ID

45867

Description

Principal Investigator: Lynne Wagenknecht, PhD, Wake Forest University School of Medicine, Winston-Salem, NC, USA MeSH: Insulin Resistance https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001014 The Insulin Resistance Atherosclerosis Study (IRAS) was an epidemiologic cohort study designed to examine the relationship between insulin resistance and carotid atherosclerosis across a range of glucose tolerance. Individuals of self-reported Mexican-American ethnicity were recruited in San Antonio, TX and San Luis Valley, CO. Recruitment was balanced across age and glucose tolerance status. GUARDIAN includes 173 individuals from the IRAS. Insulin sensitivity was obtained by FSIGT.

Link

dbGaP study = phs001014

Keywords

Versions (1)
  1. 10/24/23 10/24/23 - Simon Heim
Copyright Holder

Lynne Wagenknecht, PhD, Wake Forest University School of Medicine, Winston-Salem, NC, USA

Uploaded on

October 24, 2023

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License

Creative Commons BY 4.0
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dbGaP phs001014 GUARDIAN: IRAS (IRAS Classic)

English

Eligibility Criteria

5 forms  
Inclusion and exclusion criteria
Description

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0680251
Between October 1992 and April 1994, IRAS recruited 1,625 participants from four clinical centers located in San Antonio, TX, San Luis Valley, CO, Oakland, CA and Los Angeles, CA. The goal of sampling strategies in IRAS was to obtain representation of participants over the spectrum of glucose metabolism ranging from normal to diabetic.
Description

Between October 1992 and April 1994, IRAS recruited 1,625 participants from four clinical centers located in San Antonio, TX, San Luis Valley, CO, Oakland, CA and Los Angeles, CA. The goal of sampling strategies in IRAS was to obtain representation of participants over the spectrum of glucose metabolism ranging from normal to diabetic.

Data type

boolean

Alias
UMLS CUI [1,1]
C0332168
UMLS CUI [1,2]
C2949735
UMLS CUI [1,3]
C5575037
UMLS CUI [1,4]
C0017446
UMLS CUI [1,5]
C4505431
UMLS CUI [1,6]
C0596620
UMLS CUI [1,7]
C2827424
*Baseline Inclusion Criteria: *Men and women
Description

*Baseline Inclusion Criteria: *Men and women

Data type

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0079399
Age 40-69 years
Description

Age 40-69 years

Data type

boolean

Alias
UMLS CUI [1,1]
C0001779
Hispanic, non-Hispanic Whites and non-Hispanic Blacks.
Description

Hispanic, non-Hispanic Whites and non-Hispanic Blacks.

Data type

boolean

Alias
UMLS CUI [1,1]
C0015031
UMLS CUI [1,2]
C0019576
UMLS CUI [1,3]
C1518424
UMLS CUI [1,4]
C0085756
UMLS CUI [1,5]
C0043157
*Baseline Exclusion Criteria: *Current insulin treatment or any insulin treatment within the past five years
Description

*Baseline Exclusion Criteria: *Current insulin treatment or any insulin treatment within the past five years

Data type

boolean

Alias
UMLS CUI [1,1]
C2828389
UMLS CUI [1,2]
C0745343
UMLS CUI [1,3]
C0521116
UMLS CUI [1,4]
C0262926
Decompensated heart failure (recent worsening with weight gain, increasing edema, increasing dyspnea or orthopnea, rales)
Description

Decompensated heart failure (recent worsening with weight gain, increasing edema, increasing dyspnea or orthopnea, rales)

Data type

boolean

Alias
UMLS CUI [1,1]
C0581377
UMLS CUI [1,2]
C0442805
UMLS CUI [1,3]
C0521117
UMLS CUI [1,4]
C0043094
UMLS CUI [1,5]
C0743393
UMLS CUI [1,6]
C0013404
UMLS CUI [1,7]
C0034642
Decompensated emphysema or chronic lung disease
Description

Decompensated emphysema or chronic lung disease

Data type

boolean

Alias
UMLS CUI [1,1]
C0205434
UMLS CUI [1,2]
C0034067
UMLS CUI [1,3]
C0746102
Unstable angina
Description

Unstable angina

Data type

boolean

Alias
UMLS CUI [1,1]
C0002965
Cancer, other than skin cancer, for which the person is currently being treated
Description

Cancer, other than skin cancer, for which the person is currently being treated

Data type

boolean

Alias
UMLS CUI [1,1]
C0006826
UMLS CUI [1,2]
C0087111
UMLS CUI [1,3]
C0332300
UMLS CUI [1,4]
C0007114
Seizure disorder or epilepsy
Description

Seizure disorder or epilepsy

Data type

boolean

Alias
UMLS CUI [1,1]
C0036572
UMLS CUI [1,2]
C0014544
Kidney dialysis, transplant, or renal failure
Description

Kidney dialysis, transplant, or renal failure

Data type

boolean

Alias
UMLS CUI [1,1]
C0022671
UMLS CUI [1,2]
C0011946
UMLS CUI [1,3]
C1565489
A serious illness within the last month (e.g., heart attack, stroke, or major surgery)
Description

A serious illness within the last month (e.g., heart attack, stroke, or major surgery)

Data type

boolean

Alias
UMLS CUI [1,1]
C0262926
UMLS CUI [1,2]
C5419420
UMLS CUI [1,3]
C0332168
UMLS CUI [1,4]
C0027051
UMLS CUI [1,5]
C0038454
UMLS CUI [1,6]
C0679637
Treatment with oral, i.m., or i.v. cortisone, prednisone or other steroids
Description

Treatment with oral, i.m., or i.v. cortisone, prednisone or other steroids

Data type

boolean

Alias
UMLS CUI [1,1]
C0087111
UMLS CUI [1,2]
C1527415
UMLS CUI [1,3]
C1556154
UMLS CUI [1,4]
C1522726
UMLS CUI [1,5]
C0010137
UMLS CUI [1,6]
C0032952
UMLS CUI [1,7]
C0038317
Pregnancy
Description

Pregnancy

Data type

boolean

Alias
UMLS CUI [1,1]
C0032961
Breast cancer treated with surgery or radiation
Description

Breast cancer treated with surgery or radiation

Data type

boolean

Alias
UMLS CUI [1,1]
C0006142
UMLS CUI [1,2]
C0087111
UMLS CUI [1,3]
C0543467
UMLS CUI [1,4]
C1522449
Severe limitation of caloric intake ( < 800 calories)
Description

Severe limitation of caloric intake ( < 800 calories)

Data type

boolean

Alias
UMLS CUI [1,1]
C2164132
UMLS CUI [1,2]
C4489696
Obvious mental disability as noted in the screening interview.
Description

Obvious mental disability as noted in the screening interview.

Data type

boolean

Alias
UMLS CUI [1,1]
C0423893
UMLS CUI [1,2]
C5706969
UMLS CUI [1,3]
C0021822
UMLS CUI [1,4]
C0220908
A subset of IRAS Study participants were included in the genotyping study: Hispanics only; without diabetes; with insulin sensitivity obtained by frequently sampled intravenous glucose tolerance test; and providing consent for genetic studies.
Description

A subset of IRAS Study participants were included in the genotyping study: Hispanics only; without diabetes; with insulin sensitivity obtained by frequently sampled intravenous glucose tolerance test; and providing consent for genetic studies.

Data type

boolean

Alias
UMLS CUI [1,1]
C4554048
UMLS CUI [1,2]
C1515021
UMLS CUI [1,3]
C1285573
UMLS CUI [1,4]
C0086409
UMLS CUI [1,5]
C1549059
UMLS CUI [1,6]
C0011849
UMLS CUI [1,7]
C0920563
UMLS CUI [1,8]
C0332183
UMLS CUI [1,9]
C0870078
UMLS CUI [1,10]
C0021911
UMLS CUI [1,11]
C0021430
UMLS CUI [1,12]
C2827447
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Similar models

Eligibility Criteria

5 forms
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
Between October 1992 and April 1994, IRAS recruited 1,625 participants from four clinical centers located in San Antonio, TX, San Luis Valley, CO, Oakland, CA and Los Angeles, CA. The goal of sampling strategies in IRAS was to obtain representation of participants over the spectrum of glucose metabolism ranging from normal to diabetic.
Item
Between October 1992 and April 1994, IRAS recruited 1,625 participants from four clinical centers located in San Antonio, TX, San Luis Valley, CO, Oakland, CA and Los Angeles, CA. The goal of sampling strategies in IRAS was to obtain representation of participants over the spectrum of glucose metabolism ranging from normal to diabetic.
boolean
C0332168 (UMLS CUI [1,1])
C2949735 (UMLS CUI [1,2])
C5575037 (UMLS CUI [1,3])
C0017446 (UMLS CUI [1,4])
C4505431 (UMLS CUI [1,5])
C0596620 (UMLS CUI [1,6])
C2827424 (UMLS CUI [1,7])
*Baseline Inclusion Criteria: *Men and women
Item
*Baseline Inclusion Criteria: *Men and women
boolean
C1512693 (UMLS CUI [1,1])
C0079399 (UMLS CUI [1,2])
Age 40-69 years
Item
Age 40-69 years
boolean
C0001779 (UMLS CUI [1,1])
Hispanic, non-Hispanic Whites and non-Hispanic Blacks.
Item
Hispanic, non-Hispanic Whites and non-Hispanic Blacks.
boolean
C0015031 (UMLS CUI [1,1])
C0019576 (UMLS CUI [1,2])
C1518424 (UMLS CUI [1,3])
C0085756 (UMLS CUI [1,4])
C0043157 (UMLS CUI [1,5])
*Baseline Exclusion Criteria: *Current insulin treatment or any insulin treatment within the past five years
Item
*Baseline Exclusion Criteria: *Current insulin treatment or any insulin treatment within the past five years
boolean
C2828389 (UMLS CUI [1,1])
C0745343 (UMLS CUI [1,2])
C0521116 (UMLS CUI [1,3])
C0262926 (UMLS CUI [1,4])
Decompensated heart failure (recent worsening with weight gain, increasing edema, increasing dyspnea or orthopnea, rales)
Item
Decompensated heart failure (recent worsening with weight gain, increasing edema, increasing dyspnea or orthopnea, rales)
boolean
C0581377 (UMLS CUI [1,1])
C0442805 (UMLS CUI [1,2])
C0521117 (UMLS CUI [1,3])
C0043094 (UMLS CUI [1,4])
C0743393 (UMLS CUI [1,5])
C0013404 (UMLS CUI [1,6])
C0034642 (UMLS CUI [1,7])
Decompensated emphysema or chronic lung disease
Item
Decompensated emphysema or chronic lung disease
boolean
C0205434 (UMLS CUI [1,1])
C0034067 (UMLS CUI [1,2])
C0746102 (UMLS CUI [1,3])
Unstable angina
Item
Unstable angina
boolean
C0002965 (UMLS CUI [1,1])
Cancer, other than skin cancer, for which the person is currently being treated
Item
Cancer, other than skin cancer, for which the person is currently being treated
boolean
C0006826 (UMLS CUI [1,1])
C0087111 (UMLS CUI [1,2])
C0332300 (UMLS CUI [1,3])
C0007114 (UMLS CUI [1,4])
Seizure disorder or epilepsy
Item
Seizure disorder or epilepsy
boolean
C0036572 (UMLS CUI [1,1])
C0014544 (UMLS CUI [1,2])
Kidney dialysis, transplant, or renal failure
Item
Kidney dialysis, transplant, or renal failure
boolean
C0022671 (UMLS CUI [1,1])
C0011946 (UMLS CUI [1,2])
C1565489 (UMLS CUI [1,3])
A serious illness within the last month (e.g., heart attack, stroke, or major surgery)
Item
A serious illness within the last month (e.g., heart attack, stroke, or major surgery)
boolean
C0262926 (UMLS CUI [1,1])
C5419420 (UMLS CUI [1,2])
C0332168 (UMLS CUI [1,3])
C0027051 (UMLS CUI [1,4])
C0038454 (UMLS CUI [1,5])
C0679637 (UMLS CUI [1,6])
Treatment with oral, i.m., or i.v. cortisone, prednisone or other steroids
Item
Treatment with oral, i.m., or i.v. cortisone, prednisone or other steroids
boolean
C0087111 (UMLS CUI [1,1])
C1527415 (UMLS CUI [1,2])
C1556154 (UMLS CUI [1,3])
C1522726 (UMLS CUI [1,4])
C0010137 (UMLS CUI [1,5])
C0032952 (UMLS CUI [1,6])
C0038317 (UMLS CUI [1,7])
Pregnancy
Item
Pregnancy
boolean
C0032961 (UMLS CUI [1,1])
Breast cancer treated with surgery or radiation
Item
Breast cancer treated with surgery or radiation
boolean
C0006142 (UMLS CUI [1,1])
C0087111 (UMLS CUI [1,2])
C0543467 (UMLS CUI [1,3])
C1522449 (UMLS CUI [1,4])
Severe limitation of caloric intake ( < 800 calories)
Item
Severe limitation of caloric intake ( < 800 calories)
boolean
C2164132 (UMLS CUI [1,1])
C4489696 (UMLS CUI [1,2])
Obvious mental disability as noted in the screening interview.
Item
Obvious mental disability as noted in the screening interview.
boolean
C0423893 (UMLS CUI [1,1])
C5706969 (UMLS CUI [1,2])
C0021822 (UMLS CUI [1,3])
C0220908 (UMLS CUI [1,4])
A subset of IRAS Study participants were included in the genotyping study: Hispanics only; without diabetes; with insulin sensitivity obtained by frequently sampled intravenous glucose tolerance test; and providing consent for genetic studies.
Item
A subset of IRAS Study participants were included in the genotyping study: Hispanics only; without diabetes; with insulin sensitivity obtained by frequently sampled intravenous glucose tolerance test; and providing consent for genetic studies.
boolean
C4554048 (UMLS CUI [1,1])
C1515021 (UMLS CUI [1,2])
C1285573 (UMLS CUI [1,3])
C0086409 (UMLS CUI [1,4])
C1549059 (UMLS CUI [1,5])
C0011849 (UMLS CUI [1,6])
C0920563 (UMLS CUI [1,7])
C0332183 (UMLS CUI [1,8])
C0870078 (UMLS CUI [1,9])
C0021911 (UMLS CUI [1,10])
C0021430 (UMLS CUI [1,11])
C2827447 (UMLS CUI [1,12])
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