ID

45875

Description

Principal Investigator: Lynne Wagenknecht, Wake Forest University School of Medicine, University of North Carolina, Winston-Salem, NC, USA MeSH: Insulin Resistance https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001008 TThe IRAS Family Study was a family study designed to examine the genetic and epidemiologic basis of glucose homeostasis traits and abdominal adiposity. Briefly, self-reported Mexican pedigrees were recruited in San Antonio, TX and San Luis Valley, CO. Probands with large families were recruited from the initial non-family-based IRAS Study, which was modestly enriched for impaired glucose tolerance and T2D. GUARDIAN includes 1,024 individuals in 88 pedigrees from the IRAS Family Study. Insulin sensitivity was obtained by FSIGT.

Link

dbGaP study = phs001008

Keywords

Versions (1)
  1. 10/31/23 10/31/23 - Simon Heim
Copyright Holder

Lynne Wagenknecht, Wake Forest University School of Medicine, University of North Carolina, Winston-Salem, NC, USA

Uploaded on

October 31, 2023

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Creative Commons BY 4.0
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dbGaP phs001008 GUARDIAN: IRAS FAMILY STUDY (IRASFS)

English

Eligibility Criteria

6 forms  
Inclusion and exclusion criteria
Description

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0680251
Probands for the IRAS Family Study were generally recruited from the parent IRAS study. Criteria for selection were based on reported family size but not on affection (diabetes) status. The minimum pedigree structure to be considered potentially eligible included four full siblings and five natural children. Individual family members were excluded if they were adopted or were less than 18 years of age.
Description

Probands for the IRAS Family Study were generally recruited from the parent IRAS study. Criteria for selection were based on reported family size but not on affection (diabetes) status. The minimum pedigree structure to be considered potentially eligible included four full siblings and five natural children. Individual family members were excluded if they were adopted or were less than 18 years of age.

Data type

boolean

Alias
UMLS CUI [1,1]
C1948021
UMLS CUI [1,2]
C0199236
UMLS CUI [1,3]
C2949735
UMLS CUI [2,1]
C0242801
UMLS CUI [2,2]
C0015611
UMLS CUI [2,3]
C0392760
UMLS CUI [2,4]
C0011849
UMLS CUI [3,1]
C0030761
UMLS CUI [3,2]
C0013893
UMLS CUI [3,3]
C2348717
UMLS CUI [3,4]
C0337540
UMLS CUI [3,5]
C1265611
UMLS CUI [4,1]
C0680251
UMLS CUI [4,2]
C0086282
UMLS CUI [4,3]
C0337541
UMLS CUI [4,4]
C0001779
In addition, individuals were excluded from participation in particular components of the protocol if they were deemed to have conditions which would place the participant at undue risk, interfere with the measurement of insulin resistance, or jeopardize the validity of self-reported data. Presence of these conditions resulted in complete exclusion or partial exams. These conditions included:Current insulin treatment
Description

In addition, individuals were excluded from participation in particular components of the protocol if they were deemed to have conditions which would place the participant at undue risk, interfere with the measurement of insulin resistance, or jeopardize the validity of self-reported data. Presence of these conditions resulted in complete exclusion or partial exams. These conditions included:Current insulin treatment

Data type

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0679823
UMLS CUI [1,3]
C2348563
UMLS CUI [1,4]
C0035647
UMLS CUI [1,5]
C0205231
UMLS CUI [1,6]
C0521102
UMLS CUI [1,7]
C0242485
UMLS CUI [1,8]
C0021655
UMLS CUI [1,9]
C0681906
UMLS CUI [1,10]
C1519941
UMLS CUI [1,11]
C3846158
UMLS CUI [1,12]
C0521116
UMLS CUI [1,13]
C0745343
Heart failure
Description

Heart failure

Data type

boolean

Alias
UMLS CUI [1,1]
C0018802
Decompensated emphysema or chronic lung disease
Description

Decompensated emphysema or chronic lung disease

Data type

boolean

Alias
UMLS CUI [1,1]
C0231187
UMLS CUI [1,2]
C0034067
UMLS CUI [1,3]
C0746102
Current shortness of breath or pulmonary obstructive disease
Description

Current shortness of breath or pulmonary obstructive disease

Data type

boolean

Alias
UMLS CUI [1,1]
C0521116
UMLS CUI [1,2]
C0013404
UMLS CUI [1,3]
C0600260
Crescendo angina
Description

Crescendo angina

Data type

boolean

Alias
UMLS CUI [1,1]
C0002965
Cancer, other than skin cancer, for which the person is currently being treated
Description

Cancer, other than skin cancer, for which the person is currently being treated

Data type

boolean

Alias
UMLS CUI [1,1]
C0006826
UMLS CUI [1,2]
C4723751
UMLS CUI [1,3]
C0007114
UMLS CUI [1,4]
C2827774
Seizure disorder or epilepsy
Description

Seizure disorder or epilepsy

Data type

boolean

Alias
UMLS CUI [1,1]
C0014544
UMLS CUI [1,2]
C0036572
Kidney dialysis, transplant, or renal failure
Description

Kidney dialysis, transplant, or renal failure

Data type

boolean

Alias
UMLS CUI [1,1]
C0011946
UMLS CUI [1,2]
C0035078
UMLS CUI [1,3]
C0022671
A serious illness within the last 6 months (e.g., heart attack, stroke, or major surgery)
Description

A serious illness within the last 6 months (e.g., heart attack, stroke, or major surgery)

Data type

boolean

Alias
UMLS CUI [1,1]
C5419420
UMLS CUI [1,2]
C3828652
UMLS CUI [1,3]
C0027051
UMLS CUI [1,4]
C0038454
UMLS CUI [1,5]
C0679637
Treatment with steroids in the past 6 months
Description

Treatment with steroids in the past 6 months

Data type

boolean

Alias
UMLS CUI [1,1]
C0149783
UMLS CUI [1,2]
C3828652
Pregnancy or breast feeding
Description

Pregnancy or breast feeding

Data type

boolean

Alias
UMLS CUI [1,1]
C0032961
UMLS CUI [1,2]
C0006147
Breast cancer treated with surgery or radiation
Description

Breast cancer treated with surgery or radiation

Data type

boolean

Alias
UMLS CUI [1,1]
C0006142
UMLS CUI [1,2]
C1522449
UMLS CUI [1,3]
C0543467
Obvious mental disability as noted in the screening interview.
Description

Obvious mental disability as noted in the screening interview.

Data type

boolean

Alias
UMLS CUI [1,1]
C0423893
UMLS CUI [1,2]
C5706969
UMLS CUI [1,3]
C0021822
A subset of IRAS Family Study participants were included in the genotyping study: Hispanics only; without diabetes; with insulin sensitivity obtained by frequently sampled intravenous glucose tolerance test, and providing consent for genetic studies.
Description

A subset of IRAS Family Study participants were included in the genotyping study: Hispanics only; without diabetes; with insulin sensitivity obtained by frequently sampled intravenous glucose tolerance test, and providing consent for genetic studies.

Data type

boolean

Alias
UMLS CUI [1,1]
C0199236
UMLS CUI [1,2]
C4554048
UMLS CUI [1,3]
C1515021
UMLS CUI [1,4]
C1285573
UMLS CUI [2,1]
C0086409
UMLS CUI [2,2]
C0686906
UMLS CUI [2,3]
C0011849
UMLS CUI [2,4]
C0920563
UMLS CUI [2,5]
C1277697
UMLS CUI [2,6]
C0021911
UMLS CUI [2,7]
C4034855
UMLS CUI [2,8]
C2827447
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Similar models

Eligibility Criteria

6 forms
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
Probands for the IRAS Family Study were generally recruited from the parent IRAS study. Criteria for selection were based on reported family size but not on affection (diabetes) status. The minimum pedigree structure to be considered potentially eligible included four full siblings and five natural children. Individual family members were excluded if they were adopted or were less than 18 years of age.
Item
Probands for the IRAS Family Study were generally recruited from the parent IRAS study. Criteria for selection were based on reported family size but not on affection (diabetes) status. The minimum pedigree structure to be considered potentially eligible included four full siblings and five natural children. Individual family members were excluded if they were adopted or were less than 18 years of age.
boolean
C1948021 (UMLS CUI [1,1])
C0199236 (UMLS CUI [1,2])
C2949735 (UMLS CUI [1,3])
C0242801 (UMLS CUI [2,1])
C0015611 (UMLS CUI [2,2])
C0392760 (UMLS CUI [2,3])
C0011849 (UMLS CUI [2,4])
C0030761 (UMLS CUI [3,1])
C0013893 (UMLS CUI [3,2])
C2348717 (UMLS CUI [3,3])
C0337540 (UMLS CUI [3,4])
C1265611 (UMLS CUI [3,5])
C0680251 (UMLS CUI [4,1])
C0086282 (UMLS CUI [4,2])
C0337541 (UMLS CUI [4,3])
C0001779 (UMLS CUI [4,4])
In addition, individuals were excluded from participation in particular components of the protocol if they were deemed to have conditions which would place the participant at undue risk, interfere with the measurement of insulin resistance, or jeopardize the validity of self-reported data. Presence of these conditions resulted in complete exclusion or partial exams. These conditions included:Current insulin treatment
Item
In addition, individuals were excluded from participation in particular components of the protocol if they were deemed to have conditions which would place the participant at undue risk, interfere with the measurement of insulin resistance, or jeopardize the validity of self-reported data. Presence of these conditions resulted in complete exclusion or partial exams. These conditions included:Current insulin treatment
boolean
C0680251 (UMLS CUI [1,1])
C0679823 (UMLS CUI [1,2])
C2348563 (UMLS CUI [1,3])
C0035647 (UMLS CUI [1,4])
C0205231 (UMLS CUI [1,5])
C0521102 (UMLS CUI [1,6])
C0242485 (UMLS CUI [1,7])
C0021655 (UMLS CUI [1,8])
C0681906 (UMLS CUI [1,9])
C1519941 (UMLS CUI [1,10])
C3846158 (UMLS CUI [1,11])
C0521116 (UMLS CUI [1,12])
C0745343 (UMLS CUI [1,13])
Heart failure
Item
Heart failure
boolean
C0018802 (UMLS CUI [1,1])
Decompensated emphysema or chronic lung disease
Item
Decompensated emphysema or chronic lung disease
boolean
C0231187 (UMLS CUI [1,1])
C0034067 (UMLS CUI [1,2])
C0746102 (UMLS CUI [1,3])
Current shortness of breath or pulmonary obstructive disease
Item
Current shortness of breath or pulmonary obstructive disease
boolean
C0521116 (UMLS CUI [1,1])
C0013404 (UMLS CUI [1,2])
C0600260 (UMLS CUI [1,3])
Crescendo angina
Item
Crescendo angina
boolean
C0002965 (UMLS CUI [1,1])
Cancer, other than skin cancer, for which the person is currently being treated
Item
Cancer, other than skin cancer, for which the person is currently being treated
boolean
C0006826 (UMLS CUI [1,1])
C4723751 (UMLS CUI [1,2])
C0007114 (UMLS CUI [1,3])
C2827774 (UMLS CUI [1,4])
Seizure disorder or epilepsy
Item
Seizure disorder or epilepsy
boolean
C0014544 (UMLS CUI [1,1])
C0036572 (UMLS CUI [1,2])
Kidney dialysis, transplant, or renal failure
Item
Kidney dialysis, transplant, or renal failure
boolean
C0011946 (UMLS CUI [1,1])
C0035078 (UMLS CUI [1,2])
C0022671 (UMLS CUI [1,3])
A serious illness within the last 6 months (e.g., heart attack, stroke, or major surgery)
Item
A serious illness within the last 6 months (e.g., heart attack, stroke, or major surgery)
boolean
C5419420 (UMLS CUI [1,1])
C3828652 (UMLS CUI [1,2])
C0027051 (UMLS CUI [1,3])
C0038454 (UMLS CUI [1,4])
C0679637 (UMLS CUI [1,5])
Treatment with steroids in the past 6 months
Item
Treatment with steroids in the past 6 months
boolean
C0149783 (UMLS CUI [1,1])
C3828652 (UMLS CUI [1,2])
Pregnancy or breast feeding
Item
Pregnancy or breast feeding
boolean
C0032961 (UMLS CUI [1,1])
C0006147 (UMLS CUI [1,2])
Breast cancer treated with surgery or radiation
Item
Breast cancer treated with surgery or radiation
boolean
C0006142 (UMLS CUI [1,1])
C1522449 (UMLS CUI [1,2])
C0543467 (UMLS CUI [1,3])
Obvious mental disability as noted in the screening interview.
Item
Obvious mental disability as noted in the screening interview.
boolean
C0423893 (UMLS CUI [1,1])
C5706969 (UMLS CUI [1,2])
C0021822 (UMLS CUI [1,3])
A subset of IRAS Family Study participants were included in the genotyping study: Hispanics only; without diabetes; with insulin sensitivity obtained by frequently sampled intravenous glucose tolerance test, and providing consent for genetic studies.
Item
A subset of IRAS Family Study participants were included in the genotyping study: Hispanics only; without diabetes; with insulin sensitivity obtained by frequently sampled intravenous glucose tolerance test, and providing consent for genetic studies.
boolean
C0199236 (UMLS CUI [1,1])
C4554048 (UMLS CUI [1,2])
C1515021 (UMLS CUI [1,3])
C1285573 (UMLS CUI [1,4])
C0086409 (UMLS CUI [2,1])
C0686906 (UMLS CUI [2,2])
C0011849 (UMLS CUI [2,3])
C0920563 (UMLS CUI [2,4])
C1277697 (UMLS CUI [2,5])
C0021911 (UMLS CUI [2,6])
C4034855 (UMLS CUI [2,7])
C2827447 (UMLS CUI [2,8])
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