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dbGaP phs000361 Genome-Wide Association Studies in Upper Gastrointestinal Cancers (Asian) - pht002221.v1.p1

- 10/12/22 - 4 forms, 1 itemgroup, 3 items, 1 language
Itemgroup: pht002221
Principal Investigator: Philip R. Taylor, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA MeSH: Squamous Cell Carcinoma,Esophageal Cancer,Gastric Cancer https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000361 This project aims to conduct genome-wide association studies (GWAS) in two anatomically different upper gastrointestinal (UGI) cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cell carcinomas (ESCCs) and gastric cancers (GCs) and is comprised of Asians (*the "Asian UGI GWAS"*), while the other population has low rates of ESCC and GC and includes non-Asians from the Americas, Europe, and Australia (*the "Non-Asian UGI GWAS"*). Study participants for the Asian UGI GWAS reported here (Illumina 660W Quad chip) were drawn from 2 studies, the Shanxi Upper Gastrointestinal Cancer Genetics Project (Shanxi) and the Linxian Nutrition Intervention Trial (NIT), a prospective cohort, and included a total of 1898 ESCCs, 1625 GCs, and 2100 controls. For the 2nd phase (8 TaqMan SNPs), additional subjects from Shanxi and NIT as well as subjects from the Shanghai Men's Health Study (SMHS), the Shanghai Women's Health Study (SWHS), and the Singapore Chinese Health Study (SCHS) were also included (217 ESCCs, 615 GCs, 1202 controls). Altogether 2115 ESCCs, 2240 GCs, and 3302 controls were genotyped in this study.

pht002222.v1.p1

1 itemgroup 2 items

pht002223.v1.p1

1 itemgroup 5 items

Eligibility

1 itemgroup 3 items

Eligibility Ovarian, Non-Small Cell Lung, Prostate, Colorectal, Gastroesophageal Cancers and Squamous Cell Carcinoma of the Head and Neck NCT01059643

- 9/3/18 - 1 form, 2 itemgroups, 13 items, 1 language
Itemgroups: Inclusion Criteria, Exclusion Criteria
A Study in Ovarian, Non-Small Cell Lung, Prostate, Colorectal, Gastroesophageal Cancers, and Squamous Cell Carcinoma of the Head and Neck; ODM derived from: https://clinicaltrials.gov/show/NCT01059643 Sponsor: Eli Lilly and Company Information provided by (Responsible Party): Eli Lilly and Company

Eligibility Head and Neck Squamous Cell Carcinomas (HNSCCs) NCT02025062

- 1/16/19 - 1 form, 2 itemgroups, 9 items, 1 language
Itemgroups: Inclusion Criteria, Exclusion Criteria
Comprehensive Geriatric Assessment and Head and Neck Elderly Cancer Patients; ODM derived from: https://clinicaltrials.gov/show/NCT02025062

Eligibility Squamous Cell Carcinoma of the Head and Neck NCT01528163

- 9/17/21 - 1 form, 2 itemgroups, 26 items, 1 language
Itemgroups: Inclusion Criteria, Exclusion Criteria
Study Comparing Two Treatments in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck; ODM derived from: https://clinicaltrials.gov/show/NCT01528163

Eligibility Head and Neck Squamous Cell Carcinoma NCT02143622

- 10/18/15 - 1 form, 2 itemgroups, 10 items, 1 language
Itemgroups: Inclusion Criteria, Exclusion Criteria
Study of Efficacy and Safety of LJM716 and Cetuximab in Head and Neck Squamous Cell Carcinoma Patients; ODM derived from: https://clinicaltrials.gov/show/NCT02143622

Eligibility DRKS00005561 NCT00508664 Squamous Cell Carcinoma of the Hypopharynx - Eligibility

- 9/20/21 - 1 form, 2 itemgroups, 31 items, 2 languages
Itemgroups: Inclusion Criteria, Exclusion Criteria
ODM derived from http://clinicaltrials.gov/show/NCT00508664

dbGaP phs000716 GWAS of Lung Cancer Susceptibility in Never-Smoking Women in Asia - Eligibility

- 12/14/22 - 5 forms, 1 itemgroup, 3 items, 1 language
Itemgroup: IG.elig
Principal Investigator: Qing Lan, MD, PhD, MPH, National Institutes of Health, Bethesda, MD, USA MeSH: Lung Neoplasms,Adenocarcinoma,Squamous Cell Carcinoma https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000716 To learn about the etiology of lung cancer among never-smoking women in Asia, we formed the Female Lung Cancer Consortium in Asia (FLCCA), which includes studies of lung cancer in Eastern Asia and conducted a GWAS. We analyzed a total of 5510 lung cancer cases and 4544 controls and identified 3 novel loci (Lan et al., 2012). Of these study subjects, 4922 lung cancer cases and 3959 controls are available for posting. Lan et al.., Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Nat Genet. 2012 Dec;44(12):1330-5. doi: 10.1038/ng.2456. Epub 2012 Nov 11. PubMed PMID: 23143601.

pht003705.v1.p1

1 itemgroup 3 items

pht003706.v1.p1

1 itemgroup 2 items

pht003708.v1.p1

1 itemgroup 4 items

pht003707.v1.p1

1 itemgroup 7 items

dbGaP phs000830 XPC and Non-XPC Cutaneous Squamous Cell Carcinoma Mutation Rate Study - pht004920.v1.p1

- 3/9/24 - 4 forms, 1 itemgroup, 4 items, 1 language
Itemgroup: pht004920
Principal Investigator: Raymond J. Cho, MD, PhD, University of California, San Francisco, CA, USA MeSH: Xeroderma Pigmentosum, Complementation Group C,Carcinoma, Squamous Cell,Skin Neoplasms https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000830 Base mutations occur at higher frequencies within heterochromatin and late-replicating DNA. In this study, we show that regional differences in mutation frequency are absent in portions of the genome that are not transcribed within cutaneous squamous cell carcinomas (cSCCs) with an XPC-\- genetic background. The XPC-\- genetic background predicates a loss of global genome nucleotide excision repair (GG-NER), thus our data shows that regional differences in mutation frequency are a result of differential access of DNA repair protein. Unexpectedly, we also note that greater transcription reduces mutations on both strands of genes in heterochromatin, and only to those levels observed in euchromatin, in a XPC-dependent fashion. Therefore, transcription likely reduces mutation prevalence by increasing access to DNA repair proteins. This tripartite relationship between DNA repair, transcription, and chromatin state shows a new cancer risk factor in human populations.

pht004921.v1.p1

1 itemgroup 5 items

pht004922.v1.p1

1 itemgroup 3 items

pht004923.v1.p1

1 itemgroup 8 items

Eligibility Carcinoma of Unknown Primary NCT00388024

- 1/25/17 - 1 form, 1 itemgroup, 18 items, 1 language
Itemgroup: Criteria
PET Scans and CT Scans in Patients With Locally Advanced Head and Neck Cancer Undergoing Chemotherapy and Radiation Therapy; ODM derived from: https://clinicaltrials.gov/show/NCT00388024

Eligibility Squamous Cell Carcinoma of the Head and Neck NCT02454179

- 6/30/21 - 1 form, 2 itemgroups, 8 items, 1 language
Itemgroups: Inclusion Criteria, Exclusion Criteria
Study of the Combination of ACP-196 and Pembrolizumab in Subjects With Advanced Head and Neck Squamous Cell Carcinoma; ODM derived from: https://clinicaltrials.gov/show/NCT02454179

Eligibility Squamous Cell Carcinoma of the Oropharynx NCT01586182

- 9/15/21 - 1 form, 2 itemgroups, 11 items, 1 language
Itemgroups: Inclusion Criteria, Exclusion Criteria
Stereotactic Boost for Oropharyngeal Squamous Cell Carcinoma; ODM derived from: https://clinicaltrials.gov/show/NCT01586182

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