMLS CUI [1,2])
C0750502 (UMLS CUI [2,1])
C0559546 (UMLS CUI [2,2])
C2607417 (UMLS CUI [2,3])
C1527304 (UMLS CUI [3,1])
C2607417 (UMLS CUI [3,2])
C2348205 (UMLS CUI [3,3])
C0750502 (UMLS CUI [4,1])
C0559546 (UMLS CUI [4,2])
C2607417 (UMLS CUI [4,3])
C2348205 (UMLS CUI [4,4])
C3543440 (UMLS CUI [1,2])
C0304229 (UMLS CUI [1,2])
C2348568 (UMLS CUI [2,1])
C0025080 (UMLS CUI [2,2])
C0525058 (UMLS CUI [1,2])
C0022423 (UMLS CUI [1,3])
C0008961 (UMLS CUI [1,4])