ID

45579

Beschreibung

Principal Investigator: David Goldstein, PhD, Duke University, Durham, NC, USA MeSH: Schizophrenia,Schizoaffective disorder,Attention Deficit Hyperactivity Disorder,Seizures,Oppositional defiant disorder,Anxiety,Depression,Autism,Autism Spectrum Disorders,Bipolar Disorder,Developmental Disabilities,Ataxia,Migraine,Paranoid schizophrenia,Obsessive compulsive disorder,Kluver-Bucy syndrome,Intellectual disability https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000682 Although schizophrenia is a highly heritable disease, relatively little progress had been made in securely identifying the genetic causes of this disorder, and most instances of schizophrenia in the general population remain unexplained. One avenue of explanation for the genetic basis of schizophrenia, however, has been effectively closed by recent research. Genome-wide association studies (GWAS) have now shown that common variation makes at most a modest contribution to the risk of schizophrenia. At the same time that the role of common variation has been circumscribed by GWAS, however, the analysis of copy number variants that are detectable on a genome-wide scale has revealed and replicated a number of very rare variants that associate with schizophrenia. These rare copy number variants that have been implicated in schizophrenia, however, have one striking feature in common: they are all risk factors for other brain related disorders beyond schizophrenia such as mental retardation, autism and epilepsy. These findings argue that genetic risk factors may confer a highly penetrant vulnerability to neuropsychiatric disorder, which is then further modified by interacting genetic or environmental factors to determine the ultimate manifestation. Most schizophrenia collections that are being studied today, however, have been selected precisely for their homogeneity: including only schizophrenia patients with no comorbidities, or schizophrenia patients with relatives who have schizophrenia but no other neuropsychiatric conditions. These selection criteria are inconsistent with what we now know about the bulk of the genetic differences that have been associated with disease. The central hypothesis of this project is that there are rare genetic variants that strongly elevate the risk of various neuropsychiatric diseases, and that these risk factors can be identified most readily in families segregating multiple neuropsychiatric conditions.

Link

dbGaP-study=phs000682

Stichworte

Versionen (1)
  1. 2023-01-24 2023-01-24 - Chiara Middel
Rechteinhaber

David Goldstein, PhD, Duke University, Durham, NC, USA

Hochgeladen am

24 januari 2023

DOI

Für eine Beantragung loggen Sie sich ein.

Lizenz

Creative Commons BY 4.0
Modell Kommentare :

Hier können Sie das Modell kommentieren. Über die Sprechblasen an den Itemgruppen und Items können Sie diese spezifisch kommentieren.

Zurück zu Modell Kommentaren
Itemgroup Kommentare für :

Item Kommentare für :

Um Formulare herunterzuladen müssen Sie angemeldet sein. Bitte loggen Sie sich ein oder registrieren Sie sich kostenlos.

dbGaP phs000682 Genetics of Neuropsychiatric and Neurodevelopmental Disorders

Englisch

Eligibility Criteria

6 Formulare  
Inclusion and exclusion criteria
Beschreibung

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0680251
This study initially aimed to sequence 100 probands. A supplement was later submitted to sequence an additional 125 individuals, including affected children and their families. The inclusion and exclusion criteria for both sections of the study are listed below.
Beschreibung

Elig.phs000682.v1.p1.1

Datentyp

boolean

Alias
UMLS CUI [1,1]
C1947946
UMLS CUI [1,2]
C0008972
UMLS CUI [1,3]
C1561491
UMLS CUI [1,4]
C1265611
UMLS CUI [1,5]
C0681850
UMLS CUI [2,1]
C2348609
UMLS CUI [2,2]
C1561491
UMLS CUI [2,3]
C1524062
UMLS CUI [2,4]
C0681850
UMLS CUI [2,5]
C0522476
UMLS CUI [2,6]
C0008059
UMLS CUI [2,7]
C0015576
Our patient selection criteria was based on two hypotheses: first, that patients with rare highly penetrant genetic contributors to schizophrenia also have affected family members, and second, that because all known genes contributing to schizophrenia also contribute to other disorders such as mental retardation, epilepsy and autism, families that segregate more than one of these conditions will be most likely to contain highly penetrant genetic contributors. For this research, in order to maximize the chances of selecting patients with genetic variants with high penetrance, we recruited only schizophrenia or schizoaffective patients who manifest other serious neuropsychiatric problems in themselves or their close relatives. The following inclusion criteria was therefore used: (i) DSM-IV diagnosis of schizophrenia or schizoaffective disorder; (ii) at least one first or second degree relative (parent, child or sibling OR grandparent, grandchild, half-sibling, aunt, uncle, nephew or niece) with schizophrenia or schizoaffective disorder and (iii) EITHER (i) one of the following co-morbid conditions: mental retardation, seizure disorder, pervasive developmental disorder (PDD) in the proband OR (ii) at least two first, second or third degree relatives with mental retardation, seizure disorder or PDD. In addition to the proband, we also recruited at least one affected and one non-affected first or second degree relative with schizophrenia per proband, and as many other first, second or third degree relatives as were accessible and willing to enroll in the study. For each relative, we collected blood, administered the SCID to screen for mental disorders and collected information on other aspects of their medical history, education and employment history.
Beschreibung

Elig.phs000682.v1.p1.2

Datentyp

boolean

Alias
UMLS CUI [1,1]
C1512571
UMLS CUI [1,2]
C0030705
UMLS CUI [1,3]
C0522498
UMLS CUI [1,4]
C0314603
UMLS CUI [1,5]
C1880177
UMLS CUI [1,6]
C0036341
UMLS CUI [1,7]
C0086282
UMLS CUI [1,8]
C0522476
UMLS CUI [2,1]
C1512571
UMLS CUI [2,2]
C0205309
UMLS CUI [2,3]
C0314603
UMLS CUI [2,4]
C1880177
UMLS CUI [2,5]
C0036341
UMLS CUI [2,6]
C0205394
UMLS CUI [2,7]
C0012634
UMLS CUI [2,8]
C0025362
UMLS CUI [2,9]
C0014544
UMLS CUI [2,10]
C0522476
UMLS CUI [2,11]
C0015576
UMLS CUI [2,12]
C2700400
UMLS CUI [2,13]
C0730319
UMLS CUI [3,1]
C0242802
UMLS CUI [3,2]
C0036341
UMLS CUI [3,3]
C0036337
UMLS CUI [3,4]
C1280464
UMLS CUI [3,5]
C0205394
UMLS CUI [3,6]
C3203509
UMLS CUI [4,1]
C1512693
UMLS CUI [4,2]
C0220952
UMLS CUI [4,3]
C0036341
UMLS CUI [4,4]
C1517194
UMLS CUI [4,5]
C1519210
UMLS CUI [4,6]
C0522476
UMLS CUI [4,7]
C1524062
UMLS CUI [4,8]
C0012634
UMLS CUI [4,9]
C0025362
UMLS CUI [4,10]
C0014544
UMLS CUI [4,11]
C0524528
UMLS CUI [5,1]
C1512693
UMLS CUI [5,2]
C0220952
UMLS CUI [5,3]
C0036341
UMLS CUI [5,4]
C1517194
UMLS CUI [5,5]
C1519210
UMLS CUI [5,6]
C0522476
UMLS CUI [5,7]
C1524031
UMLS CUI [5,8]
C0205448
UMLS CUI [5,9]
C1517194
UMLS CUI [5,10]
C1519210
UMLS CUI [5,11]
C3639750
UMLS CUI [5,12]
C0011900
UMLS CUI [5,13]
C0025362
UMLS CUI [5,14]
C0014544
UMLS CUI [5,15]
C0524528
UMLS CUI [6,1]
C0242800
UMLS CUI [6,2]
C0522476
UMLS CUI [6,3]
C0522477
UMLS CUI [6,4]
C1517194
UMLS CUI [6,5]
C1519210
UMLS CUI [6,6]
C0600109
UMLS CUI [6,7]
C1516879
UMLS CUI [7,1]
C0005834
UMLS CUI [7,2]
C1537054
UMLS CUI [7,3]
C0262926
UMLS CUI [7,4]
C0013658
UMLS CUI [7,5]
C0242271
Inclusion criteria (for the supplement study):
Beschreibung

Elig.phs000682.v1.p1.3

Datentyp

boolean

Alias
UMLS CUI [1,1]
C1512693
Proband is under 18 years of age and meets an axis I DSM-IV-TR criteria for one of the following disorders: Obsessive-compulsive disorder, Schizophrenia, Bipolar Disorder, Attention-Deficient and Hyperactivity Disorder, Major Depression, or Sensory Integration Disorder.
Beschreibung

Elig.phs000682.v1.p1.4

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0001779
UMLS CUI [1,2]
C0270287
UMLS CUI [1,3]
C0220952
UMLS CUI [1,4]
C0028768
UMLS CUI [1,5]
C0005586
UMLS CUI [1,6]
C0036341
UMLS CUI [1,7]
C1263846
UMLS CUI [1,8]
C1269683
UMLS CUI [1,9]
C1960557
Proband must have two or more affected first or second degree relatives with at least one of the above listed Axis I qualifying disorders and/or co-morbidities of developmental delay, mental retardation, or seizures.
Beschreibung

Elig.phs000682.v1.p1.5

Datentyp

boolean

Alias
UMLS CUI [1,1]
C1517194
UMLS CUI [1,2]
C1519210
UMLS CUI [1,3]
C0522476
UMLS CUI [1,4]
C0270287
UMLS CUI [2,1]
C1524062
UMLS CUI [2,2]
C0012634
UMLS CUI [2,3]
C0424605
UMLS CUI [2,4]
C0025362
UMLS CUI [2,5]
C0036572
Proband does not have a known diagnosis of genetic syndrome or disorder.
Beschreibung

Elig.phs000682.v1.p1.6

Datentyp

boolean

Alias
UMLS CUI [1,1]
C1298908
UMLS CUI [1,2]
C0011900
UMLS CUI [1,3]
C0314603
UMLS CUI [1,4]
C0039082
UMLS CUI [1,5]
C0012634
Proband has negative karyotype and/or clinical chromosome microarray, negative newborn screen (if applied), negative basic metabolic screen including plasma amino acid, urine organic acid, and acylcarnitine profile, negative FMR1 DNA test or other genetic tests if apply.
Beschreibung

Elig.phs000682.v1.p1.7

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0205160
UMLS CUI [1,2]
C1261273
UMLS CUI [1,3]
C0200867
UMLS CUI [1,4]
C1709016
UMLS CUI [2,1]
C0205160
UMLS CUI [2,2]
C0027617
UMLS CUI [3,1]
C0205160
UMLS CUI [3,2]
C0870883
UMLS CUI [3,3]
C0220908
UMLS CUI [3,4]
C0032105
UMLS CUI [3,5]
C0002520
UMLS CUI [3,6]
C0428157
UMLS CUI [3,7]
C0523446
UMLS CUI [3,8]
C0205160
UMLS CUI [3,9]
C1414649
UMLS CUI [3,10]
C1658606
UMLS CUI [3,11]
C0205160
UMLS CUI [3,12]
C0205394
UMLS CUI [3,13]
C0679560
Parents, unaffected siblings, and other extended family members indicated are available for the study.
Beschreibung

Elig.phs000682.v1.p1.8

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0470187
UMLS CUI [1,2]
C0030551
UMLS CUI [1,3]
C0037047
UMLS CUI [1,4]
C0086282
UMLS CUI [1,5]
C0015341
Exclusion criteria
Beschreibung

Elig.phs000682.v1.p1.9

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0680251
Proband has a significant history of prematurity (birth weight <1500g).
Beschreibung

Elig.phs000682.v1.p1.10

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0262926
UMLS CUI [1,2]
C0151526
UMLS CUI [1,3]
C0005612
Proband has a history of brain injury including hypoxia, CNS infection, accident, and toxin, etc.
Beschreibung

Elig.phs000682.v1.p1.11

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0262926
UMLS CUI [1,2]
C0242184
UMLS CUI [1,3]
C0007684
UMLS CUI [1,4]
C0876926
UMLS CUI [1,5]
C0040549
Proband is confirmed or strongly suspected for a known genetic syndrome.
Beschreibung

Elig.phs000682.v1.p1.12

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0242114
UMLS CUI [1,2]
C0750484
UMLS CUI [1,3]
C0205309
UMLS CUI [1,4]
C0019247
Abnormal molecular or genetic study such as finding of known pathologic CNVs or abnormal biochemical profile of unclear significance.
Beschreibung

Elig.phs000682.v1.p1.13

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0205161
UMLS CUI [1,2]
C1513380
UMLS CUI [1,3]
C0813145
UMLS CUI [1,4]
C1521733
UMLS CUI [1,5]
C3516217
UMLS CUI [1,6]
C0205474
UMLS CUI [1,7]
C2022317
Proband has severe and profound mental retardation.
Beschreibung

Elig.phs000682.v1.p1.14

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0205082
UMLS CUI [1,2]
C0020796
Immediate and extended family members are not available for study.
Beschreibung

Elig.phs000682.v1.p1.15

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0686905
UMLS CUI [1,2]
C0015341
UMLS CUI [1,3]
C2371717
Zum Seitenanfang zurückkehren

Ähnliche Modelle

Eligibility Criteria

6 Formulare
Name
Typ
Description | Question | Decode (Coded Value)
Datentyp
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
Elig.phs000682.v1.p1.1
Item
This study initially aimed to sequence 100 probands. A supplement was later submitted to sequence an additional 125 individuals, including affected children and their families. The inclusion and exclusion criteria for both sections of the study are listed below.
boolean
C1947946 (UMLS CUI [1,1])
C0008972 (UMLS CUI [1,2])
C1561491 (UMLS CUI [1,3])
C1265611 (UMLS CUI [1,4])
C0681850 (UMLS CUI [1,5])
C2348609 (UMLS CUI [2,1])
C1561491 (UMLS CUI [2,2])
C1524062 (UMLS CUI [2,3])
C0681850 (UMLS CUI [2,4])
C0522476 (UMLS CUI [2,5])
C0008059 (UMLS CUI [2,6])
C0015576 (UMLS CUI [2,7])
Elig.phs000682.v1.p1.2
Item
Our patient selection criteria was based on two hypotheses: first, that patients with rare highly penetrant genetic contributors to schizophrenia also have affected family members, and second, that because all known genes contributing to schizophrenia also contribute to other disorders such as mental retardation, epilepsy and autism, families that segregate more than one of these conditions will be most likely to contain highly penetrant genetic contributors. For this research, in order to maximize the chances of selecting patients with genetic variants with high penetrance, we recruited only schizophrenia or schizoaffective patients who manifest other serious neuropsychiatric problems in themselves or their close relatives. The following inclusion criteria was therefore used: (i) DSM-IV diagnosis of schizophrenia or schizoaffective disorder; (ii) at least one first or second degree relative (parent, child or sibling OR grandparent, grandchild, half-sibling, aunt, uncle, nephew or niece) with schizophrenia or schizoaffective disorder and (iii) EITHER (i) one of the following co-morbid conditions: mental retardation, seizure disorder, pervasive developmental disorder (PDD) in the proband OR (ii) at least two first, second or third degree relatives with mental retardation, seizure disorder or PDD. In addition to the proband, we also recruited at least one affected and one non-affected first or second degree relative with schizophrenia per proband, and as many other first, second or third degree relatives as were accessible and willing to enroll in the study. For each relative, we collected blood, administered the SCID to screen for mental disorders and collected information on other aspects of their medical history, education and employment history.
boolean
C1512571 (UMLS CUI [1,1])
C0030705 (UMLS CUI [1,2])
C0522498 (UMLS CUI [1,3])
C0314603 (UMLS CUI [1,4])
C1880177 (UMLS CUI [1,5])
C0036341 (UMLS CUI [1,6])
C0086282 (UMLS CUI [1,7])
C0522476 (UMLS CUI [1,8])
C1512571 (UMLS CUI [2,1])
C0205309 (UMLS CUI [2,2])
C0314603 (UMLS CUI [2,3])
C1880177 (UMLS CUI [2,4])
C0036341 (UMLS CUI [2,5])
C0205394 (UMLS CUI [2,6])
C0012634 (UMLS CUI [2,7])
C0025362 (UMLS CUI [2,8])
C0014544 (UMLS CUI [2,9])
C0522476 (UMLS CUI [2,10])
C0015576 (UMLS CUI [2,11])
C2700400 (UMLS CUI [2,12])
C0730319 (UMLS CUI [2,13])
C0242802 (UMLS CUI [3,1])
C0036341 (UMLS CUI [3,2])
C0036337 (UMLS CUI [3,3])
C1280464 (UMLS CUI [3,4])
C0205394 (UMLS CUI [3,5])
C3203509 (UMLS CUI [3,6])
C1512693 (UMLS CUI [4,1])
C0220952 (UMLS CUI [4,2])
C0036341 (UMLS CUI [4,3])
C1517194 (UMLS CUI [4,4])
C1519210 (UMLS CUI [4,5])
C0522476 (UMLS CUI [4,6])
C1524062 (UMLS CUI [4,7])
C0012634 (UMLS CUI [4,8])
C0025362 (UMLS CUI [4,9])
C0014544 (UMLS CUI [4,10])
C0524528 (UMLS CUI [4,11])
C1512693 (UMLS CUI [5,1])
C0220952 (UMLS CUI [5,2])
C0036341 (UMLS CUI [5,3])
C1517194 (UMLS CUI [5,4])
C1519210 (UMLS CUI [5,5])
C0522476 (UMLS CUI [5,6])
C1524031 (UMLS CUI [5,7])
C0205448 (UMLS CUI [5,8])
C1517194 (UMLS CUI [5,9])
C1519210 (UMLS CUI [5,10])
C3639750 (UMLS CUI [5,11])
C0011900 (UMLS CUI [5,12])
C0025362 (UMLS CUI [5,13])
C0014544 (UMLS CUI [5,14])
C0524528 (UMLS CUI [5,15])
C0242800 (UMLS CUI [6,1])
C0522476 (UMLS CUI [6,2])
C0522477 (UMLS CUI [6,3])
C1517194 (UMLS CUI [6,4])
C1519210 (UMLS CUI [6,5])
C0600109 (UMLS CUI [6,6])
C1516879 (UMLS CUI [6,7])
C0005834 (UMLS CUI [7,1])
C1537054 (UMLS CUI [7,2])
C0262926 (UMLS CUI [7,3])
C0013658 (UMLS CUI [7,4])
C0242271 (UMLS CUI [7,5])
Elig.phs000682.v1.p1.3
Item
Inclusion criteria (for the supplement study):
boolean
C1512693 (UMLS CUI [1,1])
Elig.phs000682.v1.p1.4
Item
Proband is under 18 years of age and meets an axis I DSM-IV-TR criteria for one of the following disorders: Obsessive-compulsive disorder, Schizophrenia, Bipolar Disorder, Attention-Deficient and Hyperactivity Disorder, Major Depression, or Sensory Integration Disorder.
boolean
C0001779 (UMLS CUI [1,1])
C0270287 (UMLS CUI [1,2])
C0220952 (UMLS CUI [1,3])
C0028768 (UMLS CUI [1,4])
C0005586 (UMLS CUI [1,5])
C0036341 (UMLS CUI [1,6])
C1263846 (UMLS CUI [1,7])
C1269683 (UMLS CUI [1,8])
C1960557 (UMLS CUI [1,9])
Elig.phs000682.v1.p1.5
Item
Proband must have two or more affected first or second degree relatives with at least one of the above listed Axis I qualifying disorders and/or co-morbidities of developmental delay, mental retardation, or seizures.
boolean
C1517194 (UMLS CUI [1,1])
C1519210 (UMLS CUI [1,2])
C0522476 (UMLS CUI [1,3])
C0270287 (UMLS CUI [1,4])
C1524062 (UMLS CUI [2,1])
C0012634 (UMLS CUI [2,2])
C0424605 (UMLS CUI [2,3])
C0025362 (UMLS CUI [2,4])
C0036572 (UMLS CUI [2,5])
Elig.phs000682.v1.p1.6
Item
Proband does not have a known diagnosis of genetic syndrome or disorder.
boolean
C1298908 (UMLS CUI [1,1])
C0011900 (UMLS CUI [1,2])
C0314603 (UMLS CUI [1,3])
C0039082 (UMLS CUI [1,4])
C0012634 (UMLS CUI [1,5])
Elig.phs000682.v1.p1.7
Item
Proband has negative karyotype and/or clinical chromosome microarray, negative newborn screen (if applied), negative basic metabolic screen including plasma amino acid, urine organic acid, and acylcarnitine profile, negative FMR1 DNA test or other genetic tests if apply.
boolean
C0205160 (UMLS CUI [1,1])
C1261273 (UMLS CUI [1,2])
C0200867 (UMLS CUI [1,3])
C1709016 (UMLS CUI [1,4])
C0205160 (UMLS CUI [2,1])
C0027617 (UMLS CUI [2,2])
C0205160 (UMLS CUI [3,1])
C0870883 (UMLS CUI [3,2])
C0220908 (UMLS CUI [3,3])
C0032105 (UMLS CUI [3,4])
C0002520 (UMLS CUI [3,5])
C0428157 (UMLS CUI [3,6])
C0523446 (UMLS CUI [3,7])
C0205160 (UMLS CUI [3,8])
C1414649 (UMLS CUI [3,9])
C1658606 (UMLS CUI [3,10])
C0205160 (UMLS CUI [3,11])
C0205394 (UMLS CUI [3,12])
C0679560 (UMLS CUI [3,13])
Elig.phs000682.v1.p1.8
Item
Parents, unaffected siblings, and other extended family members indicated are available for the study.
boolean
C0470187 (UMLS CUI [1,1])
C0030551 (UMLS CUI [1,2])
C0037047 (UMLS CUI [1,3])
C0086282 (UMLS CUI [1,4])
C0015341 (UMLS CUI [1,5])
Elig.phs000682.v1.p1.9
Item
Exclusion criteria
boolean
C0680251 (UMLS CUI [1,1])
Elig.phs000682.v1.p1.10
Item
Proband has a significant history of prematurity (birth weight <1500g).
boolean
C0262926 (UMLS CUI [1,1])
C0151526 (UMLS CUI [1,2])
C0005612 (UMLS CUI [1,3])
Elig.phs000682.v1.p1.11
Item
Proband has a history of brain injury including hypoxia, CNS infection, accident, and toxin, etc.
boolean
C0262926 (UMLS CUI [1,1])
C0242184 (UMLS CUI [1,2])
C0007684 (UMLS CUI [1,3])
C0876926 (UMLS CUI [1,4])
C0040549 (UMLS CUI [1,5])
Elig.phs000682.v1.p1.12
Item
Proband is confirmed or strongly suspected for a known genetic syndrome.
boolean
C0242114 (UMLS CUI [1,1])
C0750484 (UMLS CUI [1,2])
C0205309 (UMLS CUI [1,3])
C0019247 (UMLS CUI [1,4])
Elig.phs000682.v1.p1.13
Item
Abnormal molecular or genetic study such as finding of known pathologic CNVs or abnormal biochemical profile of unclear significance.
boolean
C0205161 (UMLS CUI [1,1])
C1513380 (UMLS CUI [1,2])
C0813145 (UMLS CUI [1,3])
C1521733 (UMLS CUI [1,4])
C3516217 (UMLS CUI [1,5])
C0205474 (UMLS CUI [1,6])
C2022317 (UMLS CUI [1,7])
Elig.phs000682.v1.p1.14
Item
Proband has severe and profound mental retardation.
boolean
C0205082 (UMLS CUI [1,1])
C0020796 (UMLS CUI [1,2])
Elig.phs000682.v1.p1.15
Item
Immediate and extended family members are not available for study.
boolean
C0686905 (UMLS CUI [1,1])
C0015341 (UMLS CUI [1,2])
C2371717 (UMLS CUI [1,3])
Zum Seitenanfang zurückkehren 

Kontakt

Benutzen Sie dieses Formular für Rückmeldungen, Fragen und Verbesserungsvorschläge.

Mit * gekennzeichnete Felder sind notwendig.

Hilfe

Benötigen Sie Hilfe bei der Suche? Um mehr Details zu erfahren und die Suche effektiver nutzen zu können schauen Sie sich doch das entsprechende Video auf unserer Tutorial Seite an.

Zum Video