ID
45879
Beschreibung
Principal Investigator: Zhaoxi Wang, PhD, MD, Harvard T.H. Chan School of Public Health, Boston, MA, USA MeSH: https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000996 Cognitive development is known to be highly heritable, but various genome wide association studies (GWAS) have failed to find common single nucleotide polymorphisms (SNPs) which can explain a large proportion of the variance in cognitive ability. We hypothesized that an interaction between genes and exposure to potentially toxic metals may account for some proportion of this missing heritability. We genotyped 749 infants in Mexico and 636 infants in Bangladesh. Criteria for inclusion into the study are given below. We then performed a Genome Wide Environmental Interaction Study (GWEIS) with neurodevelopment outcomes. There were 552,487 SNPs in common between the two cohorts.
Link
Stichworte
Versionen (1)
- 09.11.23 09.11.23 - Simon Heim
Rechteinhaber
Zhaoxi Wang, PhD, MD, Harvard T.H. Chan School of Public Health, Boston, MA, USA
Hochgeladen am
9. November 2023
DOI
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Lizenz
Creative Commons BY 4.0
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dbGaP phs000996 Gene-Environment Interaction Effects in Neurodevelopment
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent file includes subject IDs and consent information.
- This data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs.
- This subject phenotype table contains subject IDs, age, sex, and race of participant.
- This sample attributes table contains sample IDs, body site where sample was collected, analyte type, and histological type.
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Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent file includes subject IDs and consent information.
- This data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs.
- This subject phenotype table contains subject IDs, age, sex, and race of participant.
- This sample attributes table contains sample IDs, body site where sample was collected, analyte type, and histological type.
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C4321237 (UMLS CUI [2,2])
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C1705492 (UMLS CUI [2,4])
C1882460 (UMLS CUI [2,5])
C0021270 (UMLS CUI [3,1])
C1285573 (UMLS CUI [3,2])
C0034378 (UMLS CUI [3,3])
C0033011 (UMLS CUI [1,2])
C0004732 (UMLS CUI [1,3])
C1511481 (UMLS CUI [1,4])
C1516879 (UMLS CUI [1,5])
C1301732 (UMLS CUI [1,6])
C0005615 (UMLS CUI [1,7])
C0020003 (UMLS CUI [1,8])
C0001779 (UMLS CUI [1,9])
C000473 (UMLS CUI [1,10])
C2828389 (UMLS CUI [2,1])
C4321237 (UMLS CUI [2,2])
C1547655 (UMLS CUI [2,3])
C1705492 (UMLS CUI [2,4])
C1882460 (UMLS CUI [2,5])
C0021270 (UMLS CUI [3,1])
C1285573 (UMLS CUI [3,2])
C0034378 (UMLS CUI [3,3])