ID

45888

Beschreibung

Principal Investigator: Susan R. Heckbert, MD, PhD, University of Washington, Seattle, WA, USA MeSH: Cardiovascular Disease,Venous Thrombosis,Atrial Fibrillation https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000993 *Objectives*br The Heart and Vascular Health Study (HVH) is a case-control study of risk factors for the development of myocardial infarction (MI), stroke, venous thrombosis (VT), and atrial fibrillation (AF). The study setting is Group Health, an integrated health care delivery system in Washington State. Only VT cases and early-onset AF cases are included as part of TOPMed. *Background*br The HVH study originated in 1988 with the examination of risk factors for MI. Over the ensuing years, the study has been funded by a series of grants which have added case subjects with stroke, VT, and AF. Study aims focused on the associations of medication use with cardiovascular events, and starting in 1997, the study aims expanded to include genetic associations with cardiovascular disease. Participants recruited in 2009 or later who provided blood samples for genetic analysis were asked for consent to deposit genetic and phenotypic data in dbGaP. *Design*br As part of the HVH study, case subjects were identified by searching for ICD-9 codes consistent with MI, stroke, VT, or AF, and medical records were reviewed to confirm the diagnosis. Control subjects were identified at random from the Group Health enrollment and were matched to MI cases. All subjects have an index date. For cases, the index date was assigned as the date that the cardiovascular event (MI, stroke, VT, or AF) came to clinical attention. For controls, the index date was a random date within the range of the case index dates. For both cases and controls, information was collected from the inpatient and outpatient medical record, by telephone interview with consenting survivors, and from the Group Health pharmacy and laboratory databases. Consenting participants provided a blood specimen. *Subjects*br Only VT and early-onset AF cases from HVH are included in TOPMed. Within the HVH study, VT and AF cases were diagnosed in both inpatient and outpatient settings, and only incident cases are eligible for inclusion in TOPMed. *Genetic Research*br Genetic factors underlying cardiovascular disease are studied using DNA isolated from the blood samples. Phenotype data for HVH study participants are available through dbGaP phs001013.

Link

dbGaP study = phs000993

Stichworte

Versionen (1)
  1. 25.11.23 25.11.23 - Simon Heim
Rechteinhaber

Susan R. Heckbert, MD, PhD, University of Washington, Seattle, WA, USA

Hochgeladen am

25. November 2023

DOI

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Lizenz

Creative Commons BY 4.0
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dbGaP phs000993 NHLBI TOPMed: Heart and Vascular Health Study (HVH)

Englisch

Eligibility Criteria

4 Formulare  
Inclusion and exclusion criteria
Beschreibung

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0680251
*Early Onset AF*<br> The AF study identified early onset AF cases with a date of clinically recognized AF onset between January 2005 and June 2007. Early onset AF is defined as AF first recognized at ages 30-65 in a person with no known heart disease, and includes both AF and atrial flutter. First-time episodes of AF diagnosed in inpatient and outpatient settings were included. AF and its date of onset were verified by review of the inpatient and outpatient medical records. First-time episodes of AF that occurred during or after a surgical procedure and had resolved by the time of hospital discharge were not included. However, if a person had surgery-related AF that resolved, and later in time had AF that occurred in the absence of surgery, that second event was eligible as a first lifetime episode of non-surgery-related AF. If the onset of AF was recognized in a subject who already had clinically recognized heart disease, including heart failure, myocardial infarction, probable or definite angina, coronary bypass, coronary angioplasty, moderate or severe valvular heart disease, severe left ventricular hypertrophy, congenital heart disease, implanted pacemaker/AICD, or poor left ventricular systolic function, the AF case was not included. If a diagnosis of hyperthyroidism, pneumonia, active alcoholism, or another specific condition was identified as precipitating the AF, the AF case was not included.
Beschreibung

*Early Onset AF*<br> The AF study identified early onset AF cases with a date of clinically recognized AF onset between January 2005 and June 2007. Early onset AF is defined as AF first recognized at ages 30-65 in a person with no known heart disease, and includes both AF and atrial flutter. First-time episodes of AF diagnosed in inpatient and outpatient settings were included. AF and its date of onset were verified by review of the inpatient and outpatient medical records. First-time episodes of AF that occurred during or after a surgical procedure and had resolved by the time of hospital discharge were not included. However, if a person had surgery-related AF that resolved, and later in time had AF that occurred in the absence of surgery, that second event was eligible as a first lifetime episode of non-surgery-related AF. If the onset of AF was recognized in a subject who already had clinically recognized heart disease, including heart failure, myocardial infarction, probable or definite angina, coronary bypass, coronary angioplasty, moderate or severe valvular heart disease, severe left ventricular hypertrophy, congenital heart disease, implanted pacemaker/AICD, or poor left ventricular systolic function, the AF case was not included. If a diagnosis of hyperthyroidism, pneumonia, active alcoholism, or another specific condition was identified as precipitating the AF, the AF case was not included.

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0004238
UMLS CUI [1,2]
C0814120
UMLS CUI [1,3]
C0947630
UMLS CUI [1,4]
C2316983
UMLS CUI [2,1]
C0004238
UMLS CUI [2,2]
C0004239
UMLS CUI [2,3]
C0814120
UMLS CUI [2,4]
C0001779
UMLS CUI [2,5]
C0686906
UMLS CUI [2,6]
C0018799
UMLS CUI [3,1]
C0439615
UMLS CUI [3,2]
C0004238
UMLS CUI [3,3]
C2700399
UMLS CUI [3,4]
C0021562
UMLS CUI [3,5]
C0029921
UMLS CUI [4,1]
C0004238
UMLS CUI [4,2]
C2316983
UMLS CUI [4,3]
C1711411
UMLS CUI [4,4]
C0021562
UMLS CUI [4,5]
C0029921
UMLS CUI [4,6]
C0730229
UMLS CUI [5,1]
C0004238
UMLS CUI [5,2]
C0439615
UMLS CUI [5,3]
C1707834
UMLS CUI [5,4]
C0543467
UMLS CUI [5,5]
C2699488
UMLS CUI [5,6]
C0586003
UMLS CUI [5,7]
C2828389
UMLS CUI [6,1]
C0004238
UMLS CUI [6,2]
C1709305
UMLS CUI [6,3]
C1442880
UMLS CUI [6,4]
C0231290
UMLS CUI [6,5]
C2700399
UMLS CUI [7,1]
C0004238
UMLS CUI [7,2]
C0011900
UMLS CUI [7,3]
C0018799
UMLS CUI [7,4]
C0018801
UMLS CUI [7,5]
C0027051
UMLS CUI [7,6]
C0002962
UMLS CUI [7,7]
C0010055
UMLS CUI [7,8]
C0190211
UMLS CUI [7,9]
C0018824
UMLS CUI [7,10]
C5395245
UMLS CUI [7,11]
C0152021
UMLS CUI [7,12]
C0848753
UMLS CUI [7,13]
C5195258
UMLS CUI [7,14]
C2828389
UMLS CUI [8,1]
C0020550
UMLS CUI [8,2]
C0032285
UMLS CUI [8,3]
C0699757
UMLS CUI [8,4]
C0032930
UMLS CUI [8,5]
C0004238
UMLS CUI [8,6]
C2828389
*Idiopathic Venous Thrombosis (VT)*<br> The TOPMed VT project included idiopathic VT events identified between January 2002 and December 2012. Idiopathic events were those whose VT was diagnosed in the absence of precipitating factors such as cancer or surgery.
Beschreibung

*Idiopathic Venous Thrombosis (VT)*<br> The TOPMed VT project included idiopathic VT events identified between January 2002 and December 2012. Idiopathic events were those whose VT was diagnosed in the absence of precipitating factors such as cancer or surgery.

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0042487
UMLS CUI [1,2]
C0332240
UMLS CUI [1,3]
C0700032
UMLS CUI [1,4]
C0332168
UMLS CUI [2,1]
C0011900
UMLS CUI [2,2]
C0332197
UMLS CUI [2,3]
C0032930
UMLS CUI [2,4]
C0006826
UMLS CUI [2,5]
C0543467
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Ähnliche Modelle

Eligibility Criteria

4 Formulare
Name
Typ
Description | Question | Decode (Coded Value)
Datentyp
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
*Early Onset AF*<br> The AF study identified early onset AF cases with a date of clinically recognized AF onset between January 2005 and June 2007. Early onset AF is defined as AF first recognized at ages 30-65 in a person with no known heart disease, and includes both AF and atrial flutter. First-time episodes of AF diagnosed in inpatient and outpatient settings were included. AF and its date of onset were verified by review of the inpatient and outpatient medical records. First-time episodes of AF that occurred during or after a surgical procedure and had resolved by the time of hospital discharge were not included. However, if a person had surgery-related AF that resolved, and later in time had AF that occurred in the absence of surgery, that second event was eligible as a first lifetime episode of non-surgery-related AF. If the onset of AF was recognized in a subject who already had clinically recognized heart disease, including heart failure, myocardial infarction, probable or definite angina, coronary bypass, coronary angioplasty, moderate or severe valvular heart disease, severe left ventricular hypertrophy, congenital heart disease, implanted pacemaker/AICD, or poor left ventricular systolic function, the AF case was not included. If a diagnosis of hyperthyroidism, pneumonia, active alcoholism, or another specific condition was identified as precipitating the AF, the AF case was not included.
Item
*Early Onset AF*<br> The AF study identified early onset AF cases with a date of clinically recognized AF onset between January 2005 and June 2007. Early onset AF is defined as AF first recognized at ages 30-65 in a person with no known heart disease, and includes both AF and atrial flutter. First-time episodes of AF diagnosed in inpatient and outpatient settings were included. AF and its date of onset were verified by review of the inpatient and outpatient medical records. First-time episodes of AF that occurred during or after a surgical procedure and had resolved by the time of hospital discharge were not included. However, if a person had surgery-related AF that resolved, and later in time had AF that occurred in the absence of surgery, that second event was eligible as a first lifetime episode of non-surgery-related AF. If the onset of AF was recognized in a subject who already had clinically recognized heart disease, including heart failure, myocardial infarction, probable or definite angina, coronary bypass, coronary angioplasty, moderate or severe valvular heart disease, severe left ventricular hypertrophy, congenital heart disease, implanted pacemaker/AICD, or poor left ventricular systolic function, the AF case was not included. If a diagnosis of hyperthyroidism, pneumonia, active alcoholism, or another specific condition was identified as precipitating the AF, the AF case was not included.
boolean
C0004238 (UMLS CUI [1,1])
C0814120 (UMLS CUI [1,2])
C0947630 (UMLS CUI [1,3])
C2316983 (UMLS CUI [1,4])
C0004238 (UMLS CUI [2,1])
C0004239 (UMLS CUI [2,2])
C0814120 (UMLS CUI [2,3])
C0001779 (UMLS CUI [2,4])
C0686906 (UMLS CUI [2,5])
C0018799 (UMLS CUI [2,6])
C0439615 (UMLS CUI [3,1])
C0004238 (UMLS CUI [3,2])
C2700399 (UMLS CUI [3,3])
C0021562 (UMLS CUI [3,4])
C0029921 (UMLS CUI [3,5])
C0004238 (UMLS CUI [4,1])
C2316983 (UMLS CUI [4,2])
C1711411 (UMLS CUI [4,3])
C0021562 (UMLS CUI [4,4])
C0029921 (UMLS CUI [4,5])
C0730229 (UMLS CUI [4,6])
C0004238 (UMLS CUI [5,1])
C0439615 (UMLS CUI [5,2])
C1707834 (UMLS CUI [5,3])
C0543467 (UMLS CUI [5,4])
C2699488 (UMLS CUI [5,5])
C0586003 (UMLS CUI [5,6])
C2828389 (UMLS CUI [5,7])
C0004238 (UMLS CUI [6,1])
C1709305 (UMLS CUI [6,2])
C1442880 (UMLS CUI [6,3])
C0231290 (UMLS CUI [6,4])
C2700399 (UMLS CUI [6,5])
C0004238 (UMLS CUI [7,1])
C0011900 (UMLS CUI [7,2])
C0018799 (UMLS CUI [7,3])
C0018801 (UMLS CUI [7,4])
C0027051 (UMLS CUI [7,5])
C0002962 (UMLS CUI [7,6])
C0010055 (UMLS CUI [7,7])
C0190211 (UMLS CUI [7,8])
C0018824 (UMLS CUI [7,9])
C5395245 (UMLS CUI [7,10])
C0152021 (UMLS CUI [7,11])
C0848753 (UMLS CUI [7,12])
C5195258 (UMLS CUI [7,13])
C2828389 (UMLS CUI [7,14])
C0020550 (UMLS CUI [8,1])
C0032285 (UMLS CUI [8,2])
C0699757 (UMLS CUI [8,3])
C0032930 (UMLS CUI [8,4])
C0004238 (UMLS CUI [8,5])
C2828389 (UMLS CUI [8,6])
*Idiopathic Venous Thrombosis (VT)*<br> The TOPMed VT project included idiopathic VT events identified between January 2002 and December 2012. Idiopathic events were those whose VT was diagnosed in the absence of precipitating factors such as cancer or surgery.
Item
*Idiopathic Venous Thrombosis (VT)*<br> The TOPMed VT project included idiopathic VT events identified between January 2002 and December 2012. Idiopathic events were those whose VT was diagnosed in the absence of precipitating factors such as cancer or surgery.
boolean
C0042487 (UMLS CUI [1,1])
C0332240 (UMLS CUI [1,2])
C0700032 (UMLS CUI [1,3])
C0332168 (UMLS CUI [1,4])
C0011900 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C0032930 (UMLS CUI [2,3])
C0006826 (UMLS CUI [2,4])
C0543467 (UMLS CUI [2,5])
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