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dbGaP phs001219 Detection of Genes Predisposing to Hematologic Malignancies - pht007857.v1.p1

- 26/04/23 - 6 moduli, 1 ItemGroup, 2 elementi, 1 linguaggio

ItemGroup: pht007857

Principal Investigator: Neil E. Caporaso, MD, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA MeSH: Leukemia, Lymphocytic, Chronic, B-Cell,Hodgkin Disease,Lymphoma, Non-Hodgkin,Waldenstrom Macroglobulinemia,Leukemia, Hairy Cell,Leukemia, Myeloid, Acute,Leukemia, Myelomonocytic, Juvenile https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001219 We have been conducting genetic studies on families at high risk of different hematologic malignancies, in order to define the related tumors in the families, define precursor and other related conditions, and map and identify susceptibility genes. We have focused mainly on four types of lymphoid malignancies: chronic lymphocytic leukemia (CLL), Hodgkin lymphoma (HL), non-Hodgkin lymphoma (NHL), and Waldenström macroglobulinemia (WM). A few families with a rare lymphoma subtype, hairy cell leukemia (HCL) are included. In addition, single large pedigrees with acute myeloid leukemia (AML), and juvenile myelomocytic leukemia (JMML) are included. Families are ascertained for having at least two patients with the same hematologic malignancy and are classified by the type of malignancy that predominates in the family. Multiple types of lymphoid malignancies are often found in the same family. Other data has shown that these conditions aggregate together in families. Verification of cancer diagnoses is obtained through medical records, pathology reports, and flow cytometry. Family members with precursor traits are also included, monoclonal B-cell lymphocytosis (MBL) in CLL families and IgM monoclonal gammopathy of undetermined significance (MGUS) in WM families.

dbGaP phs000671 Somatic Mutations in Variant and IGHV4-34 Expressing Hairy Cell Leukemia - pht003546.v1.p1

- 09/01/23 - 5 moduli, 1 ItemGroup, 3 elementi, 1 linguaggio

ItemGroup: pht003546

Principal Investigator: Paul S. Meltzer, PhD, MD, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA MeSH: Leukemia, Hairy Cell https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000671 To understand the genetic mechanisms driving variant and IGHV4-34 expressing hairy-cell leukemia, we performed whole exome sequencing of tumor/normal pairs from ten patients.

Leukemia, Hairy Cell

Klinische Dokumentation Med. V - Follow Up CLL/HCL - Klinische Dokumentation Med. V CLL/HCL

- 31/01/22 - 1 modulo, 9 itemgroups, 68 elementi, 2 lingue

Itemgroups: Patienten-Stammdaten, Diagnose: CLL/ HCL, Charakteristika bei Erstdiagnose, Zytogenetik und Mutationsstatus, Nebendiagnosen, Biobank, Aktuelle Diagnostik, Aktueller Patientenstatus, Therapieverlauf

Dokumentation des Follow-Up für Patienten mit CLL/HCL am Universitätsklinikum Heidelberg. Prof. Dr. med. Sascha Dietrich; Dr. med. Tim Sauer; Medizinischen Klinik V - Klinik für Hämatologie, Onkologie, Rheumatologie - Universitätsklinikum Heidelberg

Eligibility Hairy Cell Leukemia (HCL) NCT01087333

- 22/12/19 - 1 modulo, 2 itemgroups, 22 elementi, 1 linguaggio

Itemgroups: Criteria, Exclusion Criteria

Collection of Human Samples to Study Hairy Cell and Other Leukemias, and to Develop Recombinant Immunotoxins for Cancer Treatment; ODM derived from: https://clinicaltrials.gov/show/NCT01087333

Eligibility Hairy Cell Leukemia NCT00001567

- 24/02/16 - 1 modulo, 1 ItemGroup, 15 elementi, 1 linguaggio

ItemGroup: Criteria

A Phase II Efficacy Study of Roferon-A in Hairy Cell Leukemia; ODM derived from: https://clinicaltrials.gov/show/NCT00001567

Eligibility Leukemia NCT00003746

- 11/01/16 - 1 modulo, 1 ItemGroup, 12 elementi, 1 linguaggio

ItemGroup: Criteria

Daily or Weekly Cladribine in Treating Patients With Hairy Cell Leukemia; ODM derived from: https://clinicaltrials.gov/show/NCT00003746

Toxicity - Hairy Cell Leukemia (HCL) - Adverse Event Form - 2019371v3.0 - Hairy Cell Leukemia (HCL) - Adverse Event Form

- 09/01/15 - 1 modulo, 4 itemgroups, 25 elementi, 1 linguaggio

Itemgroups: CRF Header, HCL: Form Administration, HCL: Adverse Events, Comments

Hairy Cell Leukemia (HCL) - Adverse Event Form Source Form: NCI FormBuilder: https://formbuilder.nci.nih.gov/FormBuilder/formDetailsAction.do?method=getFormDetails&formIdSeq=1A9D318C-7E76-6C12-E044-0003BA3F9857

On-Study - Hairy Cell Leukemia (HCL) - On-Study Form - Previously Untreated Patients - 2019401v3.0 - Hairy Cell Leukemia (HCL) - On-Study Form - Previously Untreated Patients

- 09/01/15 - 1 modulo, 4 itemgroups, 27 elementi, 1 linguaggio

Itemgroups: CRF Header, HCL: Form Administration, HCL: Disease Description, Comments

Hairy Cell Leukemia (HCL) - On-Study Form - Previously Untreated Patients Source Form: NCI FormBuilder: https://formbuilder.nci.nih.gov/FormBuilder/formDetailsAction.do?method=getFormDetails&formIdSeq=1B4E6D15-F366-6825-E044-0003BA3F9857

On-Study - Hairy Cell Leukemia (HCL) - On-Study Form - Relapse/Refractory Treatment - 2019360v3.0 - Hairy Cell Leukemia (HCL) - On-Study Form - Relapse/Refractory Treatment

- 09/01/15 - 1 modulo, 4 itemgroups, 30 elementi, 1 linguaggio

Itemgroups: CRF Header, HCL: Form Administration, HCL: Disease Description, Comments

Hairy Cell Leukemia (HCL) - On-Study Form - Relapse/Refractory Treatment Source Form: NCI FormBuilder: https://formbuilder.nci.nih.gov/FormBuilder/formDetailsAction.do?method=getFormDetails&formIdSeq=1B4E70DB-BC4A-6870-E044-0003BA3F9857

Follow-Up - Hairy Cell Leukemia (HCL) - Follow-Up Form - 2019377v3.0 - Hairy Cell Leukemia (HCL) - Follow-Up Form

- 08/01/15 - 1 modulo, 6 itemgroups, 32 elementi, 1 linguaggio

Itemgroups: CRF Header, HCL: Form Administration, HCL: Vital Status, HCL: Disease Follow-Up Status, HCL: Notice of Progression, Comments

Hairy Cell Leukemia (HCL) - Follow-Up Form Source Form: NCI FormBuilder: https://formbuilder.nci.nih.gov/FormBuilder/formDetailsAction.do?method=getFormDetails&formIdSeq=1AADC1DC-7623-1FD6-E044-0003BA3F9857

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dbGaP phs001219 Detection of Genes Predisposing to Hematologic Malignancies - pht007857.v1.p1

pht007858.v1.p1

Eligibility

pht007859.v1.p1

pht007860.v1.p1

pht007861.v1.p1