Description:

Study Title: LEOSS: Lean European Open Survey on SARS-CoV-2 Infected Patients https://leoss.net Study Indication: COVID-19 Date: 19.03.2021 Published with permission by Prof. Dr. med. J.-J. Vehreschild. LEOSS, a multi-center cohort study, has been created to get more in-depth knowledge about the epidemiology and clinical course of patients infected with SARS-CoV-2. Initiated by the ESCMID Emerging Infections Task Force (EITaF) and the German Infectious Disease Society, and supported by all German Centers for Health Research (DZG), LEOSS has developed into an international network of contributors. Via an integrative research approach with anonymous recruitment and collection of routine data in an open science context, LEOSS is building a uniform clinical dataset and providing real-time analyses. For more information feel free to explore https://leoss.net/. Please note that only cases with known outcome are collected! Baseline / diagnosis is defined as the day the sample of the first positive SARS-CoV-2 result was taken. Criteria of the Uncomplicated Phase: Asymptomatic OR Symptoms of upper respiratory tract infection and/or Nausea, emesis, diarrhea and/or Fever Remember: The Uncomplicated Phase ends, if a previously febrile patient has no fever anymore and has completed 14 days of follow-up without entering Complicated or Critical Phase; then move to Recovery Phase. Also, as soon as one of the criteria of the Complicated or Critical Phase are fulfilled, Uncomplicated Phase ends; move over to there. If the patient has died, the phase ends with the death of the patient. If the patient has died, do not report terminal values, e.g. those recorded after switching off life-support or heart rate "0" after death of the patient. Criteria of the Complicated Phase: * Need for oxygen supplementation (In patients with prior oxygen home therapy, clinically meaningful increase in need for oxygenation.) * paO2 at room air < 70 mmHg * SO2 at room air < 90 % * GOT or GPT > 5x ULN * New cardiac arrhythmia * New pericardial effusion >1cm * New heart failure with pulmonary edema, congestive hepatopathy or peripheral edema Remember: The Complicated Phase ends, if none of the criteria for the Complicated Phase is fulfilled anymore AND the patient is free of fever; then move to Recovery Phase. Also, as soon as one of the criteria of the Critical Phase are fulfilled, Complicated Phase ends; move over to Critical Phase. If the patient has died, the phase ends with the death of the patient. If the patient has died, do not report terminal values, e.g. those recorded after switching off life-support or heart rate "0" after death of the patient. Criteria of the Critical Phase: * Need for catecholamines * Life-threatening cardiac arrhythmia * Mechanical ventilation (invasive or non-invasive) * Liver failure with Quick< 50% * qSOFA >= 2 * Renal failure in need of dialysis Remember: The Critical Phase ends as soon as none of the criteria for the Critical Phase is fulfilled anymore AND the patient is free of fever. If the patient has died, it ends with the death of the patient. If the patient has died, do not report terminal values, i.e. those recorded after turning off life-support or heart rate "0" after death of the patient. Criteria of the Recovery Phase: *Improvement by at least one phase, i.e. Critical to Complicated or Complicated to Uncomplicated * Defervescence Remember: Uncomplicated asymptomatic patients enter recovery phase after 14 days of observation without disease progression No further progression or re-hospitalization If a text field can't be filled out, note 'ND' (for not determined).

Link:

https://leoss.net

Keywords:
Versions (3) ▾
  1. 7/2/21
  2. 7/15/21
  3. 7/16/21
Copyright Holder:
LEOSS
Uploaded on:

July 16, 2021

DOI:

10.21961/mdm:42476

License:
Creative Commons BY 4.0
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LEOSS: Lean European Open Survey on SARS-CoV-2 Infected Patients

Baseline I

Sociodemography
Age at diagnosis
Gender
Ethnicity
Country of residence
Indicate if the patient is involved in the health care sector
Where did the patient stay before SARS-CoV-2 detection?
Where did the patient stay after the follow-up period?
Comorbidities, Central nervous system / Neurological disesases
Hemiplegia
Dementia
Cerebrovascular disease, stroke, TIA
Motoneuron disease (e.g. amyotrophic lateral sclerosis, spinal muscular atrophy)
Movement disorder (e.g. Parkinson's disease, Dystonia, Ataxia, Tremor)
Multiple sclerosis
Myasthenia gravis
Neuromyelitis optica spectrum disorder (NMOSD)
Other neurological autoimmune diseases
Other prior neurological disease
Comorbidities, Cardiovascular diseases
Myocardial infarction
Aortic stenosis
AV block
Carotid arterial disease
Chronic heart failure
Peripheral vascular disease
Hypertension
Atrial fibrillation
Coronary artery disease
Other cardiovascular disease
Comorbidities, Pulmonary diseases
COPD
Asthma
Other chronic pulmonary diseases
Comorbidities, Hematological / oncological diseases
Leukemia
Lymphoma
Solid tumor
Solid tumor, metastasized
Stem cell transplantation
Other hematological disease
Comorbidities, Rheumatological diseases
Rheumatic disease (e.g. rheumatoid arthritis, vasculitis, spondyloarthritis, psoriatic arthritis)
Connective tissue disease (e.g. systemic lupus erythematosus, dermatomyositis, Sjögren's syndrome)
Comorbidities, Allergology
Pollen sensitization
Dust mite senzitization
Other sensitization
Comorbidities, Other internal disorders
Peptic ulcer disease
Chronic liver disease
Liver cirrhosis
Diabetes, no end-organ damage
Diabetes, with end-organ damage
Chronic kidney disease
On dialysis
Comorbidities, Other conditions
Organ transplantation
HIV/AIDS
Traumatic injury (e.g. head, chest, abdominal and skeletal injuries)
Burn
Alcohol abuse
Body-Mass-Index (BMI)
Body-Mass-Index (BMI)
Smoking status
Smoking status
Use of e-cigarettes and / or vaporizer?
Use of e-cigarettes and / or vaporizer?
Pre-existing treatment
ACE inhibitors (e.g. enalapril, captopril, most drugs ending on -pril)
AT-1 inhibitors (e.g. candesartan, losartan, most drugs ending on -sartan)
Statines (e.g. atorvastatin, pravastatin, most drugs ending on -statin)
Ibuprofen
Vitamin D
Vaccinated for COVID-19
weeks
weeks
Vaccine used for COVID-19
Immunosuppressive medication in the past 3 months?
Immunosuppressive medication in the past 3 months?
Known colonisation with multi-resistant pathogens
MRSA (Methicillin-resistant St. aureus)
VRE (Vancomycin-resistant Enterococci)
3rd generation cephalosporin-resistant enterobacteriacae (3GCREB)
Other known colonisation
Did the patient suffer from a life limiting disease with a prognosis of less than one year to live before first positive testing of SARS-CoV-2?
Did the patient suffer from a life limiting disease with a prognosis of less than one year to live before first positive testing of SARS-CoV-2?
Days of follow-up since the day the sample of the first positive SARS-CoV-2 result was taken
days
Last known status
Last known status
Context of diagnosis
Month of first diagnosis
Context of diagnosis
Is the first known contact with infected person traceable?
days
Country of diagnosis
Phase at diagnosis
How did the patient come to the health care facility?
Details regarding the COVID-19 diagnosis
Can the current SARS-CoV-2 infection be considered as a re-infection?
months
Is this case linked to a variant of concern (VOC) identified via sequencing?
Complications at baseline: Thrombotic and thromboembolic manifestations
Abdominal thrombosis/thromboembolism (venous or arterial)
Myocardial infarction
Venous thrombosis, e.g. deep leg vein thrombosis
Pulmonary embolism
Microangiopathies and microthromboses
Complications at baseline: Neurological
Intracerebral bleeding
Ischemic Stroke
Meningitis / Encephalitis
Critical Illness Myopathy (CIM)
Critical Illness Polyneuropathy (CIP)
Seizure
Complications at baseline: Other severe organ damage
Acute renal failure
Severe liver failure
Congestive heart failure
Complications at baseline: Other
Life threatening cardiac arrhythmia
Myocarditis
Vasculitis
Gastrointestinal bleeding
Endotracheal bleeding
Other complication
Disease course within observational period
Presence of uncomplicated phase
Presence of complicated phase
Presence of critical phase
Presence of recovery phase
Did the patient come through the emergency room?
Duration (days) of...
days
days
days
days
days
days
Symptoms: Please click all symptoms which occurred in the respective clinical phase
Baseline (BL): None / asymptomatic
Baseline (BL): Runny nose
Baseline (BL): Sore throat
Baseline (BL): Dry cough
Baseline (BL): Productive cough
Baseline (BL): Wheezing
Baseline (BL): Dyspnoe
Baseline (BL): Palpitations
Baseline (BL): Diarrhea
Baseline (BL): Nausea / Emesis
Baseline (BL): Muscle aches
Baseline (BL): Muscle weakness
Baseline (BL): Fever
Baseline (BL): Delirium
Baseline (BL): Excessive tiredness
Baseline (BL): Headache
Baseline (BL): Meningism
Baseline (BL): Smell disorder
Baseline (BL): Taste disorder
Baseline (BL): Other neurological symptoms
Baseline (BL): Red eye
Baseline (BL): Skin rash
Baseline (BL): Swollen lymph nodes
Uncomplicated (UC): None / asymptomatic
Uncomplicated (UC): Runny nose
Uncomplicated (UC): Sore throat
Uncomplicated (UC): Dry cough
Uncomplicated (UC): Productive cough
Uncomplicated (UC): Wheezing
Uncomplicated (UC): Dyspnoe
Uncomplicated (UC): Palpitations
Uncomplicated (UC): Diarrhea
Uncomplicated (UC): Nausea / Emesis
Uncomplicated (UC): Muscle aches
Uncomplicated (UC): Muscle weakness
Uncomplicated (UC): Fever
Uncomplicated (UC): Delirium
Uncomplicated (UC): Excessive tiredness
Uncomplicated (UC): Headache
Uncomplicated (UC): Meningism
Uncomplicated (UC): Smell disorder
Uncomplicated (UC): Taste disorder
Uncomplicated (UC): Other neurological symptoms
Uncomplicated (UC): Red eye
Uncomplicated (UC): Skin rash
Uncomplicated (UC): Swollen lymph nodes
Complicated (CO): None / asymptomatic
Complicated (CO): Runny nose
Complicated (CO): Sore throat
Complicated (CO): Dry cough
Complicated (CO): Productive cough
Complicated (CO): Wheezing
Complicated (CO): Dyspnoe
Complicated (CO): Palpitations
Complicated (CO): Diarrhea
Complicated (CO): Nausea / Emesis
Complicated (CO): Muscle aches
Complicated (CO): Muscle weakness
Complicated (CO): Fever
Complicated (CO): Delirium
Complicated (CO): Excessive tiredness
Complicated (CO): Headache
Complicated (CO): Meningism
Complicated (CO): Smell disorder
Complicated (CO): Taste disorder
Complicated (CO): Other neurological symptoms
Complicated (CO): Red eye
Complicated (CO): Skin rash
Complicated (CO): Swollen lymph nodes
Critical (CR): None / asymptomatic
Critical (CR): Runny nose
Critical (CR): Sore throat
Critical (CR): Dry cough
Critical (CR): Productive cough
Critical (CR): Wheezing
Critical (CR): Dyspnoe
Critical (CR): Palpitations
Critical (CR): Diarrhea
Critical (CR): Nausea / Emesis
Critical (CR): Muscle aches
Critical (CR): Muscle weakness
Critical (CR): Fever
Critical (CR): Delirium
Critical (CR): Excessive tiredness
Critical (CR): Headache
Critical (CR): Meningism
Critical (CR): Smell disorder
Critical (CR): Taste disorder
Critical (CR): Other neurological symptoms
Critical (CR): Red eye
Critical (CR): Skin rash
Critical (CR): Swollen lymph nodes
Vital signs
Systolic BP at Baseline
Diastolic BP at Baseline
Pulse at Baseline
SO2 at Baseline
paO2 at Baseline
paCO2 at Baseline
Temperature at Baseline
Respiratory rate / minute at Baseline
Glasgow Coma Scale at Baseline
Lung ultrasound results at SARS-CoV-2 detection
B lines (multifocal, discrete or confluent)
Confluent B lines
Consolidation
Multilobar distribution of abnormalities
Small lesions
Thickened pleural line
Indicate other relevant lung ultrasound results
No abnormal findings
Not done
Chest CT results at SARS-CoV-2 detection
Air trapping
Areas of consolidation
Bronchiolitis
Crazy paving pattern
Ground glass opacities
Interlobular septal thickening
Nodulary lesions
Pleural effusion
Chest x-ray done
Other relevant CT results
Normal CT
Not done
Heart function: Ejection fraction (EF) at SARS-CoV-2 detection
Heart function: Ejection fraction (EF) at SARS-CoV-2 detection
Has a cardiovascular magnetic resonance imaging (CMR) been performed in any clinical phase?
Has a cardiovascular magnetic resonance imaging (CMR) been performed in any clinical phase?
Has neurological diagnostic taken place in the various phases?
Neurological diagnostic at Baseline
Neurological diagnostic at Uncomplicated phase
Neurological diagnostic at Complicated phase
Neurological diagnostic at Critical phase
Was complementary and/or integrative medicine (CIM) used in any phase?
Was complementary and/or integrative medicine (CIM) used in any phase?
Was limitation of therapy discussed at any time during the SARS-CoV-2 infection?
Was limitation of therapy discussed at any time during the SARS-CoV-2 infection?
Did the patient receive specialist palliative care during the SARS-CoV-2 infection?
Did the patient receive specialist palliative care during the SARS-CoV-2 infection?
Has the patient signed a general agreement to share data for scientific purposes?
Yes, to share data
Yes, to share biomaterial samples
No
Unknown
Is biomaterial of this patient available for research proposes?
Serum
Blood
Cells
Stool
Cerebrospinal fluid
Other biomaterial
None
Unknown
Did the patient participate in an interventional clinical trial?
Did the patient participate in an interventional clinical trial?

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