- 10/12/22 - 6 forms, 1 itemgroup, 5 items, 1 language
Itemgroup: pht001553
Principal Investigator: Zemin Zhang, PhD, Genentech Inc., South San Francisco, CA, USA MeSH: Lung Neoplasms,Carcinoma, Non-Small-Cell Lung https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000299 Version 1 Whole genome sequencing was applied to tumor and adjacent normal lung tissue in an individual non-small-cell lung cancer patient. We present an analysis of somatic changes identified throughout the tumor genome, including single-nucleotide variants, copy number variants, and large-scale chromosomal rearrangements. Over 50,000 high-confidence single-nucleotide variants were identified, revealing evidence of substantial smoking-related DNA damage as well as distinct mutational pressures within the tumor resulting in uneven distribution of somatic mutations across the genome. Version 2 Lung cancer is a highly heterogeneous disease in terms of both underlying genetic lesions and response to therapeutic treatments. We performed deep whole genome sequencing and transcriptome sequencing on 19 lung cancer cell lines and 3 lung tumor/normal pairs. Overall, our data show that cell line models exhibit similar mutation spectra to human tumor samples. Smoker and never-smoker cancer samples exhibit distinguishable patterns of mutations. A number of epigenetic regulators are frequently altered by mutations or copy number changes. A systematic survey of splice-site mutations identified over 100 splice site mutations associated with cancer specific aberrant splicing, including mutations in several known cancer-related genes. Differential usages of splice isoforms were also studied. Taken together, these data present a comprehensive genomic landscape of a large number of lung cancer samples and further demonstrate that cancer specific alternative splicing is a widespread phenomenon that has potential utility as therapeutic biomarkers.

pht001881.v2.p1

1 itemgroup 2 items

pht001882.v2.p1

1 itemgroup 7 items

pht001551.v2.p1

1 itemgroup 5 items

pht001552.v2.p1

1 itemgroup 5 items

Eligibility

1 itemgroup 4 items
- 9/20/21 - 1 form, 13 itemgroups, 75 items, 1 language
Itemgroups: Header Module, Patient demographics, Data amendment, Pre-Treatment Characteristics, Pre-Treatment Characteristics1, Advanced NSCLC Disease Description, Metastatic Site, Medical History, Pre-Registration Hematology/Chemistry, Advanced NSCLC Prior Treatment, NSCLC Brain Metastases, Baseline Abnormalities, Comments

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