ID

45915

Beskrivning

Principal Investigator: James D. Crapo, National Jewish Health, Denver, CO, USA MeSH: Pulmonary Disease, Chronic Obstructive,Emphysema https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000951 Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States, and the only leading cause of death that is steadily increasing in frequency. This project established a racially diverse cohort that is sufficiently large and appropriately designed for genome-wide association analysis of COPD. A total of 10,720 subjects were recruited, including control smokers and nonsmokers, definite COPD cases (GOLD Stage 2 to 4), and subjects not included in either group (GOLD 1 and PRISm). This cohort is being used for cross-sectional analysis, and long-term longitudinal follow-up visits after five years and after ten years are also being performed. The primary focus of the study is to identify the genetic risk factors that determine susceptibility for COPD and COPD-related phenotypes. Detailed phenotyping of both cases and controls, including chest CT scan assessment of emphysema and airway disease, will allow identification of genetic determinants for the heterogeneous components of the COPD syndrome. The aims for this study are: - Precise phenotypic characterization of COPD subjects using computed tomography, as well as clinical and physiological measures, that will provide data to enable the broad COPD syndrome to be decomposed into clinically significant subtype; - Genome-wide association studies will identify genetic determinants for COPD susceptibility that will provide insight into clinically relevant COPD subtypes; - Distinct genetic determinants influence the development of emphysema and airway disease. The TOPMed analysis will include approximately 10,500 subjects with whole genome sequencing after quality control is completed. Comprehensive phenotypic data for COPDGene subjects is available through dbGaP study phs000179.

Länk

dbGaP study = phs000951

Nyckelord

Versioner (1)
  1. 2024-01-30 2024-01-30 - Simon Heim
Rättsinnehavare

James D. Crapo, National Jewish Health, Denver, CO, USA

Uppladdad den

30 januari 2024

DOI

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Licens

Creative Commons BY 4.0
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dbGaP phs000951 NHLBI TOPMed: Genetic Epidemiology of COPD (COPDGene)

Engelsk

Eligibility Criteria

4 Formulär  
Inclusion and exclusion criteria
Beskrivning

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0680251
*COPD Cases:*
Beskrivning

*COPD Cases:*

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0024117
UMLS CUI [1,2]
C1706256
Inclusion CriteriaAge at Enrollment: 45 - 80 years
Beskrivning

Inclusion CriteriaAge at Enrollment: 45 - 80 years

Datatyp

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C1516879
UMLS CUI [1,3]
C0001779
Smoking history of = 10 pack-years
Beskrivning

Smoking history of = 10 pack-years

Datatyp

boolean

Alias
UMLS CUI [1,1]
C1519384
UMLS CUI [1,2]
C1277691
UMLS CUI [1,3]
C0449788
Diagnosis of COPD Stages 2, 3 and 4 by GOLD criteria (post-bronchodilator FEV1/FVC < 0.70 and FEV1 < 80% predicted)
Beskrivning

Diagnosis of COPD Stages 2, 3 and 4 by GOLD criteria (post-bronchodilator FEV1/FVC < 0.70 and FEV1 < 80% predicted)

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0011900
UMLS CUI [1,2]
C0024117
UMLS CUI [1,3]
C0679228
UMLS CUI [1,4]
C5204349
Non-Hispanic White or non-Hispanic African American
Beskrivning

Non-Hispanic White or non-Hispanic African American

Datatyp

boolean

Alias
UMLS CUI [1,1]
C1518424
UMLS CUI [1,2]
C0085756
UMLS CUI [1,3]
C0007457
Exclusion CriteriaConcomitant respiratory disorder other than asthma or COPD (such as, but not limited to, diffuse bronchiectasis, cystic fibrosis, or interstitial lung disease)
Beskrivning

Exclusion CriteriaConcomitant respiratory disorder other than asthma or COPD (such as, but not limited to, diffuse bronchiectasis, cystic fibrosis, or interstitial lung disease)

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0243087
UMLS CUI [1,3]
C0024115
UMLS CUI [1,4]
C4723751
UMLS CUI [1,5]
C0024117
UMLS CUI [1,6]
C0004096
Lung surgery with removal of a lobe or more (including lung volume reduction surgery or lung transplantation)
Beskrivning

Lung surgery with removal of a lobe or more (including lung volume reduction surgery or lung transplantation)

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0038903
UMLS CUI [1,2]
C0189497
UMLS CUI [1,3]
C0524689
UMLS CUI [1,4]
C0024128
Lung cancer, known or suspected
Beskrivning

Lung cancer, known or suspected

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0242379
UMLS CUI [1,2]
C0277540
UMLS CUI [1,3]
C0011900
Surgical or bronchoscopic lung volume reduction
Beskrivning

Surgical or bronchoscopic lung volume reduction

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0524689
UMLS CUI [1,2]
C3697654
Pregnancy or suspected pregnancy
Beskrivning

Pregnancy or suspected pregnancy

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0032961
UMLS CUI [1,2]
C5670366
Uncontrolled cancer, defined as ongoing radiation therapy, ongoing chemotherapy, narcotics for pain control, or known metastatic disease
Beskrivning

Uncontrolled cancer, defined as ongoing radiation therapy, ongoing chemotherapy, narcotics for pain control, or known metastatic disease

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0006826
UMLS CUI [1,2]
C0205318
UMLS CUI [1,3]
C0549178
UMLS CUI [1,4]
C1522449
UMLS CUI [1,5]
C0392920
UMLS CUI [1,6]
C0027627
UMLS CUI [1,7]
C3898936
History of radiation therapy to the chest (other than for breast cancer)
Beskrivning

History of radiation therapy to the chest (other than for breast cancer)

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0262926
UMLS CUI [1,2]
C1522449
UMLS CUI [1,3]
C0817096
UMLS CUI [1,4]
C4723751
UMLS CUI [1,5]
C0678222
Use of antibiotics and/or systemic steroids (new prescription or increased dose) for a COPD exacerbation or respiratory infection within the last month
Beskrivning

Use of antibiotics and/or systemic steroids (new prescription or increased dose) for a COPD exacerbation or respiratory infection within the last month

Datatyp

boolean

Alias
UMLS CUI [1,1]
C1524063
UMLS CUI [1,2]
C0003232
UMLS CUI [1,3]
C2825233
UMLS CUI [1,4]
C0740304
UMLS CUI [1,5]
C0035243
UMLS CUI [1,6]
C1948053
UMLS CUI [1,7]
C4331910
Inability to use albuterol
Beskrivning

Inability to use albuterol

Datatyp

boolean

Alias
UMLS CUI [1,1]
C1299582
UMLS CUI [1,2]
C1524063
UMLS CUI [1,3]
C0001927
First or second degree relative (parent, brother, sister, daughter, son, aunt, uncle, nephew, niece, half-sibling, grandparent, grandchild) of a subject enrolled in COPDGene
Beskrivning

First or second degree relative (parent, brother, sister, daughter, son, aunt, uncle, nephew, niece, half-sibling, grandparent, grandchild) of a subject enrolled in COPDGene

Datatyp

boolean

Alias
UMLS CUI [1,1]
C1517194
UMLS CUI [1,2]
C1519210
UMLS CUI [1,3]
C0337514
UMLS CUI [1,4]
C0337527
UMLS CUI [1,5]
C0337576
UMLS CUI [1,6]
C0337577
UMLS CUI [1,7]
C0337471
UMLS CUI [1,8]
C0337548
UMLS CUI [1,9]
C0337505
UMLS CUI [1,10]
C1553703
UMLS CUI [1,11]
C0030551
UMLS CUI [1,12]
C0008059
UMLS CUI [1,13]
C5419021
Subjects who indicate they are in more than one racial category
Beskrivning

Subjects who indicate they are in more than one racial category

Datatyp

boolean

Alias
UMLS CUI [1,1]
C3146298
UMLS CUI [1,2]
C0034510
UMLS CUI [1,3]
C5142998
Metal objects that may interfere with chest CT quantification including presence of a cardiac pacemaker, defibrillator, metal prosthetic heart valve, or metal shoulder prosthesis
Beskrivning

Metal objects that may interfere with chest CT quantification including presence of a cardiac pacemaker, defibrillator, metal prosthetic heart valve, or metal shoulder prosthesis

Datatyp

boolean

Alias
UMLS CUI [1,1]
C2984008
UMLS CUI [1,2]
C0040405
UMLS CUI [1,3]
C2240369
UMLS CUI [1,4]
C4270802
UMLS CUI [1,5]
C1385346
UMLS CUI [1,6]
C0493002
Subjects with affirmative answers to the following:
Beskrivning

Subjects with affirmative answers to the following:

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0681799
UMLS CUI [1,2]
C1706817
UMLS CUI [1,3]
C1446409
chest or abdominal surgery in the past three months
Beskrivning

chest or abdominal surgery in the past three months

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0524832
UMLS CUI [1,2]
C0198482
UMLS CUI [1,3]
C4086725
a heart attack in the last three months
Beskrivning

a heart attack in the last three months

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0027051
UMLS CUI [1,2]
C4086725
detached retina or eye surgery in the past three months
Beskrivning

detached retina or eye surgery in the past three months

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0035305
UMLS CUI [1,2]
C0038901
UMLS CUI [1,3]
C4086725
hospitalization for any other heart problem in the past month
Beskrivning

hospitalization for any other heart problem in the past month

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0019993
UMLS CUI [1,2]
C0795691
UMLS CUI [1,3]
C4331910
Participation in the ECLIPSE study, Boston Early-Onset COPD Study, or International COPD Genetics Network (Selected replication cohorts)
Beskrivning

Participation in the ECLIPSE study, Boston Early-Onset COPD Study, or International COPD Genetics Network (Selected replication cohorts)

Datatyp

boolean

Alias
UMLS CUI [1,1]
C2348568
UMLS CUI [1,2]
C0947630
UMLS CUI [1,3]
C0024117
*Smokers without COPD:*
Beskrivning

*Smokers without COPD:*

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0337664
UMLS CUI [1,2]
C0332288
UMLS CUI [1,3]
C0024117
Inclusion CriteriaAge at Enrollment: 45 - 80 years
Beskrivning

Inclusion CriteriaAge at Enrollment: 45 - 80 years

Datatyp

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C1516879
UMLS CUI [1,3]
C0001779
UMLS CUI [1,4]
C1442880
History (current or former) of cigarette smoking = 10 pack-years
Beskrivning

History (current or former) of cigarette smoking = 10 pack-years

Datatyp

boolean

Alias
UMLS CUI [1,1]
C1519384
UMLS CUI [1,2]
C1277691
Post-bronchodilator FEV1/FVC = 0.70 and FEV1 = 80% predicted
Beskrivning

Post-bronchodilator FEV1/FVC = 0.70 and FEV1 = 80% predicted

Datatyp

boolean

Alias
UMLS CUI [1,1]
C5204349
UMLS CUI [1,2]
C0849974
Non-Hispanic White or non-Hispanic African American
Beskrivning

Non-Hispanic White or non-Hispanic African American

Datatyp

boolean

Alias
UMLS CUI [1,1]
C1518424
UMLS CUI [1,2]
C0085756
UMLS CUI [1,3]
C0007457
Exclusion CriteriaPhysician diagnosed respiratory disease other than COPD or asthma (based on subject report)
Beskrivning

Exclusion CriteriaPhysician diagnosed respiratory disease other than COPD or asthma (based on subject report)

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0011900
UMLS CUI [1,3]
C0031831
UMLS CUI [1,4]
C4723751
UMLS CUI [1,5]
C0004096
UMLS CUI [1,6]
C0024117
Lung surgery with removal of a lobe or more (including lung volume reduction surgery and lung transplantation)
Beskrivning

Lung surgery with removal of a lobe or more (including lung volume reduction surgery and lung transplantation)

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0038903
UMLS CUI [1,2]
C0189497
UMLS CUI [1,3]
C0524689
UMLS CUI [1,4]
C0024128
Pregnancy or suspected pregnancy
Beskrivning

Pregnancy or suspected pregnancy

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0032961
UMLS CUI [1,2]
C5670366
Lung cancer, known or suspected
Beskrivning

Lung cancer, known or suspected

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0242379
UMLS CUI [1,2]
C0277540
UMLS CUI [1,3]
C0011900
Uncontrolled cancer, defined as ongoing radiation therapy, ongoing chemotherapy, narcotics for pain control, or known metastatic disease
Beskrivning

Uncontrolled cancer, defined as ongoing radiation therapy, ongoing chemotherapy, narcotics for pain control, or known metastatic disease

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0006826
UMLS CUI [1,2]
C0205318
UMLS CUI [1,3]
C0549178
UMLS CUI [1,4]
C1522449
UMLS CUI [1,5]
C0392920
UMLS CUI [1,6]
C0027627
UMLS CUI [1,7]
C3898936
History of radiation therapy to the chest
Beskrivning

History of radiation therapy to the chest

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0262926
UMLS CUI [1,2]
C1522449
UMLS CUI [1,3]
C0817096
Use of antibiotics (new prescription or increased dose) for a respiratory infection within the past month
Beskrivning

Use of antibiotics (new prescription or increased dose) for a respiratory infection within the past month

Datatyp

boolean

Alias
UMLS CUI [1,1]
C1524063
UMLS CUI [1,2]
C0003232
UMLS CUI [1,3]
C2825233
UMLS CUI [1,4]
C0740304
UMLS CUI [1,5]
C0035243
UMLS CUI [1,6]
C1948053
UMLS CUI [1,7]
C4331910
Use of systemic corticosteroids (new prescription or increased dose) for a respiratory process within the past month
Beskrivning

Use of systemic corticosteroids (new prescription or increased dose) for a respiratory process within the past month

Datatyp

boolean

Alias
UMLS CUI [1,1]
C1524063
UMLS CUI [1,2]
C0003232
UMLS CUI [1,3]
C2825233
UMLS CUI [1,4]
C1948053
UMLS CUI [1,5]
C4331910
Inability to use albuterol
Beskrivning

Inability to use albuterol

Datatyp

boolean

Alias
UMLS CUI [1,1]
C1299582
UMLS CUI [1,2]
C1524063
UMLS CUI [1,3]
C0001927
First or second degree relative (parent, brother, sister, daughter, son, aunt, uncle, nephew, niece, half-sibling, grandparent, or grandchild) of a subject enrolled in COPDGene
Beskrivning

First or second degree relative (parent, brother, sister, daughter, son, aunt, uncle, nephew, niece, half-sibling, grandparent, or grandchild) of a subject enrolled in COPDGene

Datatyp

boolean

Alias
UMLS CUI [1,1]
C1517194
UMLS CUI [1,2]
C1519210
UMLS CUI [1,3]
C0337514
UMLS CUI [1,4]
C0337527
UMLS CUI [1,5]
C0337576
UMLS CUI [1,6]
C0337577
UMLS CUI [1,7]
C0337471
UMLS CUI [1,8]
C0337548
UMLS CUI [1,9]
C0337505
UMLS CUI [1,10]
C1553703
UMLS CUI [1,11]
C0030551
UMLS CUI [1,12]
C0008059
UMLS CUI [1,13]
C5419021
Subjects who indicate they are in more than one racial category
Beskrivning

Subjects who indicate they are in more than one racial category

Datatyp

boolean

Alias
UMLS CUI [1,1]
C3146298
UMLS CUI [1,2]
C0034510
UMLS CUI [1,3]
C5142998
Metal objects that may interfere with chest CT quantification including presence of a cardiac pacemaker, defibrillator, metal prosthetic heart valve, or metal shoulder prosthesis
Beskrivning

Metal objects that may interfere with chest CT quantification including presence of a cardiac pacemaker, defibrillator, metal prosthetic heart valve, or metal shoulder prosthesis

Datatyp

boolean

Alias
UMLS CUI [1,1]
C2984008
UMLS CUI [1,2]
C0040405
UMLS CUI [1,3]
C2240369
UMLS CUI [1,4]
C4270802
UMLS CUI [1,5]
C1385346
UMLS CUI [1,6]
C0493002
Subjects with affirmative answers to the following:
Beskrivning

Subjects with affirmative answers to the following:

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0681799
UMLS CUI [1,2]
C1706817
UMLS CUI [1,3]
C1446409
chest or abdominal surgery in the past three months
Beskrivning

chest or abdominal surgery in the past three months

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0524832
UMLS CUI [1,2]
C0198482
UMLS CUI [1,3]
C4086725
a heart attack in the last three months
Beskrivning

a heart attack in the last three months

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0027051
UMLS CUI [1,2]
C4086725
detached retina or eye surgery in the past three months
Beskrivning

detached retina or eye surgery in the past three months

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0035305
UMLS CUI [1,2]
C0038901
UMLS CUI [1,3]
C4086725
hospitalization for any other heart problem in the past month
Beskrivning

hospitalization for any other heart problem in the past month

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0019993
UMLS CUI [1,2]
C0795691
UMLS CUI [1,3]
C4331910
Participation in the ECLIPSE study, Boston Early-Onset COPD Study, or International COPD Genetics Network (Selected replication cohorts)
Beskrivning

Participation in the ECLIPSE study, Boston Early-Onset COPD Study, or International COPD Genetics Network (Selected replication cohorts)

Datatyp

boolean

Alias
UMLS CUI [1,1]
C2348568
UMLS CUI [1,2]
C0947630
UMLS CUI [1,3]
C0024117
*Note that similar enrollment criteria were utilized for lifelong nonsmoking control subjects.*
Beskrivning

*Note that similar enrollment criteria were utilized for lifelong nonsmoking control subjects.*

Datatyp

boolean

Alias
UMLS CUI [1,1]
C1516879
UMLS CUI [1,2]
C2348205
UMLS CUI [1,3]
C0425293
UMLS CUI [1,4]
C0009932
Tillbaka till toppen

Similar models

Eligibility Criteria

4 Formulär
Name
Typ
Description | Question | Decode (Coded Value)
Datatyp
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
*COPD Cases:*
Item
*COPD Cases:*
boolean
C0024117 (UMLS CUI [1,1])
C1706256 (UMLS CUI [1,2])
Inclusion CriteriaAge at Enrollment: 45 - 80 years
Item
Inclusion CriteriaAge at Enrollment: 45 - 80 years
boolean
C1512693 (UMLS CUI [1,1])
C1516879 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
Smoking history of = 10 pack-years
Item
Smoking history of = 10 pack-years
boolean
C1519384 (UMLS CUI [1,1])
C1277691 (UMLS CUI [1,2])
C0449788 (UMLS CUI [1,3])
Diagnosis of COPD Stages 2, 3 and 4 by GOLD criteria (post-bronchodilator FEV1/FVC < 0.70 and FEV1 < 80% predicted)
Item
Diagnosis of COPD Stages 2, 3 and 4 by GOLD criteria (post-bronchodilator FEV1/FVC < 0.70 and FEV1 < 80% predicted)
boolean
C0011900 (UMLS CUI [1,1])
C0024117 (UMLS CUI [1,2])
C0679228 (UMLS CUI [1,3])
C5204349 (UMLS CUI [1,4])
Non-Hispanic White or non-Hispanic African American
Item
Non-Hispanic White or non-Hispanic African American
boolean
C1518424 (UMLS CUI [1,1])
C0085756 (UMLS CUI [1,2])
C0007457 (UMLS CUI [1,3])
Exclusion CriteriaConcomitant respiratory disorder other than asthma or COPD (such as, but not limited to, diffuse bronchiectasis, cystic fibrosis, or interstitial lung disease)
Item
Exclusion CriteriaConcomitant respiratory disorder other than asthma or COPD (such as, but not limited to, diffuse bronchiectasis, cystic fibrosis, or interstitial lung disease)
boolean
C0680251 (UMLS CUI [1,1])
C0243087 (UMLS CUI [1,2])
C0024115 (UMLS CUI [1,3])
C4723751 (UMLS CUI [1,4])
C0024117 (UMLS CUI [1,5])
C0004096 (UMLS CUI [1,6])
Lung surgery with removal of a lobe or more (including lung volume reduction surgery or lung transplantation)
Item
Lung surgery with removal of a lobe or more (including lung volume reduction surgery or lung transplantation)
boolean
C0038903 (UMLS CUI [1,1])
C0189497 (UMLS CUI [1,2])
C0524689 (UMLS CUI [1,3])
C0024128 (UMLS CUI [1,4])
Lung cancer, known or suspected
Item
Lung cancer, known or suspected
boolean
C0242379 (UMLS CUI [1,1])
C0277540 (UMLS CUI [1,2])
C0011900 (UMLS CUI [1,3])
Surgical or bronchoscopic lung volume reduction
Item
Surgical or bronchoscopic lung volume reduction
boolean
C0524689 (UMLS CUI [1,1])
C3697654 (UMLS CUI [1,2])
Pregnancy or suspected pregnancy
Item
Pregnancy or suspected pregnancy
boolean
C0032961 (UMLS CUI [1,1])
C5670366 (UMLS CUI [1,2])
Uncontrolled cancer, defined as ongoing radiation therapy, ongoing chemotherapy, narcotics for pain control, or known metastatic disease
Item
Uncontrolled cancer, defined as ongoing radiation therapy, ongoing chemotherapy, narcotics for pain control, or known metastatic disease
boolean
C0006826 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0549178 (UMLS CUI [1,3])
C1522449 (UMLS CUI [1,4])
C0392920 (UMLS CUI [1,5])
C0027627 (UMLS CUI [1,6])
C3898936 (UMLS CUI [1,7])
History of radiation therapy to the chest (other than for breast cancer)
Item
History of radiation therapy to the chest (other than for breast cancer)
boolean
C0262926 (UMLS CUI [1,1])
C1522449 (UMLS CUI [1,2])
C0817096 (UMLS CUI [1,3])
C4723751 (UMLS CUI [1,4])
C0678222 (UMLS CUI [1,5])
Use of antibiotics and/or systemic steroids (new prescription or increased dose) for a COPD exacerbation or respiratory infection within the last month
Item
Use of antibiotics and/or systemic steroids (new prescription or increased dose) for a COPD exacerbation or respiratory infection within the last month
boolean
C1524063 (UMLS CUI [1,1])
C0003232 (UMLS CUI [1,2])
C2825233 (UMLS CUI [1,3])
C0740304 (UMLS CUI [1,4])
C0035243 (UMLS CUI [1,5])
C1948053 (UMLS CUI [1,6])
C4331910 (UMLS CUI [1,7])
Inability to use albuterol
Item
Inability to use albuterol
boolean
C1299582 (UMLS CUI [1,1])
C1524063 (UMLS CUI [1,2])
C0001927 (UMLS CUI [1,3])
First or second degree relative (parent, brother, sister, daughter, son, aunt, uncle, nephew, niece, half-sibling, grandparent, grandchild) of a subject enrolled in COPDGene
Item
First or second degree relative (parent, brother, sister, daughter, son, aunt, uncle, nephew, niece, half-sibling, grandparent, grandchild) of a subject enrolled in COPDGene
boolean
C1517194 (UMLS CUI [1,1])
C1519210 (UMLS CUI [1,2])
C0337514 (UMLS CUI [1,3])
C0337527 (UMLS CUI [1,4])
C0337576 (UMLS CUI [1,5])
C0337577 (UMLS CUI [1,6])
C0337471 (UMLS CUI [1,7])
C0337548 (UMLS CUI [1,8])
C0337505 (UMLS CUI [1,9])
C1553703 (UMLS CUI [1,10])
C0030551 (UMLS CUI [1,11])
C0008059 (UMLS CUI [1,12])
C5419021 (UMLS CUI [1,13])
Subjects who indicate they are in more than one racial category
Item
Subjects who indicate they are in more than one racial category
boolean
C3146298 (UMLS CUI [1,1])
C0034510 (UMLS CUI [1,2])
C5142998 (UMLS CUI [1,3])
Metal objects that may interfere with chest CT quantification including presence of a cardiac pacemaker, defibrillator, metal prosthetic heart valve, or metal shoulder prosthesis
Item
Metal objects that may interfere with chest CT quantification including presence of a cardiac pacemaker, defibrillator, metal prosthetic heart valve, or metal shoulder prosthesis
boolean
C2984008 (UMLS CUI [1,1])
C0040405 (UMLS CUI [1,2])
C2240369 (UMLS CUI [1,3])
C4270802 (UMLS CUI [1,4])
C1385346 (UMLS CUI [1,5])
C0493002 (UMLS CUI [1,6])
Subjects with affirmative answers to the following:
Item
Subjects with affirmative answers to the following:
boolean
C0681799 (UMLS CUI [1,1])
C1706817 (UMLS CUI [1,2])
C1446409 (UMLS CUI [1,3])
chest or abdominal surgery in the past three months
Item
chest or abdominal surgery in the past three months
boolean
C0524832 (UMLS CUI [1,1])
C0198482 (UMLS CUI [1,2])
C4086725 (UMLS CUI [1,3])
a heart attack in the last three months
Item
a heart attack in the last three months
boolean
C0027051 (UMLS CUI [1,1])
C4086725 (UMLS CUI [1,2])
detached retina or eye surgery in the past three months
Item
detached retina or eye surgery in the past three months
boolean
C0035305 (UMLS CUI [1,1])
C0038901 (UMLS CUI [1,2])
C4086725 (UMLS CUI [1,3])
hospitalization for any other heart problem in the past month
Item
hospitalization for any other heart problem in the past month
boolean
C0019993 (UMLS CUI [1,1])
C0795691 (UMLS CUI [1,2])
C4331910 (UMLS CUI [1,3])
Participation in the ECLIPSE study, Boston Early-Onset COPD Study, or International COPD Genetics Network (Selected replication cohorts)
Item
Participation in the ECLIPSE study, Boston Early-Onset COPD Study, or International COPD Genetics Network (Selected replication cohorts)
boolean
C2348568 (UMLS CUI [1,1])
C0947630 (UMLS CUI [1,2])
C0024117 (UMLS CUI [1,3])
*Smokers without COPD:*
Item
*Smokers without COPD:*
boolean
C0337664 (UMLS CUI [1,1])
C0332288 (UMLS CUI [1,2])
C0024117 (UMLS CUI [1,3])
Inclusion CriteriaAge at Enrollment: 45 - 80 years
Item
Inclusion CriteriaAge at Enrollment: 45 - 80 years
boolean
C1512693 (UMLS CUI [1,1])
C1516879 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
C1442880 (UMLS CUI [1,4])
History (current or former) of cigarette smoking = 10 pack-years
Item
History (current or former) of cigarette smoking = 10 pack-years
boolean
C1519384 (UMLS CUI [1,1])
C1277691 (UMLS CUI [1,2])
Post-bronchodilator FEV1/FVC = 0.70 and FEV1 = 80% predicted
Item
Post-bronchodilator FEV1/FVC = 0.70 and FEV1 = 80% predicted
boolean
C5204349 (UMLS CUI [1,1])
C0849974 (UMLS CUI [1,2])
Non-Hispanic White or non-Hispanic African American
Item
Non-Hispanic White or non-Hispanic African American
boolean
C1518424 (UMLS CUI [1,1])
C0085756 (UMLS CUI [1,2])
C0007457 (UMLS CUI [1,3])
Exclusion CriteriaPhysician diagnosed respiratory disease other than COPD or asthma (based on subject report)
Item
Exclusion CriteriaPhysician diagnosed respiratory disease other than COPD or asthma (based on subject report)
boolean
C0680251 (UMLS CUI [1,1])
C0011900 (UMLS CUI [1,2])
C0031831 (UMLS CUI [1,3])
C4723751 (UMLS CUI [1,4])
C0004096 (UMLS CUI [1,5])
C0024117 (UMLS CUI [1,6])
Lung surgery with removal of a lobe or more (including lung volume reduction surgery and lung transplantation)
Item
Lung surgery with removal of a lobe or more (including lung volume reduction surgery and lung transplantation)
boolean
C0038903 (UMLS CUI [1,1])
C0189497 (UMLS CUI [1,2])
C0524689 (UMLS CUI [1,3])
C0024128 (UMLS CUI [1,4])
Pregnancy or suspected pregnancy
Item
Pregnancy or suspected pregnancy
boolean
C0032961 (UMLS CUI [1,1])
C5670366 (UMLS CUI [1,2])
Lung cancer, known or suspected
Item
Lung cancer, known or suspected
boolean
C0242379 (UMLS CUI [1,1])
C0277540 (UMLS CUI [1,2])
C0011900 (UMLS CUI [1,3])
Uncontrolled cancer, defined as ongoing radiation therapy, ongoing chemotherapy, narcotics for pain control, or known metastatic disease
Item
Uncontrolled cancer, defined as ongoing radiation therapy, ongoing chemotherapy, narcotics for pain control, or known metastatic disease
boolean
C0006826 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0549178 (UMLS CUI [1,3])
C1522449 (UMLS CUI [1,4])
C0392920 (UMLS CUI [1,5])
C0027627 (UMLS CUI [1,6])
C3898936 (UMLS CUI [1,7])
History of radiation therapy to the chest
Item
History of radiation therapy to the chest
boolean
C0262926 (UMLS CUI [1,1])
C1522449 (UMLS CUI [1,2])
C0817096 (UMLS CUI [1,3])
Use of antibiotics (new prescription or increased dose) for a respiratory infection within the past month
Item
Use of antibiotics (new prescription or increased dose) for a respiratory infection within the past month
boolean
C1524063 (UMLS CUI [1,1])
C0003232 (UMLS CUI [1,2])
C2825233 (UMLS CUI [1,3])
C0740304 (UMLS CUI [1,4])
C0035243 (UMLS CUI [1,5])
C1948053 (UMLS CUI [1,6])
C4331910 (UMLS CUI [1,7])
Use of systemic corticosteroids (new prescription or increased dose) for a respiratory process within the past month
Item
Use of systemic corticosteroids (new prescription or increased dose) for a respiratory process within the past month
boolean
C1524063 (UMLS CUI [1,1])
C0003232 (UMLS CUI [1,2])
C2825233 (UMLS CUI [1,3])
C1948053 (UMLS CUI [1,4])
C4331910 (UMLS CUI [1,5])
Inability to use albuterol
Item
Inability to use albuterol
boolean
C1299582 (UMLS CUI [1,1])
C1524063 (UMLS CUI [1,2])
C0001927 (UMLS CUI [1,3])
First or second degree relative (parent, brother, sister, daughter, son, aunt, uncle, nephew, niece, half-sibling, grandparent, or grandchild) of a subject enrolled in COPDGene
Item
First or second degree relative (parent, brother, sister, daughter, son, aunt, uncle, nephew, niece, half-sibling, grandparent, or grandchild) of a subject enrolled in COPDGene
boolean
C1517194 (UMLS CUI [1,1])
C1519210 (UMLS CUI [1,2])
C0337514 (UMLS CUI [1,3])
C0337527 (UMLS CUI [1,4])
C0337576 (UMLS CUI [1,5])
C0337577 (UMLS CUI [1,6])
C0337471 (UMLS CUI [1,7])
C0337548 (UMLS CUI [1,8])
C0337505 (UMLS CUI [1,9])
C1553703 (UMLS CUI [1,10])
C0030551 (UMLS CUI [1,11])
C0008059 (UMLS CUI [1,12])
C5419021 (UMLS CUI [1,13])
Subjects who indicate they are in more than one racial category
Item
Subjects who indicate they are in more than one racial category
boolean
C3146298 (UMLS CUI [1,1])
C0034510 (UMLS CUI [1,2])
C5142998 (UMLS CUI [1,3])
Metal objects that may interfere with chest CT quantification including presence of a cardiac pacemaker, defibrillator, metal prosthetic heart valve, or metal shoulder prosthesis
Item
Metal objects that may interfere with chest CT quantification including presence of a cardiac pacemaker, defibrillator, metal prosthetic heart valve, or metal shoulder prosthesis
boolean
C2984008 (UMLS CUI [1,1])
C0040405 (UMLS CUI [1,2])
C2240369 (UMLS CUI [1,3])
C4270802 (UMLS CUI [1,4])
C1385346 (UMLS CUI [1,5])
C0493002 (UMLS CUI [1,6])
Subjects with affirmative answers to the following:
Item
Subjects with affirmative answers to the following:
boolean
C0681799 (UMLS CUI [1,1])
C1706817 (UMLS CUI [1,2])
C1446409 (UMLS CUI [1,3])
chest or abdominal surgery in the past three months
Item
chest or abdominal surgery in the past three months
boolean
C0524832 (UMLS CUI [1,1])
C0198482 (UMLS CUI [1,2])
C4086725 (UMLS CUI [1,3])
a heart attack in the last three months
Item
a heart attack in the last three months
boolean
C0027051 (UMLS CUI [1,1])
C4086725 (UMLS CUI [1,2])
detached retina or eye surgery in the past three months
Item
detached retina or eye surgery in the past three months
boolean
C0035305 (UMLS CUI [1,1])
C0038901 (UMLS CUI [1,2])
C4086725 (UMLS CUI [1,3])
hospitalization for any other heart problem in the past month
Item
hospitalization for any other heart problem in the past month
boolean
C0019993 (UMLS CUI [1,1])
C0795691 (UMLS CUI [1,2])
C4331910 (UMLS CUI [1,3])
Participation in the ECLIPSE study, Boston Early-Onset COPD Study, or International COPD Genetics Network (Selected replication cohorts)
Item
Participation in the ECLIPSE study, Boston Early-Onset COPD Study, or International COPD Genetics Network (Selected replication cohorts)
boolean
C2348568 (UMLS CUI [1,1])
C0947630 (UMLS CUI [1,2])
C0024117 (UMLS CUI [1,3])
*Note that similar enrollment criteria were utilized for lifelong nonsmoking control subjects.*
Item
*Note that similar enrollment criteria were utilized for lifelong nonsmoking control subjects.*
boolean
C1516879 (UMLS CUI [1,1])
C2348205 (UMLS CUI [1,2])
C0425293 (UMLS CUI [1,3])
C0009932 (UMLS CUI [1,4])
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