0 Ratings
ID

45913

Description

Principal Investigator: David Christiani, MD, MPH, Harvard T.H. Chan School of Public Health, Boston, MA, USA MeSH: Cardiovascular Disease https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000968 The study was initially designed as a longitudinal cohort study of cardiovascular effects of particulate exposure. Participants were boilermaker construction workers who were exposed to particulate matter (PM) component (e.g. a focus on metal constituents) while performing welding, grinding or cutting work in the welding plants. Participants were followed up approximately half a year for a non-work day and a work day from 1999 to 2012, and blood, urine, blood pressure, as well as real-time PM2.5 samples were collected from each participant. In this specific study, we conducted epigenome-wide DNA methylation profiling through Center for Inherited Disease Research (CIDR) services using Illumina Infinium HumanMethylation450, which will give us more compete epigenome-wide coverage. Genome-wide DNA methylation was carried out on paired samples pre- and post-work shift at a welding apprentice school. With transcriptomic and metabolomic data already generated from the same panel study, we will be able to conduct integrative analysis to gain insights into mechanisms of gene-metal interactions and maximize the probability of finding genes functionally relevant to PM-induced adverse cardiovascular outcomes.

Link

dbGaP study = phs000968

Keywords

Versions (1)
  1. 1/26/24 1/26/24 - Simon Heim
Copyright Holder

David Christiani, MD, MPH, Harvard T.H. Chan School of Public Health, Boston, MA, USA

Uploaded on

January 26, 2024

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Creative Commons BY 4.0
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    dbGaP phs000968 The Cardiopulmonary Effects of Particulate Exposure

    English

    Eligibility Criteria

    5 forms  
    Inclusion and exclusion criteria
    Description

    Inclusion and exclusion criteria

    Alias
    UMLS CUI [1,1]
    C1512693
    UMLS CUI [1,2]
    C0680251
    *Inclusion*: Active contractor of a local boilermaker union in Quincy, Massachusetts, USA.
    Description

    *Inclusion*: Active contractor of a local boilermaker union in Quincy, Massachusetts, USA.

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C1512693
    UMLS CUI [1,2]
    C1511499
    UMLS CUI [1,3]
    C0679217
    UMLS CUI [1,4]
    C0028811
    UMLS CUI [1,5]
    C3846158
    UMLS CUI [1,6]
    C2825217
    UMLS CUI [1,7]
    C0024874
    *Exclusion*: Unstable angina symptoms, left bundle branch block, atrial fibrillation, atrial flutter and other rhythms that would compromise interpretation of heart rate variability (HRV), which measures the cardiovascular autonomic responses.
    Description

    *Exclusion*: Unstable angina symptoms, left bundle branch block, atrial fibrillation, atrial flutter and other rhythms that would compromise interpretation of heart rate variability (HRV), which measures the cardiovascular autonomic responses.

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0680251
    UMLS CUI [1,2]
    C0002965
    UMLS CUI [1,3]
    C1457887
    UMLS CUI [1,4]
    C0023211
    UMLS CUI [1,5]
    C0004238
    UMLS CUI [1,6]
    C0004239
    UMLS CUI [1,7]
    C0232187
    UMLS CUI [1,8]
    C2945640
    UMLS CUI [1,9]
    C0459471
    UMLS CUI [1,10]
    C4761043
    UMLS CUI [1,11]
    C0242485
    UMLS CUI [1,12]
    C0234597
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    Similar models

    Eligibility Criteria

    5 forms
    Name
    Type
    Description | Question | Decode (Coded Value)
    Data type
    Alias
    Item Group
    Inclusion and exclusion criteria
    C1512693 (UMLS CUI [1,1])
    C0680251 (UMLS CUI [1,2])
    *Inclusion*: Active contractor of a local boilermaker union in Quincy, Massachusetts, USA.
    Item
    *Inclusion*: Active contractor of a local boilermaker union in Quincy, Massachusetts, USA.
    boolean
    C1512693 (UMLS CUI [1,1])
    C1511499 (UMLS CUI [1,2])
    C0679217 (UMLS CUI [1,3])
    C0028811 (UMLS CUI [1,4])
    C3846158 (UMLS CUI [1,5])
    C2825217 (UMLS CUI [1,6])
    C0024874 (UMLS CUI [1,7])
    *Exclusion*: Unstable angina symptoms, left bundle branch block, atrial fibrillation, atrial flutter and other rhythms that would compromise interpretation of heart rate variability (HRV), which measures the cardiovascular autonomic responses.
    Item
    *Exclusion*: Unstable angina symptoms, left bundle branch block, atrial fibrillation, atrial flutter and other rhythms that would compromise interpretation of heart rate variability (HRV), which measures the cardiovascular autonomic responses.
    boolean
    C0680251 (UMLS CUI [1,1])
    C0002965 (UMLS CUI [1,2])
    C1457887 (UMLS CUI [1,3])
    C0023211 (UMLS CUI [1,4])
    C0004238 (UMLS CUI [1,5])
    C0004239 (UMLS CUI [1,6])
    C0232187 (UMLS CUI [1,7])
    C2945640 (UMLS CUI [1,8])
    C0459471 (UMLS CUI [1,9])
    C4761043 (UMLS CUI [1,10])
    C0242485 (UMLS CUI [1,11])
    C0234597 (UMLS CUI [1,12])
    Back to the top of the page 

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