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dbGaP phs000720 Genomic sequencing of Pediatric Rhabdomyosarcoma - Eligibility

- 2025-01-29 - 5 Formulär, 1 Item-grupp, 1 Dataelement, 1 Språk

Item-grupp: IG.elig

Principal Investigator: Javed Khan, MD, National Institutes of Health, Bethesda, MD, USA MeSH: Rhabdomyosarcoma,Rhabdomyosarcoma, Alveolar,Rhabdomyosarcoma, Embryonal https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000720 Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood accounting for approximately 350 newly diagnosed cases yearly in the United States. With the development of multimodal chemotherapy regimens, relapse-free survival rates have improved to 70-80% in patients with localized disease albeit with significant toxicity. Unfortunately, despite aggressive treatment, patients with metastatic or recurrent disease continue to suffer from high mortality. Further characterization of the genetic events underlying this tumor type is critical for the development of more effective diagnostic, prognostic and therapeutic strategies. In a collaborative effort between the National Cancer Institute, the Children's Oncology Group, and the Broad Institute, we use a combination of whole-genome and whole-exome sequencing to characterize the landscape of somatic alterations in 147 tumor/normal pairs.

Rhabdomyosarcoma treatment CWS-2007-HR DRKS00003774 NCT00876031 - Treatment B4 - Block 6 O-TE Rhabdomyosarcoma NCT00876031

- 2015-06-11 - 1 Formulär, 11 Item-grupper, 30 Dataelement, 2 Språk

Item-grupper: Block O-TE, Toxicity common, Toxicity hematology, Toxicity infection, Toxicity gastrointestinal, Toxicity kidney, Toxicity neurology, Toxicity liver, Toxicity Herz, Toxicity other, Toxicity comment

CWS-2007-HR: A randomised phase-III trial of the Cooperative Soft-Tissue-Study-Group for localised high-risk rhabdomyosarcoma and localised Rhabdomyosarcoma-like Soft Tissue Sarcoma in children, adolescents, and young adults http://clinicaltrials.gov/show/NCT00876031 http://www.cws.olgahospital-stuttgart.de

Rhabdomyosarcoma treatment CWS-2007-HR DRKS00003774 NCT00876031 - Treatment B4 - Block 4 O-TE Rhabdomyosarcoma NCT00876031

- 2015-06-11 - 1 Formulär, 11 Item-grupper, 30 Dataelement, 2 Språk

Item-grupper: Block O-TE, Toxicity common, Toxicity hematology, Toxicity infection, Toxicity gastrointestinal, Toxicity kidney, Toxicity neurology, Toxicity liver, Toxicity Herz, Toxicity other, Toxicity comment

CWS-2007-HR: A randomised phase-III trial of the Cooperative Soft-Tissue-Study-Group for localised high-risk rhabdomyosarcoma and localised Rhabdomyosarcoma-like Soft Tissue Sarcoma in children, adolescents, and young adults http://clinicaltrials.gov/show/NCT00876031 http://www.cws.olgahospital-stuttgart.de

Rhabdomyosarcoma Treatment CWS-2007-HR DRKS00003774 NCT00876031 - Treatment Rhabdomyosarcoma B4 - Block 5 O-TI NCT00876031

- 2015-06-11 - 1 Formulär, 12 Item-grupper, 33 Dataelement, 2 Språk

Item-grupper: O-TIE body dimensions, Block O-TI , Toxicity common, Hematologic toxicity, Toxicity infection, Toxicity gastrointestinal, Toxicity kidney, Toxicity neurology, Toxicity liver, Toxicity Herz, Toxicity other, Toxicity comment

CWS-2007-HR: A randomised phase-III trial of the Cooperative Soft-Tissue-Study-Group for localised high-risk rhabdomyosarcoma and localised Rhabdomyosarcoma-like Soft Tissue Sarcoma in children, adolescents, and young adults http://clinicaltrials.gov/show/NCT00876031 http://www.cws.olgahospital-stuttgart.de

Rhabdomyosarcoma Treatment CWS-2007-HR DRKS00003774 NCT00876031 - Treatment B4 - Block 2 O-TE Rhabdomyosarcoma NCT00876031

- 2015-06-06 - 1 Formulär, 11 Item-grupper, 30 Dataelement, 2 Språk

Item-grupper: Block O-TE, Toxicity common, Toxicity hematology, Toxicity infection, Toxicity gastrointestinal, Toxicity kidney, Toxicity neurology, Toxicity liver, Toxicity Herz, Toxicity other, Toxicity comment

CWS-2007-HR: A randomised phase-III trial of the Cooperative Soft-Tissue-Study-Group for localised high-risk rhabdomyosarcoma and localised Rhabdomyosarcoma-like Soft Tissue Sarcoma in children, adolescents, and young adults http://clinicaltrials.gov/show/NCT00876031 http://www.cws.olgahospital-stuttgart.de