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dbGaP phs000766 GEI Studies - Psoriasis - Eligibility

- 2025-01-29 - 5 Formulär, 1 Item-grupp, 1 Dataelement, 1 Språk
Item-grupp: IG.elig
Principal Investigator: Richard Gibbs, Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA MeSH: Psoriasis,Arthritic psoriasis https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000766 The GEI Studies Project was started as an NIH consortium involving 5 disease groups with funding provided through the Genes, Environment, and Health Initiative (GEI). The objective of the project was to optimize strategies for identifying rare variants as a follow up to genome-wide association studies (GWAS) using next-generation sequencing technology. One of the five targeted diseases, Psoriasis, is a multifactorial skin disease characterized by epidermal hyperproliferation and chronic inflammation that affects approximately 2% of Americans. Because only about one-third of all patients with psoriasis have a relative who is also affected with the disorder, psoriasis is not widely recognized as a genetic disease. However, previous research on families and identical twins has shown psoriasis has a strong genetic component, although environmental factors (such as infections, stress, and injuries) are also important. Although no definite psoriasis gene has yet been identified, research during the last ten years has revealed over forty potential gene locations that may contribute to the disease. Large amounts of data generated using next-generation sequencing technology would provide a more detailed characterization of sequence variation which would in turn increase the likelihood of detecting causative loci. With the presumption that rare variants are frequently the cause of a large portion of phenotypic variation, it was necessary to use large sample sets. In the main body of this study, we sequenced 4,966 samples (812 dermatologist-diagnosed cases of purely cutaneous psoriasis (PsC), 1,497 cases of rheumatologist-diagnosed psoriatic arthritis, 665 cases of cutaneous psoriasis with uncertain psoriatic arthritis status (PsV) and 1,992 controls) across 5.7 Mb of sequence containing 100 psoriasis candidate loci and 769 genes. For each candidate locus, we considered sequences within 250 kb of the strongest association signal. Within this window, three strategies were employed. For ten of the strongest psoriasis signals, we used a whole-region approach which included non-coding intergenic and intronic sequence. For four established loci of lesser significance, we targeted all full transcription units within the +/- 250 kb interval. For the remaining signals, we targeted the exons of all transcription units within the +/- 250 kb interval. Due to complexities of high-efficiency targeting of HLA genes we selected 5 specific candidate genes for sequencing near the HLA-C gene.

pht003938.v1.p1

1 Item-grupp 5 Dataelement

pht003940.v1.p1

1 Item-grupp 2 Dataelement

pht003941.v1.p1

1 Item-grupp 3 Dataelement

pht003939.v1.p1

1 Item-grupp 5 Dataelement

dbGaP phs001306 Large Scale Meta-analysis Characterizes Genetic Architecture for Common Psoriasis-associated Variants - Eligibility

- 2023-02-01 - 5 Formulär, 1 Item-grupp, 2 Dataelement, 1 Språk
Item-grupp: IG.elig
Principal Investigator: James T. Elder, MD, PhD, Department of Dermatology, University of Michigan, Ann Arbor, MI, USA MeSH: Psoriasis https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001306 The genotypes obtained from the Affymetrix Biobank Plus array constituted one of eight Caucasian datasets used in a large genome-wide meta-analysis of the association of psoriasis cases versus unaffected controls. With a combined effective sample size of 39,000 individuals, this study identified 16 new psoriasis loci achieving genome-wide significance, increasing the total number of identified psoriasis loci for European-ancestry populations to 63.

pht006187.v1.p1

1 Item-grupp 3 Dataelement

pht006188.v1.p1

1 Item-grupp 3 Dataelement

pht006189.v1.p1

1 Item-grupp 5 Dataelement

pht006190.v1.p1

1 Item-grupp 12 Dataelement

dbGaP phs001298 Fine Mapping of Eight Psoriasis Susceptibility Loci - pht008646.v1.p1

- 2023-02-01 - 5 Formulär, 1 Item-grupp, 5 Dataelement, 1 Språk
Item-grupp: pht008646
Principal Investigator: James T. Elder, Department of Dermatology, University of Michigan, Ann Arbor, MI, USA MeSH: Psoriasis https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001298 Psoriasis is a common immune-mediate disease identified through scaly patches of the skin. In this study we collected genotype information on 5,067 samples of European ancestry as a follow-up study of our initial GWAS (Nair et al. 2009). We designed an Illumina iSelect custom genotyping array with 2,269 tagging SNPs in the eight known psoriasis susceptibility regions (MHC, IL12B, IL23R, IL23A, TNFAIP3, IL13, RNF114, and TNIP1). The custom array also included 5,463 SNPs outside the eight known susceptibility regions, which were selected based on their association p-values in a meta-analysis of HapMap-imputed genotypes of two published GWAS-CASP (Nair et al. 2009) and (Ellinghaus et al. 2010). After quality control we analyzed 4,806 samples (2,699 cases and 2,107 controls). Please note: The accession number for this dbGaP study was incorrectly listed in the relevant publication (Das et al., 2015, Eur. J. Hum. Genet 23:844-853) as phs000019.v1.p1.

Eligibility

1 Item-grupp 1 Dataelement

pht008647.v1.p1

1 Item-grupp 3 Dataelement

pht008648.v1.p1

1 Item-grupp 4 Dataelement

pht008649.v1.p1

1 Item-grupp 6 Dataelement

44967_dbGaP phs000019 Collaborative Association Study of Psoriasis - pht000063.v1.p1

- 2022-10-12 - 5 Formulär, 1 Item-grupp, 18 Dataelement, 1 Språk
Item-grupp: pht000063
Principal Investigator: Gonçalo R. Abecasis, University of Michigan School of Public Health, Ann Arbor, MI, USA MeSH: Psoriasis,Psoriatic Arthritis https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000019 The goal of this collaborative study is to combine the resources and expertise of three groups with long-standing studies of psoriasis genetics in order to identify new genetic susceptibility factors for psoriasis, a common inflammatory skin disease that affects over 4 million Americans. *Consent groups and participant set* - General research use (GRU): 1677 (950 cases, 692 controls, 35 others) - Autoimmune disease (AD): 1198 (449 cases, 734 controls, 15 others)

pht000064.v1.p1

1 Item-grupp 4 Dataelement

pht000179.v1.p1

1 Item-grupp 3 Dataelement

pht000180.v1.p1

1 Item-grupp 7 Dataelement

pht000181.v1.p1

1 Item-grupp 3 Dataelement

Screening Visit 1 Psoriasis NCT02695940

- 2021-09-27 - 1 Formulär, 10 Item-grupper, 62 Dataelement, 1 Språk
Item-grupper: Administrative data, Eligibility criteria, Demography, Medical History, Treated body regions, Vital signs, ECG, Blood sample, Urine sample, miscellaneous
NCT02695940 A Phase 2a, Proof of Concept Trial, Testing Twice Daily Application of LEO 124249 Ointment 30 mg/g in the Treatment of Mild to Moderate Inverse Psoriasis. Quelle: Prof. Dr. Dr. h.c. Thomas Luger University Hospital of Muenster Department of Dermatology

Eligibility NCT00408187 Psoriasis - Eligibility

- 2021-09-20 - 1 Formulär, 2 Item-grupper, 30 Dataelement, 2 Språk
Item-grupper: Inclusion Criteria, Exclusion Criteria
ODM derived from http://clinicaltrials.gov/show/NCT00408187

Eligibility NCT00606450 Psoriasis - Eligibility

- 2021-09-20 - 1 Formulär, 2 Item-grupper, 24 Dataelement, 2 Språk
Item-grupper: Inclusion Criteria, Exclusion Criteria
ODM derived from http://clinicaltrials.gov/show/NCT00606450

Eligibility NCT01194219 Plaque Psoriasis - Eligibility

- 2021-09-20 - 1 Formulär, 2 Item-grupper, 29 Dataelement, 2 Språk
Item-grupper: Inclusion Criteria, Exclusion Criteria
ODM derived from http://clinicaltrials.gov/show/NCT01194219

Eligibility NCT00852670 Plaque Psoriasis - Eligibility

- 2021-09-17 - 1 Formulär, 2 Item-grupper, 7 Dataelement, 2 Språk
Item-grupper: Inclusion Criteria, Exclusion Criteria
ODM derived from http://clinicaltrials.gov/show/NCT00852670

Eligibility NCT00245765 Chronic Plaque Psoriasis - Eligibility

- 2021-09-17 - 1 Formulär, 2 Item-grupper, 12 Dataelement, 2 Språk
Item-grupper: Inclusion Criteria, Exclusion Criteria
ODM derived from http://clinicaltrials.gov/show/NCT00245765

Eligibility NCT00574249 Chronic Plaque Psoriasis - Eligibility

- 2021-09-17 - 1 Formulär, 2 Item-grupper, 11 Dataelement, 2 Språk
Item-grupper: Inclusion Criteria, Exclusion Criteria
ODM derived from http://clinicaltrials.gov/show/NCT00574249

Eligibility NCT00329303 Psoriasis - Eligibility

- 2021-09-17 - 1 Formulär, 2 Item-grupper, 10 Dataelement, 2 Språk
Item-grupper: Inclusion Criteria, Exclusion Criteria
ODM derived from http://clinicaltrials.gov/show/NCT00329303

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