ID

16936

Description

NINDS Common Data Elements, Multiple Sclerosis Laboratory Tests Recommendations Table 3 – CSF and Table 4 – CSF Culture Used from the National Institute of Neurological Disorders and Stroke Common Data Elements (https://www.commondataelements.ninds.nih.gov/) References: Grinnon ST, Miller K, Marler JR, Lu Y, Stout A, Odenkirchen J, Kunitz S. National Institute of Neurological Disorders and Stroke Common Data Element Project - approach and methods. Clin Trials. 2012;9(3):322-9.

Link

https://www.commondataelements.ninds.nih.gov/

Keywords

Versions (1)
  1. 8/15/16 8/15/16 -
Uploaded on

August 15, 2016

DOI

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License

Creative Commons BY-NC 3.0
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NINDS CDE Laboratory Tests Recommendations Table 3 – CSF and Table 4 – CSF Culture Multiple Sclerosis

English

Laboratory Tests Recommendations Table 3 – CSF and Table 4 – CSF Culture

1 forms  
Table 3 – CSF
Description

Table 3 – CSF

Alias
UMLS CUI-1
C0007806
Albumin index
Description

CSF to serum albumin ratio, x100. Reflects BBB permeability.

Data type

float

Measurement units
  • mg/dL
Alias
UMLS CUI [1]
C0201838
mg/dL
Albumin, CSF
Description

Major CSF protein component. Originates from blood.

Data type

float

Measurement units
  • mg/dL
Alias
UMLS CUI [1,1]
C0201838
UMLS CUI [1,2]
C0007806
mg/dL
Cell count and Diff, CSF
Description

WBC components. Predominantly mononuclears (lymphocytes, monocytes) but can also include neutrophils, eosinophils, plasma cells and other cells.

Data type

float

Measurement units
  • cells/µL
Alias
UMLS CUI [1]
C0007584
cells/µL
CSF lactate
Description

CSF lactic acid level. Increased with tissue acidosis, anaerobic metabolism.

Data type

float

Measurement units
  • mmol/L
Alias
UMLS CUI [1,1]
C0202113
UMLS CUI [1,2]
C0007806
mmol/L
CSF PCR for viruses
Description

Virus nucleic acid (DNA or RNA) detection in CSF.

Data type

text

Alias
UMLS CUI [1,1]
C0032520
UMLS CUI [1,2]
C0042776
UMLS CUI [1,3]
C0007806
Cytopathology, CSF
Description

Specialized technique to collect CSF cells with preserved morphology; used to detect malignant cells.

Data type

text

Alias
UMLS CUI [1,1]
C0456521
UMLS CUI [1,2]
C0007806
Glucose, CSF
Description

Measures glucose level in CSF; dependent on blood level (normally 60 to 80% of blood level)

Data type

float

Measurement units
  • mg/dL
Alias
UMLS CUI [1,1]
C0202042
UMLS CUI [1,2]
C0007806
mg/dL
IgG, CSF
Description

Quantitative IgG level in CSF.

Data type

float

Measurement units
  • mg/dL
Alias
UMLS CUI [1,1]
C0202087
UMLS CUI [1,2]
C0007806
mg/dL
IgG Index, CSF
Description

Measures intrathecal IgG production. Derived from ratio of CSF IgG to CSF albumin compared to serum IgG to serum albumin ratio (quantitative abnormality).

Data type

float

Measurement units
  • mg/dL
Alias
UMLS CUI [1,1]
C0202087
UMLS CUI [1,2]
C0007806
mg/dL
Immunofixation Electrophoresis, Serum
Description

Proteins are separated by electrophoresis, and then immune reactions are used to visualize and identify proteins.

Data type

text

Alias
UMLS CUI [1,1]
C1611269
UMLS CUI [1,2]
C0229671
Lyme Disease Ab, CSF
Description

Positive; Negative. Immunoglobulin reactivity to B Burgdorferi. Measured by ELISA and/or Western blot.

Data type

text

Alias
UMLS CUI [1,1]
C0024198
UMLS CUI [1,2]
C0007806
MRZ Reaction
Description

May be decreased by treatments that change intrathecal immunoglobulin production. Antibody index, q-specific versus the q IgG, localized in spinal fluid; 1.5 cutoff.

Data type

text

Oligoclonal Banding, CSF
Description

Positive; Negative. Two or more discrete IgG electrophoretic bands in CSF not in serum. Reflects restricted intrathecal IgG production (qualitative abnormality).

Data type

text

Alias
UMLS CUI [1]
C0201942
Protein, CSF
Description

Measures total protein level in CSF predominantly albumin; reflects serum proteins with trace CNS components and intrathecal modified components.

Data type

float

Measurement units
  • mg/dL
Alias
UMLS CUI [1]
C0201943
mg/dL
Red Blood Cell Count, CSF
Description

Erythrocytes detected in CSF, RBCs per mm3.

Data type

float

Measurement units
  • cells/mm3
Alias
UMLS CUI [1]
C3888459
cells/mm3
VDRL, CSF
Description

Positive; Negative. Nonspecific serologic test for syphilis; Venereal Disease Research Laboratory test is used to screen CSF for reagin antibodies diagnostic for neurosyphyilis.

Data type

text

Alias
UMLS CUI [1]
C0236336
CSF Antibodies against CNS antigens
Description

Detection of CSG antibodies directed against a specific CNS autoantigen target.

Data type

text

CSF CXCL13
Description

Quantitative measure of CXCL13 chemokine levels in CSF.

Data type

float

Measurement units
  • pg
Alias
UMLS CUI [1]
C3847043
pg
CSF cytokines and chemokines
Description

Quantitative detection of levels of a specific cytokine/chemokine in CSF.

Data type

text

Alias
UMLS CUI [1,1]
C0010813
UMLS CUI [1,2]
C0282554
UMLS CUI [1,3]
C0007806
CSF glial fibrillary acidic protein (GFAP)
Description

Quantitative measure of soluble GFAP in CSF.

Data type

text

Measurement units
  • ng/mL
Alias
UMLS CUI [1,1]
C0017626
UMLS CUI [1,2]
C0007806
ng/mL
CSF IgM index
Description

Measures intrathecal IgM production. Derived from ratio of CSF IgM to CSF albumin compared to serum IgM to serum albumin.

Data type

float

Measurement units
  • mg/dL
Alias
UMLS CUI [1]
C1628437
mg/dL
CSF immunophenotyping by FACS
Description

CSF cell population identification by antigens expressed by the cells, detected by specific antibodies.

Data type

text

Alias
UMLS CUI [1,1]
C0079611
UMLS CUI [1,2]
C0007806
CSF kappa
Description

Quantitative measure of kappa free light chains in CSF.

Data type

text

Alias
UMLS CUI [1]
C1954403
CSF myelin basic protein (MBP)
Description

Quantitative measure of detectable MBP like material in CSF.

Data type

text

Alias
UMLS CUI [1]
C0364783
CSF neural cell adhesion molecule (NCAM)
Description

Quantitative measure of soluble NCAM in CSF.

Data type

float

Measurement units
  • ng/mL
Alias
UMLS CUI [1,1]
C0282587
UMLS CUI [1,2]
C0007806
ng/mL
CSF neurofilament light chains
Description

neurofilament CSF

Data type

text

Alias
UMLS CUI [1,1]
C0027834
UMLS CUI [1,2]
C0007806
CSF NMO IgG
Description

IgG antibodies reacting to aquaporin 4. Biomarker for NMO Devic spectrum disorder.

Data type

text

Alias
UMLS CUI [1]
C1830792
Tears OCB
Description

Qualitative detection of two or more IgG electrophoretic bands in tears but not blood.

Data type

text

Table 4 – CSF Culture
Description

Table 4 – CSF Culture

Alias
UMLS CUI-1
C0430403
Bacterial, Fungal culture
Description

Cryptococcus neoformans antigen; Mycobacteria culture. Culture of CSF to identify presence of a bacterial or fungal pathogen.

Data type

text

Alias
UMLS CUI [1]
C0430402
UMLS CUI [2]
C0200954
Sterile fluid culture
Description

Gram stain. No identification/growth of any microbial pathogen from CSF cultures.

Data type

text

Alias
UMLS CUI [1]
C0367249
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Similar models

Laboratory Tests Recommendations Table 3 – CSF and Table 4 – CSF Culture

1 forms
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
Table 3 – CSF
C0007806 (UMLS CUI-1)
Albumin
Item
Albumin index
float
C0201838 (UMLS CUI [1])
Albumin CSF
Item
Albumin, CSF
float
C0201838 (UMLS CUI [1,1])
C0007806 (UMLS CUI [1,2])
Cell count
Item
Cell count and Diff, CSF
float
C0007584 (UMLS CUI [1])
lactate CSF
Item
CSF lactate
float
C0202113 (UMLS CUI [1,1])
C0007806 (UMLS CUI [1,2])
PCR virus CSF
Item
CSF PCR for viruses
text
C0032520 (UMLS CUI [1,1])
C0042776 (UMLS CUI [1,2])
C0007806 (UMLS CUI [1,3])
Cytopathology CSF
Item
Cytopathology, CSF
text
C0456521 (UMLS CUI [1,1])
C0007806 (UMLS CUI [1,2])
Glucose CSF
Item
Glucose, CSF
float
C0202042 (UMLS CUI [1,1])
C0007806 (UMLS CUI [1,2])
IgG CSF
Item
IgG, CSF
float
C0202087 (UMLS CUI [1,1])
C0007806 (UMLS CUI [1,2])
IgG CSF
Item
IgG Index, CSF
float
C0202087 (UMLS CUI [1,1])
C0007806 (UMLS CUI [1,2])
Immunofixation Electrophoresis Serum
Item
Immunofixation Electrophoresis, Serum
text
C1611269 (UMLS CUI [1,1])
C0229671 (UMLS CUI [1,2])
Lyme Disease CSF
Item
Lyme Disease Ab, CSF
text
C0024198 (UMLS CUI [1,1])
C0007806 (UMLS CUI [1,2])
MRZ Reaction
Item
MRZ Reaction
text
Oligoclonal Banding CSF
Item
Oligoclonal Banding, CSF
text
C0201942 (UMLS CUI [1])
Protein, CSF
Item
Protein, CSF
float
C0201943 (UMLS CUI [1])
Red Blood Cell Count, CSF
Item
Red Blood Cell Count, CSF
float
C3888459 (UMLS CUI [1])
VDRL, CSF
Item
VDRL, CSF
text
C0236336 (UMLS CUI [1])
CSF Antibodies against CNS antigens
Item
CSF Antibodies against CNS antigens
text
CSF CXCL13
Item
CSF CXCL13
float
C3847043 (UMLS CUI [1])
cytokines chemokines CSF
Item
CSF cytokines and chemokines
text
C0010813 (UMLS CUI [1,1])
C0282554 (UMLS CUI [1,2])
C0007806 (UMLS CUI [1,3])
Glial Fibrillary Acidic Protein CSF
Item
CSF glial fibrillary acidic protein (GFAP)
text
C0017626 (UMLS CUI [1,1])
C0007806 (UMLS CUI [1,2])
CSF IgM
Item
CSF IgM index
float
C1628437 (UMLS CUI [1])
Immunophenotyping CSF
Item
CSF immunophenotyping by FACS
text
C0079611 (UMLS CUI [1,1])
C0007806 (UMLS CUI [1,2])
CSF kappa
Item
CSF kappa
text
C1954403 (UMLS CUI [1])
CSF myelin basic protein
Item
CSF myelin basic protein (MBP)
text
C0364783 (UMLS CUI [1])
Neural Cell Adhesion Molecules CSF
Item
CSF neural cell adhesion molecule (NCAM)
float
C0282587 (UMLS CUI [1,1])
C0007806 (UMLS CUI [1,2])
neurofilament CSF
Item
CSF neurofilament light chains
text
C0027834 (UMLS CUI [1,1])
C0007806 (UMLS CUI [1,2])
CSF NMO IgG
Item
CSF NMO IgG
text
C1830792 (UMLS CUI [1])
Tears OCB
Item
Tears OCB
text
Item Group
Table 4 – CSF Culture
C0430403 (UMLS CUI-1)
Bacterial culture; Fungal culture
Item
Bacterial, Fungal culture
text
C0430402 (UMLS CUI [1])
C0200954 (UMLS CUI [2])
Sterile fluid culture
Item
Sterile fluid culture
text
C0367249 (UMLS CUI [1])
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