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45915

Beschreibung

Principal Investigator: James D. Crapo, National Jewish Health, Denver, CO, USA MeSH: Pulmonary Disease, Chronic Obstructive,Emphysema https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000951 Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States, and the only leading cause of death that is steadily increasing in frequency. This project established a racially diverse cohort that is sufficiently large and appropriately designed for genome-wide association analysis of COPD. A total of 10,720 subjects were recruited, including control smokers and nonsmokers, definite COPD cases (GOLD Stage 2 to 4), and subjects not included in either group (GOLD 1 and PRISm). This cohort is being used for cross-sectional analysis, and long-term longitudinal follow-up visits after five years and after ten years are also being performed. The primary focus of the study is to identify the genetic risk factors that determine susceptibility for COPD and COPD-related phenotypes. Detailed phenotyping of both cases and controls, including chest CT scan assessment of emphysema and airway disease, will allow identification of genetic determinants for the heterogeneous components of the COPD syndrome. The aims for this study are: - Precise phenotypic characterization of COPD subjects using computed tomography, as well as clinical and physiological measures, that will provide data to enable the broad COPD syndrome to be decomposed into clinically significant subtype; - Genome-wide association studies will identify genetic determinants for COPD susceptibility that will provide insight into clinically relevant COPD subtypes; - Distinct genetic determinants influence the development of emphysema and airway disease. The TOPMed analysis will include approximately 10,500 subjects with whole genome sequencing after quality control is completed. Comprehensive phenotypic data for COPDGene subjects is available through dbGaP study phs000179.

Link

dbGaP study = phs000951

Stichworte

Versionen (1)
  1. 30.01.24 30.01.24 - Simon Heim
Rechteinhaber

James D. Crapo, National Jewish Health, Denver, CO, USA

Hochgeladen am

30. Januar 2024

DOI

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Creative Commons BY 4.0
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    dbGaP phs000951 NHLBI TOPMed: Genetic Epidemiology of COPD (COPDGene)

    Englisch

    Eligibility Criteria

    4 Formulare  
    Inclusion and exclusion criteria
    Beschreibung

    Inclusion and exclusion criteria

    Alias
    UMLS CUI [1,1]
    C1512693
    UMLS CUI [1,2]
    C0680251
    *COPD Cases:*
    Beschreibung

    *COPD Cases:*

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C0024117
    UMLS CUI [1,2]
    C1706256
    Inclusion CriteriaAge at Enrollment: 45 - 80 years
    Beschreibung

    Inclusion CriteriaAge at Enrollment: 45 - 80 years

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C1512693
    UMLS CUI [1,2]
    C1516879
    UMLS CUI [1,3]
    C0001779
    Smoking history of = 10 pack-years
    Beschreibung

    Smoking history of = 10 pack-years

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C1519384
    UMLS CUI [1,2]
    C1277691
    UMLS CUI [1,3]
    C0449788
    Diagnosis of COPD Stages 2, 3 and 4 by GOLD criteria (post-bronchodilator FEV1/FVC < 0.70 and FEV1 < 80% predicted)
    Beschreibung

    Diagnosis of COPD Stages 2, 3 and 4 by GOLD criteria (post-bronchodilator FEV1/FVC < 0.70 and FEV1 < 80% predicted)

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C0011900
    UMLS CUI [1,2]
    C0024117
    UMLS CUI [1,3]
    C0679228
    UMLS CUI [1,4]
    C5204349
    Non-Hispanic White or non-Hispanic African American
    Beschreibung

    Non-Hispanic White or non-Hispanic African American

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C1518424
    UMLS CUI [1,2]
    C0085756
    UMLS CUI [1,3]
    C0007457
    Exclusion CriteriaConcomitant respiratory disorder other than asthma or COPD (such as, but not limited to, diffuse bronchiectasis, cystic fibrosis, or interstitial lung disease)
    Beschreibung

    Exclusion CriteriaConcomitant respiratory disorder other than asthma or COPD (such as, but not limited to, diffuse bronchiectasis, cystic fibrosis, or interstitial lung disease)

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C0680251
    UMLS CUI [1,2]
    C0243087
    UMLS CUI [1,3]
    C0024115
    UMLS CUI [1,4]
    C4723751
    UMLS CUI [1,5]
    C0024117
    UMLS CUI [1,6]
    C0004096
    Lung surgery with removal of a lobe or more (including lung volume reduction surgery or lung transplantation)
    Beschreibung

    Lung surgery with removal of a lobe or more (including lung volume reduction surgery or lung transplantation)

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C0038903
    UMLS CUI [1,2]
    C0189497
    UMLS CUI [1,3]
    C0524689
    UMLS CUI [1,4]
    C0024128
    Lung cancer, known or suspected
    Beschreibung

    Lung cancer, known or suspected

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C0242379
    UMLS CUI [1,2]
    C0277540
    UMLS CUI [1,3]
    C0011900
    Surgical or bronchoscopic lung volume reduction
    Beschreibung

    Surgical or bronchoscopic lung volume reduction

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C0524689
    UMLS CUI [1,2]
    C3697654
    Pregnancy or suspected pregnancy
    Beschreibung

    Pregnancy or suspected pregnancy

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C0032961
    UMLS CUI [1,2]
    C5670366
    Uncontrolled cancer, defined as ongoing radiation therapy, ongoing chemotherapy, narcotics for pain control, or known metastatic disease
    Beschreibung

    Uncontrolled cancer, defined as ongoing radiation therapy, ongoing chemotherapy, narcotics for pain control, or known metastatic disease

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C0006826
    UMLS CUI [1,2]
    C0205318
    UMLS CUI [1,3]
    C0549178
    UMLS CUI [1,4]
    C1522449
    UMLS CUI [1,5]
    C0392920
    UMLS CUI [1,6]
    C0027627
    UMLS CUI [1,7]
    C3898936
    History of radiation therapy to the chest (other than for breast cancer)
    Beschreibung

    History of radiation therapy to the chest (other than for breast cancer)

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C0262926
    UMLS CUI [1,2]
    C1522449
    UMLS CUI [1,3]
    C0817096
    UMLS CUI [1,4]
    C4723751
    UMLS CUI [1,5]
    C0678222
    Use of antibiotics and/or systemic steroids (new prescription or increased dose) for a COPD exacerbation or respiratory infection within the last month
    Beschreibung

    Use of antibiotics and/or systemic steroids (new prescription or increased dose) for a COPD exacerbation or respiratory infection within the last month

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C1524063
    UMLS CUI [1,2]
    C0003232
    UMLS CUI [1,3]
    C2825233
    UMLS CUI [1,4]
    C0740304
    UMLS CUI [1,5]
    C0035243
    UMLS CUI [1,6]
    C1948053
    UMLS CUI [1,7]
    C4331910
    Inability to use albuterol
    Beschreibung

    Inability to use albuterol

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C1299582
    UMLS CUI [1,2]
    C1524063
    UMLS CUI [1,3]
    C0001927
    First or second degree relative (parent, brother, sister, daughter, son, aunt, uncle, nephew, niece, half-sibling, grandparent, grandchild) of a subject enrolled in COPDGene
    Beschreibung

    First or second degree relative (parent, brother, sister, daughter, son, aunt, uncle, nephew, niece, half-sibling, grandparent, grandchild) of a subject enrolled in COPDGene

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C1517194
    UMLS CUI [1,2]
    C1519210
    UMLS CUI [1,3]
    C0337514
    UMLS CUI [1,4]
    C0337527
    UMLS CUI [1,5]
    C0337576
    UMLS CUI [1,6]
    C0337577
    UMLS CUI [1,7]
    C0337471
    UMLS CUI [1,8]
    C0337548
    UMLS CUI [1,9]
    C0337505
    UMLS CUI [1,10]
    C1553703
    UMLS CUI [1,11]
    C0030551
    UMLS CUI [1,12]
    C0008059
    UMLS CUI [1,13]
    C5419021
    Subjects who indicate they are in more than one racial category
    Beschreibung

    Subjects who indicate they are in more than one racial category

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C3146298
    UMLS CUI [1,2]
    C0034510
    UMLS CUI [1,3]
    C5142998
    Metal objects that may interfere with chest CT quantification including presence of a cardiac pacemaker, defibrillator, metal prosthetic heart valve, or metal shoulder prosthesis
    Beschreibung

    Metal objects that may interfere with chest CT quantification including presence of a cardiac pacemaker, defibrillator, metal prosthetic heart valve, or metal shoulder prosthesis

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C2984008
    UMLS CUI [1,2]
    C0040405
    UMLS CUI [1,3]
    C2240369
    UMLS CUI [1,4]
    C4270802
    UMLS CUI [1,5]
    C1385346
    UMLS CUI [1,6]
    C0493002
    Subjects with affirmative answers to the following:
    Beschreibung

    Subjects with affirmative answers to the following:

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C0681799
    UMLS CUI [1,2]
    C1706817
    UMLS CUI [1,3]
    C1446409
    chest or abdominal surgery in the past three months
    Beschreibung

    chest or abdominal surgery in the past three months

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C0524832
    UMLS CUI [1,2]
    C0198482
    UMLS CUI [1,3]
    C4086725
    a heart attack in the last three months
    Beschreibung

    a heart attack in the last three months

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C0027051
    UMLS CUI [1,2]
    C4086725
    detached retina or eye surgery in the past three months
    Beschreibung

    detached retina or eye surgery in the past three months

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C0035305
    UMLS CUI [1,2]
    C0038901
    UMLS CUI [1,3]
    C4086725
    hospitalization for any other heart problem in the past month
    Beschreibung

    hospitalization for any other heart problem in the past month

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C0019993
    UMLS CUI [1,2]
    C0795691
    UMLS CUI [1,3]
    C4331910
    Participation in the ECLIPSE study, Boston Early-Onset COPD Study, or International COPD Genetics Network (Selected replication cohorts)
    Beschreibung

    Participation in the ECLIPSE study, Boston Early-Onset COPD Study, or International COPD Genetics Network (Selected replication cohorts)

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C2348568
    UMLS CUI [1,2]
    C0947630
    UMLS CUI [1,3]
    C0024117
    *Smokers without COPD:*
    Beschreibung

    *Smokers without COPD:*

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C0337664
    UMLS CUI [1,2]
    C0332288
    UMLS CUI [1,3]
    C0024117
    Inclusion CriteriaAge at Enrollment: 45 - 80 years
    Beschreibung

    Inclusion CriteriaAge at Enrollment: 45 - 80 years

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C1512693
    UMLS CUI [1,2]
    C1516879
    UMLS CUI [1,3]
    C0001779
    UMLS CUI [1,4]
    C1442880
    History (current or former) of cigarette smoking = 10 pack-years
    Beschreibung

    History (current or former) of cigarette smoking = 10 pack-years

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C1519384
    UMLS CUI [1,2]
    C1277691
    Post-bronchodilator FEV1/FVC = 0.70 and FEV1 = 80% predicted
    Beschreibung

    Post-bronchodilator FEV1/FVC = 0.70 and FEV1 = 80% predicted

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C5204349
    UMLS CUI [1,2]
    C0849974
    Non-Hispanic White or non-Hispanic African American
    Beschreibung

    Non-Hispanic White or non-Hispanic African American

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C1518424
    UMLS CUI [1,2]
    C0085756
    UMLS CUI [1,3]
    C0007457
    Exclusion CriteriaPhysician diagnosed respiratory disease other than COPD or asthma (based on subject report)
    Beschreibung

    Exclusion CriteriaPhysician diagnosed respiratory disease other than COPD or asthma (based on subject report)

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C0680251
    UMLS CUI [1,2]
    C0011900
    UMLS CUI [1,3]
    C0031831
    UMLS CUI [1,4]
    C4723751
    UMLS CUI [1,5]
    C0004096
    UMLS CUI [1,6]
    C0024117
    Lung surgery with removal of a lobe or more (including lung volume reduction surgery and lung transplantation)
    Beschreibung

    Lung surgery with removal of a lobe or more (including lung volume reduction surgery and lung transplantation)

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C0038903
    UMLS CUI [1,2]
    C0189497
    UMLS CUI [1,3]
    C0524689
    UMLS CUI [1,4]
    C0024128
    Pregnancy or suspected pregnancy
    Beschreibung

    Pregnancy or suspected pregnancy

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C0032961
    UMLS CUI [1,2]
    C5670366
    Lung cancer, known or suspected
    Beschreibung

    Lung cancer, known or suspected

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C0242379
    UMLS CUI [1,2]
    C0277540
    UMLS CUI [1,3]
    C0011900
    Uncontrolled cancer, defined as ongoing radiation therapy, ongoing chemotherapy, narcotics for pain control, or known metastatic disease
    Beschreibung

    Uncontrolled cancer, defined as ongoing radiation therapy, ongoing chemotherapy, narcotics for pain control, or known metastatic disease

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C0006826
    UMLS CUI [1,2]
    C0205318
    UMLS CUI [1,3]
    C0549178
    UMLS CUI [1,4]
    C1522449
    UMLS CUI [1,5]
    C0392920
    UMLS CUI [1,6]
    C0027627
    UMLS CUI [1,7]
    C3898936
    History of radiation therapy to the chest
    Beschreibung

    History of radiation therapy to the chest

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C0262926
    UMLS CUI [1,2]
    C1522449
    UMLS CUI [1,3]
    C0817096
    Use of antibiotics (new prescription or increased dose) for a respiratory infection within the past month
    Beschreibung

    Use of antibiotics (new prescription or increased dose) for a respiratory infection within the past month

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C1524063
    UMLS CUI [1,2]
    C0003232
    UMLS CUI [1,3]
    C2825233
    UMLS CUI [1,4]
    C0740304
    UMLS CUI [1,5]
    C0035243
    UMLS CUI [1,6]
    C1948053
    UMLS CUI [1,7]
    C4331910
    Use of systemic corticosteroids (new prescription or increased dose) for a respiratory process within the past month
    Beschreibung

    Use of systemic corticosteroids (new prescription or increased dose) for a respiratory process within the past month

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C1524063
    UMLS CUI [1,2]
    C0003232
    UMLS CUI [1,3]
    C2825233
    UMLS CUI [1,4]
    C1948053
    UMLS CUI [1,5]
    C4331910
    Inability to use albuterol
    Beschreibung

    Inability to use albuterol

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C1299582
    UMLS CUI [1,2]
    C1524063
    UMLS CUI [1,3]
    C0001927
    First or second degree relative (parent, brother, sister, daughter, son, aunt, uncle, nephew, niece, half-sibling, grandparent, or grandchild) of a subject enrolled in COPDGene
    Beschreibung

    First or second degree relative (parent, brother, sister, daughter, son, aunt, uncle, nephew, niece, half-sibling, grandparent, or grandchild) of a subject enrolled in COPDGene

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C1517194
    UMLS CUI [1,2]
    C1519210
    UMLS CUI [1,3]
    C0337514
    UMLS CUI [1,4]
    C0337527
    UMLS CUI [1,5]
    C0337576
    UMLS CUI [1,6]
    C0337577
    UMLS CUI [1,7]
    C0337471
    UMLS CUI [1,8]
    C0337548
    UMLS CUI [1,9]
    C0337505
    UMLS CUI [1,10]
    C1553703
    UMLS CUI [1,11]
    C0030551
    UMLS CUI [1,12]
    C0008059
    UMLS CUI [1,13]
    C5419021
    Subjects who indicate they are in more than one racial category
    Beschreibung

    Subjects who indicate they are in more than one racial category

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C3146298
    UMLS CUI [1,2]
    C0034510
    UMLS CUI [1,3]
    C5142998
    Metal objects that may interfere with chest CT quantification including presence of a cardiac pacemaker, defibrillator, metal prosthetic heart valve, or metal shoulder prosthesis
    Beschreibung

    Metal objects that may interfere with chest CT quantification including presence of a cardiac pacemaker, defibrillator, metal prosthetic heart valve, or metal shoulder prosthesis

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C2984008
    UMLS CUI [1,2]
    C0040405
    UMLS CUI [1,3]
    C2240369
    UMLS CUI [1,4]
    C4270802
    UMLS CUI [1,5]
    C1385346
    UMLS CUI [1,6]
    C0493002
    Subjects with affirmative answers to the following:
    Beschreibung

    Subjects with affirmative answers to the following:

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C0681799
    UMLS CUI [1,2]
    C1706817
    UMLS CUI [1,3]
    C1446409
    chest or abdominal surgery in the past three months
    Beschreibung

    chest or abdominal surgery in the past three months

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C0524832
    UMLS CUI [1,2]
    C0198482
    UMLS CUI [1,3]
    C4086725
    a heart attack in the last three months
    Beschreibung

    a heart attack in the last three months

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C0027051
    UMLS CUI [1,2]
    C4086725
    detached retina or eye surgery in the past three months
    Beschreibung

    detached retina or eye surgery in the past three months

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C0035305
    UMLS CUI [1,2]
    C0038901
    UMLS CUI [1,3]
    C4086725
    hospitalization for any other heart problem in the past month
    Beschreibung

    hospitalization for any other heart problem in the past month

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C0019993
    UMLS CUI [1,2]
    C0795691
    UMLS CUI [1,3]
    C4331910
    Participation in the ECLIPSE study, Boston Early-Onset COPD Study, or International COPD Genetics Network (Selected replication cohorts)
    Beschreibung

    Participation in the ECLIPSE study, Boston Early-Onset COPD Study, or International COPD Genetics Network (Selected replication cohorts)

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C2348568
    UMLS CUI [1,2]
    C0947630
    UMLS CUI [1,3]
    C0024117
    *Note that similar enrollment criteria were utilized for lifelong nonsmoking control subjects.*
    Beschreibung

    *Note that similar enrollment criteria were utilized for lifelong nonsmoking control subjects.*

    Datentyp

    boolean

    Alias
    UMLS CUI [1,1]
    C1516879
    UMLS CUI [1,2]
    C2348205
    UMLS CUI [1,3]
    C0425293
    UMLS CUI [1,4]
    C0009932
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    Ähnliche Modelle

    Eligibility Criteria

    4 Formulare
    Name
    Typ
    Description | Question | Decode (Coded Value)
    Datentyp
    Alias
    Item Group
    Inclusion and exclusion criteria
    C1512693 (UMLS CUI [1,1])
    C0680251 (UMLS CUI [1,2])
    *COPD Cases:*
    Item
    *COPD Cases:*
    boolean
    C0024117 (UMLS CUI [1,1])
    C1706256 (UMLS CUI [1,2])
    Inclusion CriteriaAge at Enrollment: 45 - 80 years
    Item
    Inclusion CriteriaAge at Enrollment: 45 - 80 years
    boolean
    C1512693 (UMLS CUI [1,1])
    C1516879 (UMLS CUI [1,2])
    C0001779 (UMLS CUI [1,3])
    Smoking history of = 10 pack-years
    Item
    Smoking history of = 10 pack-years
    boolean
    C1519384 (UMLS CUI [1,1])
    C1277691 (UMLS CUI [1,2])
    C0449788 (UMLS CUI [1,3])
    Diagnosis of COPD Stages 2, 3 and 4 by GOLD criteria (post-bronchodilator FEV1/FVC < 0.70 and FEV1 < 80% predicted)
    Item
    Diagnosis of COPD Stages 2, 3 and 4 by GOLD criteria (post-bronchodilator FEV1/FVC < 0.70 and FEV1 < 80% predicted)
    boolean
    C0011900 (UMLS CUI [1,1])
    C0024117 (UMLS CUI [1,2])
    C0679228 (UMLS CUI [1,3])
    C5204349 (UMLS CUI [1,4])
    Non-Hispanic White or non-Hispanic African American
    Item
    Non-Hispanic White or non-Hispanic African American
    boolean
    C1518424 (UMLS CUI [1,1])
    C0085756 (UMLS CUI [1,2])
    C0007457 (UMLS CUI [1,3])
    Exclusion CriteriaConcomitant respiratory disorder other than asthma or COPD (such as, but not limited to, diffuse bronchiectasis, cystic fibrosis, or interstitial lung disease)
    Item
    Exclusion CriteriaConcomitant respiratory disorder other than asthma or COPD (such as, but not limited to, diffuse bronchiectasis, cystic fibrosis, or interstitial lung disease)
    boolean
    C0680251 (UMLS CUI [1,1])
    C0243087 (UMLS CUI [1,2])
    C0024115 (UMLS CUI [1,3])
    C4723751 (UMLS CUI [1,4])
    C0024117 (UMLS CUI [1,5])
    C0004096 (UMLS CUI [1,6])
    Lung surgery with removal of a lobe or more (including lung volume reduction surgery or lung transplantation)
    Item
    Lung surgery with removal of a lobe or more (including lung volume reduction surgery or lung transplantation)
    boolean
    C0038903 (UMLS CUI [1,1])
    C0189497 (UMLS CUI [1,2])
    C0524689 (UMLS CUI [1,3])
    C0024128 (UMLS CUI [1,4])
    Lung cancer, known or suspected
    Item
    Lung cancer, known or suspected
    boolean
    C0242379 (UMLS CUI [1,1])
    C0277540 (UMLS CUI [1,2])
    C0011900 (UMLS CUI [1,3])
    Surgical or bronchoscopic lung volume reduction
    Item
    Surgical or bronchoscopic lung volume reduction
    boolean
    C0524689 (UMLS CUI [1,1])
    C3697654 (UMLS CUI [1,2])
    Pregnancy or suspected pregnancy
    Item
    Pregnancy or suspected pregnancy
    boolean
    C0032961 (UMLS CUI [1,1])
    C5670366 (UMLS CUI [1,2])
    Uncontrolled cancer, defined as ongoing radiation therapy, ongoing chemotherapy, narcotics for pain control, or known metastatic disease
    Item
    Uncontrolled cancer, defined as ongoing radiation therapy, ongoing chemotherapy, narcotics for pain control, or known metastatic disease
    boolean
    C0006826 (UMLS CUI [1,1])
    C0205318 (UMLS CUI [1,2])
    C0549178 (UMLS CUI [1,3])
    C1522449 (UMLS CUI [1,4])
    C0392920 (UMLS CUI [1,5])
    C0027627 (UMLS CUI [1,6])
    C3898936 (UMLS CUI [1,7])
    History of radiation therapy to the chest (other than for breast cancer)
    Item
    History of radiation therapy to the chest (other than for breast cancer)
    boolean
    C0262926 (UMLS CUI [1,1])
    C1522449 (UMLS CUI [1,2])
    C0817096 (UMLS CUI [1,3])
    C4723751 (UMLS CUI [1,4])
    C0678222 (UMLS CUI [1,5])
    Use of antibiotics and/or systemic steroids (new prescription or increased dose) for a COPD exacerbation or respiratory infection within the last month
    Item
    Use of antibiotics and/or systemic steroids (new prescription or increased dose) for a COPD exacerbation or respiratory infection within the last month
    boolean
    C1524063 (UMLS CUI [1,1])
    C0003232 (UMLS CUI [1,2])
    C2825233 (UMLS CUI [1,3])
    C0740304 (UMLS CUI [1,4])
    C0035243 (UMLS CUI [1,5])
    C1948053 (UMLS CUI [1,6])
    C4331910 (UMLS CUI [1,7])
    Inability to use albuterol
    Item
    Inability to use albuterol
    boolean
    C1299582 (UMLS CUI [1,1])
    C1524063 (UMLS CUI [1,2])
    C0001927 (UMLS CUI [1,3])
    First or second degree relative (parent, brother, sister, daughter, son, aunt, uncle, nephew, niece, half-sibling, grandparent, grandchild) of a subject enrolled in COPDGene
    Item
    First or second degree relative (parent, brother, sister, daughter, son, aunt, uncle, nephew, niece, half-sibling, grandparent, grandchild) of a subject enrolled in COPDGene
    boolean
    C1517194 (UMLS CUI [1,1])
    C1519210 (UMLS CUI [1,2])
    C0337514 (UMLS CUI [1,3])
    C0337527 (UMLS CUI [1,4])
    C0337576 (UMLS CUI [1,5])
    C0337577 (UMLS CUI [1,6])
    C0337471 (UMLS CUI [1,7])
    C0337548 (UMLS CUI [1,8])
    C0337505 (UMLS CUI [1,9])
    C1553703 (UMLS CUI [1,10])
    C0030551 (UMLS CUI [1,11])
    C0008059 (UMLS CUI [1,12])
    C5419021 (UMLS CUI [1,13])
    Subjects who indicate they are in more than one racial category
    Item
    Subjects who indicate they are in more than one racial category
    boolean
    C3146298 (UMLS CUI [1,1])
    C0034510 (UMLS CUI [1,2])
    C5142998 (UMLS CUI [1,3])
    Metal objects that may interfere with chest CT quantification including presence of a cardiac pacemaker, defibrillator, metal prosthetic heart valve, or metal shoulder prosthesis
    Item
    Metal objects that may interfere with chest CT quantification including presence of a cardiac pacemaker, defibrillator, metal prosthetic heart valve, or metal shoulder prosthesis
    boolean
    C2984008 (UMLS CUI [1,1])
    C0040405 (UMLS CUI [1,2])
    C2240369 (UMLS CUI [1,3])
    C4270802 (UMLS CUI [1,4])
    C1385346 (UMLS CUI [1,5])
    C0493002 (UMLS CUI [1,6])
    Subjects with affirmative answers to the following:
    Item
    Subjects with affirmative answers to the following:
    boolean
    C0681799 (UMLS CUI [1,1])
    C1706817 (UMLS CUI [1,2])
    C1446409 (UMLS CUI [1,3])
    chest or abdominal surgery in the past three months
    Item
    chest or abdominal surgery in the past three months
    boolean
    C0524832 (UMLS CUI [1,1])
    C0198482 (UMLS CUI [1,2])
    C4086725 (UMLS CUI [1,3])
    a heart attack in the last three months
    Item
    a heart attack in the last three months
    boolean
    C0027051 (UMLS CUI [1,1])
    C4086725 (UMLS CUI [1,2])
    detached retina or eye surgery in the past three months
    Item
    detached retina or eye surgery in the past three months
    boolean
    C0035305 (UMLS CUI [1,1])
    C0038901 (UMLS CUI [1,2])
    C4086725 (UMLS CUI [1,3])
    hospitalization for any other heart problem in the past month
    Item
    hospitalization for any other heart problem in the past month
    boolean
    C0019993 (UMLS CUI [1,1])
    C0795691 (UMLS CUI [1,2])
    C4331910 (UMLS CUI [1,3])
    Participation in the ECLIPSE study, Boston Early-Onset COPD Study, or International COPD Genetics Network (Selected replication cohorts)
    Item
    Participation in the ECLIPSE study, Boston Early-Onset COPD Study, or International COPD Genetics Network (Selected replication cohorts)
    boolean
    C2348568 (UMLS CUI [1,1])
    C0947630 (UMLS CUI [1,2])
    C0024117 (UMLS CUI [1,3])
    *Smokers without COPD:*
    Item
    *Smokers without COPD:*
    boolean
    C0337664 (UMLS CUI [1,1])
    C0332288 (UMLS CUI [1,2])
    C0024117 (UMLS CUI [1,3])
    Inclusion CriteriaAge at Enrollment: 45 - 80 years
    Item
    Inclusion CriteriaAge at Enrollment: 45 - 80 years
    boolean
    C1512693 (UMLS CUI [1,1])
    C1516879 (UMLS CUI [1,2])
    C0001779 (UMLS CUI [1,3])
    C1442880 (UMLS CUI [1,4])
    History (current or former) of cigarette smoking = 10 pack-years
    Item
    History (current or former) of cigarette smoking = 10 pack-years
    boolean
    C1519384 (UMLS CUI [1,1])
    C1277691 (UMLS CUI [1,2])
    Post-bronchodilator FEV1/FVC = 0.70 and FEV1 = 80% predicted
    Item
    Post-bronchodilator FEV1/FVC = 0.70 and FEV1 = 80% predicted
    boolean
    C5204349 (UMLS CUI [1,1])
    C0849974 (UMLS CUI [1,2])
    Non-Hispanic White or non-Hispanic African American
    Item
    Non-Hispanic White or non-Hispanic African American
    boolean
    C1518424 (UMLS CUI [1,1])
    C0085756 (UMLS CUI [1,2])
    C0007457 (UMLS CUI [1,3])
    Exclusion CriteriaPhysician diagnosed respiratory disease other than COPD or asthma (based on subject report)
    Item
    Exclusion CriteriaPhysician diagnosed respiratory disease other than COPD or asthma (based on subject report)
    boolean
    C0680251 (UMLS CUI [1,1])
    C0011900 (UMLS CUI [1,2])
    C0031831 (UMLS CUI [1,3])
    C4723751 (UMLS CUI [1,4])
    C0004096 (UMLS CUI [1,5])
    C0024117 (UMLS CUI [1,6])
    Lung surgery with removal of a lobe or more (including lung volume reduction surgery and lung transplantation)
    Item
    Lung surgery with removal of a lobe or more (including lung volume reduction surgery and lung transplantation)
    boolean
    C0038903 (UMLS CUI [1,1])
    C0189497 (UMLS CUI [1,2])
    C0524689 (UMLS CUI [1,3])
    C0024128 (UMLS CUI [1,4])
    Pregnancy or suspected pregnancy
    Item
    Pregnancy or suspected pregnancy
    boolean
    C0032961 (UMLS CUI [1,1])
    C5670366 (UMLS CUI [1,2])
    Lung cancer, known or suspected
    Item
    Lung cancer, known or suspected
    boolean
    C0242379 (UMLS CUI [1,1])
    C0277540 (UMLS CUI [1,2])
    C0011900 (UMLS CUI [1,3])
    Uncontrolled cancer, defined as ongoing radiation therapy, ongoing chemotherapy, narcotics for pain control, or known metastatic disease
    Item
    Uncontrolled cancer, defined as ongoing radiation therapy, ongoing chemotherapy, narcotics for pain control, or known metastatic disease
    boolean
    C0006826 (UMLS CUI [1,1])
    C0205318 (UMLS CUI [1,2])
    C0549178 (UMLS CUI [1,3])
    C1522449 (UMLS CUI [1,4])
    C0392920 (UMLS CUI [1,5])
    C0027627 (UMLS CUI [1,6])
    C3898936 (UMLS CUI [1,7])
    History of radiation therapy to the chest
    Item
    History of radiation therapy to the chest
    boolean
    C0262926 (UMLS CUI [1,1])
    C1522449 (UMLS CUI [1,2])
    C0817096 (UMLS CUI [1,3])
    Use of antibiotics (new prescription or increased dose) for a respiratory infection within the past month
    Item
    Use of antibiotics (new prescription or increased dose) for a respiratory infection within the past month
    boolean
    C1524063 (UMLS CUI [1,1])
    C0003232 (UMLS CUI [1,2])
    C2825233 (UMLS CUI [1,3])
    C0740304 (UMLS CUI [1,4])
    C0035243 (UMLS CUI [1,5])
    C1948053 (UMLS CUI [1,6])
    C4331910 (UMLS CUI [1,7])
    Use of systemic corticosteroids (new prescription or increased dose) for a respiratory process within the past month
    Item
    Use of systemic corticosteroids (new prescription or increased dose) for a respiratory process within the past month
    boolean
    C1524063 (UMLS CUI [1,1])
    C0003232 (UMLS CUI [1,2])
    C2825233 (UMLS CUI [1,3])
    C1948053 (UMLS CUI [1,4])
    C4331910 (UMLS CUI [1,5])
    Inability to use albuterol
    Item
    Inability to use albuterol
    boolean
    C1299582 (UMLS CUI [1,1])
    C1524063 (UMLS CUI [1,2])
    C0001927 (UMLS CUI [1,3])
    First or second degree relative (parent, brother, sister, daughter, son, aunt, uncle, nephew, niece, half-sibling, grandparent, or grandchild) of a subject enrolled in COPDGene
    Item
    First or second degree relative (parent, brother, sister, daughter, son, aunt, uncle, nephew, niece, half-sibling, grandparent, or grandchild) of a subject enrolled in COPDGene
    boolean
    C1517194 (UMLS CUI [1,1])
    C1519210 (UMLS CUI [1,2])
    C0337514 (UMLS CUI [1,3])
    C0337527 (UMLS CUI [1,4])
    C0337576 (UMLS CUI [1,5])
    C0337577 (UMLS CUI [1,6])
    C0337471 (UMLS CUI [1,7])
    C0337548 (UMLS CUI [1,8])
    C0337505 (UMLS CUI [1,9])
    C1553703 (UMLS CUI [1,10])
    C0030551 (UMLS CUI [1,11])
    C0008059 (UMLS CUI [1,12])
    C5419021 (UMLS CUI [1,13])
    Subjects who indicate they are in more than one racial category
    Item
    Subjects who indicate they are in more than one racial category
    boolean
    C3146298 (UMLS CUI [1,1])
    C0034510 (UMLS CUI [1,2])
    C5142998 (UMLS CUI [1,3])
    Metal objects that may interfere with chest CT quantification including presence of a cardiac pacemaker, defibrillator, metal prosthetic heart valve, or metal shoulder prosthesis
    Item
    Metal objects that may interfere with chest CT quantification including presence of a cardiac pacemaker, defibrillator, metal prosthetic heart valve, or metal shoulder prosthesis
    boolean
    C2984008 (UMLS CUI [1,1])
    C0040405 (UMLS CUI [1,2])
    C2240369 (UMLS CUI [1,3])
    C4270802 (UMLS CUI [1,4])
    C1385346 (UMLS CUI [1,5])
    C0493002 (UMLS CUI [1,6])
    Subjects with affirmative answers to the following:
    Item
    Subjects with affirmative answers to the following:
    boolean
    C0681799 (UMLS CUI [1,1])
    C1706817 (UMLS CUI [1,2])
    C1446409 (UMLS CUI [1,3])
    chest or abdominal surgery in the past three months
    Item
    chest or abdominal surgery in the past three months
    boolean
    C0524832 (UMLS CUI [1,1])
    C0198482 (UMLS CUI [1,2])
    C4086725 (UMLS CUI [1,3])
    a heart attack in the last three months
    Item
    a heart attack in the last three months
    boolean
    C0027051 (UMLS CUI [1,1])
    C4086725 (UMLS CUI [1,2])
    detached retina or eye surgery in the past three months
    Item
    detached retina or eye surgery in the past three months
    boolean
    C0035305 (UMLS CUI [1,1])
    C0038901 (UMLS CUI [1,2])
    C4086725 (UMLS CUI [1,3])
    hospitalization for any other heart problem in the past month
    Item
    hospitalization for any other heart problem in the past month
    boolean
    C0019993 (UMLS CUI [1,1])
    C0795691 (UMLS CUI [1,2])
    C4331910 (UMLS CUI [1,3])
    Participation in the ECLIPSE study, Boston Early-Onset COPD Study, or International COPD Genetics Network (Selected replication cohorts)
    Item
    Participation in the ECLIPSE study, Boston Early-Onset COPD Study, or International COPD Genetics Network (Selected replication cohorts)
    boolean
    C2348568 (UMLS CUI [1,1])
    C0947630 (UMLS CUI [1,2])
    C0024117 (UMLS CUI [1,3])
    *Note that similar enrollment criteria were utilized for lifelong nonsmoking control subjects.*
    Item
    *Note that similar enrollment criteria were utilized for lifelong nonsmoking control subjects.*
    boolean
    C1516879 (UMLS CUI [1,1])
    C2348205 (UMLS CUI [1,2])
    C0425293 (UMLS CUI [1,3])
    C0009932 (UMLS CUI [1,4])
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