ID

4577

Description

The goal of the study is to examine the cortical activity during speech perception and speech production in idiopathic stutterers compared to fluent speakers. Therefore, the noninvasive method of magnetoencephalography (MEG) is used. A better understanding for the complexity of speech perception and its pathology should be developed. Fundamental properties of stuttering are repetitions, prolongations, and blocks. In most cases stuttering emerges between 2 and 5 years of age. The auditory feedback should become less important during development, as soon as information about mispronounced words does not occur anymore. During speech development this control function should be adopted by other systems. In stutterers the dominance of the acoustic control should remain. Brain imaging studies with positron emission tomography (PET) or magnetic resonance imaging (MRI) show defects in the network of motor system, in the lateralization of speech areas, and functions of the auditory cortex. Magnetoencephalographic studies describe a similar variety as cause of stuttering. There may be defects in the auditory feedback, a modification of the lateralization of speech areas, or an alteration of co-action of motor planning and auditory system. The benefit of magnetoencephalography is a very good temporal resolution in the range of milliseconds combined with good spatial resolution. Therefore, it is well suited to examine the dynamics of cortical processing during stuttering. In this study evoked components of the auditory systems related to complex sounds, vocals, consonant-vocal combinations, and single words are analyzed. Differences of these components in the auditory cortices of stutterers and fluent speakers are hypothesized as well in temporal structure as in localization and lateralization.

Keywords

Versions (1)
  1. 12/11/13 12/11/13 - Martin Dugas
Uploaded on

December 11, 2013

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License

Creative Commons BY-NC 3.0 Legacy
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Eligibility NCT00148161 # Stuttering

German English

Eligibility

1 forms  
  1. StudyEvent: Eligibility
    1. Eligibility
Inclusion criteria
Description

Inclusion criteria

18 Years and older
Description

Age

Data type

boolean

Alias
UMLS CUI
C0001779
SNOMED CT 2010_0731
424144002
LNC
MTHU010047
Male
Description

Gender

Data type

boolean

Alias
UMLS CUI
C0079399
SNOMED CT 2010_0731
263495000
LNC
MTHU002975
Accepts Healthy Volunteers
Description

Healthy Volunteers

Data type

boolean

Alias
UMLS CUI
C1708335
Subjects with idiopathic stuttering (for the group of stutterers)
Description

Subjects with idiopathic stuttering (for the group of stutterers)

Data type

boolean

Alias
UMLS CUI
C0038506
MDR
10042267
SNOMED CT 2010_0731
39423001
UMLS CUI
C0454537
SNOMED CT 2010_0731
229626005
Fluently speaking subjects (for the control group)
Description

Fluently speaking subjects (for the control group)

Data type

boolean

Alias
UMLS CUI
C1708335
Right handed
Description

Right handed

Data type

boolean

Alias
UMLS CUI
C0344333
SNOMED CT 2010_0731
46669005
Normal hearing
Description

Normal hearing

Data type

boolean

Alias
UMLS CUI
C0234725
SNOMED CT 2010_0731
162339002
Exclusion criteria
Description

Exclusion criteria

Neurological diseases
Description

Neurological diseases

Data type

boolean

Alias
UMLS CUI
C0027765
ICD10CM
G00-G99
ICD9CM
349.9
MDR
10029202
SNOMED CT 2010_0731
118940003
Psychiatric diseases
Description

Psychiatric diseases

Data type

boolean

Alias
UMLS CUI
C0004936
ICD10CM
F01-F99
ICD9CM
290-319.99
MDR
10061284
SNOMED CT 2010_0731
74732009
Medication with neurological effective drugs
Description

Medication with neurological effective drugs

Data type

boolean

Alias
UMLS CUI
C0007680
SNOMED CT 2010_0731
372752008
Implants with magnetic impact
Description

Implants with magnetic impact

Data type

boolean

Alias
UMLS CUI
C0021102
SNOMED CT 2010_0731
#####
Medical Concepts
Description

Medical Concepts

Age
Description

Age

Data type

string

Alias
UMLS CUI
C0001779
SNOMED CT 2010_0731
424144002
LNC
MTHU010047
Gender
Description

Gender

Data type

string

Alias
UMLS CUI
C0079399
SNOMED CT 2010_0731
263495000
LNC
MTHU002975
Healthy Subject
Description

Healthy Subject

Data type

string

Alias
UMLS CUI
C1708335
stuttering
Description

stuttering

Data type

string

Alias
UMLS CUI
C0038506
MDR
10042267
SNOMED CT 2010_0731
39423001
Primary stuttering
Description

Primary stuttering

Data type

string

Alias
UMLS CUI
C0454537
SNOMED CT 2010_0731
229626005
Right handed
Description

Right handed

Data type

string

Alias
UMLS CUI
C0344333
SNOMED CT 2010_0731
46669005
Hearing normal
Description

Hearing normal

Data type

string

Alias
UMLS CUI
C0234725
SNOMED CT 2010_0731
162339002
nervous system disorder
Description

nervous system disorder

Data type

string

Alias
UMLS CUI
C0027765
ICD10CM
G00-G99
ICD9CM
349.9
MDR
10029202
SNOMED CT 2010_0731
118940003
Mental disorders
Description

Mental disorders

Data type

string

Alias
UMLS CUI
C0004936
ICD10CM
F01-F99
ICD9CM
290-319.99
MDR
10061284
SNOMED CT 2010_0731
74732009
Central Nervous System Agents
Description

Central Nervous System Agents

Data type

string

Alias
UMLS CUI
C0007680
SNOMED CT 2010_0731
372752008
Implant
Description

Implant

Data type

string

Alias
UMLS CUI
C0021102
SNOMED CT 2010_0731
#####
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Similar models

Eligibility

1 forms
  1. StudyEvent: Eligibility
    1. Eligibility
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
Inclusion criteria
Age
Item
18 Years and older
boolean
C0001779 (UMLS CUI)
424144002 (SNOMED CT 2010_0731)
MTHU010047 (LNC)
Gender
Item
Male
boolean
C0079399 (UMLS CUI)
263495000 (SNOMED CT 2010_0731)
MTHU002975 (LNC)
Healthy Volunteers
Item
Accepts Healthy Volunteers
boolean
C1708335 (UMLS CUI)
Subjects with idiopathic stuttering (for the group of stutterers)
Item
Subjects with idiopathic stuttering (for the group of stutterers)
boolean
C0038506 (UMLS CUI)
10042267 (MDR)
39423001 (SNOMED CT 2010_0731)
C0454537 (UMLS CUI)
229626005 (SNOMED CT 2010_0731)
Fluently speaking subjects (for the control group)
Item
Fluently speaking subjects (for the control group)
boolean
C1708335 (UMLS CUI)
Right handed
Item
Right handed
boolean
C0344333 (UMLS CUI)
46669005 (SNOMED CT 2010_0731)
Normal hearing
Item
Normal hearing
boolean
C0234725 (UMLS CUI)
162339002 (SNOMED CT 2010_0731)
Item Group
Exclusion criteria
Neurological diseases
Item
Neurological diseases
boolean
C0027765 (UMLS CUI)
G00-G99 (ICD10CM)
349.9 (ICD9CM)
10029202 (MDR)
118940003 (SNOMED CT 2010_0731)
Psychiatric diseases
Item
Psychiatric diseases
boolean
C0004936 (UMLS CUI)
F01-F99 (ICD10CM)
290-319.99 (ICD9CM)
10061284 (MDR)
74732009 (SNOMED CT 2010_0731)
Medication with neurological effective drugs
Item
Medication with neurological effective drugs
boolean
C0007680 (UMLS CUI)
372752008 (SNOMED CT 2010_0731)
Implants with magnetic impact
Item
Implants with magnetic impact
boolean
C0021102 (UMLS CUI)
##### (SNOMED CT 2010_0731)
Item Group
Medical Concepts
Age
Item
Age
string
C0001779 (UMLS CUI)
424144002 (SNOMED CT 2010_0731)
MTHU010047 (LNC)
Gender
Item
Gender
string
C0079399 (UMLS CUI)
263495000 (SNOMED CT 2010_0731)
MTHU002975 (LNC)
Healthy Subject
Item
Healthy Subject
string
C1708335 (UMLS CUI)
stuttering
Item
stuttering
string
C0038506 (UMLS CUI)
10042267 (MDR)
39423001 (SNOMED CT 2010_0731)
Primary stuttering
Item
Primary stuttering
string
C0454537 (UMLS CUI)
229626005 (SNOMED CT 2010_0731)
Right handed
Item
Right handed
string
C0344333 (UMLS CUI)
46669005 (SNOMED CT 2010_0731)
Hearing normal
Item
Hearing normal
string
C0234725 (UMLS CUI)
162339002 (SNOMED CT 2010_0731)
nervous system disorder
Item
nervous system disorder
string
C0027765 (UMLS CUI)
G00-G99 (ICD10CM)
349.9 (ICD9CM)
10029202 (MDR)
118940003 (SNOMED CT 2010_0731)
Mental disorders
Item
Mental disorders
string
C0004936 (UMLS CUI)
F01-F99 (ICD10CM)
290-319.99 (ICD9CM)
10061284 (MDR)
74732009 (SNOMED CT 2010_0731)
Central Nervous System Agents
Item
Central Nervous System Agents
string
C0007680 (UMLS CUI)
372752008 (SNOMED CT 2010_0731)
Implant
Item
Implant
string
C0021102 (UMLS CUI)
##### (SNOMED CT 2010_0731)
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