ID
40307
Beschrijving
DELCODE is conducted by DZNE, the German Center for Neurodegenerative Diseases within the Helmholtz Association. The following information was taken from https://www.dzne.de/en/research/studies/clinical-studies/delcode/. Background and aims: One of the important aims of research into Alzheimer's is to find ways of detecting the disease early – if at all possible, as soon as the first minor symptoms appear, or even before any symptoms at all have appeared. Such detection capabilities are the necessary basis for development of therapies that can be applied at such early stages in the disease. Recent research indicates that such therapies could be more effective than therapies initiated during the disease's later stages. Over a period of several years, the DELCODE study is studying persons in early stages of the disease, along with various risk groups. The research is aimed at the development of procedures for characterizing early stages of the disease, at improving prediction of the course of the disease and at identifying new markers for early diagnosis of Alzheimer's-related dementia. Overview: DELCODE is set up to run for an initial period of three years, and to include a total of 1,000 study participants, who will be examined on a yearly basis. The group of participants will include persons with no complaints (healthy control subjects), patients with slight memory impairment or mild dementia and first-degree relatives of patients with diagnosed Alzheimer's disease. The minimum age for participants is 60. Course of the study: The examinations in the framework of the study will include a comprehensive interview carried out by a study investigator, a detailed neuropsychological examination (testing of memory functions and other areas of cognitive performance), a blood test and a cranial MRI scan. Optionally, subject to the study participant's consent in each case, a lumbar puncture (collection of cerebrospinal fluid) will be carried out." For more information (e.g. principle investigator and study coordination), please visit the above link or https://www.dzne.de. This document contains the Diagnosis criteria Diffuse Lewy Body Disease form. It has to be filled in if a Diffuse Lewy Body Disease is diagnosed.
Link
https://www.dzne.de/en/research/studies/clinical-studies/delcode/
Trefwoorden
Versies (1)
- 02-04-20 02-04-20 -
Houder van rechten
DZNE
Geüploaded op
2 april 2020
DOI
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Licentie
Creative Commons BY-NC 4.0
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DELCODE: DZNE – Longitudinal Cognitive Impairment and Dementia Study
Diagnosis criteria Diffuse Lewy Body Disease (Diagnosekriterien Diffuse Lewykörperchen Erkrankung (DLB))
Beschrijving
Diffuse Lewykörperchen Erkrankung (DLB)
Alias
- UMLS CUI-1
- C0205219
- UMLS CUI-2
- C0752347
Beschrijving
DLB: Zentrales Kriterium
Alias
- UMLS CUI-1
- C0205219
- UMLS CUI-2
- C0752347
- UMLS CUI-3
- C0243161
- UMLS CUI-4
- C0205225
Beschrijving
Dementia with impairment of daily life (in early stage of disease persistent memory impairment possible while in progression of disease usually occurs. Impairment of attention, executive functions, visuospatial ability)
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0497327
- UMLS CUI [1,2]
- C0205329
- UMLS CUI [1,3]
- C0338656
- UMLS CUI [2,1]
- C0497327
- UMLS CUI [2,2]
- C0001288
- UMLS CUI [2,3]
- C0221099
- UMLS CUI [3,1]
- C2363430
- UMLS CUI [3,2]
- C0205322
- UMLS CUI [3,3]
- C0233794
- UMLS CUI [3,4]
- C0332149
- UMLS CUI [4,1]
- C0242656
- UMLS CUI [4,2]
- C0205322
- UMLS CUI [4,3]
- C0233794
- UMLS CUI [4,4]
- C3888388
- UMLS CUI [5]
- C2678119
- UMLS CUI [6]
- C2921138
Beschrijving
DLB: Hauptkriterien
Alias
- UMLS CUI-1
- C0205219
- UMLS CUI-2
- C0752347
- UMLS CUI-3
- C0243161
- UMLS CUI-4
- C1542147
Beschrijving
Fluctuations in cognition, especially in attention
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0231239
- UMLS CUI [1,2]
- C0009240
- UMLS CUI [2,1]
- C0231239
- UMLS CUI [2,2]
- C0004268
Beschrijving
Recurring visual hallucinations (typically person character and detailed)
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0233763
- UMLS CUI [1,2]
- C2945760
- UMLS CUI [1,3]
- C3538928
- UMLS CUI [1,4]
- C0205431
- UMLS CUI [2,1]
- C0233763
- UMLS CUI [2,2]
- C2945760
- UMLS CUI [2,3]
- C3538928
- UMLS CUI [2,4]
- C0439855
Beschrijving
Spontaneous Parkinson symptoms
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0205359
- UMLS CUI [1,2]
- C0030567
- UMLS CUI [1,3]
- C1457887
Beschrijving
DLB: Zusatzkriterien
Alias
- UMLS CUI-1
- C0205219
- UMLS CUI-2
- C0752347
- UMLS CUI-3
- C0243161
- UMLS CUI-4
- C1524062
Beschrijving
REM Sleep Behavior Disorder
Datatype
integer
Alias
- UMLS CUI [1]
- C0751772
Beschrijving
Serious side effects due to the use of neuroleptics
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0041755
- UMLS CUI [1,2]
- C0205082
- UMLS CUI [1,3]
- C0040615
Beschrijving
Reduced dopamine transporter ligand storage in basal ganglia (SPECT/PET)
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0183126
- UMLS CUI [1,2]
- C0114838
- UMLS CUI [1,3]
- C0023688
- UMLS CUI [1,4]
- C1698986
- UMLS CUI [1,5]
- C0392756
- UMLS CUI [1,6]
- C0004781
- UMLS CUI [2,1]
- C0032743
- UMLS CUI [2,2]
- C0114838
- UMLS CUI [2,3]
- C0023688
- UMLS CUI [2,4]
- C1698986
- UMLS CUI [2,5]
- C0392756
- UMLS CUI [2,6]
- C0004781
Beschrijving
Occurrence of dementia before/ simultaneously parkinson symptoms
Datatype
integer
Alias
- UMLS CUI [1,1]
- C2745955
- UMLS CUI [1,2]
- C0497327
- UMLS CUI [1,3]
- C0332152
- UMLS CUI [1,4]
- C0030567
- UMLS CUI [1,5]
- C1457887
- UMLS CUI [2,1]
- C2745955
- UMLS CUI [2,2]
- C0497327
- UMLS CUI [2,3]
- C0521115
- UMLS CUI [2,4]
- C0030567
- UMLS CUI [2,5]
- C1457887
Beschrijving
(Item 1 und mind. ein Merkmale aus 2‐4 sowie mind. 1 Merkmal aus 5‐7 treffen zu; Item 8 ist erfüllt)
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0752347
- UMLS CUI [1,2]
- C0332148
Beschrijving
(Item 1 und mind. ein Merkmal aus 5‐7 treffen zu, Item 8 ist erfüllt)
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0752347
- UMLS CUI [1,2]
- C0332149
- UMLS CUI [1,3]
- C0011900
Beschrijving
Unterstützende Merkmale ohne nachweisliche diagnostische Spezifität
Alias
- UMLS CUI-1
- C4684795
- UMLS CUI-2
- C0243161
- UMLS CUI-3
- C1298908
- UMLS CUI-4
- C0456369
- UMLS CUI-5
- C1511884
Beschrijving
Frequent falls and syncopes
Datatype
integer
Alias
- UMLS CUI [1]
- C0850703
- UMLS CUI [2,1]
- C0332183
- UMLS CUI [2,2]
- C0039070
Beschrijving
Transient loss of consciousness
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0205374
- UMLS CUI [1,2]
- C0041657
Beschrijving
Severe autonomic dysfunction
Datatype
integer
Alias
- UMLS CUI [1,1]
- C3277919
- UMLS CUI [1,2]
- C0205082
Beschrijving
Hallucinations in other modalities
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0018524
- UMLS CUI [1,2]
- C0695347
- UMLS CUI [1,3]
- C0205394
Beschrijving
Delusion
Datatype
integer
Alias
- UMLS CUI [1]
- C0011253
Beschrijving
Depression
Datatype
integer
Alias
- UMLS CUI [1]
- C0011581
Beschrijving
Slightly change in medial temporal lobe (CT/MRT)
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0039485
- UMLS CUI [1,2]
- C0205098
- UMLS CUI [1,3]
- C1298908
- UMLS CUI [1,4]
- C2826293
- UMLS CUI [1,5]
- C1879646
- UMLS CUI [1,6]
- C0040405
- UMLS CUI [2,1]
- C0039485
- UMLS CUI [2,2]
- C0205098
- UMLS CUI [2,3]
- C1298908
- UMLS CUI [2,4]
- C2826293
- UMLS CUI [2,5]
- C1879646
- UMLS CUI [2,6]
- C0024485
Beschrijving
Low uptake in SPECT/PET perfusion scan with reduced occipital activity
Datatype
integer
Alias
- UMLS CUI [1,1]
- C2094594
- UMLS CUI [1,2]
- C0205251
- UMLS CUI [1,3]
- C0243144
- UMLS CUI [2,1]
- C2094594
- UMLS CUI [2,2]
- C0392756
- UMLS CUI [2,3]
- C1184145
- UMLS CUI [2,4]
- C0443158
- UMLS CUI [3,1]
- C0183126
- UMLS CUI [3,2]
- C4523908
- UMLS CUI [3,3]
- C0205251
- UMLS CUI [3,4]
- C0243144
- UMLS CUI [4,1]
- C0183126
- UMLS CUI [4,2]
- C4523908
- UMLS CUI [4,3]
- C0392756
- UMLS CUI [4,4]
- C1184145
- UMLS CUI [4,5]
- C0443158
Beschrijving
Abnormally low uptake in the MIBG Myocardial Scintigraphy
Datatype
integer
Alias
- UMLS CUI [1,1]
- C1704258
- UMLS CUI [1,2]
- C0205251
- UMLS CUI [1,3]
- C0243144
- UMLS CUI [1,4]
- C2229074
Beschrijving
Prominent slow wave activity in EEG with temporal transient sharp waves
Datatype
integer
Alias
- UMLS CUI [1]
- C2206519
- UMLS CUI [2]
- C3670521
Beschrijving
Befunde, die die Diagnose wenig wahrscheinlich machen
Alias
- UMLS CUI-1
- C0011900
- UMLS CUI-2
- C1298908
- UMLS CUI-3
- C0332148
Beschrijving
History of a brain injury
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0262926
- UMLS CUI [1,2]
- C0270611
- UMLS CUI [2,1]
- C0262926
- UMLS CUI [2,2]
- C0038454
Beschrijving
Other diseases
Datatype
integer
Alias
- UMLS CUI [1,1]
- C2359476
- UMLS CUI [1,2]
- C0681841
- UMLS CUI [1,3]
- C2987487
Beschrijving
First occurrence of parkinson symptoms in severe stage of dementia
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0205435
- UMLS CUI [1,2]
- C2745955
- UMLS CUI [1,3]
- C0030567
- UMLS CUI [1,4]
- C1457887
- UMLS CUI [1,5]
- C0497327
- UMLS CUI [1,6]
- C0699749
- UMLS CUI [1,7]
- C0205082
Similar models
Diagnosis criteria Diffuse Lewy Body Disease (Diagnosekriterien Diffuse Lewykörperchen Erkrankung (DLB))
C0752347 (UMLS CUI-2)
C0679228 (UMLS CUI [1,2])
C3846158 (UMLS CUI [1,3])
C0752347 (UMLS CUI-2)
C0243161 (UMLS CUI-3)
C0205225 (UMLS CUI-4)
C0205329 (UMLS CUI [1,2])
C0338656 (UMLS CUI [1,3])
C0497327 (UMLS CUI [2,1])
C0001288 (UMLS CUI [2,2])
C0221099 (UMLS CUI [2,3])
C2363430 (UMLS CUI [3,1])
C0205322 (UMLS CUI [3,2])
C0233794 (UMLS CUI [3,3])
C0332149 (UMLS CUI [3,4])
C0242656 (UMLS CUI [4,1])
C0205322 (UMLS CUI [4,2])
C0233794 (UMLS CUI [4,3])
C3888388 (UMLS CUI [4,4])
C2678119 (UMLS CUI [5])
C2921138 (UMLS CUI [6])
C0752347 (UMLS CUI-2)
C0243161 (UMLS CUI-3)
C1542147 (UMLS CUI-4)
C0009240 (UMLS CUI [1,2])
C0231239 (UMLS CUI [2,1])
C0004268 (UMLS CUI [2,2])
C2945760 (UMLS CUI [1,2])
C3538928 (UMLS CUI [1,3])
C0205431 (UMLS CUI [1,4])
C0233763 (UMLS CUI [2,1])
C2945760 (UMLS CUI [2,2])
C3538928 (UMLS CUI [2,3])
C0439855 (UMLS CUI [2,4])
C0030567 (UMLS CUI [1,2])
C1457887 (UMLS CUI [1,3])
C0752347 (UMLS CUI-2)
C0243161 (UMLS CUI-3)
C1524062 (UMLS CUI-4)
C0205082 (UMLS CUI [1,2])
C0040615 (UMLS CUI [1,3])
C0114838 (UMLS CUI [1,2])
C0023688 (UMLS CUI [1,3])
C1698986 (UMLS CUI [1,4])
C0392756 (UMLS CUI [1,5])
C0004781 (UMLS CUI [1,6])
C0032743 (UMLS CUI [2,1])
C0114838 (UMLS CUI [2,2])
C0023688 (UMLS CUI [2,3])
C1698986 (UMLS CUI [2,4])
C0392756 (UMLS CUI [2,5])
C0004781 (UMLS CUI [2,6])
C0497327 (UMLS CUI [1,2])
C0332152 (UMLS CUI [1,3])
C0030567 (UMLS CUI [1,4])
C1457887 (UMLS CUI [1,5])
C2745955 (UMLS CUI [2,1])
C0497327 (UMLS CUI [2,2])
C0521115 (UMLS CUI [2,3])
C0030567 (UMLS CUI [2,4])
C1457887 (UMLS CUI [2,5])
C0332148 (UMLS CUI [1,2])
C0332149 (UMLS CUI [1,2])
C0011900 (UMLS CUI [1,3])
C0243161 (UMLS CUI-2)
C1298908 (UMLS CUI-3)
C0456369 (UMLS CUI-4)
C1511884 (UMLS CUI-5)
C0332183 (UMLS CUI [2,1])
C0039070 (UMLS CUI [2,2])
C0041657 (UMLS CUI [1,2])
C0205082 (UMLS CUI [1,2])
C0695347 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
C0205098 (UMLS CUI [1,2])
C1298908 (UMLS CUI [1,3])
C2826293 (UMLS CUI [1,4])
C1879646 (UMLS CUI [1,5])
C0040405 (UMLS CUI [1,6])
C0039485 (UMLS CUI [2,1])
C0205098 (UMLS CUI [2,2])
C1298908 (UMLS CUI [2,3])
C2826293 (UMLS CUI [2,4])
C1879646 (UMLS CUI [2,5])
C0024485 (UMLS CUI [2,6])
C0205251 (UMLS CUI [1,2])
C0243144 (UMLS CUI [1,3])
C2094594 (UMLS CUI [2,1])
C0392756 (UMLS CUI [2,2])
C1184145 (UMLS CUI [2,3])
C0443158 (UMLS CUI [2,4])
C0183126 (UMLS CUI [3,1])
C4523908 (UMLS CUI [3,2])
C0205251 (UMLS CUI [3,3])
C0243144 (UMLS CUI [3,4])
C0183126 (UMLS CUI [4,1])
C4523908 (UMLS CUI [4,2])
C0392756 (UMLS CUI [4,3])
C1184145 (UMLS CUI [4,4])
C0443158 (UMLS CUI [4,5])
C0205251 (UMLS CUI [1,2])
C0243144 (UMLS CUI [1,3])
C2229074 (UMLS CUI [1,4])
C3670521 (UMLS CUI [2])
C1298908 (UMLS CUI-2)
C0332148 (UMLS CUI-3)
C0270611 (UMLS CUI [1,2])
C0262926 (UMLS CUI [2,1])
C0038454 (UMLS CUI [2,2])
C0681841 (UMLS CUI [1,2])
C2987487 (UMLS CUI [1,3])
C2745955 (UMLS CUI [1,2])
C0030567 (UMLS CUI [1,3])
C1457887 (UMLS CUI [1,4])
C0497327 (UMLS CUI [1,5])
C0699749 (UMLS CUI [1,6])
C0205082 (UMLS CUI [1,7])
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