ID
44181
Beschreibung
PART B - Period 1 - Day 1 - Ropinirole and the effect of food in early stage Parkinson’s disease subjects 101468/164 Study ID: 101468/164 Clinical Study ID: 101468/164 Study Title: An open-label, randomised, two part study to investigate the relative bioavailability of Ropinirole new and standard, marketed formulations and the effect of food on the pharmacokinetics of Ropinirole new formulation in early stage Parkinson’s disease subjects Patient Level Data: Study Listed on ClinicalStudyDataRequest.com Clinicaltrials.gov Identifier: Sponsor: GlaxoSmithKline Collaborators: N/A Phase: phase 1 Study Recruitment Status: Completed Generic Name: ropinirole Trade Name: Modutab,ZIPEREVE,ZEPREVE,REPREVE,ADARTREL,REQUIP,Zygara; Zygara,ZIPEREVE,ZEPREVE,Requip Depot,REQUIP,REPREVE,Modutab,ADARTREL Study Indication: Restless Legs Syndrome
Stichworte
Versionen (3)
- 03.10.17 03.10.17 -
- 13.04.21 13.04.21 - Dr. rer. medic Philipp Neuhaus
- 20.09.21 20.09.21 -
Rechteinhaber
glaxoSmithKline
Hochgeladen am
20. September 2021
DOI
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Lizenz
Creative Commons BY-NC 3.0
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PART B - Period 1 - Day 1 - Ropinirole and the effect of food in early stage Parkinson’s disease subjects 101468/164
PART B - Period 1 - Day 1 - Ropinirole and the effect of food in early stage Parkinson’s disease subjects 101468/164
Beschreibung
Inclusion Criteria
Alias
- UMLS CUI-1
- C1512693
Beschreibung
age and child-bearing potential contraception
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0001779
- UMLS CUI [1,2]
- C1960468
- UMLS CUI [1,3]
- C0700589
Beschreibung
idiopathic Parkinson's disease Hoehn&Yahr Stage
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0865475
- UMLS CUI [1,2]
- C3639483
Beschreibung
study subject participation status ropinirole or candidate for dopaminergic therapy
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C2348568
- UMLS CUI [1,2]
- C0244821
- UMLS CUI [2]
- C3267134
Beschreibung
bmi
Datentyp
boolean
Alias
- UMLS CUI [1]
- C1305855
Beschreibung
informed consent
Datentyp
boolean
Alias
- UMLS CUI [1]
- C0021430
Beschreibung
drug dosing ropinirole
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0244821
- UMLS CUI [1,2]
- C0678766
Beschreibung
exemption approved
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0585836
- UMLS CUI [1,2]
- C1708968
Beschreibung
Medical monitor name
Datentyp
text
Alias
- UMLS CUI [1,1]
- C0027365
- UMLS CUI [1,2]
- C1708968
Beschreibung
Date of approval
Datentyp
date
Alias
- UMLS CUI [1]
- C2346844
Beschreibung
Exclusion Criteria
Alias
- UMLS CUI-1
- C0680251
Beschreibung
physical examination abnormality
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0031809
- UMLS CUI [1,2]
- C1704258
- UMLS CUI [2]
- C0035648
Beschreibung
psychiatric, haematological, renal, hepatic, endocrinological, neurological, or cardiovascular disease or active malignancy
Datentyp
boolean
Alias
- UMLS CUI [1]
- C0004936
- UMLS CUI [2]
- C0018939
- UMLS CUI [3]
- C0022658
- UMLS CUI [4]
- C0023895
- UMLS CUI [5,1]
- C0014130
- UMLS CUI [5,2]
- C0027765
- UMLS CUI [6]
- C0007222
- UMLS CUI [7]
- C0006826
Beschreibung
laboratory abnormality or ECG abnormalities
Datentyp
boolean
Alias
- UMLS CUI [1]
- C0438215
- UMLS CUI [2]
- C0522055
Beschreibung
Hepatitis B surface antigen, Hepatitis C antibody and HIV antibody
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0019168
- UMLS CUI [1,2]
- C0166049
- UMLS CUI [2]
- C0019683
Beschreibung
alcohol breath test or blood test and/or urine drugs of abuse test at screening
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0202306
- UMLS CUI [1,2]
- C1710477
- UMLS CUI [1,3]
- C1167994
- UMLS CUI [1,4]
- C1710477
- UMLS CUI [2,1]
- C0451130
- UMLS CUI [2,2]
- C1710477
Beschreibung
syncope or orthostatic hypotension
Datentyp
boolean
Alias
- UMLS CUI [1]
- C0020651
- UMLS CUI [2,1]
- C0039070
- UMLS CUI [2,2]
- C0262926
Beschreibung
sleep disorder or Epworth Sleep Score 39
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0851578
- UMLS CUI [1,2]
- C2129304
Beschreibung
Abnormal diastolic arterial pressure or abnormal systolic arterial pressure
Datentyp
boolean
Alias
- UMLS CUI [1]
- C0277888
- UMLS CUI [2]
- C0277883
Beschreibung
L-dopa treatment must be discontinued for at least a 2-week wash-out period prior to dosing with study medication
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0013227
- UMLS CUI [1,2]
- C0023570
Beschreibung
Note: Patients on dopaminergic agonists other than ropinirole CR may be enrolled if the agent is stopped for a 2-week wash-out period prior to enrolment. Patients on selegiline, amantadine, or anticholinergics may be enrolled but must have been on a stable dose for at least one month prior to study enrolment and must remain on their current dose throughout the treatment phase of the study
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0013036
- UMLS CUI [1,2]
- C3469597
- UMLS CUI [1,3]
- C0262926
Beschreibung
hormone replacement therapy or CYP1A2 inhibitors or inducers
Datentyp
boolean
Alias
- UMLS CUI [1]
- C3850050
- UMLS CUI [2]
- C3850068
- UMLS CUI [3]
- C0282402
Beschreibung
Blood donation or significant blood loss
Datentyp
boolean
Alias
- UMLS CUI [1]
- C0005795
- UMLS CUI [2]
- C3163616
Beschreibung
personal history, or family history, of adverse reactions or hypersensitivity to ropinirole
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0020517
- UMLS CUI [1,2]
- C0244821
- UMLS CUI [1,3]
- C0241889
- UMLS CUI [1,4]
- C0559546
- UMLS CUI [1,5]
- C0244821
- UMLS CUI [1,6]
- C0241889
- UMLS CUI [2,1]
- C0020517
- UMLS CUI [2,2]
- C0244821
- UMLS CUI [2,3]
- C0332119
- UMLS CUI [3,1]
- C0559546
- UMLS CUI [3,2]
- C0244821
- UMLS CUI [3,3]
- C0332119
Beschreibung
Use of any investigational drug
Datentyp
boolean
Alias
- UMLS CUI [1]
- C0013230
Beschreibung
over-the-counter (OTC) medicine
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C2709201
- UMLS CUI [1,2]
- C0013227
Beschreibung
With alcohol abuse defined as an average weekly intake of greater than 21 units or an average daily intake of greater than 3 units for men; greater than 14 units per week or greater than 2 units per day for women. One unit is equivalent to half a pint of beer, one measure of spirits, or one glass of wine.
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C1510472
- UMLS CUI [1,2]
- C0085762
Beschreibung
drop out of the study prematurely or requirement of prohibited concomitant medication or non compliant behaviour
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C2347852
- UMLS CUI [1,2]
- C2348568
- UMLS CUI [1,3]
- C1321605
Beschreibung
pregnant or breast-feeding
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0032961
- UMLS CUI [1,2]
- C0006147
Beschreibung
exemption approved
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0585836
- UMLS CUI [1,2]
- C1708968
Beschreibung
Medical monitor name
Datentyp
text
Alias
- UMLS CUI [1,1]
- C0027365
- UMLS CUI [1,2]
- C1708968
Beschreibung
Date of approval
Datentyp
date
Alias
- UMLS CUI [1]
- C2346844
Beschreibung
Physical examination
Alias
- UMLS CUI-1
- C0031809
Beschreibung
Body system
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C1268086
- UMLS CUI [1,2]
- C0449913
Beschreibung
Body system abnormality
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C0460002
- UMLS CUI [1,2]
- C1704258
Beschreibung
Describe abnormality body system
Datentyp
text
Alias
- UMLS CUI [1,1]
- C0459424
- UMLS CUI [1,2]
- C0031809
- UMLS CUI [1,3]
- C0678257
Beschreibung
Pregnancy test
Alias
- UMLS CUI-1
- C0032976
Beschreibung
pregnancy test
Datentyp
integer
Alias
- UMLS CUI [1]
- C0032976
Beschreibung
pregnancy test
Datentyp
integer
Alias
- UMLS CUI [1]
- C0032976
Beschreibung
Date of pregnancy test
Datentyp
date
Alias
- UMLS CUI [1,1]
- C0032976
- UMLS CUI [1,2]
- C0011008
Beschreibung
Result of pregnancy test
Datentyp
integer
Alias
- UMLS CUI [1]
- C0427777
Beschreibung
Alcohol breath/ blood test
Alias
- UMLS CUI-1
- C0202304
Beschreibung
Perform Alcohol Breath/Blood Test and attach printout
Datentyp
time
Alias
- UMLS CUI [1,1]
- C0202304
- UMLS CUI [1,2]
- C0040223
Beschreibung
Result of alcohol test
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C0202304
- UMLS CUI [1,2]
- C1274040
Beschreibung
alcohol consumption
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0001948
- UMLS CUI [1,2]
- C0443288
Beschreibung
Drug screening (urine)
Alias
- UMLS CUI-1
- C0202274
Beschreibung
Time of drug screening
Datentyp
time
Alias
- UMLS CUI [1,1]
- C0040223
- UMLS CUI [1,2]
- C0202274
Beschreibung
Cannabinoids urine
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C0202274
- UMLS CUI [1,2]
- C0006864
Beschreibung
Morphine and morphine derivates urine
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C0202274
- UMLS CUI [1,2]
- C0279996
Beschreibung
Amphetamine urine
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C0202274
- UMLS CUI [1,2]
- C0002667
Beschreibung
Barbiturates urine
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C0202274
- UMLS CUI [1,2]
- C0004745
Beschreibung
Benzodiazepines urine
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C0202274
- UMLS CUI [1,2]
- C0005064
Beschreibung
Cocaine urine
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C0202274
- UMLS CUI [1,2]
- C0009170
Beschreibung
Tricyclic antidepressants urine
Datentyp
integer
Alias
- UMLS CUI [1]
- C0003290
Beschreibung
Urine drug screening positive specify
Datentyp
text
Alias
- UMLS CUI [1,1]
- C2711519
- UMLS CUI [1,2]
- C1521902
Beschreibung
Orthostatic blood pressure / Pulse - Predose
Alias
- UMLS CUI-1
- C0518766
- UMLS CUI-2
- C1095971
- UMLS CUI-3
- C0232117
- UMLS CUI-4
- C3812758
Beschreibung
For the pre-dose measurements in Part A, Day 1 of Periods 1 and 2, and Part B, Day 1 of Periods 1 and 2, 3 sets of semi-supine and erect blood pressure and pulse measurements will be taken, commencing approximately 40 minutes prior to dosing and each set will be separated by 10 minutes rest in the semi- supine position. Three stable measurements should be recorded In this instance stable is defined as the three semi-supine diastolic measurements being within 15 mmHg of the lowest measurement. This rule also applies for the semi-supine systolic and erect systolic and diastolic measurements. A maximum of six attempts can be made to obtain measurements pre-dose. If three consecutive stable measurements of blood pressure cannot be obtained then the Investigator should contact the Medical Monitor to discuss whether the patient can be included/continue in the study.
Datentyp
date
Alias
- UMLS CUI [1,1]
- C1320303
- UMLS CUI [1,2]
- C3812758
Beschreibung
Heart rate Semi-Supine
Datentyp
integer
Maßeinheiten
- bpm
Alias
- UMLS CUI [1,1]
- C0018810
- UMLS CUI [1,2]
- C0038846
- UMLS CUI [1,3]
- C3812758
Beschreibung
Heart Rate standing
Datentyp
integer
Maßeinheiten
- bpm
Alias
- UMLS CUI [1,1]
- C2029905
- UMLS CUI [1,2]
- C3812758
Beschreibung
Systolic blood pressure semi-supine
Datentyp
integer
Maßeinheiten
- mmHg
Alias
- UMLS CUI [1,1]
- C0871470
- UMLS CUI [1,2]
- C0038846
- UMLS CUI [1,3]
- C3812758
Beschreibung
Diastolic blood pressure semi-supine
Datentyp
integer
Maßeinheiten
- mmHg
Alias
- UMLS CUI [1,1]
- C0428883
- UMLS CUI [1,2]
- C0038846
- UMLS CUI [1,3]
- C3812758
Beschreibung
Systolic blood pressure standing
Datentyp
integer
Maßeinheiten
- mmHg
Alias
- UMLS CUI [1,1]
- C0871470
- UMLS CUI [1,2]
- C0231472
- UMLS CUI [1,3]
- C3812758
Beschreibung
Diastolic blood pressure standing
Datentyp
integer
Maßeinheiten
- mmHg
Alias
- UMLS CUI [1,1]
- C1303019
- UMLS CUI [1,2]
- C3812758
Beschreibung
Concomitant medication
Alias
- UMLS CUI-1
- C2347852
Beschreibung
If 'Yes', please document on the Concomitant Medication Report Forms.
Datentyp
integer
Alias
- UMLS CUI [1]
- C0580105
Beschreibung
tobacco use unchanged
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C0543414
- UMLS CUI [1,2]
- C0442739
Beschreibung
dietary restrictions
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C0425422
- UMLS CUI [1,2]
- C1321605
Beschreibung
Adverse event
Alias
- UMLS CUI-1
- C0877248
Beschreibung
Patient diary
Alias
- UMLS CUI-1
- C3890583
Beschreibung
Patient diary
Datentyp
text
Alias
- UMLS CUI [1]
- C3890583
Beschreibung
Randomization
Alias
- UMLS CUI-1
- C0034656
Beschreibung
study subject participation status eligibility
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C2348568
- UMLS CUI [1,2]
- C0013893
Beschreibung
Randomization
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C0034656
- UMLS CUI [1,2]
- C1522541
Beschreibung
High fat breakfast
Alias
- UMLS CUI-1
- C2698559
- UMLS CUI-2
- C0521974
Beschreibung
High fat breakfast started
Datentyp
time
Alias
- UMLS CUI [1,1]
- C2698559
- UMLS CUI [1,2]
- C0521974
- UMLS CUI [1,3]
- C0439659
Beschreibung
The suggested time for breakfast is 20 minutes
Datentyp
time
Alias
- UMLS CUI [1,1]
- C2698559
- UMLS CUI [1,2]
- C0521974
- UMLS CUI [1,3]
- C0444930
Beschreibung
Breakfast completed
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C0814440
- UMLS CUI [1,2]
- C0205197
Beschreibung
Breakfast not completed comment
Datentyp
text
Alias
- UMLS CUI [1,1]
- C0947611
- UMLS CUI [1,2]
- C0814440
- UMLS CUI [1,3]
- C0205197
Beschreibung
Study Drug Dosing
Alias
- UMLS CUI-1
- C0013175
- UMLS CUI-2
- C0678766
Beschreibung
The subject will not be allowed to lie down or sleep for 4 hours after the morning dose
Datentyp
time
Maßeinheiten
- 24hr:min
Alias
- UMLS CUI [1,1]
- C0178602
- UMLS CUI [1,2]
- C0040223
Beschreibung
Witness 1
Datentyp
text
Alias
- UMLS CUI [1,1]
- C0682356
- UMLS CUI [1,2]
- C0001555
Beschreibung
Witness date 1
Datentyp
date
Alias
- UMLS CUI [1,1]
- C4263486
- UMLS CUI [1,2]
- C0011008
Beschreibung
Witness 2
Datentyp
text
Alias
- UMLS CUI [1,1]
- C0682356
- UMLS CUI [1,2]
- C0001555
Beschreibung
Witness date 2
Datentyp
date
Alias
- UMLS CUI [1,1]
- C4263486
- UMLS CUI [1,2]
- C0011008
Beschreibung
Orthostatic blood pressure / pulse measurement - post dose
Alias
- UMLS CUI-1
- C1095971
- UMLS CUI-2
- C0232117
- UMLS CUI-3
- C0439568
Beschreibung
Date of visit
Datentyp
date
Alias
- UMLS CUI [1]
- C1320303
Beschreibung
Post dose
Datentyp
integer
Alias
- UMLS CUI [1]
- C0439568
Beschreibung
Time post dose
Datentyp
time
Alias
- UMLS CUI [1,1]
- C0439568
- UMLS CUI [1,2]
- C0040223
Beschreibung
Heart rate Semi-Supine
Datentyp
integer
Maßeinheiten
- bpm
Alias
- UMLS CUI [1,1]
- C0018810
- UMLS CUI [1,2]
- C0038846
- UMLS CUI [1,3]
- C0439568
Beschreibung
Heart Rate standing
Datentyp
integer
Maßeinheiten
- bpm
Alias
- UMLS CUI [1,1]
- C2029905
- UMLS CUI [1,2]
- C0439568
Beschreibung
Systolic blood pressure semi-supine
Datentyp
integer
Maßeinheiten
- mmHg
Alias
- UMLS CUI [1,1]
- C0871470
- UMLS CUI [1,2]
- C0038846
- UMLS CUI [1,3]
- C0439568
Beschreibung
Diastolic blood pressure semi-supine
Datentyp
integer
Maßeinheiten
- mmHg
Alias
- UMLS CUI [1,1]
- C0428883
- UMLS CUI [1,2]
- C0038846
- UMLS CUI [1,3]
- C0439568
Beschreibung
Systolic blood pressure standing
Datentyp
integer
Maßeinheiten
- mmHg
Alias
- UMLS CUI [1,1]
- C0871470
- UMLS CUI [1,2]
- C0231472
- UMLS CUI [1,3]
- C0439568
Beschreibung
Diastolic blood pressure standing
Datentyp
integer
Maßeinheiten
- mmHg
Alias
- UMLS CUI [1,1]
- C0428883
- UMLS CUI [1,2]
- C0231472
- UMLS CUI [1,3]
- C0439568
Beschreibung
Adverse Event - post dosing
Alias
- UMLS CUI-1
- C0877248
- UMLS CUI-2
- C0439568
Beschreibung
If Yes , please document on the Adverse Event Report Forms
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C0877248
- UMLS CUI [1,2]
- C0439574
Beschreibung
If Yes , please document on the Adverse Event Report Forms
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C0877248
- UMLS CUI [1,2]
- C1439442
Beschreibung
If Yes , please document on the Adverse Event Report Forms
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C0877248
- UMLS CUI [1,2]
- C1439477
Beschreibung
Pharmacokinetic sampling post dosing
Alias
- UMLS CUI-1
- C0031328
Beschreibung
Sample ID and specified time
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C1299222
- UMLS CUI [1,2]
- C1444698
Beschreibung
Actual time pharmacokinetics
Datentyp
time
Alias
- UMLS CUI [1,1]
- C0031328
- UMLS CUI [1,2]
- C0040223
Beschreibung
Date sample
Datentyp
date
Alias
- UMLS CUI [1,1]
- C0031328
- UMLS CUI [1,2]
- C1302413
Beschreibung
Discharge
Alias
- UMLS CUI-1
- C0030685
Beschreibung
Discharge Time
Datentyp
time
Alias
- UMLS CUI [1]
- C3864299
Beschreibung
Advise the subject to refrain from consuming xanthine containing beverages and foods (Coffee, tea, cola beverages, cocoa chocolate), grapefruit containing products, quinine - containing products and food containing CYP1A2-inducing constituents (Brussel sprouts, broccoli, cabbage, etc ), from 24 h before the PK evaluation day, Periods 1 and 2 in Part B, until completion of assessments 24 h afterwards
Datentyp
date
Alias
- UMLS CUI [1]
- C1545257
Ähnliche Modelle
PART B - Period 1 - Day 1 - Ropinirole and the effect of food in early stage Parkinson’s disease subjects 101468/164
C0244821 (UMLS CUI [1,2])
C1960468 (UMLS CUI [1,2])
C0700589 (UMLS CUI [1,3])
C3639483 (UMLS CUI [1,2])
C0244821 (UMLS CUI [1,2])
C3267134 (UMLS CUI [2])
C0678766 (UMLS CUI [1,2])
C1708968 (UMLS CUI [1,2])
C1708968 (UMLS CUI [1,2])
C1704258 (UMLS CUI [1,2])
C0035648 (UMLS CUI [2])
C0018939 (UMLS CUI [2])
C0022658 (UMLS CUI [3])
C0023895 (UMLS CUI [4])
C0014130 (UMLS CUI [5,1])
C0027765 (UMLS CUI [5,2])
C0007222 (UMLS CUI [6])
C0006826 (UMLS CUI [7])
C0522055 (UMLS CUI [2])
C0166049 (UMLS CUI [1,2])
C0019683 (UMLS CUI [2])
C1710477 (UMLS CUI [1,2])
C1167994 (UMLS CUI [1,3])
C1710477 (UMLS CUI [1,4])
C0451130 (UMLS CUI [2,1])
C1710477 (UMLS CUI [2,2])
C0039070 (UMLS CUI [2,1])
C0262926 (UMLS CUI [2,2])
C2129304 (UMLS CUI [1,2])
C0277883 (UMLS CUI [2])
C0023570 (UMLS CUI [1,2])
C3469597 (UMLS CUI [1,2])
C0262926 (UMLS CUI [1,3])
C3850068 (UMLS CUI [2])
C0282402 (UMLS CUI [3])
C3163616 (UMLS CUI [2])
C0244821 (UMLS CUI [1,2])
C0241889 (UMLS CUI [1,3])
C0559546 (UMLS CUI [1,4])
C0244821 (UMLS CUI [1,5])
C0241889 (UMLS CUI [1,6])
C0020517 (UMLS CUI [2,1])
C0244821 (UMLS CUI [2,2])
C0332119 (UMLS CUI [2,3])
C0559546 (UMLS CUI [3,1])
C0244821 (UMLS CUI [3,2])
C0332119 (UMLS CUI [3,3])
C0013227 (UMLS CUI [1,2])
C0085762 (UMLS CUI [1,2])
C2348568 (UMLS CUI [1,2])
C1321605 (UMLS CUI [1,3])
C0006147 (UMLS CUI [1,2])
C1708968 (UMLS CUI [1,2])
C1708968 (UMLS CUI [1,2])
C1704258 (UMLS CUI [1,2])
C0031809 (UMLS CUI [1,2])
C0678257 (UMLS CUI [1,3])
C0011008 (UMLS CUI [1,2])
C0040223 (UMLS CUI [1,2])
C0443288 (UMLS CUI [1,2])
C0202274 (UMLS CUI [1,2])
C0279996 (UMLS CUI [1,2])
C0005064 (UMLS CUI [1,2])
C1521902 (UMLS CUI [1,2])
C1095971 (UMLS CUI-2)
C0232117 (UMLS CUI-3)
C3812758 (UMLS CUI-4)
C3812758 (UMLS CUI [1,2])
C0038846 (UMLS CUI [1,2])
C3812758 (UMLS CUI [1,3])
C3812758 (UMLS CUI [1,2])
C0038846 (UMLS CUI [1,2])
C3812758 (UMLS CUI [1,3])
C0038846 (UMLS CUI [1,2])
C3812758 (UMLS CUI [1,3])
C0231472 (UMLS CUI [1,2])
C3812758 (UMLS CUI [1,3])
C3812758 (UMLS CUI [1,2])
C0442739 (UMLS CUI [1,2])
C1321605 (UMLS CUI [1,2])
C0013893 (UMLS CUI [1,2])
C1522541 (UMLS CUI [1,2])
C0521974 (UMLS CUI [1,2])
C0439659 (UMLS CUI [1,3])
C0521974 (UMLS CUI [1,2])
C0444930 (UMLS CUI [1,3])
C0205197 (UMLS CUI [1,2])
C0814440 (UMLS CUI [1,2])
C0205197 (UMLS CUI [1,3])
C0040223 (UMLS CUI [1,2])
C0001555 (UMLS CUI [1,2])
C0011008 (UMLS CUI [1,2])
C0001555 (UMLS CUI [1,2])
C0011008 (UMLS CUI [1,2])
C0232117 (UMLS CUI-2)
C0439568 (UMLS CUI-3)
C0040223 (UMLS CUI [1,2])
C0038846 (UMLS CUI [1,2])
C0439568 (UMLS CUI [1,3])
C0439568 (UMLS CUI [1,2])
C0038846 (UMLS CUI [1,2])
C0439568 (UMLS CUI [1,3])
C0038846 (UMLS CUI [1,2])
C0439568 (UMLS CUI [1,3])
C0231472 (UMLS CUI [1,2])
C0439568 (UMLS CUI [1,3])
C0231472 (UMLS CUI [1,2])
C0439568 (UMLS CUI [1,3])
C0439568 (UMLS CUI-2)
C0439574 (UMLS CUI [1,2])
C1439442 (UMLS CUI [1,2])
C1439477 (UMLS CUI [1,2])
C1444698 (UMLS CUI [1,2])
C0040223 (UMLS CUI [1,2])
C1302413 (UMLS CUI [1,2])