ID
45913
Description
Principal Investigator: David Christiani, MD, MPH, Harvard T.H. Chan School of Public Health, Boston, MA, USA MeSH: Cardiovascular Disease https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000968 The study was initially designed as a longitudinal cohort study of cardiovascular effects of particulate exposure. Participants were boilermaker construction workers who were exposed to particulate matter (PM) component (e.g. a focus on metal constituents) while performing welding, grinding or cutting work in the welding plants. Participants were followed up approximately half a year for a non-work day and a work day from 1999 to 2012, and blood, urine, blood pressure, as well as real-time PM2.5 samples were collected from each participant. In this specific study, we conducted epigenome-wide DNA methylation profiling through Center for Inherited Disease Research (CIDR) services using Illumina Infinium HumanMethylation450, which will give us more compete epigenome-wide coverage. Genome-wide DNA methylation was carried out on paired samples pre- and post-work shift at a welding apprentice school. With transcriptomic and metabolomic data already generated from the same panel study, we will be able to conduct integrative analysis to gain insights into mechanisms of gene-metal interactions and maximize the probability of finding genes functionally relevant to PM-induced adverse cardiovascular outcomes.
Link
Keywords
Versions (1)
- 1/26/24 1/26/24 - Simon Heim
Copyright Holder
David Christiani, MD, MPH, Harvard T.H. Chan School of Public Health, Boston, MA, USA
Uploaded on
January 26, 2024
DOI
To request one please log in.
License
Creative Commons BY 4.0
Model comments :
You can comment on the data model here. Via the speech bubbles at the itemgroups and items you can add comments to those specificially.
Itemgroup comments for :
Item comments for :
In order to download data models you must be logged in. Please log in or register for free.
dbGaP phs000968 The Cardiopulmonary Effects of Particulate Exposure
The subject consent file includes subject ID and consent information.
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent file includes subject ID and consent information.
- pht004913.v2.p1
- This subject phenotype table contains de-identified subject ID, retirement status, current smoking status, age, gender, race, weight, height and BMI of the participant, and number of years as a boilermaker.
- This sample attributes table contains de-identified sample ID, body site, analyte type, tumor status, histological type, blood collections before and after metal fume exposure, and sample collections on a welding and non-welding day.
Similar models
The subject consent file includes subject ID and consent information.
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent file includes subject ID and consent information.
- pht004913.v2.p1
- This subject phenotype table contains de-identified subject ID, retirement status, current smoking status, age, gender, race, weight, height and BMI of the participant, and number of years as a boilermaker.
- This sample attributes table contains de-identified sample ID, body site, analyte type, tumor status, histological type, blood collections before and after metal fume exposure, and sample collections on a welding and non-welding day.
No comments