ID
40307
Descripción
DELCODE is conducted by DZNE, the German Center for Neurodegenerative Diseases within the Helmholtz Association. The following information was taken from https://www.dzne.de/en/research/studies/clinical-studies/delcode/. Background and aims: One of the important aims of research into Alzheimer's is to find ways of detecting the disease early – if at all possible, as soon as the first minor symptoms appear, or even before any symptoms at all have appeared. Such detection capabilities are the necessary basis for development of therapies that can be applied at such early stages in the disease. Recent research indicates that such therapies could be more effective than therapies initiated during the disease's later stages. Over a period of several years, the DELCODE study is studying persons in early stages of the disease, along with various risk groups. The research is aimed at the development of procedures for characterizing early stages of the disease, at improving prediction of the course of the disease and at identifying new markers for early diagnosis of Alzheimer's-related dementia. Overview: DELCODE is set up to run for an initial period of three years, and to include a total of 1,000 study participants, who will be examined on a yearly basis. The group of participants will include persons with no complaints (healthy control subjects), patients with slight memory impairment or mild dementia and first-degree relatives of patients with diagnosed Alzheimer's disease. The minimum age for participants is 60. Course of the study: The examinations in the framework of the study will include a comprehensive interview carried out by a study investigator, a detailed neuropsychological examination (testing of memory functions and other areas of cognitive performance), a blood test and a cranial MRI scan. Optionally, subject to the study participant's consent in each case, a lumbar puncture (collection of cerebrospinal fluid) will be carried out." For more information (e.g. principle investigator and study coordination), please visit the above link or https://www.dzne.de. This document contains the Diagnosis criteria Diffuse Lewy Body Disease form. It has to be filled in if a Diffuse Lewy Body Disease is diagnosed.
Link
https://www.dzne.de/en/research/studies/clinical-studies/delcode/
Palabras clave
Versiones (1)
- 2/4/20 2/4/20 -
Titular de derechos de autor
DZNE
Subido en
2 de abril de 2020
DOI
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Licencia
Creative Commons BY-NC 4.0
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DELCODE: DZNE – Longitudinal Cognitive Impairment and Dementia Study
Diagnosis criteria Diffuse Lewy Body Disease (Diagnosekriterien Diffuse Lewykörperchen Erkrankung (DLB))
Descripción
Diffuse Lewykörperchen Erkrankung (DLB)
Alias
- UMLS CUI-1
- C0205219
- UMLS CUI-2
- C0752347
Descripción
DLB: Zentrales Kriterium
Alias
- UMLS CUI-1
- C0205219
- UMLS CUI-2
- C0752347
- UMLS CUI-3
- C0243161
- UMLS CUI-4
- C0205225
Descripción
Dementia with impairment of daily life (in early stage of disease persistent memory impairment possible while in progression of disease usually occurs. Impairment of attention, executive functions, visuospatial ability)
Tipo de datos
integer
Alias
- UMLS CUI [1,1]
- C0497327
- UMLS CUI [1,2]
- C0205329
- UMLS CUI [1,3]
- C0338656
- UMLS CUI [2,1]
- C0497327
- UMLS CUI [2,2]
- C0001288
- UMLS CUI [2,3]
- C0221099
- UMLS CUI [3,1]
- C2363430
- UMLS CUI [3,2]
- C0205322
- UMLS CUI [3,3]
- C0233794
- UMLS CUI [3,4]
- C0332149
- UMLS CUI [4,1]
- C0242656
- UMLS CUI [4,2]
- C0205322
- UMLS CUI [4,3]
- C0233794
- UMLS CUI [4,4]
- C3888388
- UMLS CUI [5]
- C2678119
- UMLS CUI [6]
- C2921138
Descripción
DLB: Hauptkriterien
Alias
- UMLS CUI-1
- C0205219
- UMLS CUI-2
- C0752347
- UMLS CUI-3
- C0243161
- UMLS CUI-4
- C1542147
Descripción
Fluctuations in cognition, especially in attention
Tipo de datos
integer
Alias
- UMLS CUI [1,1]
- C0231239
- UMLS CUI [1,2]
- C0009240
- UMLS CUI [2,1]
- C0231239
- UMLS CUI [2,2]
- C0004268
Descripción
Recurring visual hallucinations (typically person character and detailed)
Tipo de datos
integer
Alias
- UMLS CUI [1,1]
- C0233763
- UMLS CUI [1,2]
- C2945760
- UMLS CUI [1,3]
- C3538928
- UMLS CUI [1,4]
- C0205431
- UMLS CUI [2,1]
- C0233763
- UMLS CUI [2,2]
- C2945760
- UMLS CUI [2,3]
- C3538928
- UMLS CUI [2,4]
- C0439855
Descripción
Spontaneous Parkinson symptoms
Tipo de datos
integer
Alias
- UMLS CUI [1,1]
- C0205359
- UMLS CUI [1,2]
- C0030567
- UMLS CUI [1,3]
- C1457887
Descripción
DLB: Zusatzkriterien
Alias
- UMLS CUI-1
- C0205219
- UMLS CUI-2
- C0752347
- UMLS CUI-3
- C0243161
- UMLS CUI-4
- C1524062
Descripción
REM Sleep Behavior Disorder
Tipo de datos
integer
Alias
- UMLS CUI [1]
- C0751772
Descripción
Serious side effects due to the use of neuroleptics
Tipo de datos
integer
Alias
- UMLS CUI [1,1]
- C0041755
- UMLS CUI [1,2]
- C0205082
- UMLS CUI [1,3]
- C0040615
Descripción
Reduced dopamine transporter ligand storage in basal ganglia (SPECT/PET)
Tipo de datos
integer
Alias
- UMLS CUI [1,1]
- C0183126
- UMLS CUI [1,2]
- C0114838
- UMLS CUI [1,3]
- C0023688
- UMLS CUI [1,4]
- C1698986
- UMLS CUI [1,5]
- C0392756
- UMLS CUI [1,6]
- C0004781
- UMLS CUI [2,1]
- C0032743
- UMLS CUI [2,2]
- C0114838
- UMLS CUI [2,3]
- C0023688
- UMLS CUI [2,4]
- C1698986
- UMLS CUI [2,5]
- C0392756
- UMLS CUI [2,6]
- C0004781
Descripción
Occurrence of dementia before/ simultaneously parkinson symptoms
Tipo de datos
integer
Alias
- UMLS CUI [1,1]
- C2745955
- UMLS CUI [1,2]
- C0497327
- UMLS CUI [1,3]
- C0332152
- UMLS CUI [1,4]
- C0030567
- UMLS CUI [1,5]
- C1457887
- UMLS CUI [2,1]
- C2745955
- UMLS CUI [2,2]
- C0497327
- UMLS CUI [2,3]
- C0521115
- UMLS CUI [2,4]
- C0030567
- UMLS CUI [2,5]
- C1457887
Descripción
(Item 1 und mind. ein Merkmale aus 2‐4 sowie mind. 1 Merkmal aus 5‐7 treffen zu; Item 8 ist erfüllt)
Tipo de datos
integer
Alias
- UMLS CUI [1,1]
- C0752347
- UMLS CUI [1,2]
- C0332148
Descripción
(Item 1 und mind. ein Merkmal aus 5‐7 treffen zu, Item 8 ist erfüllt)
Tipo de datos
integer
Alias
- UMLS CUI [1,1]
- C0752347
- UMLS CUI [1,2]
- C0332149
- UMLS CUI [1,3]
- C0011900
Descripción
Unterstützende Merkmale ohne nachweisliche diagnostische Spezifität
Alias
- UMLS CUI-1
- C4684795
- UMLS CUI-2
- C0243161
- UMLS CUI-3
- C1298908
- UMLS CUI-4
- C0456369
- UMLS CUI-5
- C1511884
Descripción
Frequent falls and syncopes
Tipo de datos
integer
Alias
- UMLS CUI [1]
- C0850703
- UMLS CUI [2,1]
- C0332183
- UMLS CUI [2,2]
- C0039070
Descripción
Transient loss of consciousness
Tipo de datos
integer
Alias
- UMLS CUI [1,1]
- C0205374
- UMLS CUI [1,2]
- C0041657
Descripción
Severe autonomic dysfunction
Tipo de datos
integer
Alias
- UMLS CUI [1,1]
- C3277919
- UMLS CUI [1,2]
- C0205082
Descripción
Hallucinations in other modalities
Tipo de datos
integer
Alias
- UMLS CUI [1,1]
- C0018524
- UMLS CUI [1,2]
- C0695347
- UMLS CUI [1,3]
- C0205394
Descripción
Delusion
Tipo de datos
integer
Alias
- UMLS CUI [1]
- C0011253
Descripción
Depression
Tipo de datos
integer
Alias
- UMLS CUI [1]
- C0011581
Descripción
Slightly change in medial temporal lobe (CT/MRT)
Tipo de datos
integer
Alias
- UMLS CUI [1,1]
- C0039485
- UMLS CUI [1,2]
- C0205098
- UMLS CUI [1,3]
- C1298908
- UMLS CUI [1,4]
- C2826293
- UMLS CUI [1,5]
- C1879646
- UMLS CUI [1,6]
- C0040405
- UMLS CUI [2,1]
- C0039485
- UMLS CUI [2,2]
- C0205098
- UMLS CUI [2,3]
- C1298908
- UMLS CUI [2,4]
- C2826293
- UMLS CUI [2,5]
- C1879646
- UMLS CUI [2,6]
- C0024485
Descripción
Low uptake in SPECT/PET perfusion scan with reduced occipital activity
Tipo de datos
integer
Alias
- UMLS CUI [1,1]
- C2094594
- UMLS CUI [1,2]
- C0205251
- UMLS CUI [1,3]
- C0243144
- UMLS CUI [2,1]
- C2094594
- UMLS CUI [2,2]
- C0392756
- UMLS CUI [2,3]
- C1184145
- UMLS CUI [2,4]
- C0443158
- UMLS CUI [3,1]
- C0183126
- UMLS CUI [3,2]
- C4523908
- UMLS CUI [3,3]
- C0205251
- UMLS CUI [3,4]
- C0243144
- UMLS CUI [4,1]
- C0183126
- UMLS CUI [4,2]
- C4523908
- UMLS CUI [4,3]
- C0392756
- UMLS CUI [4,4]
- C1184145
- UMLS CUI [4,5]
- C0443158
Descripción
Abnormally low uptake in the MIBG Myocardial Scintigraphy
Tipo de datos
integer
Alias
- UMLS CUI [1,1]
- C1704258
- UMLS CUI [1,2]
- C0205251
- UMLS CUI [1,3]
- C0243144
- UMLS CUI [1,4]
- C2229074
Descripción
Prominent slow wave activity in EEG with temporal transient sharp waves
Tipo de datos
integer
Alias
- UMLS CUI [1]
- C2206519
- UMLS CUI [2]
- C3670521
Descripción
Befunde, die die Diagnose wenig wahrscheinlich machen
Alias
- UMLS CUI-1
- C0011900
- UMLS CUI-2
- C1298908
- UMLS CUI-3
- C0332148
Descripción
History of a brain injury
Tipo de datos
integer
Alias
- UMLS CUI [1,1]
- C0262926
- UMLS CUI [1,2]
- C0270611
- UMLS CUI [2,1]
- C0262926
- UMLS CUI [2,2]
- C0038454
Descripción
Other diseases
Tipo de datos
integer
Alias
- UMLS CUI [1,1]
- C2359476
- UMLS CUI [1,2]
- C0681841
- UMLS CUI [1,3]
- C2987487
Descripción
First occurrence of parkinson symptoms in severe stage of dementia
Tipo de datos
integer
Alias
- UMLS CUI [1,1]
- C0205435
- UMLS CUI [1,2]
- C2745955
- UMLS CUI [1,3]
- C0030567
- UMLS CUI [1,4]
- C1457887
- UMLS CUI [1,5]
- C0497327
- UMLS CUI [1,6]
- C0699749
- UMLS CUI [1,7]
- C0205082
Similar models
Diagnosis criteria Diffuse Lewy Body Disease (Diagnosekriterien Diffuse Lewykörperchen Erkrankung (DLB))
C0752347 (UMLS CUI-2)
C0679228 (UMLS CUI [1,2])
C3846158 (UMLS CUI [1,3])
C0752347 (UMLS CUI-2)
C0243161 (UMLS CUI-3)
C0205225 (UMLS CUI-4)
C0205329 (UMLS CUI [1,2])
C0338656 (UMLS CUI [1,3])
C0497327 (UMLS CUI [2,1])
C0001288 (UMLS CUI [2,2])
C0221099 (UMLS CUI [2,3])
C2363430 (UMLS CUI [3,1])
C0205322 (UMLS CUI [3,2])
C0233794 (UMLS CUI [3,3])
C0332149 (UMLS CUI [3,4])
C0242656 (UMLS CUI [4,1])
C0205322 (UMLS CUI [4,2])
C0233794 (UMLS CUI [4,3])
C3888388 (UMLS CUI [4,4])
C2678119 (UMLS CUI [5])
C2921138 (UMLS CUI [6])
C0752347 (UMLS CUI-2)
C0243161 (UMLS CUI-3)
C1542147 (UMLS CUI-4)
C0009240 (UMLS CUI [1,2])
C0231239 (UMLS CUI [2,1])
C0004268 (UMLS CUI [2,2])
C2945760 (UMLS CUI [1,2])
C3538928 (UMLS CUI [1,3])
C0205431 (UMLS CUI [1,4])
C0233763 (UMLS CUI [2,1])
C2945760 (UMLS CUI [2,2])
C3538928 (UMLS CUI [2,3])
C0439855 (UMLS CUI [2,4])
C0030567 (UMLS CUI [1,2])
C1457887 (UMLS CUI [1,3])
C0752347 (UMLS CUI-2)
C0243161 (UMLS CUI-3)
C1524062 (UMLS CUI-4)
C0205082 (UMLS CUI [1,2])
C0040615 (UMLS CUI [1,3])
C0114838 (UMLS CUI [1,2])
C0023688 (UMLS CUI [1,3])
C1698986 (UMLS CUI [1,4])
C0392756 (UMLS CUI [1,5])
C0004781 (UMLS CUI [1,6])
C0032743 (UMLS CUI [2,1])
C0114838 (UMLS CUI [2,2])
C0023688 (UMLS CUI [2,3])
C1698986 (UMLS CUI [2,4])
C0392756 (UMLS CUI [2,5])
C0004781 (UMLS CUI [2,6])
C0497327 (UMLS CUI [1,2])
C0332152 (UMLS CUI [1,3])
C0030567 (UMLS CUI [1,4])
C1457887 (UMLS CUI [1,5])
C2745955 (UMLS CUI [2,1])
C0497327 (UMLS CUI [2,2])
C0521115 (UMLS CUI [2,3])
C0030567 (UMLS CUI [2,4])
C1457887 (UMLS CUI [2,5])
C0332148 (UMLS CUI [1,2])
C0332149 (UMLS CUI [1,2])
C0011900 (UMLS CUI [1,3])
C0243161 (UMLS CUI-2)
C1298908 (UMLS CUI-3)
C0456369 (UMLS CUI-4)
C1511884 (UMLS CUI-5)
C0332183 (UMLS CUI [2,1])
C0039070 (UMLS CUI [2,2])
C0041657 (UMLS CUI [1,2])
C0205082 (UMLS CUI [1,2])
C0695347 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
C0205098 (UMLS CUI [1,2])
C1298908 (UMLS CUI [1,3])
C2826293 (UMLS CUI [1,4])
C1879646 (UMLS CUI [1,5])
C0040405 (UMLS CUI [1,6])
C0039485 (UMLS CUI [2,1])
C0205098 (UMLS CUI [2,2])
C1298908 (UMLS CUI [2,3])
C2826293 (UMLS CUI [2,4])
C1879646 (UMLS CUI [2,5])
C0024485 (UMLS CUI [2,6])
C0205251 (UMLS CUI [1,2])
C0243144 (UMLS CUI [1,3])
C2094594 (UMLS CUI [2,1])
C0392756 (UMLS CUI [2,2])
C1184145 (UMLS CUI [2,3])
C0443158 (UMLS CUI [2,4])
C0183126 (UMLS CUI [3,1])
C4523908 (UMLS CUI [3,2])
C0205251 (UMLS CUI [3,3])
C0243144 (UMLS CUI [3,4])
C0183126 (UMLS CUI [4,1])
C4523908 (UMLS CUI [4,2])
C0392756 (UMLS CUI [4,3])
C1184145 (UMLS CUI [4,4])
C0443158 (UMLS CUI [4,5])
C0205251 (UMLS CUI [1,2])
C0243144 (UMLS CUI [1,3])
C2229074 (UMLS CUI [1,4])
C3670521 (UMLS CUI [2])
C1298908 (UMLS CUI-2)
C0332148 (UMLS CUI-3)
C0270611 (UMLS CUI [1,2])
C0262926 (UMLS CUI [2,1])
C0038454 (UMLS CUI [2,2])
C0681841 (UMLS CUI [1,2])
C2987487 (UMLS CUI [1,3])
C2745955 (UMLS CUI [1,2])
C0030567 (UMLS CUI [1,3])
C1457887 (UMLS CUI [1,4])
C0497327 (UMLS CUI [1,5])
C0699749 (UMLS CUI [1,6])
C0205082 (UMLS CUI [1,7])