ID
38904
Description
Study ID: 111364 Clinical Study ID: 111364 Study Title: A 28-Day, Polysomnographic and subjective assessment of Vestipitant (15mg/day) for the treatment of Primary Insomnia in adult Outpatients Patient Level Data: Study Listed on ClinicalStudyDataRequest.com Clinicaltrials.gov Identifier: NCT00992160 Clinicaltrials.gov Links: https://clinicaltrials.gov/ct2/show/NCT00992160 Sponsor: GlaxoSmithKline Collaborators: N/A Phase: Phase 2 Study Recruitment Status: Completed Generic Name: Vestipitant, Placebo Trade Name: N/A Study Indication: Primary Insomnia, Sleep Disorders This phase II, placebo-controlled, double-blind trial studies the polysomnographic and subjective effect of the neurokinin (NK1) antagonist vestipitant (15mg/day at bedtime) for the treatment of primary insomnia in adult outpatients over a period of four weeks. The study consists of a clinical Screening Visit (Visit 1), up to 21 days before investigational product/placebo initiation, two screening polysomnographies (Visits 2 and 3), followed by a placebo run-in until Visit 4, at which the subject is randomized to vestipitant or placebo, taken every night for 28 days. On Day 1 and 2 (Visits 4 and 5), polysomnographies are performed. Visit 6 is a safety visit on Day 15. On Day 27 and 28, Visits 7 and 8 are performed, which again include polysomnography studies. Subjects then undergo a 7 to 10 day placebo run-out period and have Day 7 and Day 14 Follow-Up Visit (Visits 9 and 10). The purpose of this form is to check the subject's eligibility and should be filled in at Visit 1 (Screening).
Lien
https://clinicaltrials.gov/ct2/show/NCT00992160
Mots-clés
Versions (3)
- 01/03/2019 01/03/2019 -
- 12/11/2019 12/11/2019 -
- 12/11/2019 12/11/2019 -
Détendeur de droits
GlaxoSmithKline
Téléchargé le
12 novembre 2019
DOI
Pour une demande vous connecter.
Licence
Creative Commons BY-NC 3.0
Modèle Commentaires :
Ici, vous pouvez faire des commentaires sur le modèle. À partir des bulles de texte, vous pouvez laisser des commentaires spécifiques sur les groupes Item et les Item.
Groupe Item commentaires pour :
Item commentaires pour :
Vous devez être connecté pour pouvoir télécharger des formulaires. Veuillez vous connecter ou s’inscrire gratuitement.
Polysomnographic Assessment of Vestipitant for the Treatment of Primary Insomnia NCT00992160
Eligibility Criteria
- StudyEvent: ODM
Description
Eligibility Criteria
Alias
- UMLS CUI-1
- C1516637
Description
Inclusion Criteria
Alias
- UMLS CUI-1
- C1512693
Description
Able to Read/Understand/Provide Informed Consent and Protocol Compliance
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C0586740
- UMLS CUI [1,2]
- C0021430
- UMLS CUI [2,1]
- C0021430
- UMLS CUI [2,2]
- C0162340
- UMLS CUI [3]
- C0021430
- UMLS CUI [4]
- C0525058
Description
Gender and Age
Type de données
boolean
Alias
- UMLS CUI [1]
- C0079399
- UMLS CUI [2]
- C0001779
Description
• A complaint of difficulty initiating and maintaining sleep or of nonrestorative sleep three or more times per week, for at least the 3 months preceding screening . • The sleep disturbance causes clinically significant distress or impairment in social, occupational, or other impo1tant areas of functioning. • The disturbance in sleep does not occur exclusively during the course of another sleep disorder or occur exclusively during the course of another mental disorder. • Lastly, the disturbance is not due to the direct physiological effects of a substance or general medical condition, such as lung disease, cerebrovascular disease, systemic infectious disease, cancer, chronic pain conditions (e.g. arthritis), endocrine conditions, and degenerative neurological disorders.
Type de données
boolean
Alias
- UMLS CUI [1]
- C0033139
- UMLS CUI [2]
- C0220952
Description
Self-reported history of sleep problems, by total sleep time, sleep onset latency, and wake after sleep onset
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C2700446
- UMLS CUI [1,2]
- C3539544
- UMLS CUI [2]
- C4722414
- UMLS CUI [3]
- C4505222
- UMLS CUI [4]
- C4744894
Description
Time spent in bed
Type de données
boolean
Alias
- UMLS CUI [1]
- C2135946
Description
Constant Bedtime, confirmed by diary
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C4053890
- UMLS CUI [1,2]
- C1948059
- UMLS CUI [2]
- C3890583
Description
Polysomnography results: Total sleep time, sleep latency, wake after sleep onset
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C0162701
- UMLS CUI [1,2]
- C0456984
- UMLS CUI [2]
- C4722414
- UMLS CUI [3]
- C0430629
- UMLS CUI [4]
- C4744894
Description
Non-childbearing potential defined as pre-menopausal females with a documented tubal ligation or hysterectomy; or postmenopausal defined as 12 months of spontaneous amenorrhea [in questionable cases a blood sample with simultaneous follicle stimulating hormone (FSH) > 40 MIU/ml and estradiol < 40 pg/ml (<140 pmol/L) is confirmatory].
Type de données
boolean
Alias
- UMLS CUI [1]
- C3831118
- UMLS CUI [2]
- C0700589
Description
Health Status by medical and psychiatric history, physical examination, ECG, and serum chemistry, hematology, serology, and urinalysis
Type de données
boolean
Alias
- UMLS CUI [1]
- C0018759
- UMLS CUI [2]
- C0262926
- UMLS CUI [3]
- C0748059
- UMLS CUI [4]
- C0031809
- UMLS CUI [5]
- C1623258
- UMLS CUI [6]
- C1883010
- UMLS CUI [7]
- C0474523
- UMLS CUI [8]
- C0036743
- UMLS CUI [9]
- C0042014
Description
Exclusion Criteria
Alias
- UMLS CUI-1
- C0680251
Description
Symptoms of sleep disorder other than primary insomnia, e.g. sleep apnea, restless leg syndrome, circadian rhythm disorder
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C0037088
- UMLS CUI [1,2]
- C0851578
- UMLS CUI [1,3]
- C0033139
- UMLS CUI [1,4]
- C0332300
- UMLS CUI [2]
- C0037315
- UMLS CUI [3]
- C0035258
- UMLS CUI [4]
- C0813142
Description
Significant Psychiatric Axis I except primary insomnia (by DSM-IV)
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C0270287
- UMLS CUI [1,2]
- C0004936
- UMLS CUI [1,3]
- C0750502
- UMLS CUI [1,4]
- C0033139
- UMLS CUI [1,5]
- C0332300
- UMLS CUI [2]
- C0220952
Description
Recent mood or mental disorder causing insomnia by investigator judgement
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C0525045
- UMLS CUI [1,2]
- C0332185
- UMLS CUI [1,3]
- C0566251
- UMLS CUI [1,4]
- C0917801
- UMLS CUI [1,5]
- C0022423
- UMLS CUI [1,6]
- C0008961
- UMLS CUI [2,1]
- C0205394
- UMLS CUI [2,2]
- C0004936
- UMLS CUI [2,3]
- C0332185
- UMLS CUI [2,4]
- C0566251
- UMLS CUI [2,5]
- C0917801
- UMLS CUI [2,6]
- C0022423
- UMLS CUI [2,7]
- C0008961
Description
Patients scoring 17 to 28 must be confirmed to not have major depressive illness to be eligible.
Type de données
boolean
Alias
- UMLS CUI [1]
- C2960571
Description
Recent Alcohol, Narcotic, Benzodiazepine or other Substance Abuse except tobacco use (by DSM-IV criteria)
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C0332185
- UMLS CUI [1,2]
- C0085762
- UMLS CUI [2,1]
- C0332185
- UMLS CUI [2,2]
- C0524661
- UMLS CUI [3,1]
- C0332185
- UMLS CUI [3,2]
- C0338768
- UMLS CUI [4,1]
- C0332185
- UMLS CUI [4,2]
- C0205394
- UMLS CUI [4,3]
- C0038580
- UMLS CUI [4,4]
- C1705847
- UMLS CUI [4,5]
- C0543414
- UMLS CUI [5]
- C0220952
Description
Positive Urine Drug Screen (amphetamines, barbiturates, benzodiazepines, cannabinoids, cocaine, opiates)
Type de données
boolean
Alias
- UMLS CUI [1]
- C0743300
- UMLS CUI [2]
- C0002667
- UMLS CUI [3]
- C0004745
- UMLS CUI [4]
- C0005064
- UMLS CUI [5]
- C0006864
- UMLS CUI [6]
- C0009170
- UMLS CUI [7]
- C0376196
Description
Positive Alcohol Breath Test
Type de données
boolean
Alias
- UMLS CUI [1]
- C1112499
Description
History of neurological disorder (incl. dementia, cognitive disorder, significant head injury) or seizures (except febrile seizures)
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C0262926
- UMLS CUI [1,2]
- C0027765
- UMLS CUI [2,1]
- C0262926
- UMLS CUI [2,2]
- C0497327
- UMLS CUI [3,1]
- C0262926
- UMLS CUI [3,2]
- C0009241
- UMLS CUI [4,1]
- C0262926
- UMLS CUI [4,2]
- C0018674
- UMLS CUI [4,3]
- C1546944
- UMLS CUI [5,1]
- C0262926
- UMLS CUI [5,2]
- C0036572
- UMLS CUI [5,3]
- C1705847
- UMLS CUI [5,4]
- C0009952
Description
Unstable Medical Disorder or disorder interfering pharmacodynamics/pharmacokinetics of vestipitant, safety or evaluation
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C0012634
- UMLS CUI [1,2]
- C0443343
- UMLS CUI [2,1]
- C0012634
- UMLS CUI [2,2]
- C0521102
- UMLS CUI [2,3]
- C2607417
- UMLS CUI [2,4]
- C0243145
- UMLS CUI [3,1]
- C0012634
- UMLS CUI [3,2]
- C0521102
- UMLS CUI [3,3]
- C2607417
- UMLS CUI [3,4]
- C0031328
- UMLS CUI [4,1]
- C0012634
- UMLS CUI [4,2]
- C0521102
- UMLS CUI [4,3]
- C0036043
- UMLS CUI [5,1]
- C0012634
- UMLS CUI [5,2]
- C0521102
- UMLS CUI [5,3]
- C0220825
Description
ECG Abnormalities by Sponsor criteria
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C0522055
- UMLS CUI [1,2]
- C0243161
- UMLS CUI [1,3]
- C2347796
Description
ECG Abnormalities by Investigator Judgement
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C0522055
- UMLS CUI [1,2]
- C0022423
- UMLS CUI [1,3]
- C0008961
Description
HIV, Hepatitis B or Hepatitis C
Type de données
boolean
Alias
- UMLS CUI [1]
- C0019699
- UMLS CUI [2]
- C0856706
- UMLS CUI [3]
- C1112419
Description
Positive serum/urine pregnancy test, lactating or planning to become pregnant
Type de données
boolean
Alias
- UMLS CUI [1]
- C0430059
- UMLS CUI [2]
- C0430063
- UMLS CUI [3]
- C0032992
- UMLS CUI [4]
- C0006147
Description
Laboratory Tests Abnormal by Sponsor criteria
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C0438215
- UMLS CUI [1,2]
- C0243161
- UMLS CUI [1,3]
- C2347796
Description
Laboratory Results Abnormal by Investigator Judgement
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C0438215
- UMLS CUI [1,2]
- C0022423
- UMLS CUI [1,3]
- C0008961
Description
Abnormal thyroid function
Type de données
boolean
Alias
- UMLS CUI [1]
- C0476414
Description
BMI
Type de données
boolean
Alias
- UMLS CUI [1]
- C1305855
Description
Apnea-hypopnea Index
Type de données
boolean
Alias
- UMLS CUI [1]
- C2111846
Description
Periodic Limb Movements with Arousal
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C1561887
- UMLS CUI [1,2]
- C0003808
Description
Recent or current nightshift or rotating shifts
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C0332185
- UMLS CUI [1,2]
- C4505094
- UMLS CUI [2,1]
- C0332185
- UMLS CUI [2,2]
- C4505093
- UMLS CUI [3,1]
- C0521116
- UMLS CUI [3,2]
- C4505094
- UMLS CUI [4,1]
- C0521116
- UMLS CUI [4,2]
- C4505093
Description
Recent or planned travel across time zones
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C1301732
- UMLS CUI [1,2]
- C2825194
- UMLS CUI [1,3]
- C0040802
- UMLS CUI [2,1]
- C0040802
- UMLS CUI [2,2]
- C2825194
- UMLS CUI [2,3]
- C0332185
Description
Regular Napping
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C0870935
- UMLS CUI [1,2]
- C0205272
Description
Note: 360 mL soda = ~50mg, 210 mL coffee or 60 mL espresso = ~100 mg, 210mL tea = ~75mg caffeine.
Type de données
boolean
Alias
- UMLS CUI [1]
- C0948365
- UMLS CUI [2,1]
- C0043314
- UMLS CUI [2,2]
- C1512806
Description
Smoking Status or Nighttime smoking
Type de données
boolean
Alias
- UMLS CUI [1]
- C1519386
- UMLS CUI [2,1]
- C0037369
- UMLS CUI [2,2]
- C0240526
Description
Note: 1 unit= 240mL beer, 90mL wine, or 30mL hard liquor.
Type de données
boolean
Alias
- UMLS CUI [1]
- C0001948
Description
Use of Psychotropic Medications, e.g. benzodiazepines, anxiolytics, barbiturates, narcotics, or others incl. OTC drugs affecting sleep/wake function
Type de données
boolean
Alias
- UMLS CUI [1]
- C0033978
- UMLS CUI [2]
- C0005064
- UMLS CUI [3]
- C0040616
- UMLS CUI [4]
- C0004745
- UMLS CUI [5]
- C0027415
- UMLS CUI [6,1]
- C0013227
- UMLS CUI [6,2]
- C0205394
- UMLS CUI [6,3]
- C0521102
- UMLS CUI [6,4]
- C4062291
- UMLS CUI [7,1]
- C2709201
- UMLS CUI [7,2]
- C0013227
- UMLS CUI [7,3]
- C0521102
- UMLS CUI [7,4]
- C4062291
Description
Recently started Cognitive Behavioral Therapy
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C0332185
- UMLS CUI [1,2]
- C0439659
- UMLS CUI [1,3]
- C0009244
Description
Chronic Systemic Corticosteroids, except inhaled corticosteroids in controlled asthma
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C0205191
- UMLS CUI [1,2]
- C4053960
- UMLS CUI [2,1]
- C1705847
- UMLS CUI [2,2]
- C2911690
- UMLS CUI [2,3]
- C0004096
- UMLS CUI [2,4]
- C2065041
Description
Depot Neuroleptic Use
Type de données
boolean
Alias
- UMLS CUI [1]
- C2585377
Description
Drugs (incl. OTC drugs and herbal products) metabolized by CYP3A4 or CYP3A4 inducers/inhibitors
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C0013227
- UMLS CUI [1,2]
- C1142644
- UMLS CUI [1,3]
- C1524026
- UMLS CUI [2,1]
- C1142644
- UMLS CUI [2,2]
- C1524026
- UMLS CUI [3,1]
- C0025125
- UMLS CUI [3,2]
- C1142644
- UMLS CUI [3,3]
- C1524026
- UMLS CUI [4]
- C3830624
- UMLS CUI [5]
- C3830625
Description
Allergic Reaction or significant Adverse Effects to Vestipant or similar compounds
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C1527304
- UMLS CUI [1,2]
- C2607417
- UMLS CUI [2,1]
- C0750502
- UMLS CUI [2,2]
- C0559546
- UMLS CUI [2,3]
- C2607417
- UMLS CUI [3,1]
- C1527304
- UMLS CUI [3,2]
- C2607417
- UMLS CUI [3,3]
- C2348205
- UMLS CUI [4,1]
- C0750502
- UMLS CUI [4,2]
- C0559546
- UMLS CUI [4,3]
- C2607417
- UMLS CUI [4,4]
- C2348205
Description
Hypersensitivity to NK1 Antagonists
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C0020517
- UMLS CUI [1,2]
- C3543440
Description
Drug or Device Trial Participation Status
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C2348568
- UMLS CUI [1,2]
- C0304229
- UMLS CUI [2,1]
- C2348568
- UMLS CUI [2,2]
- C0025080
Description
Noncompliance expected in investigator's opinion
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C0376405
- UMLS CUI [1,2]
- C0525058
- UMLS CUI [1,3]
- C0022423
- UMLS CUI [1,4]
- C0008961
Similar models
Eligibility Criteria
- StudyEvent: ODM
C2985720 (UMLS CUI [2])
C0021430 (UMLS CUI [1,2])
C0021430 (UMLS CUI [2,1])
C0162340 (UMLS CUI [2,2])
C0021430 (UMLS CUI [3])
C0525058 (UMLS CUI [4])
C0001779 (UMLS CUI [2])
C0220952 (UMLS CUI [2])
C3539544 (UMLS CUI [1,2])
C4722414 (UMLS CUI [2])
C4505222 (UMLS CUI [3])
C4744894 (UMLS CUI [4])
C1948059 (UMLS CUI [1,2])
C3890583 (UMLS CUI [2])
C0456984 (UMLS CUI [1,2])
C4722414 (UMLS CUI [2])
C0430629 (UMLS CUI [3])
C4744894 (UMLS CUI [4])
C0700589 (UMLS CUI [2])
C0262926 (UMLS CUI [2])
C0748059 (UMLS CUI [3])
C0031809 (UMLS CUI [4])
C1623258 (UMLS CUI [5])
C1883010 (UMLS CUI [6])
C0474523 (UMLS CUI [7])
C0036743 (UMLS CUI [8])
C0042014 (UMLS CUI [9])
C0851578 (UMLS CUI [1,2])
C0033139 (UMLS CUI [1,3])
C0332300 (UMLS CUI [1,4])
C0037315 (UMLS CUI [2])
C0035258 (UMLS CUI [3])
C0813142 (UMLS CUI [4])
C0004936 (UMLS CUI [1,2])
C0750502 (UMLS CUI [1,3])
C0033139 (UMLS CUI [1,4])
C0332300 (UMLS CUI [1,5])
C0220952 (UMLS CUI [2])
C0332185 (UMLS CUI [1,2])
C0566251 (UMLS CUI [1,3])
C0917801 (UMLS CUI [1,4])
C0022423 (UMLS CUI [1,5])
C0008961 (UMLS CUI [1,6])
C0205394 (UMLS CUI [2,1])
C0004936 (UMLS CUI [2,2])
C0332185 (UMLS CUI [2,3])
C0566251 (UMLS CUI [2,4])
C0917801 (UMLS CUI [2,5])
C0022423 (UMLS CUI [2,6])
C0008961 (UMLS CUI [2,7])
C0085762 (UMLS CUI [1,2])
C0332185 (UMLS CUI [2,1])
C0524661 (UMLS CUI [2,2])
C0332185 (UMLS CUI [3,1])
C0338768 (UMLS CUI [3,2])
C0332185 (UMLS CUI [4,1])
C0205394 (UMLS CUI [4,2])
C0038580 (UMLS CUI [4,3])
C1705847 (UMLS CUI [4,4])
C0543414 (UMLS CUI [4,5])
C0220952 (UMLS CUI [5])
C0002667 (UMLS CUI [2])
C0004745 (UMLS CUI [3])
C0005064 (UMLS CUI [4])
C0006864 (UMLS CUI [5])
C0009170 (UMLS CUI [6])
C0376196 (UMLS CUI [7])
C0027765 (UMLS CUI [1,2])
C0262926 (UMLS CUI [2,1])
C0497327 (UMLS CUI [2,2])
C0262926 (UMLS CUI [3,1])
C0009241 (UMLS CUI [3,2])
C0262926 (UMLS CUI [4,1])
C0018674 (UMLS CUI [4,2])
C1546944 (UMLS CUI [4,3])
C0262926 (UMLS CUI [5,1])
C0036572 (UMLS CUI [5,2])
C1705847 (UMLS CUI [5,3])
C0009952 (UMLS CUI [5,4])
C0443343 (UMLS CUI [1,2])
C0012634 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C2607417 (UMLS CUI [2,3])
C0243145 (UMLS CUI [2,4])
C0012634 (UMLS CUI [3,1])
C0521102 (UMLS CUI [3,2])
C2607417 (UMLS CUI [3,3])
C0031328 (UMLS CUI [3,4])
C0012634 (UMLS CUI [4,1])
C0521102 (UMLS CUI [4,2])
C0036043 (UMLS CUI [4,3])
C0012634 (UMLS CUI [5,1])
C0521102 (UMLS CUI [5,2])
C0220825 (UMLS CUI [5,3])
C0243161 (UMLS CUI [1,2])
C2347796 (UMLS CUI [1,3])
C0022423 (UMLS CUI [1,2])
C0008961 (UMLS CUI [1,3])
C0856706 (UMLS CUI [2])
C1112419 (UMLS CUI [3])
C0430063 (UMLS CUI [2])
C0032992 (UMLS CUI [3])
C0006147 (UMLS CUI [4])
C0243161 (UMLS CUI [1,2])
C2347796 (UMLS CUI [1,3])
C0022423 (UMLS CUI [1,2])
C0008961 (UMLS CUI [1,3])
C0003808 (UMLS CUI [1,2])
C4505094 (UMLS CUI [1,2])
C0332185 (UMLS CUI [2,1])
C4505093 (UMLS CUI [2,2])
C0521116 (UMLS CUI [3,1])
C4505094 (UMLS CUI [3,2])
C0521116 (UMLS CUI [4,1])
C4505093 (UMLS CUI [4,2])
C2825194 (UMLS CUI [1,2])
C0040802 (UMLS CUI [1,3])
C0040802 (UMLS CUI [2,1])
C2825194 (UMLS CUI [2,2])
C0332185 (UMLS CUI [2,3])
C0205272 (UMLS CUI [1,2])
C0043314 (UMLS CUI [2,1])
C1512806 (UMLS CUI [2,2])
C0037369 (UMLS CUI [2,1])
C0240526 (UMLS CUI [2,2])
C0005064 (UMLS CUI [2])
C0040616 (UMLS CUI [3])
C0004745 (UMLS CUI [4])
C0027415 (UMLS CUI [5])
C0013227 (UMLS CUI [6,1])
C0205394 (UMLS CUI [6,2])
C0521102 (UMLS CUI [6,3])
C4062291 (UMLS CUI [6,4])
C2709201 (UMLS CUI [7,1])
C0013227 (UMLS CUI [7,2])
C0521102 (UMLS CUI [7,3])
C4062291 (UMLS CUI [7,4])
C0439659 (UMLS CUI [1,2])
C0009244 (UMLS CUI [1,3])
C4053960 (UMLS CUI [1,2])
C1705847 (UMLS CUI [2,1])
C2911690 (UMLS CUI [2,2])
C0004096 (UMLS CUI [2,3])
C2065041 (UMLS CUI [2,4])
C1142644 (UMLS CUI [1,2])
C1524026 (UMLS CUI [1,3])
C1142644 (UMLS CUI [2,1])
C1524026 (UMLS CUI [2,2])
C0025125 (UMLS CUI [3,1])
C1142644 (UMLS CUI [3,2])
C1524026 (UMLS CUI [3,3])
C3830624 (UMLS CUI [4])
C3830625 (UMLS CUI [5])
C2607417 (UMLS CUI [1,2])
C0750502 (UMLS CUI [2,1])
C0559546 (UMLS CUI [2,2])
C2607417 (UMLS CUI [2,3])
C1527304 (UMLS CUI [3,1])
C2607417 (UMLS CUI [3,2])
C2348205 (UMLS CUI [3,3])
C0750502 (UMLS CUI [4,1])
C0559546 (UMLS CUI [4,2])
C2607417 (UMLS CUI [4,3])
C2348205 (UMLS CUI [4,4])
C3543440 (UMLS CUI [1,2])
C0304229 (UMLS CUI [1,2])
C2348568 (UMLS CUI [2,1])
C0025080 (UMLS CUI [2,2])
C0525058 (UMLS CUI [1,2])
C0022423 (UMLS CUI [1,3])
C0008961 (UMLS CUI [1,4])