ID
45792
Beschreibung
Principal Investigator: Jorg J. Goronzy, MD PhD, Stanford University, Stanford, CA, USA MeSH: Herpes Zoster,Receptors, Antigen, T-Cell, alpha-beta,Vaccination https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001082 Diversity and size of the antigen-specific T cell receptor (TCR) repertoire are two critical determinants for successful control of chronic infection. Varicella zoster virus (VZV) that establishes latency during childhood is able to escape control mechanisms, in particular with increasing age. We examined the TCR diversity of VZV-specific CD4 T cells in individuals older than 50 years by studying three identical twin pairs and three unrelated individuals before and after vaccination with live attenuated VZV. While all individuals had a small number of dominant T cell clones, the breadth of the VZV-specific repertoire differed markedly among different individuals. A genetic influence was seen for the sharing of individual TCR sequences from antigen-specific cells, but not for repertoire richness or the selection of clonal dominance. VZV vaccination favored the expansion of infrequent VZV-specific TCRs including those from naïve T cells while leaving dominant T cell clones mostly unaffected.
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Versionen (1)
- 22.06.23 22.06.23 - Chiara Middel
Rechteinhaber
Jorg J. Goronzy, MD PhD, Stanford University, Stanford, CA, USA
Hochgeladen am
22. Juni 2023
DOI
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Lizenz
Creative Commons BY 4.0
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dbGaP phs001082 T Cell Responses to Varicella Zoster Virus
The subject consent data table contains subject IDs and consent group information.
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent data table contains subject IDs and consent group information.
- This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use.
- This pedigree data table contains family relationships in the format of family IDs, subject IDs, father IDs, mother IDs, sex of subjects, and twin IDs.
- This subject phenotype table includes sex and age of subjects, occurance of herpes zoster, and detection of HSV1, HSV2, and CMV.
- This sample attributes table includes tissue type, analyte type, histological type, and day sample was collected.
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The subject consent data table contains subject IDs and consent group information.
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent data table contains subject IDs and consent group information.
- This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use.
- This pedigree data table contains family relationships in the format of family IDs, subject IDs, father IDs, mother IDs, sex of subjects, and twin IDs.
- This subject phenotype table includes sex and age of subjects, occurance of herpes zoster, and detection of HSV1, HSV2, and CMV.
- This sample attributes table includes tissue type, analyte type, histological type, and day sample was collected.
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