Información:
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ID
45884
Descripción
Principal Investigator: Timothy Chan, MD, PhD, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA MeSH: Carcinoma, Non-Small-Cell Lung https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000980 Patients with non-small cell lung cancer were treated with pembrolizumab. Their tumors and matched normal blood were sequenced.
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Versiones (1)
- 18/11/23 18/11/23 - Simon Heim
Titular de derechos de autor
Timothy Chan, MD, PhD, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Subido en
18 de noviembre de 2023
DOI
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Licencia
Creative Commons BY 4.0
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dbGaP phs000980 PD-1 Blockade in Non-Small Cell Lung Cancer
This sample attributes table contains de-identified sample ID, body site where sample was collected, analyte type, tumor status, histological type, primary tumor, metastasis, or transformed cell line, primary tumor location, tumor stage, type of tumor treatment, and names of the center which conducted genotyping and sequencing.
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent file includes subject IDs, consent information, subject aliases and affection status for case control status of the subject. All subjects are patients with non-small cell lung cancer.
- This subject sample mapping data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample aliases and sample use.
- This sample attributes table contains de-identified sample ID, body site where sample was collected, analyte type, tumor status, histological type, primary tumor, metastasis, or transformed cell line, primary tumor location, tumor stage, type of tumor treatment, and names of the center which conducted genotyping and sequencing.
- This subject phenotype table contains de-identified Subject ID, patient's cohort in current study, tumor histology, age, sex, smoking status and pack years, PD-L1 protein expression, prior courses of cytotoxic chemotherapy, pembrolizumab dose and administration, progression free survival, best overall response to pembrolizumab, durable clinical benefit and molecular smoking signature.
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This sample attributes table contains de-identified sample ID, body site where sample was collected, analyte type, tumor status, histological type, primary tumor, metastasis, or transformed cell line, primary tumor location, tumor stage, type of tumor treatment, and names of the center which conducted genotyping and sequencing.
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent file includes subject IDs, consent information, subject aliases and affection status for case control status of the subject. All subjects are patients with non-small cell lung cancer.
- This subject sample mapping data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample aliases and sample use.
- This sample attributes table contains de-identified sample ID, body site where sample was collected, analyte type, tumor status, histological type, primary tumor, metastasis, or transformed cell line, primary tumor location, tumor stage, type of tumor treatment, and names of the center which conducted genotyping and sequencing.
- This subject phenotype table contains de-identified Subject ID, patient's cohort in current study, tumor histology, age, sex, smoking status and pack years, PD-L1 protein expression, prior courses of cytotoxic chemotherapy, pembrolizumab dose and administration, progression free survival, best overall response to pembrolizumab, durable clinical benefit and molecular smoking signature.
Name
Tipo
Description | Question | Decode (Coded Value)
Tipo de datos
Alias
SAMPLE_ID
Item
De-identified Sample ID
string
C4684638 (UMLS CUI [1,1])
C1299222 (UMLS CUI [1,2])
C1299222 (UMLS CUI [1,2])
BODY_SITE
Item
Body site where sample was collected
string
C0449705 (UMLS CUI [1,1])
ANALYTE_TYPE
Item
Analyte Type
string
C4744818 (UMLS CUI [1,1])
CL Item
Is not a tumor (N)
C0027651 (UMLS CUI [1,1])
C1518422 (UMLS CUI [1,2])
C1518422 (UMLS CUI [1,2])
CL Item
Is Tumor (Y)
C0027651 (UMLS CUI [1,1])
HISTOLOGICAL_TYPE
Item
Cell or tissue type or subtype of sample
string
C2347026 (UMLS CUI [1,1])
C0007634 (UMLS CUI [1,2])
C0332307 (UMLS CUI [1,3])
C2347026 (UMLS CUI [2,1])
C0007634 (UMLS CUI [2,2])
C0449560 (UMLS CUI [2,3])
C1292533 (UMLS CUI [3,1])
C0332307 (UMLS CUI [3,2])
C1292533 (UMLS CUI [4,1])
C0449560 (UMLS CUI [4,2])
C0007634 (UMLS CUI [1,2])
C0332307 (UMLS CUI [1,3])
C2347026 (UMLS CUI [2,1])
C0007634 (UMLS CUI [2,2])
C0449560 (UMLS CUI [2,3])
C1292533 (UMLS CUI [3,1])
C0332307 (UMLS CUI [3,2])
C1292533 (UMLS CUI [4,1])
C0449560 (UMLS CUI [4,2])
PRIMARY_METASTATIC_TUMOR
Item
Primary tumor, metastasis, or transformed cell line
string
C0677930 (UMLS CUI [1,1])
C0027627 (UMLS CUI [2,1])
C0007601 (UMLS CUI [3,1])
C0027627 (UMLS CUI [2,1])
C0007601 (UMLS CUI [3,1])
PRIMARY_TUMOR_LOCATION
Item
Primary tumor location
string
C0677930 (UMLS CUI [1,1])
C0450429 (UMLS CUI [1,2])
C0450429 (UMLS CUI [1,2])
TUMOR_STAGE
Item
Tumor stage of sample
string
C1300072 (UMLS CUI [1,1])
C0370003 (UMLS CUI [1,2])
C0370003 (UMLS CUI [1,2])
TUMOR_TREATMENT
Item
Type of tumor treatment for sample
string
C0087111 (UMLS CUI [1,1])
C0027651 (UMLS CUI [1,2])
C0370003 (UMLS CUI [1,3])
C0027651 (UMLS CUI [1,2])
C0370003 (UMLS CUI [1,3])
GENOTYPING_CENTER
Item
Name of the center which conducted genotyping
string
C1301943 (UMLS CUI [1,1])
C5575037 (UMLS CUI [1,2])
C1285573 (UMLS CUI [1,3])
C5575037 (UMLS CUI [1,2])
C1285573 (UMLS CUI [1,3])
SEQUENCING_CENTER
Item
Name of the center which conducted sequencing
string
C1301943 (UMLS CUI [1,1])
C5575037 (UMLS CUI [1,2])
C1294197 (UMLS CUI [1,3])
C5575037 (UMLS CUI [1,2])
C1294197 (UMLS CUI [1,3])
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