ID

16936

Beskrivning

NINDS Common Data Elements, Multiple Sclerosis Laboratory Tests Recommendations Table 3 – CSF and Table 4 – CSF Culture Used from the National Institute of Neurological Disorders and Stroke Common Data Elements (https://www.commondataelements.ninds.nih.gov/) References: Grinnon ST, Miller K, Marler JR, Lu Y, Stout A, Odenkirchen J, Kunitz S. National Institute of Neurological Disorders and Stroke Common Data Element Project - approach and methods. Clin Trials. 2012;9(3):322-9.

Länk

https://www.commondataelements.ninds.nih.gov/

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  1. 2016-08-15 2016-08-15 -
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15 augusti 2016

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NINDS CDE Laboratory Tests Recommendations Table 3 – CSF and Table 4 – CSF Culture Multiple Sclerosis

Engelsk

Laboratory Tests Recommendations Table 3 – CSF and Table 4 – CSF Culture

1 Formulär  
Table 3 – CSF
Beskrivning

Table 3 – CSF

Alias
UMLS CUI-1
C0007806
Albumin index
Beskrivning

CSF to serum albumin ratio, x100. Reflects BBB permeability.

Datatyp

float

Måttenheter
  • mg/dL
Alias
UMLS CUI [1]
C0201838
mg/dL
Albumin, CSF
Beskrivning

Major CSF protein component. Originates from blood.

Datatyp

float

Måttenheter
  • mg/dL
Alias
UMLS CUI [1,1]
C0201838
UMLS CUI [1,2]
C0007806
mg/dL
Cell count and Diff, CSF
Beskrivning

WBC components. Predominantly mononuclears (lymphocytes, monocytes) but can also include neutrophils, eosinophils, plasma cells and other cells.

Datatyp

float

Måttenheter
  • cells/µL
Alias
UMLS CUI [1]
C0007584
cells/µL
CSF lactate
Beskrivning

CSF lactic acid level. Increased with tissue acidosis, anaerobic metabolism.

Datatyp

float

Måttenheter
  • mmol/L
Alias
UMLS CUI [1,1]
C0202113
UMLS CUI [1,2]
C0007806
mmol/L
CSF PCR for viruses
Beskrivning

Virus nucleic acid (DNA or RNA) detection in CSF.

Datatyp

text

Alias
UMLS CUI [1,1]
C0032520
UMLS CUI [1,2]
C0042776
UMLS CUI [1,3]
C0007806
Cytopathology, CSF
Beskrivning

Specialized technique to collect CSF cells with preserved morphology; used to detect malignant cells.

Datatyp

text

Alias
UMLS CUI [1,1]
C0456521
UMLS CUI [1,2]
C0007806
Glucose, CSF
Beskrivning

Measures glucose level in CSF; dependent on blood level (normally 60 to 80% of blood level)

Datatyp

float

Måttenheter
  • mg/dL
Alias
UMLS CUI [1,1]
C0202042
UMLS CUI [1,2]
C0007806
mg/dL
IgG, CSF
Beskrivning

Quantitative IgG level in CSF.

Datatyp

float

Måttenheter
  • mg/dL
Alias
UMLS CUI [1,1]
C0202087
UMLS CUI [1,2]
C0007806
mg/dL
IgG Index, CSF
Beskrivning

Measures intrathecal IgG production. Derived from ratio of CSF IgG to CSF albumin compared to serum IgG to serum albumin ratio (quantitative abnormality).

Datatyp

float

Måttenheter
  • mg/dL
Alias
UMLS CUI [1,1]
C0202087
UMLS CUI [1,2]
C0007806
mg/dL
Immunofixation Electrophoresis, Serum
Beskrivning

Proteins are separated by electrophoresis, and then immune reactions are used to visualize and identify proteins.

Datatyp

text

Alias
UMLS CUI [1,1]
C1611269
UMLS CUI [1,2]
C0229671
Lyme Disease Ab, CSF
Beskrivning

Positive; Negative. Immunoglobulin reactivity to B Burgdorferi. Measured by ELISA and/or Western blot.

Datatyp

text

Alias
UMLS CUI [1,1]
C0024198
UMLS CUI [1,2]
C0007806
MRZ Reaction
Beskrivning

May be decreased by treatments that change intrathecal immunoglobulin production. Antibody index, q-specific versus the q IgG, localized in spinal fluid; 1.5 cutoff.

Datatyp

text

Oligoclonal Banding, CSF
Beskrivning

Positive; Negative. Two or more discrete IgG electrophoretic bands in CSF not in serum. Reflects restricted intrathecal IgG production (qualitative abnormality).

Datatyp

text

Alias
UMLS CUI [1]
C0201942
Protein, CSF
Beskrivning

Measures total protein level in CSF predominantly albumin; reflects serum proteins with trace CNS components and intrathecal modified components.

Datatyp

float

Måttenheter
  • mg/dL
Alias
UMLS CUI [1]
C0201943
mg/dL
Red Blood Cell Count, CSF
Beskrivning

Erythrocytes detected in CSF, RBCs per mm3.

Datatyp

float

Måttenheter
  • cells/mm3
Alias
UMLS CUI [1]
C3888459
cells/mm3
VDRL, CSF
Beskrivning

Positive; Negative. Nonspecific serologic test for syphilis; Venereal Disease Research Laboratory test is used to screen CSF for reagin antibodies diagnostic for neurosyphyilis.

Datatyp

text

Alias
UMLS CUI [1]
C0236336
CSF Antibodies against CNS antigens
Beskrivning

Detection of CSG antibodies directed against a specific CNS autoantigen target.

Datatyp

text

CSF CXCL13
Beskrivning

Quantitative measure of CXCL13 chemokine levels in CSF.

Datatyp

float

Måttenheter
  • pg
Alias
UMLS CUI [1]
C3847043
pg
CSF cytokines and chemokines
Beskrivning

Quantitative detection of levels of a specific cytokine/chemokine in CSF.

Datatyp

text

Alias
UMLS CUI [1,1]
C0010813
UMLS CUI [1,2]
C0282554
UMLS CUI [1,3]
C0007806
CSF glial fibrillary acidic protein (GFAP)
Beskrivning

Quantitative measure of soluble GFAP in CSF.

Datatyp

text

Måttenheter
  • ng/mL
Alias
UMLS CUI [1,1]
C0017626
UMLS CUI [1,2]
C0007806
ng/mL
CSF IgM index
Beskrivning

Measures intrathecal IgM production. Derived from ratio of CSF IgM to CSF albumin compared to serum IgM to serum albumin.

Datatyp

float

Måttenheter
  • mg/dL
Alias
UMLS CUI [1]
C1628437
mg/dL
CSF immunophenotyping by FACS
Beskrivning

CSF cell population identification by antigens expressed by the cells, detected by specific antibodies.

Datatyp

text

Alias
UMLS CUI [1,1]
C0079611
UMLS CUI [1,2]
C0007806
CSF kappa
Beskrivning

Quantitative measure of kappa free light chains in CSF.

Datatyp

text

Alias
UMLS CUI [1]
C1954403
CSF myelin basic protein (MBP)
Beskrivning

Quantitative measure of detectable MBP like material in CSF.

Datatyp

text

Alias
UMLS CUI [1]
C0364783
CSF neural cell adhesion molecule (NCAM)
Beskrivning

Quantitative measure of soluble NCAM in CSF.

Datatyp

float

Måttenheter
  • ng/mL
Alias
UMLS CUI [1,1]
C0282587
UMLS CUI [1,2]
C0007806
ng/mL
CSF neurofilament light chains
Beskrivning

neurofilament CSF

Datatyp

text

Alias
UMLS CUI [1,1]
C0027834
UMLS CUI [1,2]
C0007806
CSF NMO IgG
Beskrivning

IgG antibodies reacting to aquaporin 4. Biomarker for NMO Devic spectrum disorder.

Datatyp

text

Alias
UMLS CUI [1]
C1830792
Tears OCB
Beskrivning

Qualitative detection of two or more IgG electrophoretic bands in tears but not blood.

Datatyp

text

Table 4 – CSF Culture
Beskrivning

Table 4 – CSF Culture

Alias
UMLS CUI-1
C0430403
Bacterial, Fungal culture
Beskrivning

Cryptococcus neoformans antigen; Mycobacteria culture. Culture of CSF to identify presence of a bacterial or fungal pathogen.

Datatyp

text

Alias
UMLS CUI [1]
C0430402
UMLS CUI [2]
C0200954
Sterile fluid culture
Beskrivning

Gram stain. No identification/growth of any microbial pathogen from CSF cultures.

Datatyp

text

Alias
UMLS CUI [1]
C0367249
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Similar models

Laboratory Tests Recommendations Table 3 – CSF and Table 4 – CSF Culture

1 Formulär
Name
Typ
Description | Question | Decode (Coded Value)
Datatyp
Alias
Item Group
Table 3 – CSF
C0007806 (UMLS CUI-1)
Albumin
Item
Albumin index
float
C0201838 (UMLS CUI [1])
Albumin CSF
Item
Albumin, CSF
float
C0201838 (UMLS CUI [1,1])
C0007806 (UMLS CUI [1,2])
Cell count
Item
Cell count and Diff, CSF
float
C0007584 (UMLS CUI [1])
lactate CSF
Item
CSF lactate
float
C0202113 (UMLS CUI [1,1])
C0007806 (UMLS CUI [1,2])
PCR virus CSF
Item
CSF PCR for viruses
text
C0032520 (UMLS CUI [1,1])
C0042776 (UMLS CUI [1,2])
C0007806 (UMLS CUI [1,3])
Cytopathology CSF
Item
Cytopathology, CSF
text
C0456521 (UMLS CUI [1,1])
C0007806 (UMLS CUI [1,2])
Glucose CSF
Item
Glucose, CSF
float
C0202042 (UMLS CUI [1,1])
C0007806 (UMLS CUI [1,2])
IgG CSF
Item
IgG, CSF
float
C0202087 (UMLS CUI [1,1])
C0007806 (UMLS CUI [1,2])
IgG CSF
Item
IgG Index, CSF
float
C0202087 (UMLS CUI [1,1])
C0007806 (UMLS CUI [1,2])
Immunofixation Electrophoresis Serum
Item
Immunofixation Electrophoresis, Serum
text
C1611269 (UMLS CUI [1,1])
C0229671 (UMLS CUI [1,2])
Lyme Disease CSF
Item
Lyme Disease Ab, CSF
text
C0024198 (UMLS CUI [1,1])
C0007806 (UMLS CUI [1,2])
MRZ Reaction
Item
MRZ Reaction
text
Oligoclonal Banding CSF
Item
Oligoclonal Banding, CSF
text
C0201942 (UMLS CUI [1])
Protein, CSF
Item
Protein, CSF
float
C0201943 (UMLS CUI [1])
Red Blood Cell Count, CSF
Item
Red Blood Cell Count, CSF
float
C3888459 (UMLS CUI [1])
VDRL, CSF
Item
VDRL, CSF
text
C0236336 (UMLS CUI [1])
CSF Antibodies against CNS antigens
Item
CSF Antibodies against CNS antigens
text
CSF CXCL13
Item
CSF CXCL13
float
C3847043 (UMLS CUI [1])
cytokines chemokines CSF
Item
CSF cytokines and chemokines
text
C0010813 (UMLS CUI [1,1])
C0282554 (UMLS CUI [1,2])
C0007806 (UMLS CUI [1,3])
Glial Fibrillary Acidic Protein CSF
Item
CSF glial fibrillary acidic protein (GFAP)
text
C0017626 (UMLS CUI [1,1])
C0007806 (UMLS CUI [1,2])
CSF IgM
Item
CSF IgM index
float
C1628437 (UMLS CUI [1])
Immunophenotyping CSF
Item
CSF immunophenotyping by FACS
text
C0079611 (UMLS CUI [1,1])
C0007806 (UMLS CUI [1,2])
CSF kappa
Item
CSF kappa
text
C1954403 (UMLS CUI [1])
CSF myelin basic protein
Item
CSF myelin basic protein (MBP)
text
C0364783 (UMLS CUI [1])
Neural Cell Adhesion Molecules CSF
Item
CSF neural cell adhesion molecule (NCAM)
float
C0282587 (UMLS CUI [1,1])
C0007806 (UMLS CUI [1,2])
neurofilament CSF
Item
CSF neurofilament light chains
text
C0027834 (UMLS CUI [1,1])
C0007806 (UMLS CUI [1,2])
CSF NMO IgG
Item
CSF NMO IgG
text
C1830792 (UMLS CUI [1])
Tears OCB
Item
Tears OCB
text
Item Group
Table 4 – CSF Culture
C0430403 (UMLS CUI-1)
Bacterial culture; Fungal culture
Item
Bacterial, Fungal culture
text
C0430402 (UMLS CUI [1])
C0200954 (UMLS CUI [2])
Sterile fluid culture
Item
Sterile fluid culture
text
C0367249 (UMLS CUI [1])
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