ID
28181
Descripción
NCT02641314 Phase 2 Trial of Metronomic Treatment in Children and Adolescents With Recurrent or Progressive Neuroblastoma (NB). The study investigates the tolerance and the efficacy of a new combination of five drugs consisting of propranolol (antiangiogenetic, anti-neuroblastic), Celecoxib (modulating immune response, ant-neuroblastic), cyclophosphamide (antiangiogenetic, anti-neuroblastic), etoposide (antiangiogenetic, anti-neuroblastic), and vinblastin (antiangiogenetic, anti-neuroblastic). Vinblastin is scheduled every 14 days intravenously, all other drugs are applied daily throughout 365 days (except etoposide for 4x3 weeks). The efficacies of each of the drugs have been demonstrated in vitro and in vivo in animal studies. All drugs have been used in children for other conditions. From those experiences low toxicities and a favorable Quality of life are expected. Prof. Dr. Frank Berthold Abt. für Kinderonkologie und –hämatologie Zentrum für Kinder- und Jugendmedizin Universität zu Köln
Palabras clave
Versiones (5)
- 26/12/17 26/12/17 -
- 27/12/17 27/12/17 -
- 15/3/21 15/3/21 - Dr. rer. medic Philipp Neuhaus
- 13/4/21 13/4/21 - Dr. rer. medic Philipp Neuhaus
- 20/9/21 20/9/21 -
Titular de derechos de autor
Universität zu Köln
Subido en
27 de diciembre de 2017
DOI
10.21961/mdm:28181
Licencia
Creative Commons BY-NC 3.0
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Metronomic Treatment in Children and Adolescents With Recurrent or Progressive High Risk Neuroblastoma (METRO-NB2012) NCT02641314
Medical history
- StudyEvent: Subject Protocol
- Registration
- Medical history
- Baseline
- Therapy and toxicity cycle 1-3
- Therapy and toxicity cycle 4-6
- Therapy and toxicity cycle 7-9
- Therapy and toxicity cycle 10-13
- Therapy and toxicity cycle > 13
- Reference
- Study relevant visits
- Therapeutic response
- End of therapy
- Relapse
- Second malignancy
- Death
- Follow up
Descripción
Begleiterkrankungen
Descripción
Elemente der initialen Therapie (vor jedem Rezidiv)*
Descripción
Start date therapy
Tipo de datos
boolean
Alias
- UMLS CUI [1]
- C3173309
Descripción
Einschließlich Konsolidierung mit Retinsäure oder Immuntherapie
Tipo de datos
date
Unidades de medida
- mm/dd/yyyy
Alias
- UMLS CUI [1]
- C1531784
Descripción
Monoclonal Antibody Therapy
Tipo de datos
boolean
Alias
- UMLS CUI [1]
- C0279694
Descripción
High dose Chemotherapy
Tipo de datos
boolean
Alias
- UMLS CUI [1]
- C3665472
Descripción
MIBG
Tipo de datos
boolean
Alias
- UMLS CUI [1]
- C0047506
Descripción
Radiation therapy
Tipo de datos
boolean
Alias
- UMLS CUI [1]
- C1522449
Descripción
Remission
Tipo de datos
integer
Alias
- UMLS CUI [1,1]
- C0544452
- UMLS CUI [1,2]
- C0449438
Descripción
Rezidive/Progressionen
Descripción
Angaben zu vorherigen Rezidiven
Descripción
Recurrent disease number
Tipo de datos
integer
Alias
- UMLS CUI [1,1]
- C0750480
- UMLS CUI [1,2]
- C0277556
Descripción
Date of recurrent disease
Tipo de datos
date
Alias
- UMLS CUI [1,1]
- C0011008
- UMLS CUI [1,2]
- C0277556
Descripción
Systemisch: Nachweis von Fern-Metastasen
Tipo de datos
integer
Alias
- UMLS CUI [1,1]
- C0475437
- UMLS CUI [1,2]
- C0277556
Descripción
Malignant neoplasm of bone marrow
Tipo de datos
boolean
Alias
- UMLS CUI [1,1]
- C0027627
- UMLS CUI [1,2]
- C2703042
Descripción
Cave: lokoregionäre Lymphknoten-Metastasen in derselben Höhe des Primärtumors werden nicht als Lymphknotenfernmetastasen gewertet.
Tipo de datos
boolean
Alias
- UMLS CUI [1,1]
- C0686619
- UMLS CUI [1,2]
- C0443203
Descripción
Recurrent disease liver
Tipo de datos
boolean
Alias
- UMLS CUI [1,1]
- C0277556
- UMLS CUI [1,2]
- C0023884
Descripción
Recurrent disease skin
Tipo de datos
boolean
Alias
- UMLS CUI [1,1]
- C1123023
- UMLS CUI [1,2]
- C0277556
Descripción
ZNS-Metastasen sind definiert als intrazerebrale Parenchym-Herde, rein intraspinale Parenchym-Herde oder diffuse leptomeningeale Metastasen. Nicht als ZNS-Befall gewertet wird eine regionale Mitbeteiligung der Dura bei osteomedullärer Metastasierung des angrenzenden Knochens.
Tipo de datos
boolean
Alias
- UMLS CUI [1,1]
- C3714787
- UMLS CUI [1,2]
- C0277556
Descripción
Other recurrent disease
Tipo de datos
boolean
Alias
- UMLS CUI [1,1]
- C0205394
- UMLS CUI [1,2]
- C0277556
Descripción
Other recurrent disease specify
Tipo de datos
text
Alias
- UMLS CUI [1,1]
- C0205394
- UMLS CUI [1,2]
- C0277556
Descripción
Therapie
Descripción
Start date of treatment
Tipo de datos
date
Unidades de medida
- mm/dd/yyyy
Alias
- UMLS CUI [1]
- C1531783
Descripción
Therapy end date
Tipo de datos
date
Unidades de medida
- mm/dd/yyyy
Alias
- UMLS CUI [1]
- C1531783
Descripción
Sofern vorhanden:
Tipo de datos
text
Alias
- UMLS CUI [1,1]
- C0040808
- UMLS CUI [1,2]
- C0277556
Descripción
Comment
Tipo de datos
text
Alias
- UMLS CUI [1]
- C0947611
Descripción
Monoclonal Antibody Therapy
Tipo de datos
boolean
Alias
- UMLS CUI [1]
- C0279694
Descripción
Chemotherapy
Tipo de datos
boolean
Alias
- UMLS CUI [1]
- C3665472
Descripción
mIBG
Tipo de datos
boolean
Alias
- UMLS CUI [1]
- C0454107
Descripción
Therapeutic radiology procedure
Tipo de datos
boolean
Alias
- UMLS CUI [1]
- C1522449
Descripción
Status of disease remission
Tipo de datos
integer
Alias
- UMLS CUI [1,1]
- C0679868
- UMLS CUI [1,2]
- C0231290
Descripción
Informationen zum aktuellen Rezidiv
Alias
- UMLS CUI-1
- C0277556
Descripción
Datum des Rezidivs/Progression
Tipo de datos
date
Alias
- UMLS CUI [1,1]
- C0011008
- UMLS CUI [1,2]
- C0277556
Descripción
Systemisch: Nachweis von Fern-Metastasen
Tipo de datos
integer
Alias
- UMLS CUI [1,1]
- C0475437
- UMLS CUI [1,2]
- C0277556
Descripción
Malignant neoplasm of bone marrow
Tipo de datos
boolean
Alias
- UMLS CUI [1,1]
- C0027627
- UMLS CUI [1,2]
- C2703042
Descripción
Cave: lokoregionäre Lymphknoten-Metastasen in derselben Höhe des Primärtumors werden nicht als Lymphknotenfernmetastasen gewertet.
Tipo de datos
boolean
Alias
- UMLS CUI [1,1]
- C0686619
- UMLS CUI [1,2]
- C0443203
Descripción
Recurrent disease liver
Tipo de datos
boolean
Alias
- UMLS CUI [1,1]
- C0277556
- UMLS CUI [1,2]
- C0023884
Descripción
Recurrent disease skin
Tipo de datos
boolean
Alias
- UMLS CUI [1,1]
- C1123023
- UMLS CUI [1,2]
- C0277556
Descripción
ZNS-Metastasen sind definiert als intrazerebrale Parenchym-Herde, rein intraspinale Parenchym-Herde oder diffuse leptomeningeale Metastasen. Nicht als ZNS-Befall gewertet wird eine regionale Mitbeteiligung der Dura bei osteomedullärer Metastasierung des angrenzenden Knochens.
Tipo de datos
boolean
Alias
- UMLS CUI [1,1]
- C3714787
- UMLS CUI [1,2]
- C0277556
Descripción
Other recurrent disease
Tipo de datos
boolean
Alias
- UMLS CUI [1,1]
- C0205394
- UMLS CUI [1,2]
- C0277556
Descripción
Other recurrent disease specify
Tipo de datos
text
Alias
- UMLS CUI [1,1]
- C0205394
- UMLS CUI [1,2]
- C0277556
Descripción
Footer module
Similar models
Medical history
- StudyEvent: Subject Protocol
- Registration
- Medical history
- Baseline
- Therapy and toxicity cycle 1-3
- Therapy and toxicity cycle 4-6
- Therapy and toxicity cycle 7-9
- Therapy and toxicity cycle 10-13
- Therapy and toxicity cycle > 13
- Reference
- Study relevant visits
- Therapeutic response
- End of therapy
- Relapse
- Second malignancy
- Death
- Follow up
C2316983 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,2])
(Comment:de)
C0521428 (UMLS CUI-2)
C4086990 (UMLS CUI-3)
(Comment:de)
C0521428 (UMLS CUI-2)
C4086632 (UMLS CUI-3)
(Comment:de)
(Comment:de)
(Comment:de)
(Comment:de)
(Comment:de)
(Comment:de)
C2703042 (UMLS CUI [1,2])
C0027627 (UMLS CUI [1,3])
C2939420 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,2])
C0027627 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
(Comment:de)
(Comment:de)
(Comment:de)
(Comment:de)
(Comment:de)
(Comment:de)
C0432510 (UMLS CUI [1,2])
(Comment:de)
(Comment:de)
(Comment:de)
(Comment:de)
(Comment:de)
(Comment:de)
(Comment:de)
(Comment:de)
(Comment:de)
(Comment:de)
C1521902 (UMLS CUI [1,2])
C0449438 (UMLS CUI [1,2])
(Comment:de)
(Comment:de)
(Comment:de)
(Comment:de)
(Comment:de)
(Comment:de)
C1265611 (UMLS CUI [1,2])
C0277556 (UMLS CUI [1,2])
C0277556 (UMLS CUI [1,2])
C0277556 (UMLS CUI [1,2])
(Comment:de)
(Comment:de)
C0205276 (UMLS CUI-2)
(Comment:de)
(Comment:de)
C2703042 (UMLS CUI [1,2])
C0443203 (UMLS CUI [1,2])
C0023884 (UMLS CUI [1,2])
C0277556 (UMLS CUI [1,2])
C0277556 (UMLS CUI [1,2])
C0277556 (UMLS CUI [1,2])
C0277556 (UMLS CUI [1,2])
C0277556 (UMLS CUI [1,2])
C0231290 (UMLS CUI [1,2])
(Comment:de)
(Comment:de)
(Comment:de)
(Comment:de)
(Comment:de)
(Comment:de)
C0277556 (UMLS CUI [1,2])
C0277556 (UMLS CUI [1,2])
(Comment:de)
(Comment:de)
C0205276 (UMLS CUI-2)
(Comment:de)
(Comment:de)
C2703042 (UMLS CUI [1,2])
C0443203 (UMLS CUI [1,2])
C0023884 (UMLS CUI [1,2])
C0277556 (UMLS CUI [1,2])
C0277556 (UMLS CUI [1,2])
C0277556 (UMLS CUI [1,2])
C0277556 (UMLS CUI [1,2])