ID

45879

Description

Principal Investigator: Zhaoxi Wang, PhD, MD, Harvard T.H. Chan School of Public Health, Boston, MA, USA MeSH: https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000996 Cognitive development is known to be highly heritable, but various genome wide association studies (GWAS) have failed to find common single nucleotide polymorphisms (SNPs) which can explain a large proportion of the variance in cognitive ability. We hypothesized that an interaction between genes and exposure to potentially toxic metals may account for some proportion of this missing heritability. We genotyped 749 infants in Mexico and 636 infants in Bangladesh. Criteria for inclusion into the study are given below. We then performed a Genome Wide Environmental Interaction Study (GWEIS) with neurodevelopment outcomes. There were 552,487 SNPs in common between the two cohorts.

Link

dbGaP study = phs000996

Keywords

Versions (1)
  1. 11/9/23 11/9/23 - Simon Heim
Copyright Holder

Zhaoxi Wang, PhD, MD, Harvard T.H. Chan School of Public Health, Boston, MA, USA

Uploaded on

November 9, 2023

DOI

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License

Creative Commons BY 4.0
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dbGaP phs000996 Gene-Environment Interaction Effects in Neurodevelopment

English

Eligibility Criteria

5 forms  
Inclusion and exclusion criteria
Description

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0680251
In the Mexico cohort, a total of 1054 pregnant women initially consented to be enrolled in the study. Of this sample, we excluded subjects for high levels of relatedness, high levels of missingness, and outlying principal components. In all, 749 infants were genotyped and passed quality control.
Description

In the Mexico cohort, a total of 1054 pregnant women initially consented to be enrolled in the study. Of this sample, we excluded subjects for high levels of relatedness, high levels of missingness, and outlying principal components. In all, 749 infants were genotyped and passed quality control.

Data type

boolean

Alias
UMLS CUI [1,1]
C0599755
UMLS CUI [1,2]
C0025885
UMLS CUI [1,3]
C0033011
UMLS CUI [1,4]
C1511481
UMLS CUI [1,5]
C1516879
UMLS CUI [2,1]
C2828389
UMLS CUI [2,2]
C4321237
UMLS CUI [2,3]
C1547655
UMLS CUI [2,4]
C1705492
UMLS CUI [2,5]
C1882460
UMLS CUI [3,1]
C0021270
UMLS CUI [3,2]
C1285573
UMLS CUI [3,3]
C0034378
In the Bangladesh cohort, a total of 1458 pregnant women initially consented to be enrolled in the study. These women were at least 18 years old and planned to deliver under Dhaka Community Hospital Trust supervision. We again excluded subjects for high levels of relatedness, high levels of missingness, and outlying principal components. In all, 636 infants were genotyped and passed quality control.
Description

In the Bangladesh cohort, a total of 1458 pregnant women initially consented to be enrolled in the study. These women were at least 18 years old and planned to deliver under Dhaka Community Hospital Trust supervision. We again excluded subjects for high levels of relatedness, high levels of missingness, and outlying principal components. In all, 636 infants were genotyped and passed quality control.

Data type

boolean

Alias
UMLS CUI [1,1]
C0599755
UMLS CUI [1,2]
C0033011
UMLS CUI [1,3]
C0004732
UMLS CUI [1,4]
C1511481
UMLS CUI [1,5]
C1516879
UMLS CUI [1,6]
C1301732
UMLS CUI [1,7]
C0005615
UMLS CUI [1,8]
C0020003
UMLS CUI [1,9]
C0001779
UMLS CUI [1,10]
C000473
UMLS CUI [2,1]
C2828389
UMLS CUI [2,2]
C4321237
UMLS CUI [2,3]
C1547655
UMLS CUI [2,4]
C1705492
UMLS CUI [2,5]
C1882460
UMLS CUI [3,1]
C0021270
UMLS CUI [3,2]
C1285573
UMLS CUI [3,3]
C0034378
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Similar models

Eligibility Criteria

5 forms
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
In the Mexico cohort, a total of 1054 pregnant women initially consented to be enrolled in the study. Of this sample, we excluded subjects for high levels of relatedness, high levels of missingness, and outlying principal components. In all, 749 infants were genotyped and passed quality control.
Item
In the Mexico cohort, a total of 1054 pregnant women initially consented to be enrolled in the study. Of this sample, we excluded subjects for high levels of relatedness, high levels of missingness, and outlying principal components. In all, 749 infants were genotyped and passed quality control.
boolean
C0599755 (UMLS CUI [1,1])
C0025885 (UMLS CUI [1,2])
C0033011 (UMLS CUI [1,3])
C1511481 (UMLS CUI [1,4])
C1516879 (UMLS CUI [1,5])
C2828389 (UMLS CUI [2,1])
C4321237 (UMLS CUI [2,2])
C1547655 (UMLS CUI [2,3])
C1705492 (UMLS CUI [2,4])
C1882460 (UMLS CUI [2,5])
C0021270 (UMLS CUI [3,1])
C1285573 (UMLS CUI [3,2])
C0034378 (UMLS CUI [3,3])
In the Bangladesh cohort, a total of 1458 pregnant women initially consented to be enrolled in the study. These women were at least 18 years old and planned to deliver under Dhaka Community Hospital Trust supervision. We again excluded subjects for high levels of relatedness, high levels of missingness, and outlying principal components. In all, 636 infants were genotyped and passed quality control.
Item
In the Bangladesh cohort, a total of 1458 pregnant women initially consented to be enrolled in the study. These women were at least 18 years old and planned to deliver under Dhaka Community Hospital Trust supervision. We again excluded subjects for high levels of relatedness, high levels of missingness, and outlying principal components. In all, 636 infants were genotyped and passed quality control.
boolean
C0599755 (UMLS CUI [1,1])
C0033011 (UMLS CUI [1,2])
C0004732 (UMLS CUI [1,3])
C1511481 (UMLS CUI [1,4])
C1516879 (UMLS CUI [1,5])
C1301732 (UMLS CUI [1,6])
C0005615 (UMLS CUI [1,7])
C0020003 (UMLS CUI [1,8])
C0001779 (UMLS CUI [1,9])
C000473 (UMLS CUI [1,10])
C2828389 (UMLS CUI [2,1])
C4321237 (UMLS CUI [2,2])
C1547655 (UMLS CUI [2,3])
C1705492 (UMLS CUI [2,4])
C1882460 (UMLS CUI [2,5])
C0021270 (UMLS CUI [3,1])
C1285573 (UMLS CUI [3,2])
C0034378 (UMLS CUI [3,3])
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