0 Bedömningar
ID

44928

Beskrivning

The implementation of targeted therapies for acute myeloid leukemia has been challenged by complex mutational patterns within and across patients as well as a dearth of pharmacologic agents for most mutational events. Here, we report initial findings from the Beat AML program on a cohort of 672 tumor specimens collected from 562 patients. We assessed these specimens using whole exome sequencing, RNA-sequencing, and ex vivo drug sensitivity analyses. Our data reveal novel mutational events not previously detected in AML. We show association of drug response with mutational status, including instances of drug sensitivity that are specific to combinatorial mutational events. Integration with RNA-sequencing also revealed gene expression signatures, which predict a role of specific gene networks in drug response. Collectively, this report offers a dataset, accessible by the Beat AML data viewer, that can be leveraged to address clinical, genomic, transcriptomic, and functional inquiries into the biology of AML. NCT 01728402 https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001657.v1.p1

Länk

https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001657.v1.p1

Nyckelord

Versioner (9)
  1. 2022-04-27 2022-04-27 - Martin Dugas
  2. 2022-04-27 2022-04-27 - Martin Dugas
  3. 2022-04-27 2022-04-27 - Martin Dugas
  4. 2022-04-27 2022-04-27 - Martin Dugas
  5. 2022-05-12 2022-05-12 - Martin Dugas
  6. 2022-05-12 2022-05-12 - Martin Dugas
  7. 2022-10-12 2022-10-12 - Adrian Schulz
  8. 2023-06-22 2023-06-22 - Dr. Christian Niklas
  9. 2025-01-29 2025-01-29 - Akane Nishihara
Rättsinnehavare

Jeffrey W. Tyner, PhD. Oregon Health and Science University, Knight Cancer Institute, Portland, OR, USA

Uppladdad den

27 april 2022

DOI

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Licens

Creative Commons BY-NC 4.0
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    Functional Genomic Landscape of Acute Myeloid Leukemia NCT 01728402 dbGaP Study Accession: phs001657.v1

    Engelsk

    Functional Genomic Landscape of Acute Myeloid LeukemiaNCT 01728402dbGaP Study Accession: phs001657.v1

    1 Formulär  
    Subject ID, consent group, and affection status of participants with or without acute myeloid leukemia and involved in the "Functional Genomic Landscape of Acute Myeloid Leukemia" project.
    Beskrivning

    Subject ID, consent group, and affection status of participants with or without acute myeloid leukemia and involved in the "Functional Genomic Landscape of Acute Myeloid Leukemia" project.

    De-identified subject ID
    Beskrivning

    SUBJECT_ID

    Datatyp

    text

    Alias
    UMLS CUI [1,1]
    C2348585
    UMLS CUI [1,2]
    C4684638
    Consent group as determined by DAC
    Beskrivning

    CONSENT

    Datatyp

    text

    Alias
    UMLS CUI [1,1]
    C1547872
    Case control status of the subject for leukemia [Case=subjects with acute myeloid leukemia; Control=subjects without acute myeloid leukemia]
    Beskrivning

    AFFECTION_STATUS

    Datatyp

    text

    Alias
    UMLS CUI [1,1]
    C3274646
    Subject ID, sample ID, and sample use variable participants with or without acute myeloid leukemia and involved in the "Functional Genomic Landscape of Acute Myeloid Leukemia" project.
    Beskrivning

    Subject ID, sample ID, and sample use variable participants with or without acute myeloid leukemia and involved in the "Functional Genomic Landscape of Acute Myeloid Leukemia" project.

    Subject ID
    Beskrivning

    SUBJECT_ID

    Datatyp

    string

    Alias
    UMLS CUI [1,1]
    C2348585
    Sample ID
    Beskrivning

    SAMPLE_ID

    Datatyp

    string

    Alias
    UMLS CUI [1,1]
    C1299222
    Sample Use
    Beskrivning

    SAMPLE_USE

    Datatyp

    string

    Sample ID, analyte type, and tumor status of samples obtained from participants with or without acute myeloid leukemia and involved in the "Functional Genomic Landscape of Acute Myeloid Leukemia" project.
    Beskrivning

    Sample ID, analyte type, and tumor status of samples obtained from participants with or without acute myeloid leukemia and involved in the "Functional Genomic Landscape of Acute Myeloid Leukemia" project.

    De-identified sample ID
    Beskrivning

    SAMPLE_ID

    Datatyp

    string

    Alias
    UMLS CUI [1,1]
    C1299222
    UMLS CUI [1,2]
    C4684638
    Analyte type
    Beskrivning

    ANALYTE_TYPE

    Datatyp

    string

    Alias
    UMLS CUI [1,1]
    C4744818
    Tumor status
    Beskrivning

    IS_TUMOR

    Datatyp

    text

    Alias
    UMLS CUI [1,1]
    C0475752
    Tillbaka till toppen

    Similar models

    Functional Genomic Landscape of Acute Myeloid LeukemiaNCT 01728402dbGaP Study Accession: phs001657.v1

    1 Formulär
    Name
    Typ
    Description | Question | Decode (Coded Value)
    Datatyp
    Alias
    Item Group
    Subject ID, consent group, and affection status of participants with or without acute myeloid leukemia and involved in the "Functional Genomic Landscape of Acute Myeloid Leukemia" project.
    SUBJECT_ID
    Item
    De-identified subject ID
    text
    C2348585 (UMLS CUI [1,1])
    C4684638 (UMLS CUI [1,2])
    Item
    Consent group as determined by DAC
    text
    C1547872 (UMLS CUI [1,1])
    CONSENT
    Code List
    Consent group as determined by DAC
    CL Item
    Disease-Specific (Leukemia) (DS-LEU) (1)
    Item
    Case control status of the subject for leukemia [Case=subjects with acute myeloid leukemia; Control=subjects without acute myeloid leukemia]
    text
    C3274646 (UMLS CUI [1,1])
    AFFECTION_STATUS
    Code List
    Case control status of the subject for leukemia [Case=subjects with acute myeloid leukemia; Control=subjects without acute myeloid leukemia]
    CL Item
    Case (1)
    CL Item
    Control (2)
    Item Group
    Subject ID, sample ID, and sample use variable participants with or without acute myeloid leukemia and involved in the "Functional Genomic Landscape of Acute Myeloid Leukemia" project.
    SUBJECT_ID
    Item
    Subject ID
    string
    C2348585 (UMLS CUI [1,1])
    SAMPLE_ID
    Item
    Sample ID
    string
    C1299222 (UMLS CUI [1,1])
    SAMPLE_USE
    Item
    Sample Use
    string
    Item Group
    Sample ID, analyte type, and tumor status of samples obtained from participants with or without acute myeloid leukemia and involved in the "Functional Genomic Landscape of Acute Myeloid Leukemia" project.
    SAMPLE_ID
    Item
    De-identified sample ID
    string
    C1299222 (UMLS CUI [1,1])
    C4684638 (UMLS CUI [1,2])
    ANALYTE_TYPE
    Item
    Analyte type
    string
    C4744818 (UMLS CUI [1,1])
    Item
    Tumor status
    text
    C0475752 (UMLS CUI [1,1])
    IS_TUMOR
    Code List
    Tumor status
    CL Item
    Is normal (N)
    CL Item
    Is tumor (Y)
    Tillbaka till toppen 

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