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dbGaP phs001008 GUARDIAN: IRAS FAMILY STUDY (IRASFS) - pht005107.v1.p1

- 31-10-23 - 6 Formulieren, 1 Itemgroep, 4 Data-elementen, 1 Taal
Itemgroep: pht005107
Principal Investigator: Lynne Wagenknecht, Wake Forest University School of Medicine, University of North Carolina, Winston-Salem, NC, USA MeSH: Insulin Resistance https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001008 TThe IRAS Family Study was a family study designed to examine the genetic and epidemiologic basis of glucose homeostasis traits and abdominal adiposity. Briefly, self-reported Mexican pedigrees were recruited in San Antonio, TX and San Luis Valley, CO. Probands with large families were recruited from the initial non-family-based IRAS Study, which was modestly enriched for impaired glucose tolerance and T2D. GUARDIAN includes 1,024 individuals in 88 pedigrees from the IRAS Family Study. Insulin sensitivity was obtained by FSIGT.

pht005108.v1.p1

1 Itemgroep 5 Data-elementen

pht005109.v1.p1

1 Itemgroep 3 Data-elementen

Eligibility

1 Itemgroep 15 Data-elementen

pht005110.v1.p1

1 Itemgroep 9 Data-elementen

pht005111.v1.p1

1 Itemgroep 3 Data-elementen

dbGaP phs001014 GUARDIAN: IRAS (IRAS Classic) - Eligibility

- 24-10-23 - 5 Formulieren, 1 Itemgroep, 18 Data-elementen, 1 Taal
Itemgroep: IG.elig
Principal Investigator: Lynne Wagenknecht, PhD, Wake Forest University School of Medicine, Winston-Salem, NC, USA MeSH: Insulin Resistance https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001014 The Insulin Resistance Atherosclerosis Study (IRAS) was an epidemiologic cohort study designed to examine the relationship between insulin resistance and carotid atherosclerosis across a range of glucose tolerance. Individuals of self-reported Mexican-American ethnicity were recruited in San Antonio, TX and San Luis Valley, CO. Recruitment was balanced across age and glucose tolerance status. GUARDIAN includes 173 individuals from the IRAS. Insulin sensitivity was obtained by FSIGT.

pht005113.v1.p1

1 Itemgroep 3 Data-elementen

pht005114.v1.p1

1 Itemgroep 8 Data-elementen

pht005115.v1.p1

1 Itemgroep 3 Data-elementen

pht005112.v1.p1

1 Itemgroep 4 Data-elementen

dbGaP phs001139 NextGen/GENESiPS - pht006159.v1.p1

- 16-06-23 - 4 Formulieren, 1 Itemgroep, 3 Data-elementen, 1 Taal
Itemgroep: pht006159
Principal Investigator: Thomas Quertermous, MD, Standford University, Stanford, CA, USA MeSH: Insulin Resistance,Pluripotent Stem Cells https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001139 Variability in induced pluripotent stem cell (iPSC) lines remains a roadblock for disease modeling and regenerative medicine. Through linear mixed models we have described different sources of gene expression variability from RNA sequencing data in 317 human iPSC lines from 101 individuals. We found that ~50% of genome-wide expression variability is explained by variation across individuals and identified a set of expression quantitative trait loci that contribute to this variation. These analyses coupled with allele specific expression show that iPSCs retain a subject-specific gene expression pattern. Pathway enrichment and key driver analyses, based on predictive causal gene networks, found that Polycomb targets explain a significant part of the non-genetic variability present in iPSCs within and across individuals. These publically available iPSC lines and genetic datasets will be a resource to the scientific community and will open new avenues to reduce variability in iPSCs and improve their utility in disease modeling. SNP array data from individuals included in RNA-seq transcriptome profiling study of human induced pluripotent stem cells to characterize gene expression variation across individuals and within multiple iPSC lines from the same individual. Genotyping was performed on patient blood. Data availability:- SNP-genotyping: dbGaP - current study - RNA-seq counts: GEO - GSE79636 - FASTQ files: SRA - SRP072417

pht006160.v1.p1

1 Itemgroep 3 Data-elementen

pht006161.v1.p1

1 Itemgroep 2 Data-elementen

pht006162.v1.p1

1 Itemgroep 3 Data-elementen

Eligibility Insulin Resistance NCT00508937

- 20-09-21 - 1 Formulier, 2 Itemgroepen, 15 Data-elementen, 1 Taal
Itemgroepen: Inclusion Criteria, Exclusion Criteria
Dietary Protein and Insulin Sensitivity Study; ODM derived from: https://clinicaltrials.gov/show/NCT00508937

Eligibility Insulin Resistance NCT02098980

- 22-04-20 - 1 Formulier, 2 Itemgroepen, 20 Data-elementen, 1 Taal
Itemgroepen: Inclusion Criteria, Exclusion Criteria
Nutritional Intervention of Type II Diabetes Mellitus by Vitamin D in Qatar; ODM derived from: https://clinicaltrials.gov/show/NCT02098980

Eligibility Insulin Resistance NCT01946347

- 22-04-20 - 1 Formulier, 1 Itemgroep, 33 Data-elementen, 1 Taal
Itemgroep: Criteria
Endothelial Function in Patients With Type 2 Diabetes Versus Healthy Subjects; ODM derived from: https://clinicaltrials.gov/show/NCT01946347

Eligibility Insulin Resistance NCT01690091

- 21-04-20 - 1 Formulier, 2 Itemgroepen, 26 Data-elementen, 1 Taal
Itemgroepen: Inclusion Criteria, Exclusion Criteria
Cardioprotective and Metabolic Effects of Metformin in Patients With Heart Failure and Diabetes; ODM derived from: https://clinicaltrials.gov/show/NCT01690091

Eligibility Insulin Resistance NCT01527526

- 21-04-20 - 1 Formulier, 2 Itemgroepen, 16 Data-elementen, 1 Taal
Itemgroepen: Inclusion Criteria, Exclusion Criteria
Depot-medroxyprogesterone Acetate (DMPA) Contraceptive Method and Metabolism; ODM derived from: https://clinicaltrials.gov/show/NCT01527526

Eligibility Overweight NCT01430143

- 17-01-19 - 1 Formulier, 2 Itemgroepen, 11 Data-elementen, 1 Taal
Itemgroepen: Inclusion Criteria, Exclusion Criteria
Physical Activity for a Long and Healthy Life; ODM derived from: https://clinicaltrials.gov/show/NCT01430143

Eligibility Insulin Resistance NCT02258698

- 03-01-19 - 1 Formulier, 2 Itemgroepen, 9 Data-elementen, 1 Taal
Itemgroepen: Inclusion Criteria, Exclusion Criteria
Insulin Sensitivity, Irisin and Adipokines as Outcome Parameters in Patients Undergoing Cardiac Surgery; ODM derived from: https://clinicaltrials.gov/show/NCT02258698

Eligibility Insulin Resistance and Type 2 Diabetes NCT00568620

- 08-05-18 - 1 Formulier, 2 Itemgroepen, 21 Data-elementen, 1 Taal
Itemgroepen: Inclusion Criteria, Exclusion Criteria
The Role of the Duodenum in the Pathogenesis of Insulin Resistance and Type 2 Diabetes Mellitus; ODM derived from: https://clinicaltrials.gov/show/NCT00568620

Eligibility Hepatitis C NCT00707603

- 03-03-17 - 1 Formulier, 2 Itemgroepen, 11 Data-elementen, 1 Taal
Itemgroepen: Inclusion Criteria, Exclusion Criteria
Chronic Hepatitis C and Insulin Resistance; ODM derived from: https://clinicaltrials.gov/show/NCT00707603

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