ID
44268
Beschreibung
DELCODE is conducted by DZNE, the German Center for Neurodegenerative Diseases within the Helmholtz Association. The following information was taken from https://www.dzne.de/en/research/studies/clinical-studies/delcode/. Background and aims: One of the important aims of research into Alzheimer's is to find ways of detecting the disease early – if at all possible, as soon as the first minor symptoms appear, or even before any symptoms at all have appeared. Such detection capabilities are the necessary basis for development of therapies that can be applied at such early stages in the disease. Recent research indicates that such therapies could be more effective than therapies initiated during the disease's later stages. Over a period of several years, the DELCODE study is studying persons in early stages of the disease, along with various risk groups. The research is aimed at the development of procedures for characterizing early stages of the disease, at improving prediction of the course of the disease and at identifying new markers for early diagnosis of Alzheimer's-related dementia. Overview: DELCODE is set up to run for an initial period of three years, and to include a total of 1,000 study participants, who will be examined on a yearly basis. The group of participants will include persons with no complaints (healthy control subjects), patients with slight memory impairment or mild dementia and first-degree relatives of patients with diagnosed Alzheimer's disease. The minimum age for participants is 60. Course of the study: The examinations in the framework of the study will include a comprehensive interview carried out by a study investigator, a detailed neuropsychological examination (testing of memory functions and other areas of cognitive performance), a blood test and a cranial MRI scan. Optionally, subject to the study participant's consent in each case, a lumbar puncture (collection of cerebrospinal fluid) will be carried out." For more information (e.g. principle investigator and study coordination), please visit the above link or https://www.dzne.de. This document contains the Diagnosis criteria Amyotrophic lateral sclerosis (ALS) form. It has to be filled in if an ALS is diagnosed. Note: If there is a motor neuron disease, fill in the motor neuron disease assessment!
Link
https://www.dzne.de/en/research/studies/clinical-studies/delcode/
Stichworte
Versionen (2)
- 02.04.20 02.04.20 -
- 20.09.21 20.09.21 -
Rechteinhaber
DZNE
Hochgeladen am
20. September 2021
DOI
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Lizenz
Creative Commons BY-NC 4.0
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DELCODE: DZNE – Longitudinal Cognitive Impairment and Dementia Study
Diagnosis criteria Amyotrophic lateral sclerosis (ALS) (Diagnosekriterien Amyotrophe Lateralsklerose (ALS))
Beschreibung
Amyotrophe Lateralsklerose (ALS)
Alias
- UMLS CUI-1
- C0002736
Beschreibung
Diagnosekriterien und motorische Subtypen, Klassische ALS
Alias
- UMLS CUI-1
- C0332140
- UMLS CUI-2
- C0002736
- UMLS CUI-3
- C0026649
- UMLS CUI-4
- C0449560
Beschreibung
UMN = upper motor neuron LMN = lower motor neuron
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0205329
- UMLS CUI [1,2]
- C0221198
- UMLS CUI [1,3]
- C0524458
- UMLS CUI [2,1]
- C0205329
- UMLS CUI [2,2]
- C0221198
- UMLS CUI [2,3]
- C0524459
Beschreibung
Progressive bulbar palsy
Datentyp
boolean
Alias
- UMLS CUI [1]
- C0030442
Beschreibung
Bulbar upper and lower motor neuron sign
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C1856507
- UMLS CUI [1,2]
- C0524458
- UMLS CUI [2,1]
- C1856507
- UMLS CUI [2,2]
- C0524459
Beschreibung
Man-in-the-barrel syndrome
Datentyp
boolean
Alias
- UMLS CUI [1]
- C4522181
Beschreibung
Early lower motor neuron sign cervical
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0524459
- UMLS CUI [1,2]
- C0221198
- UMLS CUI [1,3]
- C0205064
- UMLS CUI [1,4]
- C2363430
Beschreibung
Flail leg syndrome
Datentyp
boolean
Alias
- UMLS CUI [1]
- C0231717
Beschreibung
Early lower motor neuron sign lumbo‐sacral
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0524459
- UMLS CUI [1,2]
- C0221198
- UMLS CUI [1,3]
- C0024090
- UMLS CUI [1,4]
- C2363430
- UMLS CUI [2,1]
- C0524459
- UMLS CUI [2,2]
- C0221198
- UMLS CUI [2,3]
- C0036033
- UMLS CUI [2,4]
- C2363430
Beschreibung
Progressive Muscular Atrophy
Datentyp
boolean
Alias
- UMLS CUI [1]
- C0917981
Beschreibung
Multiple lower motor neuron
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0524459
- UMLS CUI [1,2]
- C0221198
- UMLS CUI [1,3]
- C0439064
Beschreibung
Primary lateral sclerosis
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0154682
- UMLS CUI [1,2]
- C0205225
Beschreibung
Early upper motor neuron lesion
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0749870
- UMLS CUI [1,2]
- C2363430
Beschreibung
Genetic ALS
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0017399
- UMLS CUI [1,2]
- C0002736
Beschreibung
Evidence for ALS mutation in upper and lower motor neuron lesion
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0002736
- UMLS CUI [1,2]
- C0026882
- UMLS CUI [2]
- C0749870
- UMLS CUI [3,1]
- C0221198
- UMLS CUI [3,2]
- C0524459
Beschreibung
ALS Ausschlusskriterien
Alias
- UMLS CUI-1
- C0002736
- UMLS CUI-2
- C0680251
Beschreibung
Diseases similar to ALS (e.g. cervical myelopathy, radiculopathy, multifocal motor neuropathy, multiple Sclerosis)
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0012634
- UMLS CUI [1,2]
- C2348205
- UMLS CUI [1,3]
- C0002736
- UMLS CUI [2,1]
- C0205064
- UMLS CUI [2,2]
- C0005956
- UMLS CUI [3]
- C0700594
- UMLS CUI [4]
- C0393847
- UMLS CUI [5]
- C0026769
Beschreibung
Diagnoseerleichterung
Alias
- UMLS CUI-1
- C0011900
- UMLS CUI-2
- C0002736
- UMLS CUI-3
- C0043232
Beschreibung
Zur Diagnoseerleichterung: Bitte die betroffenen Regionen ankreuzen. UMN = upper motor neuron LMN = lower motor neuron
Datentyp
integer
Alias
- UMLS CUI [1]
- C0026609
Beschreibung
Zur Diagnoseerleichterung: Bitte die betroffenen Regionen ankreuzen.
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0005898
- UMLS CUI [1,2]
- C1947952
Beschreibung
Zur Diagnoseerleichterung: Bitte die betroffenen Regionen ankreuzen.
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0005898
- UMLS CUI [1,2]
- C0205064
Beschreibung
Zur Diagnoseerleichterung: Bitte die betroffenen Regionen ankreuzen.
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0005898
- UMLS CUI [1,2]
- C0817096
Beschreibung
Zur Diagnoseerleichterung: Bitte die betroffenen Regionen ankreuzen.
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0005898
- UMLS CUI [1,2]
- C0450206
Beschreibung
Auftreten der ALS
Alias
- UMLS CUI-1
- C2745955
- UMLS CUI-2
- C0002736
Beschreibung
ALS occurrence: sporadic
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C2745955
- UMLS CUI [1,2]
- C0002736
- UMLS CUI [1,3]
- C0205422
Beschreibung
Wenn gegeben, bitte das Formular Anamnese zur Diagnostik – Genetik und Familienanamnese ausfüllen.
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C2745955
- UMLS CUI [1,2]
- C0002736
- UMLS CUI [1,3]
- C0017399
Beschreibung
Wenn gegeben, bitte Familienanamnese ausfüllen
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C2745955
- UMLS CUI [1,2]
- C0002736
- UMLS CUI [1,3]
- C0015576
Beschreibung
ALSni (not impaired) ohne kognitive Einschränkung
Alias
- UMLS CUI-1
- C0002736
- UMLS CUI-2
- C1298908
- UMLS CUI-3
- C0338656
Beschreibung
ALSci (cognitively impaired)
Alias
- UMLS CUI-1
- C0002736
- UMLS CUI-2
- C0338656
Beschreibung
weiter mit DESCRIBE‐FTD (gemäß den revidierten Strong‐Kriterien von 2017). ECAS = Edinburgh Cognitive and Behavioural ALS Screen.
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C0002736
- UMLS CUI [1,2]
- C0338656
- UMLS CUI [2,1]
- C0679228
- UMLS CUI [2,2]
- C3846158
- UMLS CUI [3,1]
- C0221099
- UMLS CUI [3,2]
- C0935584
- UMLS CUI [4,1]
- C0221099
- UMLS CUI [4,2]
- C0233714
Beschreibung
ALSbi (behaviourally impaired)
Alias
- UMLS CUI-1
- C0002736
- UMLS CUI-2
- C0004927
- UMLS CUI-3
- C0221099
Beschreibung
weiter mit DESCRIBE‐FTD (gemäß den revidierten Strong‐Kriterien von 2017). ECAS = Edinburgh Cognitive and Behavioural ALS Screen
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C0002736
- UMLS CUI [1,2]
- C0004927
- UMLS CUI [1,3]
- C0221099
- UMLS CUI [2,1]
- C0679228
- UMLS CUI [2,2]
- C0080103
- UMLS CUI [2,3]
- C3846158
- UMLS CUI [3,1]
- C0679228
- UMLS CUI [3,2]
- C3846158
- UMLS CUI [4]
- C0085632
- UMLS CUI [5]
- C0023380
Beschreibung
weiter mit DESCRIBE‐FTD (gemäß den revidierten Strong‐Kriterien von 2017).
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C0002736
- UMLS CUI [1,2]
- C0004927
- UMLS CUI [1,3]
- C0221099
- UMLS CUI [2,1]
- C0679228
- UMLS CUI [2,2]
- C0080103
- UMLS CUI [2,3]
- C3846158
- UMLS CUI [3,1]
- C0679228
- UMLS CUI [3,2]
- C3846158
- UMLS CUI [4]
- C0424296
- UMLS CUI [5,1]
- C1517945
- UMLS CUI [5,2]
- C0013989
- UMLS CUI [6,1]
- C1517945
- UMLS CUI [6,2]
- C0683287
- UMLS CUI [7]
- C0038271
- UMLS CUI [8]
- C1295579
- UMLS CUI [9]
- C0233651
- UMLS CUI [10]
- C1838320
- UMLS CUI [11,1]
- C0015745
- UMLS CUI [11,2]
- C0392747
- UMLS CUI [12,1]
- C1517945
- UMLS CUI [12,2]
- C0233820
- UMLS CUI [13]
- C0871189
Beschreibung
ALScbi (cognitively and behaviourally impaired)
Alias
- UMLS CUI-1
- C0002736
- UMLS CUI-2
- C0338656
- UMLS CUI-3
- C0004927
- UMLS CUI-4
- C0221099
Beschreibung
weiter mit DESCRIBE‐FTD
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C0243161
- UMLS CUI [1,2]
- C0002736
- UMLS CUI [1,3]
- C0338656
- UMLS CUI [2,1]
- C0243161
- UMLS CUI [2,2]
- C0002736
- UMLS CUI [2,3]
- C0004927
- UMLS CUI [2,4]
- C0221099
Beschreibung
ALS‐FTD
Alias
- UMLS CUI-1
- C0002736
- UMLS CUI-2
- C0338451
Beschreibung
weiter mit DESCRIBE‐FTD
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C0002736
- UMLS CUI [1,2]
- C4011788
Beschreibung
weiter mit DESCRIBE‐FTD
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C0002736
- UMLS CUI [1,2]
- C0282513
Beschreibung
ALSgen ohne kognitives Defizit aber mit genetischem Risiko für FTD
Alias
- UMLS CUI-1
- C0002736
- UMLS CUI-2
- C1298908
- UMLS CUI-3
- C0338656
- UMLS CUI-4
- C1517512
- UMLS CUI-5
- C0338451
Beschreibung
weiter mit DESCRIBE‐FTD
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C0002736
- UMLS CUI [1,2]
- C1298908
- UMLS CUI [1,3]
- C0338656
- UMLS CUI [1,4]
- C1517512
- UMLS CUI [1,5]
- C0338451
- UMLS CUI [2,1]
- C0026882
- UMLS CUI [2,2]
- C1428691
- UMLS CUI [3,1]
- C0026882
- UMLS CUI [3,2]
- C1336579
Ähnliche Modelle
Diagnosis criteria Amyotrophic lateral sclerosis (ALS) (Diagnosekriterien Amyotrophe Lateralsklerose (ALS))
C0243161 (UMLS CUI [1,2])
C3846158 (UMLS CUI [1,3])
C0002736 (UMLS CUI-2)
C0026649 (UMLS CUI-3)
C0449560 (UMLS CUI-4)
C0221198 (UMLS CUI [1,2])
C0524458 (UMLS CUI [1,3])
C0205329 (UMLS CUI [2,1])
C0221198 (UMLS CUI [2,2])
C0524459 (UMLS CUI [2,3])
C0524458 (UMLS CUI [1,2])
C1856507 (UMLS CUI [2,1])
C0524459 (UMLS CUI [2,2])
C0221198 (UMLS CUI [1,2])
C0205064 (UMLS CUI [1,3])
C2363430 (UMLS CUI [1,4])
C0221198 (UMLS CUI [1,2])
C0024090 (UMLS CUI [1,3])
C2363430 (UMLS CUI [1,4])
C0524459 (UMLS CUI [2,1])
C0221198 (UMLS CUI [2,2])
C0036033 (UMLS CUI [2,3])
C2363430 (UMLS CUI [2,4])
C0221198 (UMLS CUI [1,2])
C0439064 (UMLS CUI [1,3])
C0205225 (UMLS CUI [1,2])
C2363430 (UMLS CUI [1,2])
C0002736 (UMLS CUI [1,2])
C0026882 (UMLS CUI [1,2])
C0749870 (UMLS CUI [2])
C0221198 (UMLS CUI [3,1])
C0524459 (UMLS CUI [3,2])
C0680251 (UMLS CUI-2)
C2348205 (UMLS CUI [1,2])
C0002736 (UMLS CUI [1,3])
C0205064 (UMLS CUI [2,1])
C0005956 (UMLS CUI [2,2])
C0700594 (UMLS CUI [3])
C0393847 (UMLS CUI [4])
C0026769 (UMLS CUI [5])
C0002736 (UMLS CUI-2)
C0043232 (UMLS CUI-3)
C1947952 (UMLS CUI [1,2])
C0205064 (UMLS CUI [1,2])
C0817096 (UMLS CUI [1,2])
C0450206 (UMLS CUI [1,2])
C0002736 (UMLS CUI [1,2])
C0205422 (UMLS CUI [1,3])
C0002736 (UMLS CUI [1,2])
C0017399 (UMLS CUI [1,3])
C0002736 (UMLS CUI [1,2])
C0015576 (UMLS CUI [1,3])
C1298908 (UMLS CUI-2)
C0338656 (UMLS CUI-3)
C1298908 (UMLS CUI [1,2])
C0338656 (UMLS CUI [1,3])
C0205409 (UMLS CUI [2,1])
C0426980 (UMLS CUI [2,2])
C0338656 (UMLS CUI-2)
C0338656 (UMLS CUI [1,2])
C0679228 (UMLS CUI [2,1])
C3846158 (UMLS CUI [2,2])
C0221099 (UMLS CUI [3,1])
C0935584 (UMLS CUI [3,2])
C0221099 (UMLS CUI [4,1])
C0233714 (UMLS CUI [4,2])
C0004927 (UMLS CUI-2)
C0221099 (UMLS CUI-3)
C0004927 (UMLS CUI [1,2])
C0221099 (UMLS CUI [1,3])
C0679228 (UMLS CUI [2,1])
C0080103 (UMLS CUI [2,2])
C3846158 (UMLS CUI [2,3])
C0679228 (UMLS CUI [3,1])
C3846158 (UMLS CUI [3,2])
C0085632 (UMLS CUI [4])
C0023380 (UMLS CUI [5])
C0004927 (UMLS CUI [1,2])
C0221099 (UMLS CUI [1,3])
C0679228 (UMLS CUI [2,1])
C0080103 (UMLS CUI [2,2])
C3846158 (UMLS CUI [2,3])
C0679228 (UMLS CUI [3,1])
C3846158 (UMLS CUI [3,2])
C0424296 (UMLS CUI [4])
C1517945 (UMLS CUI [5,1])
C0013989 (UMLS CUI [5,2])
C1517945 (UMLS CUI [6,1])
C0683287 (UMLS CUI [6,2])
C0038271 (UMLS CUI [7])
C1295579 (UMLS CUI [8])
C0233651 (UMLS CUI [9])
C1838320 (UMLS CUI [10])
C0015745 (UMLS CUI [11,1])
C0392747 (UMLS CUI [11,2])
C1517945 (UMLS CUI [12,1])
C0233820 (UMLS CUI [12,2])
C0871189 (UMLS CUI [13])
C0338656 (UMLS CUI-2)
C0004927 (UMLS CUI-3)
C0221099 (UMLS CUI-4)
C0002736 (UMLS CUI [1,2])
C0338656 (UMLS CUI [1,3])
C0243161 (UMLS CUI [2,1])
C0002736 (UMLS CUI [2,2])
C0004927 (UMLS CUI [2,3])
C0221099 (UMLS CUI [2,4])
C4011788 (UMLS CUI [1,2])
C0282513 (UMLS CUI [1,2])
C1298908 (UMLS CUI-2)
C0338656 (UMLS CUI-3)
C1517512 (UMLS CUI-4)
C0338451 (UMLS CUI-5)
C1298908 (UMLS CUI [1,2])
C0338656 (UMLS CUI [1,3])
C1517512 (UMLS CUI [1,4])
C0338451 (UMLS CUI [1,5])
C0026882 (UMLS CUI [2,1])
C1428691 (UMLS CUI [2,2])
C0026882 (UMLS CUI [3,1])
C1336579 (UMLS CUI [3,2])