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ID

45189

Description

Principal Investigator: Philip R. Taylor, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA MeSH: Squamous Cell Carcinoma,Esophageal Cancer,Gastric Cancer https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000361 This project aims to conduct genome-wide association studies (GWAS) in two anatomically different upper gastrointestinal (UGI) cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cell carcinomas (ESCCs) and gastric cancers (GCs) and is comprised of Asians (*the "Asian UGI GWAS"*), while the other population has low rates of ESCC and GC and includes non-Asians from the Americas, Europe, and Australia (*the "Non-Asian UGI GWAS"*). Study participants for the Asian UGI GWAS reported here (Illumina 660W Quad chip) were drawn from 2 studies, the Shanxi Upper Gastrointestinal Cancer Genetics Project (Shanxi) and the Linxian Nutrition Intervention Trial (NIT), a prospective cohort, and included a total of 1898 ESCCs, 1625 GCs, and 2100 controls. For the 2nd phase (8 TaqMan SNPs), additional subjects from Shanxi and NIT as well as subjects from the Shanghai Men's Health Study (SMHS), the Shanghai Women's Health Study (SWHS), and the Singapore Chinese Health Study (SCHS) were also included (217 ESCCs, 615 GCs, 1202 controls). Altogether 2115 ESCCs, 2240 GCs, and 3302 controls were genotyped in this study.

Link

dbGaP study = phs000361

Keywords

Versions (2)
  1. 8/19/22 8/19/22 - Simon Heim
  2. 10/12/22 10/12/22 - Adrian Schulz
Copyright Holder

Philip R. Taylor, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

Uploaded on

October 12, 2022

DOI

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Creative Commons BY 4.0
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    dbGaP phs000361 Genome-Wide Association Studies in Upper Gastrointestinal Cancers (Asian)

    English

    Eligibility Criteria

    4 forms  
    1. StudyEvent: SEV1
      1. Eligibility Criteria
      2. Subject ID, consent group, and affection status of participants involved in genome-wide association studies in two anatomically different upper gastrointestinal cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cell carcinomas (ESCC) and gastric cancers (GC) and is comprised of Asians, while the other population has low rates of ESCC and GC and includes non-Asians from the Americas, Europe, and Australia.
      3. Sample ID and subject ID of participants involved in genome-wide association studies in two anatomically different upper gastrointestinal cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cell carcinomas (ESCC) and gastric cancers (GC) and is comprised of Asians, while the other population has low rates of ESCC and GC and includes non-Asians from the Americas, Europe, and Australia.
      4. Subject ID, study design (cohort, case or control), affection status, gender, and age of participants involved in genome-wide association studies in two anatomically different upper gastrointestinal cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cell carcinomas (ESCC) and gastric cancers (GC) and is comprised of Asians, while the other population has low rates of ESCC and GC and includes non-Asians from the Americas, Europe, and Australia.
    Inclusion and exclusion criteria
    Description

    Inclusion and exclusion criteria

    Esophageal squamous cell carcinomas (ESCCs) include incident, primary esophageal cancers with squamous histology.
    Description

    Esophageal squamous cell carcinomas (ESCCs) include incident, primary esophageal cancers with squamous histology.

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0279626
    Gastric cancers (GCs) include incident, primary gastric adenocarcinomas.
    Description

    Gastric cancers (GCs) include incident, primary gastric adenocarcinomas.

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0024623
    Controls were all cancer-free at the time of enrollment (and blood draw).
    Description

    Controls were all cancer-free at the time of enrollment (and blood draw).

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0009932
    UMLS CUI [1,2]
    C1516879
    UMLS CUI [1,3]
    C1298908
    UMLS CUI [1,4]
    C0006826
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    Similar models

    Eligibility Criteria

    4 forms
    1. StudyEvent: SEV1
      1. Eligibility Criteria
      2. Subject ID, consent group, and affection status of participants involved in genome-wide association studies in two anatomically different upper gastrointestinal cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cell carcinomas (ESCC) and gastric cancers (GC) and is comprised of Asians, while the other population has low rates of ESCC and GC and includes non-Asians from the Americas, Europe, and Australia.
      3. Sample ID and subject ID of participants involved in genome-wide association studies in two anatomically different upper gastrointestinal cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cell carcinomas (ESCC) and gastric cancers (GC) and is comprised of Asians, while the other population has low rates of ESCC and GC and includes non-Asians from the Americas, Europe, and Australia.
      4. Subject ID, study design (cohort, case or control), affection status, gender, and age of participants involved in genome-wide association studies in two anatomically different upper gastrointestinal cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cell carcinomas (ESCC) and gastric cancers (GC) and is comprised of Asians, while the other population has low rates of ESCC and GC and includes non-Asians from the Americas, Europe, and Australia.
    Name
    Type
    Description | Question | Decode (Coded Value)
    Data type
    Alias
    Item Group
    Inclusion and exclusion criteria
    Esophageal squamous cell carcinomas (ESCCs) include incident, primary esophageal cancers with squamous histology.
    Item
    Esophageal squamous cell carcinomas (ESCCs) include incident, primary esophageal cancers with squamous histology.
    boolean
    C0279626 (UMLS CUI [1,1])
    Gastric cancers (GCs) include incident, primary gastric adenocarcinomas.
    Item
    Gastric cancers (GCs) include incident, primary gastric adenocarcinomas.
    boolean
    C0024623 (UMLS CUI [1,1])
    Controls were all cancer-free at the time of enrollment (and blood draw).
    Item
    Controls were all cancer-free at the time of enrollment (and blood draw).
    boolean
    C0009932 (UMLS CUI [1,1])
    C1516879 (UMLS CUI [1,2])
    C1298908 (UMLS CUI [1,3])
    C0006826 (UMLS CUI [1,4])
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