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dbGaP phs001053 NEI Exfoliation Genotyping Study - Eligibility

- 27/02/2024 - 6 Formulaires, 1 Groupe Item, 2 Eléments de données, 1 Langue
Groupe Item: IG.elig
Principal Investigator: Janey L. Wiggs, MD PhD, Massachusetts Eye and Ear, Harvard Medical School, Boston MA USA MeSH: Glaucoma,Exfoliation Syndrome https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001053 The overall goal of our research is to elucidate the pathogenesis of exfoliation syndrome and the associated glaucoma, making it possible to implement effective screening and prevention strategies and to develop novel therapies. Cases genotyped for this project are from the Nurses Health Study (NHS), the Health Professionals Follow-up Study (HPFS), the Women's Genome Health Study (WGHS), the Massachusetts Eye and Ear Infirmary (MEEI), Mayo Clinic, the University of Iowa, the University of Miami and Duke University Medical Center. Exfoliation syndrome (XFS) is a common condition that is a major risk factor for high-tension open-angle glaucoma, pre-mature cataract formation, and increased risk of complications during cataract surgery. Previous studies suggest that exfoliation syndrome and the related glaucoma (XFG) are genetically complex, and one gene, LOXL1, has been identified as a major genetic risk factor. LOXL1 variants are found in up to 98% of affected patients; however, these same variants are also present in up to 80% of unaffected individuals, indicating that additional genetic and/or environmental factors are necessary for disease development. Samples genotyped for this study are a case set (1,096 samples) and 24 pedigrees (98 samples). Controls for association analyses are selected from the NEIGHBORHOOD study.

pht007229.v1.p1

1 Groupe Item 4 Eléments de données

pht007231.v1.p1

1 Groupe Item 5 Eléments de données

pht007232.v1.p1

1 Groupe Item 5 Eléments de données

pht007233.v1.p1

1 Groupe Item 5 Eléments de données

pht007230.v1.p1

1 Groupe Item 6 Eléments de données

Eligibility NCT00856622 Ocular Hypertension - Eligibility

- 20/09/2021 - 1 Formulaire, 2 Groupes Item, 15 Eléments de données, 2 Langues
Groupes Item: Inclusion Criteria, Exclusion Criteria
ODM derived from http://clinicaltrials.gov/show/NCT00856622

Registry of Glaucoma in Adults (planned), Department of Ophthalmology, University Medical Center Mainz - Ophthalmic Examination (Preliminary)

- 12/06/2018 - 1 Formulaire, 11 Groupes Item, 43 Eléments de données, 1 Langue
Groupes Item: Administrative Data, Visual acuity, Intraocular Pressure, Visual field, OCT, HRT, Examination of anterior segment of the eye, Examination of Fundus of Eye, Phenotype of Glaucoma, Glaucoma detection in Screening, Ocular Comorbidities
Items planned for use in a (future) Registry of Glaucoma in Adults by Department of Ophthalmology, University Medical Center Mainz, for documentation of ophthalmic examination findings. Status of the form: preliminary, needs revision Aims: Good phenotyping with exactly defined criteria for clinical trials. Collection of pre- and postoperative morphological and functional parameters, intraocular pressure as well as conservative and surgical treatments. Health Services Research Description of the situation of the medical care for outpatients. It is assumed that 95% of glaucoma patients are treated conservatively. It is unclear how often the patients are controlled ophthalmologically in everyday medical care, including visual field controls, tolerability of medication and its side effects. * Description of findings that lead to first treatment of glaucoma * Description of frequency of ophthalmological controls in glaucoma patients (quarterly, biannual, etc.) including further diagnostics (IOP: measurement and diurnal profile, visual field determination, morphometric diagnostics of the optic disc) * Description of the first treatment and its influence on IOP and visual field defects under everyday conditions * Evaluation of criteria that lead to a switch or addition of treatment * Evaluation of criteria that lead to discontinuation of a treatment

Registry of Glaucoma in Adults (planned), Department of Ophthalmology, University Medical Center Mainz - Medical History / Anamnese (preliminary)

- 12/06/2018 - 1 Formulaire, 6 Groupes Item, 17 Eléments de données, 1 Langue
Groupes Item: Administrative Data, Glaucoma Screening, Family History, Glaucoma History, Local Therapy, Surgical Treatment History of Glaucoma
Items planned for use in a (future) Registry of Glaucoma in Adults by Department of Ophthalmology, University Medical Center Mainz, for Medical History Taking. Status of the form: preliminary, needs revision Aims: Good phenotyping with exactly defined criteria for clinical trials. Collection of pre- and postoperative morphological and functional parameters, intraocular pressure as well as conservative and surgical treatments. Health Services Research Description of the situation of the medical care for outpatients. It is assumed that 95% of glaucoma patients are treated conservatively. It is unclear how often the patients are controlled ophthalmologically in everyday medical care, including visual field controls, tolerability of medication and its side effects. * Description of findings that lead to first treatment of glaucoma * Description of frequency of ophthalmological controls in glaucoma patients (quarterly, biannual, etc.) including further diagnostics (IOP: measurement and diurnal profile, visual field determination, morphometric diagnostics of the optic disc) * Description of the first treatment and its influence on IOP and visual field defects under everyday conditions * Evaluation of criteria that lead to a switch or addition of treatment * Evaluation of criteria that lead to discontinuation of a treatment

Registry of Children's Glaucoma, Department of Ophthalmology, University Medical Center Mainz - Examination under anaesthesia (NKU) Form

- 04/06/2018 - 1 Formulaire, 11 Groupes Item, 69 Eléments de données, 1 Langue
Groupes Item: Eye examination under anesthesia, Intraocular Pressure, Eye refractometry, Keratometry, Corneal diameter, Corneal Pachymetry, Anterior eyeball segment, examination fundus, Gonioscopy, Congenital Glaucoma, diagnosis
Form used for the documentation of an eye examination under (general) anesthesia for the Registry of Children's Glaucoma by Department of Ophthalmology, University Medical Center Mainz. ODM derived from original form NKUbogen20161116AS supplied by Center for Ophthalmological Epidemiology and Health Services Research, University Medical Center Mainz

Registry of Children's Glaucoma, Department of Ophthalmology, University Medical Center Mainz - Medical History Form

- 04/06/2018 - 1 Formulaire, 1 Groupe Item, 24 Eléments de données, 1 Langue
Groupe Item: Medical History
Form used for the documentation of Medical History for the Registry of Children's Glaucoma by the Department of Ophthalmology, University Medical Center Mainz. ODM derived from original form Anamnesebogen20161116, v1.0, supplied by Center for Ophthalmological Epidemiology and Health Services Research, University Medical Center Mainz

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