ID

45766

Beschreibung

Principal Investigator: Jerry L. Nadler, Eastern Virginia Medical School, Norfolk, VA, USA MeSH: Diabetes Mellitus, Type 2,Diabetes Complications https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001130 The NIDDM-Atherosclerosis Study, funded by NHLBI, was designed as a family study to examine the genetic basis of subclinical atherosclerosis and diabetes in Hispanic families. Family members of probands with T2D were recruited in the Los Angeles area. The baseline examination of the cohort included the euglycemic hyperinsulinemic clamp test from which the two key phenotypes were obtained: insulin sensitivity (M) and metabolic clearance rate of insulin (MCRI). Genome-wide genotyping was obtained under separate funding by NIDDK as a part of the GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium.

Link

dbGaP-study=phs001130

Stichworte

Versionen (1)
  1. 16/6/23 16/6/23 - Chiara Middel
Rechteinhaber

Jerry L. Nadler, Eastern Virginia Medical School, Norfolk, VA, USA

Hochgeladen am

16 de junio de 2023

DOI

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Lizenz

Creative Commons BY 4.0
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dbGaP phs001130 NIDDM-Atherosclerosis Study (NIDDM-Athero)

Englisch

Eligibility Criteria

6 Formulare  
Inclusion and exclusion criteria
Beschreibung

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0680251
*Inclusion* Probands: age 50-75; NIDDM by WHO criteria of at least 5 years duration. Probands were divided into two groups based on the presence or absence of CAD and atherosclerosis. CAD+ probands had one of the following: documented myocardial infarction, catheterization proven CAD, ischemic changes on EKG, or ischemia on stress testing. CAD- probands were free of anginal symptoms, had no history of CAD, myocardial infarction, stroke or peripheral large vessel disease, had no ischemic changes on EKG, and no evidence of vascular disease on physical exam (decreased pulses, carotid bruits, etc.). Probands needed to have a spouse and at least two adult offspring willing and able to participate in the study and to be able to give informed consent.
Beschreibung

Elig.phs001130.v1.p1.1

Datentyp

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0001779
UMLS CUI [1,3]
C0011860
UMLS CUI [1,4]
C0043237
UMLS CUI [1,5]
C0679228
UMLS CUI [1,6]
C0449238
UMLS CUI [2,1]
C0441833
UMLS CUI [2,2]
C0012634
UMLS CUI [2,3]
C0150312
UMLS CUI [2,4]
C0332197
UMLS CUI [2,5]
C1956346
UMLS CUI [2,6]
C0004153
UMLS CUI [3,1]
C1956346
UMLS CUI [3,2]
C1514241
UMLS CUI [3,3]
C0027051
UMLS CUI [3,4]
C0018795
UMLS CUI [3,5]
C1956346
UMLS CUI [3,6]
C2826576
UMLS CUI [3,7]
C0438154
UMLS CUI [3,8]
C3494508
UMLS CUI [3,9]
C0022116
UMLS CUI [4,1]
C1956346
UMLS CUI [4,2]
C0205160
UMLS CUI [4,3]
C1298908
UMLS CUI [4,4]
C0002962
UMLS CUI [4,5]
C1298908
UMLS CUI [4,6]
C0262926
UMLS CUI [4,7]
C1956346
UMLS CUI [4,8]
C1298908
UMLS CUI [4,9]
C0027051
UMLS CUI [4,10]
C0038454
UMLS CUI [4,11]
C0085096
UMLS CUI [4,12]
C1298908
UMLS CUI [4,13]
C2826576
UMLS CUI [4,14]
C0013798
UMLS CUI [4,15]
C1518340
UMLS CUI [4,16]
C0042373
UMLS CUI [4,17]
C0031809
UMLS CUI [5,1]
C0470187
UMLS CUI [5,2]
C0162409
UMLS CUI [5,3]
C0205448
UMLS CUI [5,4]
C0001675
UMLS CUI [5,5]
C0680063
UMLS CUI [5,6]
C0085732
UMLS CUI [5,7]
C0600109
UMLS CUI [5,8]
C1999230
UMLS CUI [5,9]
C0021430
UMLS CUI [5,10]
C0679823
Spouses and Offspring: age 18 - 75, able to give informed consent.
Beschreibung

Elig.phs001130.v1.p1.2

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0680063
UMLS CUI [1,2]
C0162409
UMLS CUI [1,3]
C0001779
UMLS CUI [1,4]
C0021430
UMLS CUI [1,5]
C0085732
*Exclusion* Probands and spouses only had baseline bloods drawn, including for DNA and cell lines. Offspring, who underwent extensive phenotypic testing, were excluded in the following situations: Myocardial infarction, stroke, or cardiac revascularization/angioplasty within 6 months; blood pressure >200/115 mmHg; symptoms or exam evidence of congestive heart failure or known left ventricular ejection fraction <35%; pregnancy; significant medical illness; serum potassium <3.5 or >5.5 mEq/l off medications; serum albumin <2.5 g/dl; serum creatinine >2.0 mg/dl; serum AST or ALT >3x normal; hematocrit <33%.
Beschreibung

Elig.phs001130.v1.p1.3

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0030705
UMLS CUI [1,3]
C0162409
UMLS CUI [1,4]
C0205171
UMLS CUI [1,5]
C1442488
UMLS CUI [1,6]
C1277698
UMLS CUI [1,7]
C0012854
UMLS CUI [1,8]
C0682523
UMLS CUI [2,1]
C0680063
UMLS CUI [2,2]
C0031437
UMLS CUI [2,3]
C1516048
UMLS CUI [2,4]
C0680251
UMLS CUI [2,5]
C0027051
UMLS CUI [2,6]
C0038454
UMLS CUI [2,7]
C0262926
UMLS CUI [2,8]
C0332185
UMLS CUI [2,9]
C0162577
UMLS CUI [2,10]
C0877341
UMLS CUI [2,11]
C0020538
UMLS CUI [2,12]
C0031809
UMLS CUI [2,13]
C0742758
UMLS CUI [2,14]
C0392756
UMLS CUI [2,15]
C0428772
Zum Seitenanfang zurückkehren

Ähnliche Modelle

Eligibility Criteria

6 Formulare
Name
Typ
Description | Question | Decode (Coded Value)
Datentyp
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
Elig.phs001130.v1.p1.1
Item
*Inclusion* Probands: age 50-75; NIDDM by WHO criteria of at least 5 years duration. Probands were divided into two groups based on the presence or absence of CAD and atherosclerosis. CAD+ probands had one of the following: documented myocardial infarction, catheterization proven CAD, ischemic changes on EKG, or ischemia on stress testing. CAD- probands were free of anginal symptoms, had no history of CAD, myocardial infarction, stroke or peripheral large vessel disease, had no ischemic changes on EKG, and no evidence of vascular disease on physical exam (decreased pulses, carotid bruits, etc.). Probands needed to have a spouse and at least two adult offspring willing and able to participate in the study and to be able to give informed consent.
boolean
C1512693 (UMLS CUI [1,1])
C0001779 (UMLS CUI [1,2])
C0011860 (UMLS CUI [1,3])
C0043237 (UMLS CUI [1,4])
C0679228 (UMLS CUI [1,5])
C0449238 (UMLS CUI [1,6])
C0441833 (UMLS CUI [2,1])
C0012634 (UMLS CUI [2,2])
C0150312 (UMLS CUI [2,3])
C0332197 (UMLS CUI [2,4])
C1956346 (UMLS CUI [2,5])
C0004153 (UMLS CUI [2,6])
C1956346 (UMLS CUI [3,1])
C1514241 (UMLS CUI [3,2])
C0027051 (UMLS CUI [3,3])
C0018795 (UMLS CUI [3,4])
C1956346 (UMLS CUI [3,5])
C2826576 (UMLS CUI [3,6])
C0438154 (UMLS CUI [3,7])
C3494508 (UMLS CUI [3,8])
C0022116 (UMLS CUI [3,9])
C1956346 (UMLS CUI [4,1])
C0205160 (UMLS CUI [4,2])
C1298908 (UMLS CUI [4,3])
C0002962 (UMLS CUI [4,4])
C1298908 (UMLS CUI [4,5])
C0262926 (UMLS CUI [4,6])
C1956346 (UMLS CUI [4,7])
C1298908 (UMLS CUI [4,8])
C0027051 (UMLS CUI [4,9])
C0038454 (UMLS CUI [4,10])
C0085096 (UMLS CUI [4,11])
C1298908 (UMLS CUI [4,12])
C2826576 (UMLS CUI [4,13])
C0013798 (UMLS CUI [4,14])
C1518340 (UMLS CUI [4,15])
C0042373 (UMLS CUI [4,16])
C0031809 (UMLS CUI [4,17])
C0470187 (UMLS CUI [5,1])
C0162409 (UMLS CUI [5,2])
C0205448 (UMLS CUI [5,3])
C0001675 (UMLS CUI [5,4])
C0680063 (UMLS CUI [5,5])
C0085732 (UMLS CUI [5,6])
C0600109 (UMLS CUI [5,7])
C1999230 (UMLS CUI [5,8])
C0021430 (UMLS CUI [5,9])
C0679823 (UMLS CUI [5,10])
Elig.phs001130.v1.p1.2
Item
Spouses and Offspring: age 18 - 75, able to give informed consent.
boolean
C0680063 (UMLS CUI [1,1])
C0162409 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
C0021430 (UMLS CUI [1,4])
C0085732 (UMLS CUI [1,5])
Elig.phs001130.v1.p1.3
Item
*Exclusion* Probands and spouses only had baseline bloods drawn, including for DNA and cell lines. Offspring, who underwent extensive phenotypic testing, were excluded in the following situations: Myocardial infarction, stroke, or cardiac revascularization/angioplasty within 6 months; blood pressure >200/115 mmHg; symptoms or exam evidence of congestive heart failure or known left ventricular ejection fraction <35%; pregnancy; significant medical illness; serum potassium <3.5 or >5.5 mEq/l off medications; serum albumin <2.5 g/dl; serum creatinine >2.0 mg/dl; serum AST or ALT >3x normal; hematocrit <33%.
boolean
C0680251 (UMLS CUI [1,1])
C0030705 (UMLS CUI [1,2])
C0162409 (UMLS CUI [1,3])
C0205171 (UMLS CUI [1,4])
C1442488 (UMLS CUI [1,5])
C1277698 (UMLS CUI [1,6])
C0012854 (UMLS CUI [1,7])
C0682523 (UMLS CUI [1,8])
C0680063 (UMLS CUI [2,1])
C0031437 (UMLS CUI [2,2])
C1516048 (UMLS CUI [2,3])
C0680251 (UMLS CUI [2,4])
C0027051 (UMLS CUI [2,5])
C0038454 (UMLS CUI [2,6])
C0262926 (UMLS CUI [2,7])
C0332185 (UMLS CUI [2,8])
C0162577 (UMLS CUI [2,9])
C0877341 (UMLS CUI [2,10])
C0020538 (UMLS CUI [2,11])
C0031809 (UMLS CUI [2,12])
C0742758 (UMLS CUI [2,13])
C0392756 (UMLS CUI [2,14])
C0428772 (UMLS CUI [2,15])
Zum Seitenanfang zurückkehren 

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