ID

45868

Description

Principal Investigator: Donald W. Bowden, Wake Forest School of Medicine, Winston-Salem, NC, USA MeSH: Cardiovascular Diseases,Vascular Calcification,Diabetes Mellitus https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001012 The Diabetes Heart Study is a family based study enriched for type 2 diabetes (T2D). The cohort included 1220 self-reported European Americans from 475 families (Bowden et al 2010 Review of Diabetic Studies 7:188-201: PMID: 21409311; Bowden et al 2008 Annals of Human Genetics 72:598-601 PMID: 18460048) and included siblings concordant for T2D; where possible unaffected siblings were also recruited. The cohort was recruited between 1998 and 2006. Participants were extensively phenotyped for measures of subclinical CVD and other known CVD risk factors. Primary outcomes were quantified burden of vascular calcified plaque in the coronary artery, carotid artery and abdominal aorta all determined from non-contrast computed tomography scans.

Link

dbGaP study = phs001012

Keywords

  1. 10/26/23 10/26/23 - Simon Heim
Copyright Holder

Donald W. Bowden, Wake Forest School of Medicine, Winston-Salem, NC, USA

Uploaded on

October 26, 2023

DOI

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License

Creative Commons BY 4.0

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dbGaP phs001012 The Diabetes Heart Study (DHS)

Eligibility Criteria

Inclusion and exclusion criteria
Description

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0680251
*Inclusion:* Siblings concordant for T2D developing after the age of 35 years and treated with insulin and/or oral agents and confirmed by measurement of blood glucose and glycosylated hemoglobin at recruitment.
Description

*Inclusion:* Siblings concordant for T2D developing after the age of 35 years and treated with insulin and/or oral agents and confirmed by measurement of blood glucose and glycosylated hemoglobin at recruitment.

Data type

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0037047
UMLS CUI [1,3]
C4553529
UMLS CUI [1,4]
C4014362
UMLS CUI [1,5]
C0001779
UMLS CUI [1,6]
C0087111
UMLS CUI [1,7]
C1533581
UMLS CUI [1,8]
C0935929
UMLS CUI [1,9]
C1527415
UMLS CUI [1,10]
C0474680
UMLS CUI [1,11]
C0392201
UMLS CUI [1,12]
C0242800
*Exclusion:* Historical evidence of ketoacidosis.
Description

*Exclusion:* Historical evidence of ketoacidosis.

Data type

boolean

Alias
UMLS CUI [1,1]
C2828389
UMLS CUI [1,2]
C0262926
UMLS CUI [1,3]
C0011880

Similar models

Eligibility Criteria

Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
*Inclusion:* Siblings concordant for T2D developing after the age of 35 years and treated with insulin and/or oral agents and confirmed by measurement of blood glucose and glycosylated hemoglobin at recruitment.
Item
*Inclusion:* Siblings concordant for T2D developing after the age of 35 years and treated with insulin and/or oral agents and confirmed by measurement of blood glucose and glycosylated hemoglobin at recruitment.
boolean
C1512693 (UMLS CUI [1,1])
C0037047 (UMLS CUI [1,2])
C4553529 (UMLS CUI [1,3])
C4014362 (UMLS CUI [1,4])
C0001779 (UMLS CUI [1,5])
C0087111 (UMLS CUI [1,6])
C1533581 (UMLS CUI [1,7])
C0935929 (UMLS CUI [1,8])
C1527415 (UMLS CUI [1,9])
C0474680 (UMLS CUI [1,10])
C0392201 (UMLS CUI [1,11])
C0242800 (UMLS CUI [1,12])
*Exclusion:* Historical evidence of ketoacidosis.
Item
*Exclusion:* Historical evidence of ketoacidosis.
boolean
C2828389 (UMLS CUI [1,1])
C0262926 (UMLS CUI [1,2])
C0011880 (UMLS CUI [1,3])

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