ID

16932

Description

NINDS Common Data Elements, Multiple Sclerosis Imaging Analysis Technique and Results – Follow Up Used from the National Institute of Neurological Disorders and Stroke Common Data Elements (https://www.commondataelements.ninds.nih.gov/) References: Grinnon ST, Miller K, Marler JR, Lu Y, Stout A, Odenkirchen J, Kunitz S. National Institute of Neurological Disorders and Stroke Common Data Element Project - approach and methods. Clin Trials. 2012;9(3):322-9.

Link

https://www.commondataelements.ninds.nih.gov/

Keywords

Versions (1)
  1. 8/14/16 8/14/16 -
Uploaded on

August 14, 2016

DOI

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License

Creative Commons BY-NC 3.0
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NINDS CDE Imaging Analysis Technique and Results – Follow Up Multiple Sclerosis

English

Imaging Analysis Technique and Results – Follow Up

1 forms  
T2 LESIONS ANALYSIS
Description

T2 LESIONS ANALYSIS

Alias
UMLS CUI-1
C0936012
UMLS CUI-2
C0221198
UMLS CUI-3
C0024485
Study ID
Description

Study ID

Data type

integer

Alias
UMLS CUI [1]
C2826693
Study site name
Description

Study site name

Data type

text

Alias
UMLS CUI [1]
C2825164
Subject ID
Description

Subject ID

Data type

integer

Alias
UMLS CUI [1]
C2348585
Date of MRI
Description

Date of MRI

Data type

date

Alias
UMLS CUI [1,1]
C0011008
UMLS CUI [1,2]
C0024485
1) Total volume of brain lesions on T2W image (cc):
Description

volume brain lesions

Data type

float

Measurement units
  • cc
Alias
UMLS CUI [1,1]
C0449468
UMLS CUI [1,2]
C0221505
cc
2) Change in T2 lesion(s) volume (mL); a. Total number of T2 lesions:
Description

Number of lesions volume

Data type

float

Measurement units
  • ml
Alias
UMLS CUI [1,1]
C0449791
UMLS CUI [1,2]
C0449468
ml
3) Number of new or enlarging non-enhancing T2 lesions:
Description

Number of lesions regional

Data type

integer

Alias
UMLS CUI [1,1]
C0449791
UMLS CUI [1,2]
C0205147
i. Number of periventricular lesions:
Description

Number of lesions regional periventricular lesions

Data type

integer

Alias
UMLS CUI [1,1]
C0449791
UMLS CUI [1,2]
C0205147
UMLS CUI [1,3]
C3277690
ii. Number of juxtacortical lesions:
Description

Number of lesions regional juxtacortical lesions

Data type

integer

iii. Number of posterior fossa lesions:
Description

Number of lesions regional posterior fossa

Data type

integer

Alias
UMLS CUI [1,1]
C0449791
UMLS CUI [1,2]
C0205147
UMLS CUI [1,3]
C1116439
iv. Number of cortical lesions:
Description

Number of lesions regional cortical

Data type

integer

Alias
UMLS CUI [1,1]
C0449791
UMLS CUI [1,2]
C0205147
UMLS CUI [1,3]
C0007776
v. Number of thalamus lesions:
Description

Number of lesions regional thalamus

Data type

integer

Alias
UMLS CUI [1,1]
C0449791
UMLS CUI [1,2]
C0205147
UMLS CUI [1,3]
C0039729
vi. Number of basal ganglia lesions:
Description

Number of lesions regional basal ganglia

Data type

integer

Alias
UMLS CUI [1,1]
C0449791
UMLS CUI [1,2]
C0205147
UMLS CUI [1,3]
C0004781
vii. Number of other lesions whose type is not specified:
Description

Number of lesions regional

Data type

integer

Alias
UMLS CUI [1,1]
C0449791
UMLS CUI [1,2]
C0205147
4) Technique reference for new lesions (i.e. literature citation(s), MRI Acquisition Manual or Analysis Manual. May also include visual observation, detection, etc.):
Description

reference Technique

Data type

text

Alias
UMLS CUI [1,1]
C0034925
UMLS CUI [1,2]
C0449851
GD-ENHANCING LESIONS ANALYSIS
Description

GD-ENHANCING LESIONS ANALYSIS

Alias
UMLS CUI-1
C0936012
UMLS CUI-2
C1333400
1) Total number of Gd-enhancing lesions:
Description

Number of lesions Gd-enhancing lesions

Data type

integer

Alias
UMLS CUI [1,1]
C0449791
UMLS CUI [1,2]
C1333400
2) Number of NEW Gd-enhancing lesions:
Description

Gd-enhancing lesions new

Data type

integer

Alias
UMLS CUI [1,1]
C1333400
UMLS CUI [1,2]
C0205314
3) Total volume of all Gd-enhancing lesions (cc):
Description

volume Gd-enhancing lesions

Data type

float

Measurement units
  • cc
Alias
UMLS CUI [1,1]
C0449468
UMLS CUI [1,2]
C1333400
cc
4) Change in volume of all Gd-enhancing lesions (cc):
Description

volume Gd-enhancing lesions change

Data type

float

Measurement units
  • cc
Alias
UMLS CUI [1,1]
C0449468
UMLS CUI [1,2]
C1333400
UMLS CUI [1,3]
C0392747
cc
5) Technique reference (i.e. literature citation(s), MRI Acquisition Manual or Analysis Manual):
Description

reference Technique

Data type

text

Alias
UMLS CUI [1,1]
C0034925
UMLS CUI [1,2]
C0449851
Combined Unique Active lesions
Description

Combined Unique Active lesions

Alias
UMLS CUI-1
C0221198
UMLS CUI-2
C0205195
UMLS CUI-3
C1710548
UMLS CUI-4
C0205177
1) Number of CUA lesions compared to previous time-point:
Description

lesions Combined Unique Active

Data type

integer

Alias
UMLS CUI [1,1]
C0221198
UMLS CUI [1,2]
C0205195
UMLS CUI [1,3]
C1710548
UMLS CUI [1,4]
C0205177
2) Technique reference for new lesions (i.e. literature citation(s), MRI Acquisition Manual or Analysis Manual. May also include visual observation, detection, etc.):
Description

reference Technique

Data type

text

Alias
UMLS CUI [1,1]
C0034925
UMLS CUI [1,2]
C0449851
T1 HYPOINTENSE LESIONS ANALYSIS
Description

T1 HYPOINTENSE LESIONS ANALYSIS

Alias
UMLS CUI-1
C0936012
UMLS CUI-2
C0221198
UMLS CUI-3
C0024485
1) Total number of T1 hypointense lesions:
Description

Number of lesions

Data type

integer

Alias
UMLS CUI [1]
C0449791
2) Number of new T1 hypointense lesions:
Description

Number of lesions new

Data type

integer

Alias
UMLS CUI [1,1]
C0449791
UMLS CUI [1,2]
C0205314
3) Total volume of T1 hypointense lesions (mL):
Description

volume lesion

Data type

float

Measurement units
  • ml
Alias
UMLS CUI [1,1]
C0449468
UMLS CUI [1,2]
C0221198
ml
4) Change in volume of T1 hypointense lesions (mL):
Description

volume lesion change

Data type

float

Measurement units
  • ml
Alias
UMLS CUI [1,1]
C0449468
UMLS CUI [1,2]
C0221198
UMLS CUI [1,3]
C0392747
ml
5) Technique reference ( i.e. literature citation(s), MRI Acquisition Manual or Analysis Manual):
Description

reference Technique

Data type

text

Alias
UMLS CUI [1,1]
C0034925
UMLS CUI [1,2]
C0449851
Change in brain volume analysis
Description

Change in brain volume analysis

Alias
UMLS CUI-1
C0936012
UMLS CUI-2
C1113695
UMLS CUI-3
C0392747
1) a. Change in brain volume (mL):
Description

brain volume change

Data type

float

Measurement units
  • ml
Alias
UMLS CUI [1,1]
C1113695
UMLS CUI [1,2]
C0392747
ml
1) a. Change in brain volume (%):
Description

brain volume change

Data type

float

Measurement units
  • %
Alias
UMLS CUI [1,1]
C1113695
UMLS CUI [1,2]
C0392747
%
2) a. Change in brain volume fraction (%):
Description

Volume fraction brain change

Data type

float

Measurement units
  • %
Alias
UMLS CUI [1,1]
C0560268
UMLS CUI [1,2]
C0006104
UMLS CUI [1,3]
C0392747
%
Change in ventricular volume analysis
Description

Change in ventricular volume analysis

Alias
UMLS CUI-1
C0936012
UMLS CUI-2
C1980012
UMLS CUI-3
C0392747
1) a. Change in ventricular volume (mL):
Description

Ventricular volume change

Data type

float

Measurement units
  • ml
Alias
UMLS CUI [1,1]
C1980012
UMLS CUI [1,2]
C0392747
ml
1) a. Change in ventricular volume (%):
Description

Ventricular volume change

Data type

float

Measurement units
  • %
Alias
UMLS CUI [1,1]
C1980012
UMLS CUI [1,2]
C0392747
%
2) a. Change in ventricular volume fraction (ml):
Description

Volume fraction Ventricular change

Data type

float

Measurement units
  • ml
Alias
UMLS CUI [1,1]
C0560268
UMLS CUI [1,2]
C0007799
UMLS CUI [1,3]
C0392747
ml
2) a. Change in ventricular volume fraction (%):
Description

Volume fraction Ventricular change

Data type

float

Measurement units
  • %
Alias
UMLS CUI [1,1]
C0560268
UMLS CUI [1,2]
C0007799
UMLS CUI [1,3]
C0392747
%
Gray matter volume analysis
Description

Gray matter volume analysis

Alias
UMLS CUI-1
C0936012
UMLS CUI-2
C0018220
UMLS CUI-3
C0449468
1) a. Change in gray matter volume
Description

volume Gray matter change

Data type

float

Measurement units
  • %
Alias
UMLS CUI [1,1]
C0449468
UMLS CUI [1,2]
C0018220
UMLS CUI [1,3]
C0392747
%
2) a. Change in gray matter volume fraction (%):
Description

volume fraction Gray matter change

Data type

float

Measurement units
  • %
Alias
UMLS CUI [1,1]
C0560268
UMLS CUI [1,2]
C0018220
UMLS CUI [1,3]
C0392747
%
Gray matter lesions analysis
Description

Gray matter lesions analysis

Alias
UMLS CUI-1
C0936012
UMLS CUI-2
C0018220
UMLS CUI-3
C0221198
1) Number of new gray matter lesions:
Description

Number of lesion gray matter new

Data type

integer

Alias
UMLS CUI [1,1]
C0449791
UMLS CUI [1,2]
C0018220
UMLS CUI [1,3]
C0205314
2) Total number of gray matter lesions:
Description

Number of lesion gray matter

Data type

integer

Alias
UMLS CUI [1,1]
C0449791
UMLS CUI [1,2]
C0018220
3) Total volume of gray matter lesions (mL):
Description

volume Gray matter

Data type

float

Measurement units
  • ml
Alias
UMLS CUI [1,1]
C0449468
UMLS CUI [1,2]
C0018220
ml
4) Change in volume of gray matter lesions (mL):
Description

volume Gray matter change

Data type

float

Measurement units
  • ml
Alias
UMLS CUI [1,1]
C0449468
UMLS CUI [1,2]
C0018220
UMLS CUI [1,3]
C0392747
ml
5) Technique reference for new lesions (i.e. literature citation(s), MRI Acquisition Manual or Analysis Manual. May also include visual observation, detection, etc.):
Description

reference Technique

Data type

text

Alias
UMLS CUI [1,1]
C0034925
UMLS CUI [1,2]
C0449851
White matter volume analysis
Description

White matter volume analysis

Alias
UMLS CUI-1
C0936012
UMLS CUI-2
C0682708
UMLS CUI-3
C0449468
1) a. Change in white matter volume (%):
Description

volume White matter change

Data type

float

Measurement units
  • %
Alias
UMLS CUI [1,1]
C0449468
UMLS CUI [1,2]
C0682708
UMLS CUI [1,3]
C0392747
%
2) a. Change in white matter volume fraction (%):
Description

volume fraction White matter change

Data type

float

Measurement units
  • %
Alias
UMLS CUI [1,1]
C0560268
UMLS CUI [1,2]
C0682708
UMLS CUI [1,3]
C0392747
%
3) Change in normal appearing white matter - complete as many times as needed (%):
Description

white matter appearance change

Data type

float

Measurement units
  • %
Alias
UMLS CUI [1,1]
C0682708
UMLS CUI [1,2]
C0700364
UMLS CUI [1,3]
C0392747
%
a. Timepoint: [Add protocol-specific options]
Description

Timepoint

Data type

time

Alias
UMLS CUI [1]
C2348792
Regional volumetric analysis
Description

Regional volumetric analysis

Alias
UMLS CUI-1
C3825502
UMLS CUI-2
C0205147
1) a. Change in central cerebral volume (mL):
Description

volume cerebral change

Data type

float

Measurement units
  • ml
Alias
UMLS CUI [1,1]
C0449468
UMLS CUI [1,2]
C0006104
UMLS CUI [1,3]
C0392747
ml
2) a. Change in cortical thickness (mm):
Description

Cortical thickness

Data type

float

Measurement units
  • mm
mm
3) Brain structure volumes i) Change in hippocampus (mL):
Description

volume Hippocampus change

Data type

float

Measurement units
  • ml
Alias
UMLS CUI [1,1]
C0449468
UMLS CUI [1,2]
C0019564
UMLS CUI [1,3]
C0392747
ml
i. Change in thalamus (mL):
Description

volume Thalamus change

Data type

float

Measurement units
  • ml
Alias
UMLS CUI [1,1]
C0449468
UMLS CUI [1,2]
C0039729
UMLS CUI [1,3]
C0392747
ml
Spinal cord lesions analysis
Description

Spinal cord lesions analysis

Alias
UMLS CUI-1
C0936012
UMLS CUI-2
C0241224
1) Total number of spinal cord lesions:
Description

Number of lesion spinal cord lesions

Data type

integer

Alias
UMLS CUI [1,1]
C0449791
UMLS CUI [1,2]
C0241224
2) Spinal cord lesion region (mention all that apply: C1-C7 ; T1-T12; L1-L5 ):
Description

region Spinal cord lesion

Data type

text

Alias
UMLS CUI [1,1]
C1515974
UMLS CUI [1,2]
C0241224
3) Spinal cord lesions location (mention all that apply: Anterior; Posterior; Lateral ):
Description

location Spinal cord lesions

Data type

text

Alias
UMLS CUI [1,1]
C0450429
UMLS CUI [1,2]
C0241224
4) Spinal cord area
Description

area Spinal cord

Data type

float

Measurement units
  • mm2
Alias
UMLS CUI [1,1]
C2586162
UMLS CUI [1,2]
C0037925
mm2
4) Spinal cord Volume
Description

Volume Spinal cord

Data type

float

Measurement units
  • ml
Alias
UMLS CUI [1,1]
C2700258
UMLS CUI [1,2]
C0037925
ml
5) Technique reference (i.e. literature citation(s), MRI Acquisition Manual or Analysis Manual):
Description

reference Technique

Data type

text

Alias
UMLS CUI [1,1]
C0034925
UMLS CUI [1,2]
C0449851
Tissue Integrity Measures MTR – specify units and values Table
Description

Tissue Integrity Measures MTR – specify units and values Table

Alias
UMLS CUI-1
C0518718
UMLS CUI-2
C0079809
UMLS CUI-3
C2584640
UMLS CUI-4
C0456603
Mean MTR unit
Description

MTR Mean

Data type

text

Alias
UMLS CUI [1,1]
C2584640
UMLS CUI [1,2]
C0456603
UMLS CUI [1,3]
C0444504
Whole brain
Description

brain

Data type

text

Alias
UMLS CUI [1]
C0006104
Normal Appearing WM
Description

WM Normal Appearing

Data type

text

Alias
UMLS CUI [1,1]
C0682708
UMLS CUI [1,2]
C0205307
Normal Appearing GM
Description

GM Normal Appearing

Data type

text

Alias
UMLS CUI [1,1]
C0018220
UMLS CUI [1,2]
C0205307
MTR histogram peak position unit
Description

MTR histogram peak position

Data type

text

Alias
UMLS CUI [1,1]
C2584640
UMLS CUI [1,2]
C0456603
UMLS CUI [1,3]
C2348974
UMLS CUI [1,4]
C0444505
UMLS CUI [1,5]
C0733755
Whole brain
Description

brain

Data type

text

Alias
UMLS CUI [1]
C0006104
Normal Appearing WM
Description

WM Normal Appearing

Data type

text

Alias
UMLS CUI [1,1]
C0682708
UMLS CUI [1,2]
C0205307
Normal Appearing GM
Description

GM Normal Appearing

Data type

text

Alias
UMLS CUI [1,1]
C0018220
UMLS CUI [1,2]
C0205307
MTR histogram peak height unit
Description

MTR histogram peak height

Data type

text

Alias
UMLS CUI [1,1]
C2584640
UMLS CUI [1,2]
C0456603
UMLS CUI [1,3]
C2348974
UMLS CUI [1,4]
C0444505
UMLS CUI [1,5]
C0489786
Whole brain
Description

brain

Data type

text

Alias
UMLS CUI [1]
C0006104
Normal Appearing WM
Description

WM Normal Appearing

Data type

text

Alias
UMLS CUI [1,1]
C0682708
UMLS CUI [1,2]
C0205307
Normal Appearing GM
Description

GM Normal Appearing

Data type

text

Alias
UMLS CUI [1,1]
C0018220
UMLS CUI [1,2]
C0205307
DTI – specify units and values
Description

DTI – specify units and values

Alias
UMLS CUI-1
C1537007
Mean FA unit
Description

Mean FA unit

Data type

text

Whole brain
Description

brain

Data type

text

Alias
UMLS CUI [1]
C0006104
Normal Appearing WM
Description

WM Normal Appearing

Data type

text

Alias
UMLS CUI [1,1]
C0682708
UMLS CUI [1,2]
C0205307
Normal Appearing GM
Description

GM Normal Appearing

Data type

text

Alias
UMLS CUI [1,1]
C0018220
UMLS CUI [1,2]
C0205307
Mean ADC unit
Description

Mean ADC unit

Data type

text

Whole brain
Description

brain

Data type

text

Alias
UMLS CUI [1]
C0006104
Normal Appearing WM
Description

WM Normal Appearing

Data type

text

Alias
UMLS CUI [1,1]
C0682708
UMLS CUI [1,2]
C0205307
Normal Appearing GM
Description

GM Normal Appearing

Data type

text

Alias
UMLS CUI [1,1]
C0018220
UMLS CUI [1,2]
C0205307
Mean axial diffusivity unit
Description

Mean axial diffusivity unit

Data type

text

Whole brain
Description

brain

Data type

text

Alias
UMLS CUI [1]
C0006104
Normal Appearing WM
Description

WM Normal Appearing

Data type

text

Alias
UMLS CUI [1,1]
C0682708
UMLS CUI [1,2]
C0205307
Normal Appearing GM
Description

GM Normal Appearing

Data type

text

Alias
UMLS CUI [1,1]
C0018220
UMLS CUI [1,2]
C0205307
Mean radial diffusivity unit
Description

Mean radial diffusivity unit

Data type

text

Whole brain
Description

brain

Data type

text

Alias
UMLS CUI [1]
C0006104
Normal Appearing WM
Description

WM Normal Appearing

Data type

text

Alias
UMLS CUI [1,1]
C0682708
UMLS CUI [1,2]
C0205307
Normal Appearing GM
Description

GM Normal Appearing

Data type

text

Alias
UMLS CUI [1,1]
C0018220
UMLS CUI [1,2]
C0205307
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Similar models

Imaging Analysis Technique and Results – Follow Up

1 forms
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
T2 LESIONS ANALYSIS
C0936012 (UMLS CUI-1)
C0221198 (UMLS CUI-2)
C0024485 (UMLS CUI-3)
Study ID
Item
Study ID
integer
C2826693 (UMLS CUI [1])
Study site name
Item
Study site name
text
C2825164 (UMLS CUI [1])
Subject ID
Item
Subject ID
integer
C2348585 (UMLS CUI [1])
Date of MRI
Item
Date of MRI
date
C0011008 (UMLS CUI [1,1])
C0024485 (UMLS CUI [1,2])
volume brain lesions
Item
1) Total volume of brain lesions on T2W image (cc):
float
C0449468 (UMLS CUI [1,1])
C0221505 (UMLS CUI [1,2])
Number of lesions volume
Item
2) Change in T2 lesion(s) volume (mL); a. Total number of T2 lesions:
float
C0449791 (UMLS CUI [1,1])
C0449468 (UMLS CUI [1,2])
Number of lesions regional
Item
3) Number of new or enlarging non-enhancing T2 lesions:
integer
C0449791 (UMLS CUI [1,1])
C0205147 (UMLS CUI [1,2])
Number of lesions regional periventricular lesions
Item
i. Number of periventricular lesions:
integer
C0449791 (UMLS CUI [1,1])
C0205147 (UMLS CUI [1,2])
C3277690 (UMLS CUI [1,3])
Number of lesions regional juxtacortical lesions
Item
ii. Number of juxtacortical lesions:
integer
Number of lesions regional posterior fossa
Item
iii. Number of posterior fossa lesions:
integer
C0449791 (UMLS CUI [1,1])
C0205147 (UMLS CUI [1,2])
C1116439 (UMLS CUI [1,3])
Number of lesions regional cortical
Item
iv. Number of cortical lesions:
integer
C0449791 (UMLS CUI [1,1])
C0205147 (UMLS CUI [1,2])
C0007776 (UMLS CUI [1,3])
Number of lesions regional thalamus
Item
v. Number of thalamus lesions:
integer
C0449791 (UMLS CUI [1,1])
C0205147 (UMLS CUI [1,2])
C0039729 (UMLS CUI [1,3])
Number of lesions regional basal ganglia
Item
vi. Number of basal ganglia lesions:
integer
C0449791 (UMLS CUI [1,1])
C0205147 (UMLS CUI [1,2])
C0004781 (UMLS CUI [1,3])
Number of lesions regional
Item
vii. Number of other lesions whose type is not specified:
integer
C0449791 (UMLS CUI [1,1])
C0205147 (UMLS CUI [1,2])
reference Technique
Item
4) Technique reference for new lesions (i.e. literature citation(s), MRI Acquisition Manual or Analysis Manual. May also include visual observation, detection, etc.):
text
C0034925 (UMLS CUI [1,1])
C0449851 (UMLS CUI [1,2])
Item Group
GD-ENHANCING LESIONS ANALYSIS
C0936012 (UMLS CUI-1)
C1333400 (UMLS CUI-2)
Number of lesions Gd-enhancing lesions
Item
1) Total number of Gd-enhancing lesions:
integer
C0449791 (UMLS CUI [1,1])
C1333400 (UMLS CUI [1,2])
Gd-enhancing lesions new
Item
2) Number of NEW Gd-enhancing lesions:
integer
C1333400 (UMLS CUI [1,1])
C0205314 (UMLS CUI [1,2])
volume Gd-enhancing lesions
Item
3) Total volume of all Gd-enhancing lesions (cc):
float
C0449468 (UMLS CUI [1,1])
C1333400 (UMLS CUI [1,2])
volume Gd-enhancing lesions change
Item
4) Change in volume of all Gd-enhancing lesions (cc):
float
C0449468 (UMLS CUI [1,1])
C1333400 (UMLS CUI [1,2])
C0392747 (UMLS CUI [1,3])
reference Technique
Item
5) Technique reference (i.e. literature citation(s), MRI Acquisition Manual or Analysis Manual):
text
C0034925 (UMLS CUI [1,1])
C0449851 (UMLS CUI [1,2])
Item Group
Combined Unique Active lesions
C0221198 (UMLS CUI-1)
C0205195 (UMLS CUI-2)
C1710548 (UMLS CUI-3)
C0205177 (UMLS CUI-4)
lesions Combined Unique Active
Item
1) Number of CUA lesions compared to previous time-point:
integer
C0221198 (UMLS CUI [1,1])
C0205195 (UMLS CUI [1,2])
C1710548 (UMLS CUI [1,3])
C0205177 (UMLS CUI [1,4])
reference Technique
Item
2) Technique reference for new lesions (i.e. literature citation(s), MRI Acquisition Manual or Analysis Manual. May also include visual observation, detection, etc.):
text
C0034925 (UMLS CUI [1,1])
C0449851 (UMLS CUI [1,2])
Item Group
T1 HYPOINTENSE LESIONS ANALYSIS
C0936012 (UMLS CUI-1)
C0221198 (UMLS CUI-2)
C0024485 (UMLS CUI-3)
Number of lesions
Item
1) Total number of T1 hypointense lesions:
integer
C0449791 (UMLS CUI [1])
Number of lesions new
Item
2) Number of new T1 hypointense lesions:
integer
C0449791 (UMLS CUI [1,1])
C0205314 (UMLS CUI [1,2])
volume lesion
Item
3) Total volume of T1 hypointense lesions (mL):
float
C0449468 (UMLS CUI [1,1])
C0221198 (UMLS CUI [1,2])
volume lesion change
Item
4) Change in volume of T1 hypointense lesions (mL):
float
C0449468 (UMLS CUI [1,1])
C0221198 (UMLS CUI [1,2])
C0392747 (UMLS CUI [1,3])
reference Technique
Item
5) Technique reference ( i.e. literature citation(s), MRI Acquisition Manual or Analysis Manual):
text
C0034925 (UMLS CUI [1,1])
C0449851 (UMLS CUI [1,2])
Item Group
Change in brain volume analysis
C0936012 (UMLS CUI-1)
C1113695 (UMLS CUI-2)
C0392747 (UMLS CUI-3)
brain volume change
Item
1) a. Change in brain volume (mL):
float
C1113695 (UMLS CUI [1,1])
C0392747 (UMLS CUI [1,2])
brain volume change
Item
1) a. Change in brain volume (%):
float
C1113695 (UMLS CUI [1,1])
C0392747 (UMLS CUI [1,2])
Volume fraction brain change
Item
2) a. Change in brain volume fraction (%):
float
C0560268 (UMLS CUI [1,1])
C0006104 (UMLS CUI [1,2])
C0392747 (UMLS CUI [1,3])
Item Group
Change in ventricular volume analysis
C0936012 (UMLS CUI-1)
C1980012 (UMLS CUI-2)
C0392747 (UMLS CUI-3)
Ventricular volume change
Item
1) a. Change in ventricular volume (mL):
float
C1980012 (UMLS CUI [1,1])
C0392747 (UMLS CUI [1,2])
Ventricular volume change
Item
1) a. Change in ventricular volume (%):
float
C1980012 (UMLS CUI [1,1])
C0392747 (UMLS CUI [1,2])
Volume fraction Ventricular change
Item
2) a. Change in ventricular volume fraction (ml):
float
C0560268 (UMLS CUI [1,1])
C0007799 (UMLS CUI [1,2])
C0392747 (UMLS CUI [1,3])
Volume fraction Ventricular change
Item
2) a. Change in ventricular volume fraction (%):
float
C0560268 (UMLS CUI [1,1])
C0007799 (UMLS CUI [1,2])
C0392747 (UMLS CUI [1,3])
Item Group
Gray matter volume analysis
C0936012 (UMLS CUI-1)
C0018220 (UMLS CUI-2)
C0449468 (UMLS CUI-3)
volume Gray matter change
Item
1) a. Change in gray matter volume
float
C0449468 (UMLS CUI [1,1])
C0018220 (UMLS CUI [1,2])
C0392747 (UMLS CUI [1,3])
volume fraction Gray matter change
Item
2) a. Change in gray matter volume fraction (%):
float
C0560268 (UMLS CUI [1,1])
C0018220 (UMLS CUI [1,2])
C0392747 (UMLS CUI [1,3])
Item Group
Gray matter lesions analysis
C0936012 (UMLS CUI-1)
C0018220 (UMLS CUI-2)
C0221198 (UMLS CUI-3)
Number of lesion gray matter new
Item
1) Number of new gray matter lesions:
integer
C0449791 (UMLS CUI [1,1])
C0018220 (UMLS CUI [1,2])
C0205314 (UMLS CUI [1,3])
Number of lesion gray matter
Item
2) Total number of gray matter lesions:
integer
C0449791 (UMLS CUI [1,1])
C0018220 (UMLS CUI [1,2])
volume Gray matter
Item
3) Total volume of gray matter lesions (mL):
float
C0449468 (UMLS CUI [1,1])
C0018220 (UMLS CUI [1,2])
volume Gray matter change
Item
4) Change in volume of gray matter lesions (mL):
float
C0449468 (UMLS CUI [1,1])
C0018220 (UMLS CUI [1,2])
C0392747 (UMLS CUI [1,3])
reference Technique
Item
5) Technique reference for new lesions (i.e. literature citation(s), MRI Acquisition Manual or Analysis Manual. May also include visual observation, detection, etc.):
text
C0034925 (UMLS CUI [1,1])
C0449851 (UMLS CUI [1,2])
Item Group
White matter volume analysis
C0936012 (UMLS CUI-1)
C0682708 (UMLS CUI-2)
C0449468 (UMLS CUI-3)
volume White matter change
Item
1) a. Change in white matter volume (%):
float
C0449468 (UMLS CUI [1,1])
C0682708 (UMLS CUI [1,2])
C0392747 (UMLS CUI [1,3])
volume fraction White matter change
Item
2) a. Change in white matter volume fraction (%):
float
C0560268 (UMLS CUI [1,1])
C0682708 (UMLS CUI [1,2])
C0392747 (UMLS CUI [1,3])
white matter appearance change
Item
3) Change in normal appearing white matter - complete as many times as needed (%):
float
C0682708 (UMLS CUI [1,1])
C0700364 (UMLS CUI [1,2])
C0392747 (UMLS CUI [1,3])
Timepoint
Item
a. Timepoint: [Add protocol-specific options]
time
C2348792 (UMLS CUI [1])
Item Group
Regional volumetric analysis
C3825502 (UMLS CUI-1)
C0205147 (UMLS CUI-2)
volume cerebral change
Item
1) a. Change in central cerebral volume (mL):
float
C0449468 (UMLS CUI [1,1])
C0006104 (UMLS CUI [1,2])
C0392747 (UMLS CUI [1,3])
Cortical thickness
Item
2) a. Change in cortical thickness (mm):
float
volume Hippocampus change
Item
3) Brain structure volumes i) Change in hippocampus (mL):
float
C0449468 (UMLS CUI [1,1])
C0019564 (UMLS CUI [1,2])
C0392747 (UMLS CUI [1,3])
volume Thalamus change
Item
i. Change in thalamus (mL):
float
C0449468 (UMLS CUI [1,1])
C0039729 (UMLS CUI [1,2])
C0392747 (UMLS CUI [1,3])
Item Group
Spinal cord lesions analysis
C0936012 (UMLS CUI-1)
C0241224 (UMLS CUI-2)
Number of lesion spinal cord lesions
Item
1) Total number of spinal cord lesions:
integer
C0449791 (UMLS CUI [1,1])
C0241224 (UMLS CUI [1,2])
region Spinal cord lesion
Item
2) Spinal cord lesion region (mention all that apply: C1-C7 ; T1-T12; L1-L5 ):
text
C1515974 (UMLS CUI [1,1])
C0241224 (UMLS CUI [1,2])
location Spinal cord lesions
Item
3) Spinal cord lesions location (mention all that apply: Anterior; Posterior; Lateral ):
text
C0450429 (UMLS CUI [1,1])
C0241224 (UMLS CUI [1,2])
area Spinal cord
Item
4) Spinal cord area
float
C2586162 (UMLS CUI [1,1])
C0037925 (UMLS CUI [1,2])
Volume Spinal cord
Item
4) Spinal cord Volume
float
C2700258 (UMLS CUI [1,1])
C0037925 (UMLS CUI [1,2])
reference Technique
Item
5) Technique reference (i.e. literature citation(s), MRI Acquisition Manual or Analysis Manual):
text
C0034925 (UMLS CUI [1,1])
C0449851 (UMLS CUI [1,2])
Item Group
Tissue Integrity Measures MTR – specify units and values Table
C0518718 (UMLS CUI-1)
C0079809 (UMLS CUI-2)
C2584640 (UMLS CUI-3)
C0456603 (UMLS CUI-4)
MTR Mean
Item
Mean MTR unit
text
C2584640 (UMLS CUI [1,1])
C0456603 (UMLS CUI [1,2])
C0444504 (UMLS CUI [1,3])
brain
Item
Whole brain
text
C0006104 (UMLS CUI [1])
WM Normal Appearing
Item
Normal Appearing WM
text
C0682708 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
GM Normal Appearing
Item
Normal Appearing GM
text
C0018220 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
MTR histogram peak position
Item
MTR histogram peak position unit
text
C2584640 (UMLS CUI [1,1])
C0456603 (UMLS CUI [1,2])
C2348974 (UMLS CUI [1,3])
C0444505 (UMLS CUI [1,4])
C0733755 (UMLS CUI [1,5])
brain
Item
Whole brain
text
C0006104 (UMLS CUI [1])
WM Normal Appearing
Item
Normal Appearing WM
text
C0682708 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
GM Normal Appearing
Item
Normal Appearing GM
text
C0018220 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
MTR histogram peak height
Item
MTR histogram peak height unit
text
C2584640 (UMLS CUI [1,1])
C0456603 (UMLS CUI [1,2])
C2348974 (UMLS CUI [1,3])
C0444505 (UMLS CUI [1,4])
C0489786 (UMLS CUI [1,5])
brain
Item
Whole brain
text
C0006104 (UMLS CUI [1])
WM Normal Appearing
Item
Normal Appearing WM
text
C0682708 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
GM Normal Appearing
Item
Normal Appearing GM
text
C0018220 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
Item Group
DTI – specify units and values
C1537007 (UMLS CUI-1)
Mean FA unit
Item
Mean FA unit
text
brain
Item
Whole brain
text
C0006104 (UMLS CUI [1])
WM Normal Appearing
Item
Normal Appearing WM
text
C0682708 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
GM Normal Appearing
Item
Normal Appearing GM
text
C0018220 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
Mean ADC unit
Item
Mean ADC unit
text
brain
Item
Whole brain
text
C0006104 (UMLS CUI [1])
WM Normal Appearing
Item
Normal Appearing WM
text
C0682708 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
GM Normal Appearing
Item
Normal Appearing GM
text
C0018220 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
Mean axial diffusivity unit
Item
Mean axial diffusivity unit
text
brain
Item
Whole brain
text
C0006104 (UMLS CUI [1])
WM Normal Appearing
Item
Normal Appearing WM
text
C0682708 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
GM Normal Appearing
Item
Normal Appearing GM
text
C0018220 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
Mean radial diffusivity unit
Item
Mean radial diffusivity unit
text
brain
Item
Whole brain
text
C0006104 (UMLS CUI [1])
WM Normal Appearing
Item
Normal Appearing WM
text
C0682708 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
GM Normal Appearing
Item
Normal Appearing GM
text
C0018220 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
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