ID

46153

Descrição

The implementation of targeted therapies for acute myeloid leukemia has been challenged by complex mutational patterns within and across patients as well as a dearth of pharmacologic agents for most mutational events. Here, we report initial findings from the Beat AML program on a cohort of 672 tumor specimens collected from 562 patients. We assessed these specimens using whole exome sequencing, RNA-sequencing, and ex vivo drug sensitivity analyses. Our data reveal novel mutational events not previously detected in AML. We show association of drug response with mutational status, including instances of drug sensitivity that are specific to combinatorial mutational events. Integration with RNA-sequencing also revealed gene expression signatures, which predict a role of specific gene networks in drug response. Collectively, this report offers a dataset, accessible by the Beat AML data viewer, that can be leveraged to address clinical, genomic, transcriptomic, and functional inquiries into the biology of AML. NCT 01728402 https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001657

Link

dbGaP study=phs001657

Palavras-chave

Versões (9)
  1. 27/04/2022 27/04/2022 - Martin Dugas
  2. 27/04/2022 27/04/2022 - Martin Dugas
  3. 27/04/2022 27/04/2022 - Martin Dugas
  4. 27/04/2022 27/04/2022 - Martin Dugas
  5. 12/05/2022 12/05/2022 - Martin Dugas
  6. 12/05/2022 12/05/2022 - Martin Dugas
  7. 12/10/2022 12/10/2022 - Adrian Schulz
  8. 22/06/2023 22/06/2023 - Dr. Christian Niklas
  9. 29/01/2025 29/01/2025 - Akane Nishihara
Titular dos direitos

Jeffrey W. Tyner, PhD. Oregon Health and Science University, Knight Cancer Institute, Portland, OR, USA

Transferido a

29 de janeiro de 2025

DOI

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Licença

Creative Commons BY 4.0
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dbGaP phs001657 Functional Genomic Landscape of Acute Myeloid Leukemia

Inglês

Functional Genomic Landscape of Acute Myeloid LeukemiaNCT 01728402dbGaP Study Accession: phs001657.v1

1 Formulários  
  1. StudyEvent: dbGaP phs001657 Functional Genomic Landscape of Acute Myeloid Leukemia
    1. Functional Genomic Landscape of Acute Myeloid LeukemiaNCT 01728402dbGaP Study Accession: phs001657.v1
Subject ID, consent group, and affection status of participants with or without acute myeloid leukemia and involved in the "Functional Genomic Landscape of Acute Myeloid Leukemia" project.
Descrição

Subject ID, consent group, and affection status of participants with or without acute myeloid leukemia and involved in the "Functional Genomic Landscape of Acute Myeloid Leukemia" project.

De-identified subject ID
Descrição

phv00417529

Tipo de dados

text

Alias
UMLS CUI [1,1]
C2348585
UMLS CUI [1,2]
C4684638
Consent group as determined by DAC
Descrição

phv00417530

Tipo de dados

text

Alias
UMLS CUI [1,1]
C1547872
Case control status of the subject for leukemia [Case=subjects with acute myeloid leukemia; Control=subjects without acute myeloid leukemia]
Descrição

phv00417531

Tipo de dados

text

Alias
UMLS CUI [1,1]
C3274646
Subject ID, sample ID, and sample use variable participants with or without acute myeloid leukemia and involved in the "Functional Genomic Landscape of Acute Myeloid Leukemia" project.
Descrição

Subject ID, sample ID, and sample use variable participants with or without acute myeloid leukemia and involved in the "Functional Genomic Landscape of Acute Myeloid Leukemia" project.

Subject ID
Descrição

phv00417532

Tipo de dados

string

Alias
UMLS CUI [1,1]
C2348585
Sample ID
Descrição

phv00417533

Tipo de dados

string

Alias
UMLS CUI [1,1]
C1299222
Sample Use
Descrição

phv00417534

Tipo de dados

string

Alias
UMLS CUI [1,1]
C2347026
UMLS CUI [1,2]
C1524063
Sample ID, analyte type, and tumor status of samples obtained from participants with or without acute myeloid leukemia and involved in the "Functional Genomic Landscape of Acute Myeloid Leukemia" project.
Descrição

Sample ID, analyte type, and tumor status of samples obtained from participants with or without acute myeloid leukemia and involved in the "Functional Genomic Landscape of Acute Myeloid Leukemia" project.

De-identified sample ID
Descrição

phv00417535

Tipo de dados

string

Alias
UMLS CUI [1,1]
C1299222
UMLS CUI [1,2]
C4684638
Analyte type
Descrição

phv00417536

Tipo de dados

string

Alias
UMLS CUI [1,1]
C4744818
Tumor status
Descrição

phv00417537

Tipo de dados

text

Alias
UMLS CUI [1,1]
C0475752
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Similar models

Functional Genomic Landscape of Acute Myeloid LeukemiaNCT 01728402dbGaP Study Accession: phs001657.v1

1 Formulários
  1. StudyEvent: dbGaP phs001657 Functional Genomic Landscape of Acute Myeloid Leukemia
    1. Functional Genomic Landscape of Acute Myeloid LeukemiaNCT 01728402dbGaP Study Accession: phs001657.v1
Name
Tipo
Description | Question | Decode (Coded Value)
Tipo de dados
Alias
Item Group
Subject ID, consent group, and affection status of participants with or without acute myeloid leukemia and involved in the "Functional Genomic Landscape of Acute Myeloid Leukemia" project.
phv00417529
Item
De-identified subject ID
text
C2348585 (UMLS CUI [1,1])
C4684638 (UMLS CUI [1,2])
Item
Consent group as determined by DAC
text
C1547872 (UMLS CUI [1,1])
CONSENT
Code List
Consent group as determined by DAC
CL Item
Disease-Specific (Leukemia) (DS-LEU) (1)
Item
Case control status of the subject for leukemia [Case=subjects with acute myeloid leukemia; Control=subjects without acute myeloid leukemia]
text
C3274646 (UMLS CUI [1,1])
AFFECTION_STATUS
Code List
Case control status of the subject for leukemia [Case=subjects with acute myeloid leukemia; Control=subjects without acute myeloid leukemia]
CL Item
Case (1)
CL Item
Control (2)
Item Group
Subject ID, sample ID, and sample use variable participants with or without acute myeloid leukemia and involved in the "Functional Genomic Landscape of Acute Myeloid Leukemia" project.
phv00417532
Item
Subject ID
string
C2348585 (UMLS CUI [1,1])
phv00417533
Item
Sample ID
string
C1299222 (UMLS CUI [1,1])
phv00417534
Item
Sample Use
string
C2347026 (UMLS CUI [1,1])
C1524063 (UMLS CUI [1,2])
Item Group
Sample ID, analyte type, and tumor status of samples obtained from participants with or without acute myeloid leukemia and involved in the "Functional Genomic Landscape of Acute Myeloid Leukemia" project.
phv00417535
Item
De-identified sample ID
string
C1299222 (UMLS CUI [1,1])
C4684638 (UMLS CUI [1,2])
phv00417536
Item
Analyte type
string
C4744818 (UMLS CUI [1,1])
Item
Tumor status
text
C0475752 (UMLS CUI [1,1])
IS_TUMOR
Code List
Tumor status
CL Item
Is normal (N)
CL Item
Is tumor (Y)
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