0 Valutazioni
ID

44950

Descrizione

The implementation of targeted therapies for acute myeloid leukemia has been challenged by complex mutational patterns within and across patients as well as a dearth of pharmacologic agents for most mutational events. Here, we report initial findings from the Beat AML program on a cohort of 672 tumor specimens collected from 562 patients. We assessed these specimens using whole exome sequencing, RNA-sequencing, and ex vivo drug sensitivity analyses. Our data reveal novel mutational events not previously detected in AML. We show association of drug response with mutational status, including instances of drug sensitivity that are specific to combinatorial mutational events. Integration with RNA-sequencing also revealed gene expression signatures, which predict a role of specific gene networks in drug response. Collectively, this report offers a dataset, accessible by the Beat AML data viewer, that can be leveraged to address clinical, genomic, transcriptomic, and functional inquiries into the biology of AML. NCT 01728402 https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001657.v1.p1

collegamento

https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001657.v1.p1

Keywords

versioni (9)
  1. 27/04/22 27/04/22 - Martin Dugas
  2. 27/04/22 27/04/22 - Martin Dugas
  3. 27/04/22 27/04/22 - Martin Dugas
  4. 27/04/22 27/04/22 - Martin Dugas
  5. 12/05/22 12/05/22 - Martin Dugas
  6. 12/05/22 12/05/22 - Martin Dugas
  7. 12/10/22 12/10/22 - Adrian Schulz
  8. 22/06/23 22/06/23 - Dr. Christian Niklas
  9. 29/01/25 29/01/25 - Akane Nishihara
Titolare del copyright

Jeffrey W. Tyner, PhD. Oregon Health and Science University, Knight Cancer Institute, Portland, OR, USA

Caricato su

12 maggio 2022

DOI

Per favore, per richiedere un accesso.

Licenza

Creative Commons BY 4.0
Commenti del modello :

Puoi commentare il modello dati qui. Tramite i fumetti nei gruppi di articoli e articoli è possibile aggiungere commenti a quelli in modo specifico.

Torna ai commenti del modello
Commenti del gruppo di articoli per :

Commenti dell'articolo per :

  • i più nuovi
  • i più vecchi
  • Popolare
  • i più nuovi
    • i più nuovi
    • i più vecchi
    • Popolare

    Non ci sono commenti

    Per scaricare i modelli di dati devi essere registrato. Per favore accesso o registrati GRATIS.

    dbGaP phs001657 Functional Genomic Landscape of Acute Myeloid Leukemia

    Inglese

    Functional Genomic Landscape of Acute Myeloid LeukemiaNCT 01728402dbGaP Study Accession: phs001657.v1

    1 moduli  
    Subject ID, consent group, and affection status of participants with or without acute myeloid leukemia and involved in the "Functional Genomic Landscape of Acute Myeloid Leukemia" project.
    Descrizione

    Subject ID, consent group, and affection status of participants with or without acute myeloid leukemia and involved in the "Functional Genomic Landscape of Acute Myeloid Leukemia" project.

    De-identified subject ID
    Descrizione

    SUBJECT_ID

    Tipo di dati

    text

    Alias
    UMLS CUI [1,1]
    C2348585 (Clinical Trial Subject Unique Identifier)
    UMLS CUI [1,2]
    C4684638 (De-identified Information)
    Consent group as determined by DAC
    Descrizione

    CONSENT

    Tipo di dati

    text

    Alias
    UMLS CUI [1,1]
    C1547872 (Consent Type)
    Case control status of the subject for leukemia [Case=subjects with acute myeloid leukemia; Control=subjects without acute myeloid leukemia]
    Descrizione

    AFFECTION_STATUS

    Tipo di dati

    text

    Alias
    UMLS CUI [1,1]
    C3274646 (Participant Case or Control Status)
    Subject ID, sample ID, and sample use variable participants with or without acute myeloid leukemia and involved in the "Functional Genomic Landscape of Acute Myeloid Leukemia" project.
    Descrizione

    Subject ID, sample ID, and sample use variable participants with or without acute myeloid leukemia and involved in the "Functional Genomic Landscape of Acute Myeloid Leukemia" project.

    Subject ID
    Descrizione

    SUBJECT_ID

    Tipo di dati

    string

    Alias
    UMLS CUI [1,1]
    C2348585 (Clinical Trial Subject Unique Identifier)
    Sample ID
    Descrizione

    SAMPLE_ID

    Tipo di dati

    string

    Alias
    UMLS CUI [1,1]
    C1299222 (Sample identification number)
    SNOMED
    372274003
    Sample Use
    Descrizione

    SAMPLE_USE

    Tipo di dati

    string

    Sample ID, analyte type, and tumor status of samples obtained from participants with or without acute myeloid leukemia and involved in the "Functional Genomic Landscape of Acute Myeloid Leukemia" project.
    Descrizione

    Sample ID, analyte type, and tumor status of samples obtained from participants with or without acute myeloid leukemia and involved in the "Functional Genomic Landscape of Acute Myeloid Leukemia" project.

    De-identified sample ID
    Descrizione

    SAMPLE_ID

    Tipo di dati

    string

    Alias
    UMLS CUI [1,1]
    C1299222 (Sample identification number)
    SNOMED
    372274003
    UMLS CUI [1,2]
    C4684638 (De-identified Information)
    Analyte type
    Descrizione

    ANALYTE_TYPE

    Tipo di dati

    string

    Alias
    UMLS CUI [1,1]
    C4744818 (Analyte Type)
    Tumor status
    Descrizione

    IS_TUMOR

    Tipo di dati

    text

    Alias
    UMLS CUI [1,1]
    C0475752 (Tumor status)
    SNOMED
    277058005
    Ritorna all'inizio della pagina

    Similar models

    Functional Genomic Landscape of Acute Myeloid LeukemiaNCT 01728402dbGaP Study Accession: phs001657.v1

    1 moduli
    Name
    genere
    Description | Question | Decode (Coded Value)
    Tipo di dati
    Alias
    Item Group
    Subject ID, consent group, and affection status of participants with or without acute myeloid leukemia and involved in the "Functional Genomic Landscape of Acute Myeloid Leukemia" project.
    SUBJECT_ID
    Item
    De-identified subject ID
    text
    C2348585 (UMLS CUI [1,1])
    C4684638 (UMLS CUI [1,2])
    Item
    Consent group as determined by DAC
    text
    C1547872 (UMLS CUI [1,1])
    CONSENT
    Code List
    Consent group as determined by DAC
    CL Item
    Disease-Specific (Leukemia) (DS-LEU) (1)
    Item
    Case control status of the subject for leukemia [Case=subjects with acute myeloid leukemia; Control=subjects without acute myeloid leukemia]
    text
    C3274646 (UMLS CUI [1,1])
    AFFECTION_STATUS
    Code List
    Case control status of the subject for leukemia [Case=subjects with acute myeloid leukemia; Control=subjects without acute myeloid leukemia]
    CL Item
    Case (1)
    CL Item
    Control (2)
    Item Group
    Subject ID, sample ID, and sample use variable participants with or without acute myeloid leukemia and involved in the "Functional Genomic Landscape of Acute Myeloid Leukemia" project.
    SUBJECT_ID
    Item
    Subject ID
    string
    C2348585 (UMLS CUI [1,1])
    SAMPLE_ID
    Item
    Sample ID
    string
    C1299222 (UMLS CUI [1,1])
    SAMPLE_USE
    Item
    Sample Use
    string
    Item Group
    Sample ID, analyte type, and tumor status of samples obtained from participants with or without acute myeloid leukemia and involved in the "Functional Genomic Landscape of Acute Myeloid Leukemia" project.
    SAMPLE_ID
    Item
    De-identified sample ID
    string
    C1299222 (UMLS CUI [1,1])
    C4684638 (UMLS CUI [1,2])
    ANALYTE_TYPE
    Item
    Analyte type
    string
    C4744818 (UMLS CUI [1,1])
    Item
    Tumor status
    text
    C0475752 (UMLS CUI [1,1])
    IS_TUMOR
    Code List
    Tumor status
    CL Item
    Is normal (N)
    CL Item
    Is tumor (Y)
    Ritorna all'inizio della pagina 

    Aiuto

    Do you need help on how to use the search function? Please watch the corresponding tutorial video for more details and learn how to use the search function most efficiently.

    Watch Tutorial