ID
45947
Description
Principal Investigator: Levi A. Garraway, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts and Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA MeSH: Carcinoma,Carcinoma, Non-Small-Cell Lung https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000855 The purpose of the study was to compare gene expression profiles from a cohort of crizotinib-resistant ALK-rearranged lung tumors and a cohort of treatment-naive ALK-rearranged lung tumors. Expression profiles were generated by RNA-seq. In parallel, gene expression profiles were obtained from ALK-rearranged lung cancer cell lines in the presence or absence of the ALK inhibitor TAE684. Gene expression profiles were also obtained from ALK-rearranged cells ectopically expressing genes associated with ALK inhibitor resistance that were identified from a functional genetic study.
Link
Keywords
Versions (2)
- 3/15/24 3/15/24 - Dr. Christian Niklas
- 3/16/24 3/16/24 - Madita Rudolph
Copyright Holder
Levi A. Garraway, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts and Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
Uploaded on
March 15, 2024
DOI
To request one please log in.
License
Creative Commons BY 4.0
Model comments :
You can comment on the data model here. Via the speech bubbles at the itemgroups and items you can add comments to those specificially.
Itemgroup comments for :
Item comments for :
In order to download data models you must be logged in. Please log in or register for free.
dbGaP phs000855 Resistance studies in Lung Cancer
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID and consent group of participants with lung cancer and involved in the "Resistance studies in Lung Cancer" project.
- Subject ID, sample ID, and sample use variable obtained from participants with lung cancer and involved in the "Resistance studies in Lung Cancer" project.
- Subject ID and sext of participants with lung cancer and involved in the "Resistance studies in Lung Cancer" project.
- Sample ID, sample type [tumor], and analyte type of participants with lung cancer and involved in the "Resistance studies in Lung Cancer" project.
Similar models
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID and consent group of participants with lung cancer and involved in the "Resistance studies in Lung Cancer" project.
- Subject ID, sample ID, and sample use variable obtained from participants with lung cancer and involved in the "Resistance studies in Lung Cancer" project.
- Subject ID and sext of participants with lung cancer and involved in the "Resistance studies in Lung Cancer" project.
- Sample ID, sample type [tumor], and analyte type of participants with lung cancer and involved in the "Resistance studies in Lung Cancer" project.
C0680251 (UMLS CUI [1,2])
C0750484 (UMLS CUI [1,2])
C0599161 (UMLS CUI [1,3])
C0200345 (UMLS CUI [2,1])
C0332152 (UMLS CUI [2,2])
C0087111 (UMLS CUI [2,3])
C0200345 (UMLS CUI [3,1])
C0231290 (UMLS CUI [3,2])
C2974289 (UMLS CUI [3,3])
C1514892 (UMLS CUI [3,4])