ID
42125
Beskrivning
PART A - Period 1 - Day 1 - Ropinirole and the effect of food in early stage Parkinson’s disease subjects 101468/164 Study ID: 101468/164 Clinical Study ID: 101468/164 Study Title: An open-label, randomised, two part study to investigate the relative bioavailability of Ropinirole new and standard, marketed formulations and the effect of food on the pharmacokinetics of Ropinirole new formulation in early stage Parkinson’s disease subjects Patient Level Data: Study Listed on ClinicalStudyDataRequest.com Clinicaltrials.gov Identifier: Sponsor: GlaxoSmithKline Collaborators: N/A Phase: phase 1 Study Recruitment Status: Completed Generic Name: ropinirole Trade Name: Modutab,ZIPEREVE,ZEPREVE,REPREVE,ADARTREL,REQUIP,Zygara; Zygara,ZIPEREVE,ZEPREVE,Requip Depot,REQUIP,REPREVE,Modutab,ADARTREL Study Indication: Restless Legs Syndrome
Nyckelord
Versioner (4)
- 2017-10-03 2017-10-03 -
- 2021-03-15 2021-03-15 - Dr. rer. medic Philipp Neuhaus
- 2021-04-13 2021-04-13 - Dr. rer. medic Philipp Neuhaus
- 2021-09-20 2021-09-20 -
Rättsinnehavare
GlaxoSmithKline
Uppladdad den
13 april 2021
DOI
För en begäran logga in.
Licens
Creative Commons BY-NC 3.0
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PART A - Period 1 - Day 1 - Ropinirole and the effect of food in early stage Parkinson’s disease subjects 101468/164
PART A - Period 1 - Day 1 - Ropinirole and the effect of food in early stage Parkinson’s disease subjects 101468/164
Beskrivning
Inclusion Criteria
Alias
- UMLS CUI-1
- C1512693
Beskrivning
age and child-bearing potential contraception
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0001779
- UMLS CUI [1,2]
- C1960468
- UMLS CUI [1,3]
- C0700589
Beskrivning
idiopathic Parkinson's disease Hoehn&Yahr Stage
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0865475
- UMLS CUI [1,2]
- C3639483
Beskrivning
study subject participation status ropinirole or candidate for dopaminergic therapy
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C2348568
- UMLS CUI [1,2]
- C0244821
- UMLS CUI [2]
- C3267134
Beskrivning
bmi
Datatyp
boolean
Alias
- UMLS CUI [1]
- C1305855
Beskrivning
informed consent
Datatyp
boolean
Alias
- UMLS CUI [1]
- C0021430
Beskrivning
drug dosing ropinirole
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0244821
- UMLS CUI [1,2]
- C0678766
Beskrivning
exemption approved
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0585836
- UMLS CUI [1,2]
- C1708968
Beskrivning
Medical monitor name
Datatyp
text
Alias
- UMLS CUI [1,1]
- C0027365
- UMLS CUI [1,2]
- C1708968
Beskrivning
Date of approval
Datatyp
date
Alias
- UMLS CUI [1]
- C2346844
Beskrivning
Exclusion Criteria
Alias
- UMLS CUI-1
- C0680251
Beskrivning
physical examination abnormality
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0031809
- UMLS CUI [1,2]
- C1704258
- UMLS CUI [2]
- C0035648
Beskrivning
psychiatric, haematological, renal, hepatic, endocrinological, neurological, or cardiovascular disease or active malignancy
Datatyp
boolean
Alias
- UMLS CUI [1]
- C0004936
- UMLS CUI [2]
- C0018939
- UMLS CUI [3]
- C0022658
- UMLS CUI [4]
- C0023895
- UMLS CUI [5,1]
- C0014130
- UMLS CUI [5,2]
- C0027765
- UMLS CUI [6]
- C0007222
- UMLS CUI [7]
- C4282132
Beskrivning
laboratory abnormality or ECG abnormalities
Datatyp
boolean
Alias
- UMLS CUI [1]
- C0438215
- UMLS CUI [2]
- C0522055
Beskrivning
Hepatitis B surface antigen, Hepatitis C antibody and HIV antibody
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0019168
- UMLS CUI [1,2]
- C0166049
- UMLS CUI [2]
- C0019683
Beskrivning
alcohol breath test or blood test and/or urine drugs of abuse test at screening
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0202306
- UMLS CUI [1,2]
- C1710477
- UMLS CUI [1,3]
- C1167994
- UMLS CUI [1,4]
- C1710477
- UMLS CUI [2,1]
- C0451130
- UMLS CUI [2,2]
- C1710477
Beskrivning
syncope or orthostatic hypotension
Datatyp
boolean
Alias
- UMLS CUI [1]
- C0020651
- UMLS CUI [2,1]
- C0039070
- UMLS CUI [2,2]
- C0262926
Beskrivning
sleep disorder or Epworth Sleep Score 39
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0851578
- UMLS CUI [1,2]
- C2129304
Beskrivning
Abnormal diastolic arterial pressure or abnormal systolic arterial pressure
Datatyp
boolean
Alias
- UMLS CUI [1]
- C0277888
- UMLS CUI [2]
- C0277883
Beskrivning
L-dopa treatment must be discontinued for at least a 2-week wash-out period prior to dosing with study medication
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0013227
- UMLS CUI [1,2]
- C0023570
Beskrivning
Note: Patients on dopaminergic agonists other than ropinirole CR may be enrolled if the agent is stopped for a 2-week wash-out period prior to enrolment. Patients on selegiline, amantadine, or anticholinergics may be enrolled but must have been on a stable dose for at least one month prior to study enrolment and must remain on their current dose throughout the treatment phase of the study
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0013036
- UMLS CUI [1,2]
- C3469597
- UMLS CUI [1,3]
- C0262926
Beskrivning
hormone replacement therapy or CYP1A2 inhibitors or inducers
Datatyp
boolean
Alias
- UMLS CUI [1]
- C3850050
- UMLS CUI [2]
- C3850068
- UMLS CUI [3]
- C0282402
Beskrivning
Blood donation or significant blood loss
Datatyp
boolean
Alias
- UMLS CUI [1]
- C0005795
- UMLS CUI [2]
- C3163616
Beskrivning
personal history, or family history, of adverse reactions or hypersensitivity to ropinirole
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0020517
- UMLS CUI [1,2]
- C0244821
- UMLS CUI [1,3]
- C0241889
- UMLS CUI [1,4]
- C0559546
- UMLS CUI [1,5]
- C0244821
- UMLS CUI [1,6]
- C0241889
- UMLS CUI [2,1]
- C0020517
- UMLS CUI [2,2]
- C0244821
- UMLS CUI [2,3]
- C0332119
- UMLS CUI [3,1]
- C0559546
- UMLS CUI [3,2]
- C0244821
- UMLS CUI [3,3]
- C0332119
Beskrivning
Use of any investigational drug
Datatyp
boolean
Alias
- UMLS CUI [1]
- C0013230
Beskrivning
over-the-counter (OTC) medicine
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C2709201
- UMLS CUI [1,2]
- C0013227
Beskrivning
With alcohol abuse defined as an average weekly intake of greater than 21 units or an average daily intake of greater than 3 units for men; greater than 14 units per week or greater than 2 units per day for women. One unit is equivalent to half a pint of beer, one measure of spirits, or one glass of wine.
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C1510472
- UMLS CUI [1,2]
- C0085762
Beskrivning
drop out of the study prematurely or requirement of prohibited concomitant medication or non compliant behaviour
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C2347852
- UMLS CUI [1,2]
- C2348568
- UMLS CUI [1,3]
- C1321605
Beskrivning
pregnant or breast-feeding
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0032961
- UMLS CUI [1,2]
- C0006147
Beskrivning
exemption approved
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0585836
- UMLS CUI [1,2]
- C1708968
Beskrivning
Medical monitor name
Datatyp
text
Alias
- UMLS CUI [1,1]
- C0027365
- UMLS CUI [1,2]
- C1708968
Beskrivning
Date of approval
Datatyp
date
Alias
- UMLS CUI [1]
- C2346844
Beskrivning
Physical examination
Alias
- UMLS CUI-1
- C0031809
Beskrivning
Body system
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C1268086
- UMLS CUI [1,2]
- C0449913
Beskrivning
Body system abnormality
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C0460002
- UMLS CUI [1,2]
- C1704258
Beskrivning
Describe abnormality body system
Datatyp
text
Alias
- UMLS CUI [1,1]
- C0459424
- UMLS CUI [1,2]
- C0031809
- UMLS CUI [1,3]
- C0678257
Beskrivning
Orthostatic blood pressure / Pulse - Predose
Alias
- UMLS CUI-1
- C0518766
- UMLS CUI-2
- C1095971
- UMLS CUI-3
- C0232117
- UMLS CUI-4
- C3812758
Beskrivning
For the pre-dose measurements in Part A, Day 1 of Periods 1 and 2, and Part B, Day 1 of Periods 1 and 2, 3 sets of semi-supine and erect blood pressure and pulse measurements will be taken, commencing approximately 40 minutes prior to dosing and each set will be separated by 10 minutes rest in the semi- supine position. Three stable measurements should be recorded In this instance stable is defined as the three semi-supine diastolic measurements being within 15 mmHg of the lowest measurement. This rule also applies for the semi-supine systolic and erect systolic and diastolic measurements. A maximum of six attempts can be made to obtain measurements pre-dose. If three consecutive stable measurements of blood pressure cannot be obtained then the Investigator should contact the Medical Monitor to discuss whether the patient can be included/continue in the study.
Datatyp
date
Alias
- UMLS CUI [1,1]
- C1320303
- UMLS CUI [1,2]
- C3812758
Beskrivning
Heart rate Semi-Supine
Datatyp
integer
Måttenheter
- bpm
Alias
- UMLS CUI [1,1]
- C0018810
- UMLS CUI [1,2]
- C0038846
- UMLS CUI [1,3]
- C3812758
Beskrivning
Heart Rate standing
Datatyp
integer
Måttenheter
- bpm
Alias
- UMLS CUI [1,1]
- C2029905
- UMLS CUI [1,2]
- C3812758
Beskrivning
Systolic blood pressure semi-supine
Datatyp
integer
Måttenheter
- mmHg
Alias
- UMLS CUI [1,1]
- C0871470
- UMLS CUI [1,2]
- C0038846
- UMLS CUI [1,3]
- C3812758
Beskrivning
Diastolic blood pressure semi-supine
Datatyp
integer
Måttenheter
- mmHg
Alias
- UMLS CUI [1,1]
- C0428883
- UMLS CUI [1,2]
- C0038846
- UMLS CUI [1,3]
- C3812758
Beskrivning
Systolic blood pressure standing
Datatyp
integer
Måttenheter
- mmHg
Alias
- UMLS CUI [1,1]
- C0871470
- UMLS CUI [1,2]
- C0231472
- UMLS CUI [1,3]
- C3812758
Beskrivning
Diastolic blood pressure standing
Datatyp
integer
Måttenheter
- mmHg
Alias
- UMLS CUI [1,1]
- C1303019
- UMLS CUI [1,2]
- C3812758
Beskrivning
Pregnancy test
Alias
- UMLS CUI-1
- C0032976
Beskrivning
pregnancy test
Datatyp
integer
Alias
- UMLS CUI [1]
- C0032976
Beskrivning
pregnancy test
Datatyp
integer
Alias
- UMLS CUI [1]
- C0032976
Beskrivning
Date of pregnancy test
Datatyp
date
Alias
- UMLS CUI [1,1]
- C0032976
- UMLS CUI [1,2]
- C0011008
Beskrivning
Result of pregnancy test
Datatyp
integer
Alias
- UMLS CUI [1]
- C0427777
Beskrivning
Patient diary
Alias
- UMLS CUI-1
- C3890583
Beskrivning
Patient diary
Datatyp
text
Alias
- UMLS CUI [1]
- C3890583
Beskrivning
Alcohol breath/ blood test
Alias
- UMLS CUI-1
- C0202304
Beskrivning
Perform Alcohol Breath/Blood Test and attach printout
Datatyp
time
Alias
- UMLS CUI [1,1]
- C0202304
- UMLS CUI [1,2]
- C0040223
Beskrivning
Result of alcohol test
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C0202304
- UMLS CUI [1,2]
- C1274040
Beskrivning
alcohol consumption
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0001948
- UMLS CUI [1,2]
- C0443288
Beskrivning
Drug screening (urine)
Alias
- UMLS CUI-1
- C0202274
Beskrivning
Time of drug screening
Datatyp
time
Alias
- UMLS CUI [1,1]
- C0040223
- UMLS CUI [1,2]
- C0202274
Beskrivning
Cannabinoids urine
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C0202274
- UMLS CUI [1,2]
- C0006864
Beskrivning
Morphine and morphine derivates urine
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C0202274
- UMLS CUI [1,2]
- C0279996
Beskrivning
Amphetamine urine
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C0202274
- UMLS CUI [1,2]
- C0002667
Beskrivning
Barbiturates urine
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C0202274
- UMLS CUI [1,2]
- C0004745
Beskrivning
Benzodiazepines urine
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C0202274
- UMLS CUI [1,2]
- C0005064
Beskrivning
Cocaine urine
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C0202274
- UMLS CUI [1,2]
- C0009170
Beskrivning
Tricyclic antidepressants urine
Datatyp
integer
Alias
- UMLS CUI [1]
- C0003290
Beskrivning
Urine drug screening positive specify
Datatyp
text
Alias
- UMLS CUI [1,1]
- C2711519
- UMLS CUI [1,2]
- C1521902
Beskrivning
Concomitant medication
Alias
- UMLS CUI-1
- C2347852
Beskrivning
If 'Yes', please document on the Concomitant Medication Report Forms.
Datatyp
integer
Alias
- UMLS CUI [1]
- C0580105
Beskrivning
tobacco use unchanged
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C0543414
- UMLS CUI [1,2]
- C0442739
Beskrivning
dietary restrictions
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C0425422
- UMLS CUI [1,2]
- C1321605
Beskrivning
Adverse event
Alias
- UMLS CUI-1
- C0877248
Beskrivning
Randomization
Alias
- UMLS CUI-1
- C0034656
Beskrivning
study subject participation status eligibility
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C2348568
- UMLS CUI [1,2]
- C0013893
Beskrivning
Randomization
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C0034656
- UMLS CUI [1,2]
- C1522541
Beskrivning
Standard Breakfast
Alias
- UMLS CUI-1
- C2698559
Beskrivning
Breakfast started
Datatyp
time
Alias
- UMLS CUI [1,1]
- C2698559
- UMLS CUI [1,2]
- C0439659
Beskrivning
Breakfast ended
Datatyp
time
Alias
- UMLS CUI [1,1]
- C2698559
- UMLS CUI [1,2]
- C0444930
Beskrivning
Breakfast completed
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0814440
- UMLS CUI [1,2]
- C0205197
Beskrivning
Breakfast not completed comment
Datatyp
text
Alias
- UMLS CUI [1,1]
- C0947611
- UMLS CUI [1,2]
- C0814440
- UMLS CUI [1,3]
- C0205197
Beskrivning
Study Drug Dosing
Alias
- UMLS CUI-1
- C0013175
- UMLS CUI-2
- C0678766
Beskrivning
The subject will not be allowed to lie down or sleep for 4 hours after the morning dose.
Datatyp
float
Måttenheter
- mg/day
Alias
- UMLS CUI [1]
- C0678766
Beskrivning
Dosage
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C0178602
- UMLS CUI [1,2]
- C3854006
Beskrivning
Time of Dosing
Datatyp
time
Måttenheter
- 24hr:min
Alias
- UMLS CUI [1,1]
- C0178602
- UMLS CUI [1,2]
- C0040223
Beskrivning
Witness 1
Datatyp
text
Alias
- UMLS CUI [1,1]
- C0682356
- UMLS CUI [1,2]
- C0001555
Beskrivning
Witness 2
Datatyp
text
Alias
- UMLS CUI [1,1]
- C0682356
- UMLS CUI [1,2]
- C0001555
Beskrivning
Witness date
Datatyp
date
Alias
- UMLS CUI [1,1]
- C4263486
- UMLS CUI [1,2]
- C0011008
Beskrivning
Orthostatic blood pressure / pulse measurement - post dose
Alias
- UMLS CUI-1
- C1095971
- UMLS CUI-2
- C0232117
- UMLS CUI-3
- C0439568
Beskrivning
Date of visit
Datatyp
date
Alias
- UMLS CUI [1]
- C1320303
Beskrivning
Post dose
Datatyp
integer
Alias
- UMLS CUI [1]
- C0439568
Beskrivning
Post dose
Datatyp
integer
Alias
- UMLS CUI [1]
- C0439568
Beskrivning
Time post dose
Datatyp
time
Alias
- UMLS CUI [1,1]
- C0439568
- UMLS CUI [1,2]
- C0040223
Beskrivning
Heart rate Semi-Supine
Datatyp
integer
Måttenheter
- bpm
Alias
- UMLS CUI [1,1]
- C0018810
- UMLS CUI [1,2]
- C0038846
- UMLS CUI [1,3]
- C0439568
Beskrivning
Heart Rate standing
Datatyp
integer
Måttenheter
- bpm
Alias
- UMLS CUI [1,1]
- C2029905
- UMLS CUI [1,2]
- C0439568
Beskrivning
Systolic blood pressure semi-supine
Datatyp
integer
Måttenheter
- mmHg
Alias
- UMLS CUI [1,1]
- C0871470
- UMLS CUI [1,2]
- C0038846
- UMLS CUI [1,3]
- C0439568
Beskrivning
Diastolic blood pressure semi-supine
Datatyp
integer
Måttenheter
- mmHg
Alias
- UMLS CUI [1,1]
- C0428883
- UMLS CUI [1,2]
- C0038846
- UMLS CUI [1,3]
- C0439568
Beskrivning
Systolic blood pressure standing
Datatyp
integer
Måttenheter
- mmHg
Alias
- UMLS CUI [1,1]
- C0871470
- UMLS CUI [1,2]
- C0231472
- UMLS CUI [1,3]
- C0439568
Beskrivning
Diastolic blood pressure standing
Datatyp
integer
Måttenheter
- mmHg
Alias
- UMLS CUI [1,1]
- C0428883
- UMLS CUI [1,2]
- C0231472
- UMLS CUI [1,3]
- C0439568
Beskrivning
Adverse Event - 4 hours post dosing
Alias
- UMLS CUI-1
- C0877248
- UMLS CUI-2
- C0439574
Beskrivning
Discharge
Alias
- UMLS CUI-1
- C0030685
Beskrivning
For subjects randomized to IR formulation, please ensure sufficient medication has been dispensed and that the subject is instructed re: self administration
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C3854006
- UMLS CUI [1,2]
- C0947323
Beskrivning
Discharge Time
Datatyp
time
Alias
- UMLS CUI [1]
- C3864299
Beskrivning
Date of next study visit
Datatyp
date
Alias
- UMLS CUI [1]
- C1545257
Similar models
PART A - Period 1 - Day 1 - Ropinirole and the effect of food in early stage Parkinson’s disease subjects 101468/164
C0244821 (UMLS CUI [1,2])
C1960468 (UMLS CUI [1,2])
C0700589 (UMLS CUI [1,3])
C3639483 (UMLS CUI [1,2])
C0244821 (UMLS CUI [1,2])
C3267134 (UMLS CUI [2])
C0678766 (UMLS CUI [1,2])
C1708968 (UMLS CUI [1,2])
C1708968 (UMLS CUI [1,2])
C1704258 (UMLS CUI [1,2])
C0035648 (UMLS CUI [2])
C0018939 (UMLS CUI [2])
C0022658 (UMLS CUI [3])
C0023895 (UMLS CUI [4])
C0014130 (UMLS CUI [5,1])
C0027765 (UMLS CUI [5,2])
C0007222 (UMLS CUI [6])
C4282132 (UMLS CUI [7])
C0522055 (UMLS CUI [2])
C0166049 (UMLS CUI [1,2])
C0019683 (UMLS CUI [2])
C1710477 (UMLS CUI [1,2])
C1167994 (UMLS CUI [1,3])
C1710477 (UMLS CUI [1,4])
C0451130 (UMLS CUI [2,1])
C1710477 (UMLS CUI [2,2])
C0039070 (UMLS CUI [2,1])
C0262926 (UMLS CUI [2,2])
C2129304 (UMLS CUI [1,2])
C0277883 (UMLS CUI [2])
C0023570 (UMLS CUI [1,2])
C3469597 (UMLS CUI [1,2])
C0262926 (UMLS CUI [1,3])
C3850068 (UMLS CUI [2])
C0282402 (UMLS CUI [3])
C3163616 (UMLS CUI [2])
C0244821 (UMLS CUI [1,2])
C0241889 (UMLS CUI [1,3])
C0559546 (UMLS CUI [1,4])
C0244821 (UMLS CUI [1,5])
C0241889 (UMLS CUI [1,6])
C0020517 (UMLS CUI [2,1])
C0244821 (UMLS CUI [2,2])
C0332119 (UMLS CUI [2,3])
C0559546 (UMLS CUI [3,1])
C0244821 (UMLS CUI [3,2])
C0332119 (UMLS CUI [3,3])
C0013227 (UMLS CUI [1,2])
C0085762 (UMLS CUI [1,2])
C2348568 (UMLS CUI [1,2])
C1321605 (UMLS CUI [1,3])
C0006147 (UMLS CUI [1,2])
C1708968 (UMLS CUI [1,2])
C1708968 (UMLS CUI [1,2])
C1704258 (UMLS CUI [1,2])
C0031809 (UMLS CUI [1,2])
C0678257 (UMLS CUI [1,3])
C1095971 (UMLS CUI-2)
C0232117 (UMLS CUI-3)
C3812758 (UMLS CUI-4)
C3812758 (UMLS CUI [1,2])
C0038846 (UMLS CUI [1,2])
C3812758 (UMLS CUI [1,3])
C3812758 (UMLS CUI [1,2])
C0038846 (UMLS CUI [1,2])
C3812758 (UMLS CUI [1,3])
C0038846 (UMLS CUI [1,2])
C3812758 (UMLS CUI [1,3])
C0231472 (UMLS CUI [1,2])
C3812758 (UMLS CUI [1,3])
C3812758 (UMLS CUI [1,2])
C0011008 (UMLS CUI [1,2])
C0040223 (UMLS CUI [1,2])
C0443288 (UMLS CUI [1,2])
C0202274 (UMLS CUI [1,2])
C0279996 (UMLS CUI [1,2])
C0005064 (UMLS CUI [1,2])
C1521902 (UMLS CUI [1,2])
C0442739 (UMLS CUI [1,2])
C1321605 (UMLS CUI [1,2])
C0013893 (UMLS CUI [1,2])
C1522541 (UMLS CUI [1,2])
C0439659 (UMLS CUI [1,2])
C0444930 (UMLS CUI [1,2])
C0205197 (UMLS CUI [1,2])
C0814440 (UMLS CUI [1,2])
C0205197 (UMLS CUI [1,3])
C0040223 (UMLS CUI [1,2])
C0001555 (UMLS CUI [1,2])
C0001555 (UMLS CUI [1,2])
C0011008 (UMLS CUI [1,2])
C0232117 (UMLS CUI-2)
C0439568 (UMLS CUI-3)
C0040223 (UMLS CUI [1,2])
C0038846 (UMLS CUI [1,2])
C0439568 (UMLS CUI [1,3])
C0439568 (UMLS CUI [1,2])
C0038846 (UMLS CUI [1,2])
C0439568 (UMLS CUI [1,3])
C0038846 (UMLS CUI [1,2])
C0439568 (UMLS CUI [1,3])
C0231472 (UMLS CUI [1,2])
C0439568 (UMLS CUI [1,3])
C0231472 (UMLS CUI [1,2])
C0439568 (UMLS CUI [1,3])
C0439574 (UMLS CUI-2)
C0947323 (UMLS CUI [1,2])