ID
45590
Descrição
Principal Investigator: James T. Elder, Department of Dermatology, University of Michigan, Ann Arbor, MI, USA MeSH: Psoriasis https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001298 Psoriasis is a common immune-mediate disease identified through scaly patches of the skin. In this study we collected genotype information on 5,067 samples of European ancestry as a follow-up study of our initial GWAS (Nair et al. 2009). We designed an Illumina iSelect custom genotyping array with 2,269 tagging SNPs in the eight known psoriasis susceptibility regions (MHC, IL12B, IL23R, IL23A, TNFAIP3, IL13, RNF114, and TNIP1). The custom array also included 5,463 SNPs outside the eight known susceptibility regions, which were selected based on their association p-values in a meta-analysis of HapMap-imputed genotypes of two published GWAS-CASP (Nair et al. 2009) and (Ellinghaus et al. 2010). After quality control we analyzed 4,806 samples (2,699 cases and 2,107 controls). Please note: The accession number for this dbGaP study was incorrectly listed in the relevant publication (Das et al., 2015, Eur. J. Hum. Genet 23:844-853) as phs000019.v1.p1.
Link
https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001298
Palavras-chave
Versões (1)
- 01/02/2023 01/02/2023 - Dr. med. Lucy Kessler
Titular dos direitos
James T. Elder, Department of Dermatology, University of Michigan, Ann Arbor, MI, USA
Transferido a
1 de fevereiro de 2023
DOI
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Licença
Creative Commons BY 4.0
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dbGaP phs001298 Fine Mapping of Eight Psoriasis Susceptibility Loci
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent file includes subject IDs, subject aliases, consent information, and case control status of the subject for Psoriasis.
- This data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. This mapping table also includes sample use.
- This subject phenotype table contains subject IDs, sex, race, and sample collection centers.
- This sample attribute table contains sample IDs, body site, analyte type, tumor status, histological type, and name of the center which conducted genotyping.
Similar models
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent file includes subject IDs, subject aliases, consent information, and case control status of the subject for Psoriasis.
- This data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. This mapping table also includes sample use.
- This subject phenotype table contains subject IDs, sex, race, and sample collection centers.
- This sample attribute table contains sample IDs, body site, analyte type, tumor status, histological type, and name of the center which conducted genotyping.
C0680251 (UMLS CUI [1,2])