ID

4577

Descripción

The goal of the study is to examine the cortical activity during speech perception and speech production in idiopathic stutterers compared to fluent speakers. Therefore, the noninvasive method of magnetoencephalography (MEG) is used. A better understanding for the complexity of speech perception and its pathology should be developed. Fundamental properties of stuttering are repetitions, prolongations, and blocks. In most cases stuttering emerges between 2 and 5 years of age. The auditory feedback should become less important during development, as soon as information about mispronounced words does not occur anymore. During speech development this control function should be adopted by other systems. In stutterers the dominance of the acoustic control should remain. Brain imaging studies with positron emission tomography (PET) or magnetic resonance imaging (MRI) show defects in the network of motor system, in the lateralization of speech areas, and functions of the auditory cortex. Magnetoencephalographic studies describe a similar variety as cause of stuttering. There may be defects in the auditory feedback, a modification of the lateralization of speech areas, or an alteration of co-action of motor planning and auditory system. The benefit of magnetoencephalography is a very good temporal resolution in the range of milliseconds combined with good spatial resolution. Therefore, it is well suited to examine the dynamics of cortical processing during stuttering. In this study evoked components of the auditory systems related to complex sounds, vocals, consonant-vocal combinations, and single words are analyzed. Differences of these components in the auditory cortices of stutterers and fluent speakers are hypothesized as well in temporal structure as in localization and lateralization.

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Versiones (1)
  1. 11/12/13 11/12/13 - Martin Dugas
Subido en

11 de diciembre de 2013

DOI

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Licencia

Creative Commons BY-NC 3.0 Legacy
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Eligibility NCT00148161 # Stuttering

Alemán Inglés

Eligibility

1 formularios  
  1. StudyEvent: Eligibility
    1. Eligibility
Einschlusskriterien
Descripción

Einschlusskriterien

Age
Descripción

Age

Tipo de datos

boolean

Alias
UMLS CUI
C0001779
SNOMED CT 2010_0731
424144002
LNC
MTHU010047
Gender
Descripción

Gender

Tipo de datos

boolean

Alias
UMLS CUI
C0079399
SNOMED CT 2010_0731
263495000
LNC
MTHU002975
Healthy Volunteers
Descripción

Healthy Volunteers

Tipo de datos

boolean

Alias
UMLS CUI
C1708335
Subjects with idiopathic stuttering (for the group of stutterers)
Descripción

Subjects with idiopathic stuttering (for the group of stutterers)

Tipo de datos

boolean

Alias
UMLS CUI
C0038506
MDR
10042267
SNOMED CT 2010_0731
39423001
UMLS CUI
C0454537
SNOMED CT 2010_0731
229626005
Fluently speaking subjects (for the control group)
Descripción

Fluently speaking subjects (for the control group)

Tipo de datos

boolean

Alias
UMLS CUI
C1708335
Right handed
Descripción

Right handed

Tipo de datos

boolean

Alias
UMLS CUI
C0344333
SNOMED CT 2010_0731
46669005
Normal hearing
Descripción

Normal hearing

Tipo de datos

boolean

Alias
UMLS CUI
C0234725
SNOMED CT 2010_0731
162339002
Ausschlusskriterien
Descripción

Ausschlusskriterien

Neurological diseases
Descripción

Neurological diseases

Tipo de datos

boolean

Alias
UMLS CUI
C0027765
ICD10CM
G00-G99
ICD9CM
349.9
MDR
10029202
SNOMED CT 2010_0731
118940003
Psychiatric diseases
Descripción

Psychiatric diseases

Tipo de datos

boolean

Alias
UMLS CUI
C0004936
ICD10CM
F01-F99
ICD9CM
290-319.99
MDR
10061284
SNOMED CT 2010_0731
74732009
Medication with neurological effective drugs
Descripción

Medication with neurological effective drugs

Tipo de datos

boolean

Alias
UMLS CUI
C0007680
SNOMED CT 2010_0731
372752008
Implants with magnetic impact
Descripción

Implants with magnetic impact

Tipo de datos

boolean

Alias
UMLS CUI
C0021102
SNOMED CT 2010_0731
#####
Medizinische Konzepte
Descripción

Medizinische Konzepte

Age
Descripción

Age

Tipo de datos

string

Alias
UMLS CUI
C0001779
SNOMED CT 2010_0731
424144002
LNC
MTHU010047
Gender
Descripción

Gender

Tipo de datos

string

Alias
UMLS CUI
C0079399
SNOMED CT 2010_0731
263495000
LNC
MTHU002975
Healthy Subject
Descripción

Healthy Subject

Tipo de datos

string

Alias
UMLS CUI
C1708335
stuttering
Descripción

stuttering

Tipo de datos

string

Alias
UMLS CUI
C0038506
MDR
10042267
SNOMED CT 2010_0731
39423001
Primary stuttering
Descripción

Primary stuttering

Tipo de datos

string

Alias
UMLS CUI
C0454537
SNOMED CT 2010_0731
229626005
Right handed
Descripción

Right handed

Tipo de datos

string

Alias
UMLS CUI
C0344333
SNOMED CT 2010_0731
46669005
Hearing normal
Descripción

Hearing normal

Tipo de datos

string

Alias
UMLS CUI
C0234725
SNOMED CT 2010_0731
162339002
nervous system disorder
Descripción

nervous system disorder

Tipo de datos

string

Alias
UMLS CUI
C0027765
ICD10CM
G00-G99
ICD9CM
349.9
MDR
10029202
SNOMED CT 2010_0731
118940003
Mental disorders
Descripción

Mental disorders

Tipo de datos

string

Alias
UMLS CUI
C0004936
ICD10CM
F01-F99
ICD9CM
290-319.99
MDR
10061284
SNOMED CT 2010_0731
74732009
Central Nervous System Agents
Descripción

Central Nervous System Agents

Tipo de datos

string

Alias
UMLS CUI
C0007680
SNOMED CT 2010_0731
372752008
Implant
Descripción

Implant

Tipo de datos

string

Alias
UMLS CUI
C0021102
SNOMED CT 2010_0731
#####
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Similar models

Eligibility

1 formularios
  1. StudyEvent: Eligibility
    1. Eligibility
Name
Tipo
Description | Question | Decode (Coded Value)
Tipo de datos
Alias
Item Group
Einschlusskriterien
Age
Item
boolean
C0001779 (UMLS CUI)
424144002 (SNOMED CT 2010_0731)
MTHU010047 (LNC)
Gender
Item
boolean
C0079399 (UMLS CUI)
263495000 (SNOMED CT 2010_0731)
MTHU002975 (LNC)
Healthy Volunteers
Item
boolean
C1708335 (UMLS CUI)
Subjects with idiopathic stuttering (for the group of stutterers)
Item
boolean
C0038506 (UMLS CUI)
10042267 (MDR)
39423001 (SNOMED CT 2010_0731)
C0454537 (UMLS CUI)
229626005 (SNOMED CT 2010_0731)
Fluently speaking subjects (for the control group)
Item
boolean
C1708335 (UMLS CUI)
Right handed
Item
boolean
C0344333 (UMLS CUI)
46669005 (SNOMED CT 2010_0731)
Normal hearing
Item
boolean
C0234725 (UMLS CUI)
162339002 (SNOMED CT 2010_0731)
Item Group
Ausschlusskriterien
Neurological diseases
Item
boolean
C0027765 (UMLS CUI)
G00-G99 (ICD10CM)
349.9 (ICD9CM)
10029202 (MDR)
118940003 (SNOMED CT 2010_0731)
Psychiatric diseases
Item
boolean
C0004936 (UMLS CUI)
F01-F99 (ICD10CM)
290-319.99 (ICD9CM)
10061284 (MDR)
74732009 (SNOMED CT 2010_0731)
Medication with neurological effective drugs
Item
boolean
C0007680 (UMLS CUI)
372752008 (SNOMED CT 2010_0731)
Implants with magnetic impact
Item
boolean
C0021102 (UMLS CUI)
##### (SNOMED CT 2010_0731)
Item Group
Medizinische Konzepte
Age
Item
string
C0001779 (UMLS CUI)
424144002 (SNOMED CT 2010_0731)
MTHU010047 (LNC)
Gender
Item
string
C0079399 (UMLS CUI)
263495000 (SNOMED CT 2010_0731)
MTHU002975 (LNC)
Healthy Subject
Item
string
C1708335 (UMLS CUI)
stuttering
Item
string
C0038506 (UMLS CUI)
10042267 (MDR)
39423001 (SNOMED CT 2010_0731)
Primary stuttering
Item
string
C0454537 (UMLS CUI)
229626005 (SNOMED CT 2010_0731)
Right handed
Item
string
C0344333 (UMLS CUI)
46669005 (SNOMED CT 2010_0731)
Hearing normal
Item
string
C0234725 (UMLS CUI)
162339002 (SNOMED CT 2010_0731)
nervous system disorder
Item
string
C0027765 (UMLS CUI)
G00-G99 (ICD10CM)
349.9 (ICD9CM)
10029202 (MDR)
118940003 (SNOMED CT 2010_0731)
Mental disorders
Item
string
C0004936 (UMLS CUI)
F01-F99 (ICD10CM)
290-319.99 (ICD9CM)
10061284 (MDR)
74732009 (SNOMED CT 2010_0731)
Central Nervous System Agents
Item
string
C0007680 (UMLS CUI)
372752008 (SNOMED CT 2010_0731)
Implant
Item
string
C0021102 (UMLS CUI)
##### (SNOMED CT 2010_0731)
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