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LEOSS: Lean European Open Survey on SARS-CoV-2 Infected Patients - Neurological sub-cohort

- 7/16/21 - 23 forms, 24 itemgroups, 156 items, 1 language
Itemgroups: Duration of neurological comorbidity, Neurological medication before SARS-CoV-2 infection, Neurological status, Specification of neurological comorbidities, Cerebrovascular disease, Cerebrovascular disease: Medication, Multiple Sclerosis subtype & severity, Multiple Sclerosis: Immunomodulatory medication at Baseline, MS: Immunosuppression discontinuation in context of COVID-19, Recent MS relapse treatment, Neurodegeneration, Cognitive / neuropsychiatric impairment during COVID-19 infection, Visual impairment during COVID-19, Oculomotoric impairment during COVID-19 infection, Paresis during COVID-19 infection, Abnormal muscle reflexes during COVID-19 infection, Sensory deficit during COVID-19 infection, Other neurological findings during COVID-19 infection, Neurological diagnostics; Imaging, Neurological diagnostics: EEG, Neurological diagnostics: Electrophysiology, Neurological diagnostics: Spinal tap, Neurological diagnostics: Spinal tap - pathogens, Is data entry for this section finished?
Study Title: LEOSS: Lean European Open Survey on SARS-CoV-2 Infected Patients https://leoss.net Study Indication: COVID-19 Date: 19.03.2021 Published with permission by Prof. Dr. med. J.-J. Vehreschild. LEOSS, a multi-center cohort study, has been created to get more in-depth knowledge about the epidemiology and clinical course of patients infected with SARS-CoV-2. Initiated by the ESCMID Emerging Infections Task Force (EITaF) and the German Infectious Disease Society, and supported by all German Centers for Health Research (DZG), LEOSS has developed into an international network of contributors. Via an integrative research approach with anonymous recruitment and collection of routine data in an open science context, LEOSS is building a uniform clinical dataset and providing real-time analyses. For more information feel free to explore https://leoss.net/. Please note that only cases with known outcome are collected! Baseline / diagnosis is defined as the day the sample of the first positive SARS-CoV-2 result was taken. Criteria of the Uncomplicated Phase: Asymptomatic OR Symptoms of upper respiratory tract infection and/or Nausea, emesis, diarrhea and/or Fever Remember: The Uncomplicated Phase ends, if a previously febrile patient has no fever anymore and has completed 14 days of follow-up without entering Complicated or Critical Phase; then move to Recovery Phase. Also, as soon as one of the criteria of the Complicated or Critical Phase are fulfilled, Uncomplicated Phase ends; move over to there. If the patient has died, the phase ends with the death of the patient. If the patient has died, do not report terminal values, e.g. those recorded after switching off life-support or heart rate "0" after death of the patient. Criteria of the Complicated Phase: * Need for oxygen supplementation (In patients with prior oxygen home therapy, clinically meaningful increase in need for oxygenation.) * paO2 at room air < 70 mmHg * SO2 at room air < 90 % * GOT or GPT > 5x ULN * New cardiac arrhythmia * New pericardial effusion >1cm * New heart failure with pulmonary edema, congestive hepatopathy or peripheral edema Remember: The Complicated Phase ends, if none of the criteria for the Complicated Phase is fulfilled anymore AND the patient is free of fever; then move to Recovery Phase. Also, as soon as one of the criteria of the Critical Phase are fulfilled, Complicated Phase ends; move over to Critical Phase. If the patient has died, the phase ends with the death of the patient. If the patient has died, do not report terminal values, e.g. those recorded after switching off life-support or heart rate "0" after death of the patient. Criteria of the Critical Phase: * Need for catecholamines * Life-threatening cardiac arrhythmia * Mechanical ventilation (invasive or non-invasive) * Liver failure with Quick< 50% * qSOFA >= 2 * Renal failure in need of dialysis Remember: The Critical Phase ends as soon as none of the criteria for the Critical Phase is fulfilled anymore AND the patient is free of fever. If the patient has died, it ends with the death of the patient. If the patient has died, do not report terminal values, i.e. those recorded after turning off life-support or heart rate "0" after death of the patient. Criteria of the Recovery Phase: *Improvement by at least one phase, i.e. Critical to Complicated or Complicated to Uncomplicated * Defervescence Remember: Uncomplicated asymptomatic patients enter recovery phase after 14 days of observation without disease progression No further progression or re-hospitalization If a text field can't be filled out, note 'ND' (for not determined).

LEOSS: Lean European Open Survey on SARS-CoV-2 Infected Patients - Neurological sub-cohort

- 5/27/21 - 1 form, 24 itemgroups, 156 items, 1 language
Itemgroups: Duration of neurological comorbidity, Neurological medication before SARS-CoV-2 infection, Neurological status, Specification of neurological comorbidities, Cerebrovascular disease, Cerebrovascular disease: Medication, Multiple Sclerosis subtype & severity, Multiple Sclerosis: Immunomodulatory medication at Baseline, MS: Immunosuppression discontinuation in context of COVID-19, Recent MS relapse treatment, Neurodegeneration, Cognitive / neuropsychiatric impairment during COVID-19 infection, Visual impairment during COVID-19, Oculomotoric impairment during COVID-19 infection, Paresis during COVID-19 infection, Abnormal muscle reflexes during COVID-19 infection, Sensory deficit during COVID-19 infection, Other neurological findings during COVID-19 infection, Neurological diagnostics; Imaging, Neurological diagnostics: EEG, Neurological diagnostics: Electrophysiology, Neurological diagnostics: Spinal tap, Neurological diagnostics: Spinal tap - pathogens, Is data entry for this section finished?
Study Title: LEOSS: Lean European Open Survey on SARS-CoV-2 Infected Patients https://leoss.net Study Indication: COVID-19 Date: 19.03.2021 Published with permission by Prof. Dr. med. J.-J. Vehreschild. LEOSS, a multi-center cohort study, has been created to get more in-depth knowledge about the epidemiology and clinical course of patients infected with SARS-CoV-2. Initiated by the ESCMID Emerging Infections Task Force (EITaF) and the German Infectious Disease Society, and supported by all German Centers for Health Research (DZG), LEOSS has developed into an international network of contributors. Via an integrative research approach with anonymous recruitment and collection of routine data in an open science context, LEOSS is building a uniform clinical dataset and providing real-time analyses. For more information feel free to explore https://leoss.net/. This document is for the neurological sub-cohort. If a text field can't be filled out, note 'ND'.

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