ID
45714
Description
Principal Investigator: Eric Boerwinkle, PhD, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA MeSH: Cardiovascular Diseases,Thromboembolism,Venous Thromboembolism,Arrhythmias, Cardiac,Atrial Fibrillation https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001211 Participants from the Atherosclerosis Risk in Communities (ARIC) Study, a large population-based longitudinal cohort study, have been included in this Project and whole genome sequencing will be performed to contribute to analyses of early-onset atrial fibrillation and venous thromboembolism. Additional phenotype and genotype data are available for these individuals on dbGaP and can be accessed through the parent ARIC Cohort accession (phs000280). The National Heart, Lung and Blood Institute (NHLBI) Trans-Omics for Precision Medicine (TOPMed) program is designed to generate scientific resources to enhance understanding of fundamental biological processes that underlie heart, lung, blood and sleep disorders (HLBS). It is part of a broader Precision Medicine Initiative, which aims to provide disease treatments that are tailored to an individual's unique genes and environment. TOPMed will contribute to this initiative through the integration of whole genome sequencing (WGS) and other -omics (e.g., metabolic profiles, protein and RNA expression patterns) data with molecular, behavioral, imaging, environmental, and clinical data. In doing so, this program seeks to uncover factors that increase or decrease the risk of disease, identify subtypes of disease, and develop more targeted and personalized treatments. The Whole Genome Sequencing (WGS) Project is part of NHLBI's TOPMed program and serves as an initial step for the larger initiative.
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Versions (1)
- 5/17/23 5/17/23 - Chiara Middel
Copyright Holder
Eric Boerwinkle, PhD, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA
Uploaded on
May 17, 2023
DOI
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License
Creative Commons BY 4.0
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dbGaP phs001211 NHLBI TOPMed - NHGRI CCDG: Atherosclerosis Risk in Communities (ARIC)
This sample attributes data table includes body site where sample was collected, analyte type, tumor status, sequencing center, funding source, TOPMed phase, project and study name, venous thrombus embolism group, cardiovascular disease group, and sample aliases.
- StudyEvent: SEV1
- Eligibility Criteria
- This subject consent data table contains subject IDs, consent group information, and subject aliases.
- This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs.
- This sample attributes data table includes body site where sample was collected, analyte type, tumor status, sequencing center, funding source, TOPMed phase, project and study name, venous thrombus embolism group, cardiovascular disease group, and sample aliases.
Similar models
This sample attributes data table includes body site where sample was collected, analyte type, tumor status, sequencing center, funding source, TOPMed phase, project and study name, venous thrombus embolism group, cardiovascular disease group, and sample aliases.
- StudyEvent: SEV1
- Eligibility Criteria
- This subject consent data table contains subject IDs, consent group information, and subject aliases.
- This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs.
- This sample attributes data table includes body site where sample was collected, analyte type, tumor status, sequencing center, funding source, TOPMed phase, project and study name, venous thrombus embolism group, cardiovascular disease group, and sample aliases.
C1299222 (UMLS CUI [1,2])
C1518422 (UMLS CUI [1,2])
C0565990 (UMLS CUI [1,2])
C1561491 (UMLS CUI [1,3])
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C0449416 (UMLS CUI [1,3])
C0205390 (UMLS CUI [1,2])
C1709701 (UMLS CUI [1,2])
C0243098 (UMLS CUI [1,3])
C1561491 (UMLS CUI [1,4])
C1806781 (UMLS CUI [1,2])
C2348560 (UMLS CUI [1,3])
C0441833 (UMLS CUI [1,2])
C1299222 (UMLS CUI [1,2])
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