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dbGaP phs001130 NIDDM-Atherosclerosis Study (NIDDM-Athero) - pht008417.v1.p1

- 16.06.23 - 6 Formulare, 1 Itemgruppe, 4 Datenelemente, 1 Sprache
Itemgruppe: pht008417
Principal Investigator: Jerry L. Nadler, Eastern Virginia Medical School, Norfolk, VA, USA MeSH: Diabetes Mellitus, Type 2,Diabetes Complications https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001130 The NIDDM-Atherosclerosis Study, funded by NHLBI, was designed as a family study to examine the genetic basis of subclinical atherosclerosis and diabetes in Hispanic families. Family members of probands with T2D were recruited in the Los Angeles area. The baseline examination of the cohort included the euglycemic hyperinsulinemic clamp test from which the two key phenotypes were obtained: insulin sensitivity (M) and metabolic clearance rate of insulin (MCRI). Genome-wide genotyping was obtained under separate funding by NIDDK as a part of the GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium.

pht008418.v1.p1

1 Itemgruppe 9 Datenelemente

pht008419.v1.p1

1 Itemgruppe 3 Datenelemente

Eligibility

1 Itemgruppe 3 Datenelemente

pht008415.v1.p1

1 Itemgruppe 3 Datenelemente

pht008416.v1.p1

1 Itemgruppe 5 Datenelemente

dbGaP phs000389 GENIE UK-ROI Diabetic Nephropathy GWAS - Eligibility

- 12.10.22 - 4 Formulare, 1 Itemgruppe, 3 Datenelemente, 1 Sprache
Itemgruppe: IG.elig
Principal Investigator: Joel Hirschhorn, Broad Institute and Children's Hospital Boston, Boston, MA, USA MeSH: Diabetic Nephropathy,Kidney Failure, Chronic,Albuminuria,Diabetes Mellitus, Type 1,Diabetes Complications https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000389 Diabetic kidney disease, or diabetic nephropathy (DN), is one of the leading causes of end-stage renal disease in the United States and worldwide. DN is a common complication of long-standing type 1 and type 2 diabetes. The clinical course is characterized by development of proteinuria and gradual loss of kidney function. Although existing treatments that decrease proteinuria have been shown to moderately abate progression of diabetic kidney disease, many affected patients, who do not die from cardiovascular disease, go on to develop terminal renal failure, necessitating costly renal replacement therapies, such as dialysis and renal transplantation. Type 1 diabetes (T1D) can have its onset in childhood and affected individuals often develop end-stage renal disease in early adulthood, leading to further loss of quality of life. The genetic basis of the disease is not well understood. The GENIE (*GE*netics of *N*ephropathy an *I*nternational *E*ffort) consortium was initiated to perform the most comprehensive and well powered DN susceptibility genome wide association study (GWAS) analysis to date, using the largest collection of type 1 diabetics with and without kidney disease across four study cohorts. The UK-ROI samples were genotyped as part of this project. *UK-ROI Sample Description* The UK-ROI collection consists of samples derived from the Republic of Ireland (Dr. Catherine Godson, PI, at University College, Dublin, Ireland) and the United Kingdom (Warren 3 and Genetics of Kidneys in Diabetes UK, *UK GoKinD*, Dr. Alexander P. Maxwell, PI, at Queen's University of Belfast, UK). All study subjects met the inclusion criteria: white individuals with T1D, diagnosed before 31 years of age, whose parents and grandparents were born in the British Isles.

pht002377.v1.p1

1 Itemgruppe 5 Datenelemente

pht002378.v1.p1

1 Itemgruppe 4 Datenelemente

pht002379.v1.p1

1 Itemgruppe 13 Datenelemente

Eligibility Diabetes Mellitus, With Complications NCT00539435

- 07.03.18 - 1 Formular, 2 Itemgruppen, 13 Datenelemente, 1 Sprache
Itemgruppen: Inclusion Criteria, Exclusion Criteria
Effects of Pulsatile Intravenous Insulin Therapy on Cardiac Disease in Patients With Diabetes; ODM derived from: https://clinicaltrials.gov/show/NCT00539435

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