ID
40307
Descrição
DELCODE is conducted by DZNE, the German Center for Neurodegenerative Diseases within the Helmholtz Association. The following information was taken from https://www.dzne.de/en/research/studies/clinical-studies/delcode/. Background and aims: One of the important aims of research into Alzheimer's is to find ways of detecting the disease early – if at all possible, as soon as the first minor symptoms appear, or even before any symptoms at all have appeared. Such detection capabilities are the necessary basis for development of therapies that can be applied at such early stages in the disease. Recent research indicates that such therapies could be more effective than therapies initiated during the disease's later stages. Over a period of several years, the DELCODE study is studying persons in early stages of the disease, along with various risk groups. The research is aimed at the development of procedures for characterizing early stages of the disease, at improving prediction of the course of the disease and at identifying new markers for early diagnosis of Alzheimer's-related dementia. Overview: DELCODE is set up to run for an initial period of three years, and to include a total of 1,000 study participants, who will be examined on a yearly basis. The group of participants will include persons with no complaints (healthy control subjects), patients with slight memory impairment or mild dementia and first-degree relatives of patients with diagnosed Alzheimer's disease. The minimum age for participants is 60. Course of the study: The examinations in the framework of the study will include a comprehensive interview carried out by a study investigator, a detailed neuropsychological examination (testing of memory functions and other areas of cognitive performance), a blood test and a cranial MRI scan. Optionally, subject to the study participant's consent in each case, a lumbar puncture (collection of cerebrospinal fluid) will be carried out." For more information (e.g. principle investigator and study coordination), please visit the above link or https://www.dzne.de. This document contains the Diagnosis criteria Diffuse Lewy Body Disease form. It has to be filled in if a Diffuse Lewy Body Disease is diagnosed.
Link
https://www.dzne.de/en/research/studies/clinical-studies/delcode/
Palavras-chave
Versões (1)
- 02/04/2020 02/04/2020 -
Titular dos direitos
DZNE
Transferido a
2 de abril de 2020
DOI
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Licença
Creative Commons BY-NC 4.0
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DELCODE: DZNE – Longitudinal Cognitive Impairment and Dementia Study
Diagnosis criteria Diffuse Lewy Body Disease (Diagnosekriterien Diffuse Lewykörperchen Erkrankung (DLB))
Descrição
Diffuse Lewykörperchen Erkrankung (DLB)
Alias
- UMLS CUI-1
- C0205219
- UMLS CUI-2
- C0752347
Descrição
DLB: Zentrales Kriterium
Alias
- UMLS CUI-1
- C0205219
- UMLS CUI-2
- C0752347
- UMLS CUI-3
- C0243161
- UMLS CUI-4
- C0205225
Descrição
Dementia with impairment of daily life (in early stage of disease persistent memory impairment possible while in progression of disease usually occurs. Impairment of attention, executive functions, visuospatial ability)
Tipo de dados
integer
Alias
- UMLS CUI [1,1]
- C0497327
- UMLS CUI [1,2]
- C0205329
- UMLS CUI [1,3]
- C0338656
- UMLS CUI [2,1]
- C0497327
- UMLS CUI [2,2]
- C0001288
- UMLS CUI [2,3]
- C0221099
- UMLS CUI [3,1]
- C2363430
- UMLS CUI [3,2]
- C0205322
- UMLS CUI [3,3]
- C0233794
- UMLS CUI [3,4]
- C0332149
- UMLS CUI [4,1]
- C0242656
- UMLS CUI [4,2]
- C0205322
- UMLS CUI [4,3]
- C0233794
- UMLS CUI [4,4]
- C3888388
- UMLS CUI [5]
- C2678119
- UMLS CUI [6]
- C2921138
Descrição
DLB: Hauptkriterien
Alias
- UMLS CUI-1
- C0205219
- UMLS CUI-2
- C0752347
- UMLS CUI-3
- C0243161
- UMLS CUI-4
- C1542147
Descrição
Fluctuations in cognition, especially in attention
Tipo de dados
integer
Alias
- UMLS CUI [1,1]
- C0231239
- UMLS CUI [1,2]
- C0009240
- UMLS CUI [2,1]
- C0231239
- UMLS CUI [2,2]
- C0004268
Descrição
Recurring visual hallucinations (typically person character and detailed)
Tipo de dados
integer
Alias
- UMLS CUI [1,1]
- C0233763
- UMLS CUI [1,2]
- C2945760
- UMLS CUI [1,3]
- C3538928
- UMLS CUI [1,4]
- C0205431
- UMLS CUI [2,1]
- C0233763
- UMLS CUI [2,2]
- C2945760
- UMLS CUI [2,3]
- C3538928
- UMLS CUI [2,4]
- C0439855
Descrição
Spontaneous Parkinson symptoms
Tipo de dados
integer
Alias
- UMLS CUI [1,1]
- C0205359
- UMLS CUI [1,2]
- C0030567
- UMLS CUI [1,3]
- C1457887
Descrição
DLB: Zusatzkriterien
Alias
- UMLS CUI-1
- C0205219
- UMLS CUI-2
- C0752347
- UMLS CUI-3
- C0243161
- UMLS CUI-4
- C1524062
Descrição
REM Sleep Behavior Disorder
Tipo de dados
integer
Alias
- UMLS CUI [1]
- C0751772
Descrição
Serious side effects due to the use of neuroleptics
Tipo de dados
integer
Alias
- UMLS CUI [1,1]
- C0041755
- UMLS CUI [1,2]
- C0205082
- UMLS CUI [1,3]
- C0040615
Descrição
Reduced dopamine transporter ligand storage in basal ganglia (SPECT/PET)
Tipo de dados
integer
Alias
- UMLS CUI [1,1]
- C0183126
- UMLS CUI [1,2]
- C0114838
- UMLS CUI [1,3]
- C0023688
- UMLS CUI [1,4]
- C1698986
- UMLS CUI [1,5]
- C0392756
- UMLS CUI [1,6]
- C0004781
- UMLS CUI [2,1]
- C0032743
- UMLS CUI [2,2]
- C0114838
- UMLS CUI [2,3]
- C0023688
- UMLS CUI [2,4]
- C1698986
- UMLS CUI [2,5]
- C0392756
- UMLS CUI [2,6]
- C0004781
Descrição
Occurrence of dementia before/ simultaneously parkinson symptoms
Tipo de dados
integer
Alias
- UMLS CUI [1,1]
- C2745955
- UMLS CUI [1,2]
- C0497327
- UMLS CUI [1,3]
- C0332152
- UMLS CUI [1,4]
- C0030567
- UMLS CUI [1,5]
- C1457887
- UMLS CUI [2,1]
- C2745955
- UMLS CUI [2,2]
- C0497327
- UMLS CUI [2,3]
- C0521115
- UMLS CUI [2,4]
- C0030567
- UMLS CUI [2,5]
- C1457887
Descrição
(Item 1 und mind. ein Merkmale aus 2‐4 sowie mind. 1 Merkmal aus 5‐7 treffen zu; Item 8 ist erfüllt)
Tipo de dados
integer
Alias
- UMLS CUI [1,1]
- C0752347
- UMLS CUI [1,2]
- C0332148
Descrição
(Item 1 und mind. ein Merkmal aus 5‐7 treffen zu, Item 8 ist erfüllt)
Tipo de dados
integer
Alias
- UMLS CUI [1,1]
- C0752347
- UMLS CUI [1,2]
- C0332149
- UMLS CUI [1,3]
- C0011900
Descrição
Unterstützende Merkmale ohne nachweisliche diagnostische Spezifität
Alias
- UMLS CUI-1
- C4684795
- UMLS CUI-2
- C0243161
- UMLS CUI-3
- C1298908
- UMLS CUI-4
- C0456369
- UMLS CUI-5
- C1511884
Descrição
Frequent falls and syncopes
Tipo de dados
integer
Alias
- UMLS CUI [1]
- C0850703
- UMLS CUI [2,1]
- C0332183
- UMLS CUI [2,2]
- C0039070
Descrição
Transient loss of consciousness
Tipo de dados
integer
Alias
- UMLS CUI [1,1]
- C0205374
- UMLS CUI [1,2]
- C0041657
Descrição
Severe autonomic dysfunction
Tipo de dados
integer
Alias
- UMLS CUI [1,1]
- C3277919
- UMLS CUI [1,2]
- C0205082
Descrição
Hallucinations in other modalities
Tipo de dados
integer
Alias
- UMLS CUI [1,1]
- C0018524
- UMLS CUI [1,2]
- C0695347
- UMLS CUI [1,3]
- C0205394
Descrição
Delusion
Tipo de dados
integer
Alias
- UMLS CUI [1]
- C0011253
Descrição
Depression
Tipo de dados
integer
Alias
- UMLS CUI [1]
- C0011581
Descrição
Slightly change in medial temporal lobe (CT/MRT)
Tipo de dados
integer
Alias
- UMLS CUI [1,1]
- C0039485
- UMLS CUI [1,2]
- C0205098
- UMLS CUI [1,3]
- C1298908
- UMLS CUI [1,4]
- C2826293
- UMLS CUI [1,5]
- C1879646
- UMLS CUI [1,6]
- C0040405
- UMLS CUI [2,1]
- C0039485
- UMLS CUI [2,2]
- C0205098
- UMLS CUI [2,3]
- C1298908
- UMLS CUI [2,4]
- C2826293
- UMLS CUI [2,5]
- C1879646
- UMLS CUI [2,6]
- C0024485
Descrição
Low uptake in SPECT/PET perfusion scan with reduced occipital activity
Tipo de dados
integer
Alias
- UMLS CUI [1,1]
- C2094594
- UMLS CUI [1,2]
- C0205251
- UMLS CUI [1,3]
- C0243144
- UMLS CUI [2,1]
- C2094594
- UMLS CUI [2,2]
- C0392756
- UMLS CUI [2,3]
- C1184145
- UMLS CUI [2,4]
- C0443158
- UMLS CUI [3,1]
- C0183126
- UMLS CUI [3,2]
- C4523908
- UMLS CUI [3,3]
- C0205251
- UMLS CUI [3,4]
- C0243144
- UMLS CUI [4,1]
- C0183126
- UMLS CUI [4,2]
- C4523908
- UMLS CUI [4,3]
- C0392756
- UMLS CUI [4,4]
- C1184145
- UMLS CUI [4,5]
- C0443158
Descrição
Abnormally low uptake in the MIBG Myocardial Scintigraphy
Tipo de dados
integer
Alias
- UMLS CUI [1,1]
- C1704258
- UMLS CUI [1,2]
- C0205251
- UMLS CUI [1,3]
- C0243144
- UMLS CUI [1,4]
- C2229074
Descrição
Prominent slow wave activity in EEG with temporal transient sharp waves
Tipo de dados
integer
Alias
- UMLS CUI [1]
- C2206519
- UMLS CUI [2]
- C3670521
Descrição
Befunde, die die Diagnose wenig wahrscheinlich machen
Alias
- UMLS CUI-1
- C0011900
- UMLS CUI-2
- C1298908
- UMLS CUI-3
- C0332148
Descrição
History of a brain injury
Tipo de dados
integer
Alias
- UMLS CUI [1,1]
- C0262926
- UMLS CUI [1,2]
- C0270611
- UMLS CUI [2,1]
- C0262926
- UMLS CUI [2,2]
- C0038454
Descrição
Other diseases
Tipo de dados
integer
Alias
- UMLS CUI [1,1]
- C2359476
- UMLS CUI [1,2]
- C0681841
- UMLS CUI [1,3]
- C2987487
Descrição
First occurrence of parkinson symptoms in severe stage of dementia
Tipo de dados
integer
Alias
- UMLS CUI [1,1]
- C0205435
- UMLS CUI [1,2]
- C2745955
- UMLS CUI [1,3]
- C0030567
- UMLS CUI [1,4]
- C1457887
- UMLS CUI [1,5]
- C0497327
- UMLS CUI [1,6]
- C0699749
- UMLS CUI [1,7]
- C0205082
Similar models
Diagnosis criteria Diffuse Lewy Body Disease (Diagnosekriterien Diffuse Lewykörperchen Erkrankung (DLB))
C0752347 (UMLS CUI-2)
C0679228 (UMLS CUI [1,2])
C3846158 (UMLS CUI [1,3])
C0752347 (UMLS CUI-2)
C0243161 (UMLS CUI-3)
C0205225 (UMLS CUI-4)
C0205329 (UMLS CUI [1,2])
C0338656 (UMLS CUI [1,3])
C0497327 (UMLS CUI [2,1])
C0001288 (UMLS CUI [2,2])
C0221099 (UMLS CUI [2,3])
C2363430 (UMLS CUI [3,1])
C0205322 (UMLS CUI [3,2])
C0233794 (UMLS CUI [3,3])
C0332149 (UMLS CUI [3,4])
C0242656 (UMLS CUI [4,1])
C0205322 (UMLS CUI [4,2])
C0233794 (UMLS CUI [4,3])
C3888388 (UMLS CUI [4,4])
C2678119 (UMLS CUI [5])
C2921138 (UMLS CUI [6])
C0752347 (UMLS CUI-2)
C0243161 (UMLS CUI-3)
C1542147 (UMLS CUI-4)
C0009240 (UMLS CUI [1,2])
C0231239 (UMLS CUI [2,1])
C0004268 (UMLS CUI [2,2])
C2945760 (UMLS CUI [1,2])
C3538928 (UMLS CUI [1,3])
C0205431 (UMLS CUI [1,4])
C0233763 (UMLS CUI [2,1])
C2945760 (UMLS CUI [2,2])
C3538928 (UMLS CUI [2,3])
C0439855 (UMLS CUI [2,4])
C0030567 (UMLS CUI [1,2])
C1457887 (UMLS CUI [1,3])
C0752347 (UMLS CUI-2)
C0243161 (UMLS CUI-3)
C1524062 (UMLS CUI-4)
C0205082 (UMLS CUI [1,2])
C0040615 (UMLS CUI [1,3])
C0114838 (UMLS CUI [1,2])
C0023688 (UMLS CUI [1,3])
C1698986 (UMLS CUI [1,4])
C0392756 (UMLS CUI [1,5])
C0004781 (UMLS CUI [1,6])
C0032743 (UMLS CUI [2,1])
C0114838 (UMLS CUI [2,2])
C0023688 (UMLS CUI [2,3])
C1698986 (UMLS CUI [2,4])
C0392756 (UMLS CUI [2,5])
C0004781 (UMLS CUI [2,6])
C0497327 (UMLS CUI [1,2])
C0332152 (UMLS CUI [1,3])
C0030567 (UMLS CUI [1,4])
C1457887 (UMLS CUI [1,5])
C2745955 (UMLS CUI [2,1])
C0497327 (UMLS CUI [2,2])
C0521115 (UMLS CUI [2,3])
C0030567 (UMLS CUI [2,4])
C1457887 (UMLS CUI [2,5])
C0332148 (UMLS CUI [1,2])
C0332149 (UMLS CUI [1,2])
C0011900 (UMLS CUI [1,3])
C0243161 (UMLS CUI-2)
C1298908 (UMLS CUI-3)
C0456369 (UMLS CUI-4)
C1511884 (UMLS CUI-5)
C0332183 (UMLS CUI [2,1])
C0039070 (UMLS CUI [2,2])
C0041657 (UMLS CUI [1,2])
C0205082 (UMLS CUI [1,2])
C0695347 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
C0205098 (UMLS CUI [1,2])
C1298908 (UMLS CUI [1,3])
C2826293 (UMLS CUI [1,4])
C1879646 (UMLS CUI [1,5])
C0040405 (UMLS CUI [1,6])
C0039485 (UMLS CUI [2,1])
C0205098 (UMLS CUI [2,2])
C1298908 (UMLS CUI [2,3])
C2826293 (UMLS CUI [2,4])
C1879646 (UMLS CUI [2,5])
C0024485 (UMLS CUI [2,6])
C0205251 (UMLS CUI [1,2])
C0243144 (UMLS CUI [1,3])
C2094594 (UMLS CUI [2,1])
C0392756 (UMLS CUI [2,2])
C1184145 (UMLS CUI [2,3])
C0443158 (UMLS CUI [2,4])
C0183126 (UMLS CUI [3,1])
C4523908 (UMLS CUI [3,2])
C0205251 (UMLS CUI [3,3])
C0243144 (UMLS CUI [3,4])
C0183126 (UMLS CUI [4,1])
C4523908 (UMLS CUI [4,2])
C0392756 (UMLS CUI [4,3])
C1184145 (UMLS CUI [4,4])
C0443158 (UMLS CUI [4,5])
C0205251 (UMLS CUI [1,2])
C0243144 (UMLS CUI [1,3])
C2229074 (UMLS CUI [1,4])
C3670521 (UMLS CUI [2])
C1298908 (UMLS CUI-2)
C0332148 (UMLS CUI-3)
C0270611 (UMLS CUI [1,2])
C0262926 (UMLS CUI [2,1])
C0038454 (UMLS CUI [2,2])
C0681841 (UMLS CUI [1,2])
C2987487 (UMLS CUI [1,3])
C2745955 (UMLS CUI [1,2])
C0030567 (UMLS CUI [1,3])
C1457887 (UMLS CUI [1,4])
C0497327 (UMLS CUI [1,5])
C0699749 (UMLS CUI [1,6])
C0205082 (UMLS CUI [1,7])