0 Ratings
ID

45868

Description

Principal Investigator: Donald W. Bowden, Wake Forest School of Medicine, Winston-Salem, NC, USA MeSH: Cardiovascular Diseases,Vascular Calcification,Diabetes Mellitus https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001012 The Diabetes Heart Study is a family based study enriched for type 2 diabetes (T2D). The cohort included 1220 self-reported European Americans from 475 families (Bowden et al 2010 Review of Diabetic Studies 7:188-201: PMID: 21409311; Bowden et al 2008 Annals of Human Genetics 72:598-601 PMID: 18460048) and included siblings concordant for T2D; where possible unaffected siblings were also recruited. The cohort was recruited between 1998 and 2006. Participants were extensively phenotyped for measures of subclinical CVD and other known CVD risk factors. Primary outcomes were quantified burden of vascular calcified plaque in the coronary artery, carotid artery and abdominal aorta all determined from non-contrast computed tomography scans.

Link

dbGaP study = phs001012

Keywords

Versions (1)
  1. 10/26/23 10/26/23 - Simon Heim
Copyright Holder

Donald W. Bowden, Wake Forest School of Medicine, Winston-Salem, NC, USA

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October 26, 2023

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License

Creative Commons BY 4.0
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    dbGaP phs001012 The Diabetes Heart Study (DHS)

    English

    The dataset includes diagnosis information of participants (Type 2 diabetes), blood test results for high and low density lipoproteins, triglycerides, and C-reactive protein, BMI values, IMT thickness and extent of calcified carotid plaques.

    6 forms  
    pht005550
    Description

    pht005550

    Alias
    UMLS CUI [1,1]
    C3846158
    De-identified Subject ID
    Description

    SUBJECT_ID

    Data type

    string

    Alias
    UMLS CUI [1,1]
    C4684638
    UMLS CUI [1,2]
    C2348585
    Age at recruitment
    Description

    age

    Data type

    text

    Measurement units
    • Years
    Alias
    UMLS CUI [1,1]
    C0001779
    UMLS CUI [1,2]
    C2985691
    Years
    Gender of participant
    Description

    gender

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C0079399
    Type 2 diabetes affected
    Description

    t2dm_affected

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C4014362
    First admixture proportion
    Description

    admix1

    Data type

    float

    Alias
    UMLS CUI [1,1]
    C1510816
    UMLS CUI [1,2]
    C1709707
    UMLS CUI [1,3]
    C0205435
    Secondary admixture proportion
    Description

    admix2

    Data type

    float

    Alias
    UMLS CUI [1,1]
    C1510816
    UMLS CUI [1,2]
    C1709707
    UMLS CUI [1,3]
    C0205436
    Coronary artery calcified plaque
    Description

    avecac

    Data type

    float

    Alias
    UMLS CUI [1,1]
    C4697970
    UMLS CUI [1,2]
    C0205042
    Carotid artery calcified plaque (130)
    Description

    avecarotid

    Data type

    float

    Alias
    UMLS CUI [1,1]
    C4697970
    UMLS CUI [1,2]
    C0007272
    Abdominal aortic calcified plaque
    Description

    aorta

    Data type

    float

    Alias
    UMLS CUI [1,1]
    C4697970
    UMLS CUI [1,2]
    C0003484
    Aortic intima-media thickness
    Description

    imt

    Data type

    float

    Measurement units
    • mm
    Alias
    UMLS CUI [1,1]
    C1960467
    UMLS CUI [1,2]
    C0003483
    mm
    Body mass index
    Description

    bmi

    Data type

    float

    Measurement units
    • kg/m2
    Alias
    UMLS CUI [1,1]
    C1305855
    kg/m2
    Triglycerides
    Description

    trig

    Data type

    float

    Measurement units
    • mg/dl
    Alias
    UMLS CUI [1,1]
    C0202236
    mg/dl
    High density lipoprotein
    Description

    hdl

    Data type

    float

    Measurement units
    • mg/dl
    Alias
    UMLS CUI [1,1]
    C0392885
    mg/dl
    Low density lipoprotein
    Description

    ldl

    Data type

    float

    Measurement units
    • mg/dl
    Alias
    UMLS CUI [1,1]
    C0202117
    mg/dl
    C-reactive protein
    Description

    crp

    Data type

    float

    Measurement units
    • mg/dl
    Alias
    UMLS CUI [1,1]
    C0006560
    mg/dl
    Total cholesterol
    Description

    chol

    Data type

    float

    Measurement units
    • mg/dl
    Alias
    UMLS CUI [1,1]
    C1445957
    mg/dl
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    Similar models

    The dataset includes diagnosis information of participants (Type 2 diabetes), blood test results for high and low density lipoproteins, triglycerides, and C-reactive protein, BMI values, IMT thickness and extent of calcified carotid plaques.

    6 forms
    Name
    Type
    Description | Question | Decode (Coded Value)
    Data type
    Alias
    Item Group
    pht005550
    C3846158 (UMLS CUI [1,1])
    SUBJECT_ID
    Item
    De-identified Subject ID
    string
    C4684638 (UMLS CUI [1,1])
    C2348585 (UMLS CUI [1,2])
    age
    Item
    Age at recruitment
    text
    C0001779 (UMLS CUI [1,1])
    C2985691 (UMLS CUI [1,2])
    Item
    Gender of participant
    text
    C0079399 (UMLS CUI [1,1])
    gender
    Code List
    Gender of participant
    CL Item
    Male (0)
    C0086582 (UMLS CUI [1,1])
    CL Item
    Female (1)
    C0086287 (UMLS CUI [1,1])
    CL Item
    Missing (NA)
    Item
    Type 2 diabetes affected
    text
    C4014362 (UMLS CUI [1,1])
    t2dm_affected
    Code List
    Type 2 diabetes affected
    CL Item
    Not affected (0)
    CL Item
    Affected (1)
    C3274647 (UMLS CUI [1,1])
    CL Item
    Missing (NA)
    admix1
    Item
    First admixture proportion
    float
    C1510816 (UMLS CUI [1,1])
    C1709707 (UMLS CUI [1,2])
    C0205435 (UMLS CUI [1,3])
    admix2
    Item
    Secondary admixture proportion
    float
    C1510816 (UMLS CUI [1,1])
    C1709707 (UMLS CUI [1,2])
    C0205436 (UMLS CUI [1,3])
    avecac
    Item
    Coronary artery calcified plaque
    float
    C4697970 (UMLS CUI [1,1])
    C0205042 (UMLS CUI [1,2])
    avecarotid
    Item
    Carotid artery calcified plaque (130)
    float
    C4697970 (UMLS CUI [1,1])
    C0007272 (UMLS CUI [1,2])
    aorta
    Item
    Abdominal aortic calcified plaque
    float
    C4697970 (UMLS CUI [1,1])
    C0003484 (UMLS CUI [1,2])
    imt
    Item
    Aortic intima-media thickness
    float
    C1960467 (UMLS CUI [1,1])
    C0003483 (UMLS CUI [1,2])
    bmi
    Item
    Body mass index
    float
    C1305855 (UMLS CUI [1,1])
    trig
    Item
    Triglycerides
    float
    C0202236 (UMLS CUI [1,1])
    hdl
    Item
    High density lipoprotein
    float
    C0392885 (UMLS CUI [1,1])
    ldl
    Item
    Low density lipoprotein
    float
    C0202117 (UMLS CUI [1,1])
    crp
    Item
    C-reactive protein
    float
    C0006560 (UMLS CUI [1,1])
    chol
    Item
    Total cholesterol
    float
    C1445957 (UMLS CUI [1,1])
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