ID
45189
Descrição
Principal Investigator: Philip R. Taylor, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA MeSH: Squamous Cell Carcinoma,Esophageal Cancer,Gastric Cancer https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000361 This project aims to conduct genome-wide association studies (GWAS) in two anatomically different upper gastrointestinal (UGI) cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cell carcinomas (ESCCs) and gastric cancers (GCs) and is comprised of Asians (*the "Asian UGI GWAS"*), while the other population has low rates of ESCC and GC and includes non-Asians from the Americas, Europe, and Australia (*the "Non-Asian UGI GWAS"*). Study participants for the Asian UGI GWAS reported here (Illumina 660W Quad chip) were drawn from 2 studies, the Shanxi Upper Gastrointestinal Cancer Genetics Project (Shanxi) and the Linxian Nutrition Intervention Trial (NIT), a prospective cohort, and included a total of 1898 ESCCs, 1625 GCs, and 2100 controls. For the 2nd phase (8 TaqMan SNPs), additional subjects from Shanxi and NIT as well as subjects from the Shanghai Men's Health Study (SMHS), the Shanghai Women's Health Study (SWHS), and the Singapore Chinese Health Study (SCHS) were also included (217 ESCCs, 615 GCs, 1202 controls). Altogether 2115 ESCCs, 2240 GCs, and 3302 controls were genotyped in this study.
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Versões (2)
- 19/08/2022 19/08/2022 - Simon Heim
- 12/10/2022 12/10/2022 - Adrian Schulz
Titular dos direitos
Philip R. Taylor, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Transferido a
12 de outubro de 2022
DOI
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Licença
Creative Commons BY 4.0
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dbGaP phs000361 Genome-Wide Association Studies in Upper Gastrointestinal Cancers (Asian)
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent group, and affection status of participants involved in genome-wide association studies in two anatomically different upper gastrointestinal cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cell carcinomas (ESCC) and gastric cancers (GC) and is comprised of Asians, while the other population has low rates of ESCC and GC and includes non-Asians from the Americas, Europe, and Australia.
- Sample ID and subject ID of participants involved in genome-wide association studies in two anatomically different upper gastrointestinal cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cell carcinomas (ESCC) and gastric cancers (GC) and is comprised of Asians, while the other population has low rates of ESCC and GC and includes non-Asians from the Americas, Europe, and Australia.
- Subject ID, study design (cohort, case or control), affection status, gender, and age of participants involved in genome-wide association studies in two anatomically different upper gastrointestinal cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cell carcinomas (ESCC) and gastric cancers (GC) and is comprised of Asians, while the other population has low rates of ESCC and GC and includes non-Asians from the Americas, Europe, and Australia.
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Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent group, and affection status of participants involved in genome-wide association studies in two anatomically different upper gastrointestinal cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cell carcinomas (ESCC) and gastric cancers (GC) and is comprised of Asians, while the other population has low rates of ESCC and GC and includes non-Asians from the Americas, Europe, and Australia.
- Sample ID and subject ID of participants involved in genome-wide association studies in two anatomically different upper gastrointestinal cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cell carcinomas (ESCC) and gastric cancers (GC) and is comprised of Asians, while the other population has low rates of ESCC and GC and includes non-Asians from the Americas, Europe, and Australia.
- Subject ID, study design (cohort, case or control), affection status, gender, and age of participants involved in genome-wide association studies in two anatomically different upper gastrointestinal cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cell carcinomas (ESCC) and gastric cancers (GC) and is comprised of Asians, while the other population has low rates of ESCC and GC and includes non-Asians from the Americas, Europe, and Australia.
C1516879 (UMLS CUI [1,2])
C1298908 (UMLS CUI [1,3])
C0006826 (UMLS CUI [1,4])
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